The default mode network in healthy aging and Alzheimer's disease

International Journal of Alzheimer's Disease

Volumn , Issue , 2011, Pages

  Desgranges, Béatrice ^a   Mevel, Katell ^a   Chételat, Gal ^a   Eustache, Francis ^a  

^a CHU CÔTE DE NACRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4;

AGING; ALZHEIMER DISEASE; BRAIN REGION; COGNITION; DEFAULT MODE NETWORK; HUMAN; MILD COGNITIVE IMPAIRMENT; NEUROANATOMY; NEUROIMAGING; POSTERIOR CINGULATE; PRIORITY JOURNAL; REVIEW;

EID: 80052663726     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.4061/2011/535816     Document Type: Review

References (99)

1. Ghatan P. H., Hsieh J. C., Wirsen-Meurling A., Wredling R., Eriksson L., Stone-Elander S., Levander S., Ingvar M., Brain activation induced by the perceptual maze test: a PET study of cognitive performance NeuroImage 1995 2 2 112 124
2. Hutchinson M., Schiffer W., Joseffer S., Liu A., Schlosser R., Dikshit S., Goldberg E., Brodie J. D., Task-specific deactivation patterns in functional magnetic resonance imaging Magnetic Resonance Imaging 1999 17 10 1427 1436
3. Gusnard D. A., Raichle M. E., Searching for a baseline: functional imaging and the resting human brain Nature Reviews Neuroscience 2001 2 10 685 694 (Pubitemid 33674814)
4. Newman S. D., Twieg D. B., Carpenter P. A., Baseline conditions and subtractive logic in neuroimaging Human Brain Mapping 2001 14 4 228 235 (Pubitemid 33117501)
5. McKiernan K. A., Kaufman J. N., Kucera-Thompson J., Binder J. R., A parametric manipulation of factors affecting task-induced deactivation in functional neuroimaging Journal of Cognitive Neuroscience 2003 15 3 394 408 (Pubitemid 36438949)
6. Rombouts S. A. R. B., Barkhof F., Goekoop R., Stam C. J., Scheltens P., Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study Human Brain Mapping 2005 26 4 231 239 (Pubitemid 41759880)
7. Persson J., Lustig C., Nelson J. K., Reuter-Lorenz P. A., Age differences in deactivation: a link to cognitive control? Journal of Cognitive Neuroscience 2007 19 6 1021 1032 (Pubitemid 46849737)
8. Logothetis N. K., The underpinnings of the BOLD functional magnetic resonance imaging signal Journal of Neuroscience 2003 23 10 3963 3971 (Pubitemid 36958412)
9. Raichle M. E., Mintun M. A., Brain work and brain imaging Annual Review of Neuroscience 2006 29 449 476 (Pubitemid 44476853)
10. Fukunaga M., Horovitz S. G., van Gelderen P., de Zwart J. A., Jansma J. M., Ikonomidou V. N., Chu R., Deckers R. H. R., Leopold D. A., Duyn J. H., Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages Magnetic Resonance Imaging 2006 24 8 979 992 (Pubitemid 44425396)
11. Shmueli K., van Gelderen P., de Zwart J. A., Horovitz S. G., Fukunaga M., Jansma J. M., Duyn J. H., Low-frequency fluctuations in the cardiac rate as a source of variance in the resting-state fMRI BOLD signal NeuroImage 2007 38 2 306 320 (Pubitemid 47534282)
12. Boly M., Phillips C., Tshibanda L., Vanhaudenhuyse A., Schabus M., Dang-Vu T. T., Moonen G., Hustinx R., Maquet P., Laureys S., Intrinsic brain activity in altered states of consciousness: how conscious is the default mode of brain function? Annals of the New York Academy of Sciences 2008 1129 119 129 (Pubitemid 351990285)
13. Buckner R. L., Andrews-Hanna J. R., Schacter D. L., The brain's default network: anatomy, function, and relevance to disease Annals of the New York Academy of Sciences 2008 1124 1 38 (Pubitemid 351506788)
14. Martuzzi R., Ramani R., Qiu M., Rajeevan N., Constable R. T., Functional connectivity and alterations in baseline brain state in humans NeuroImage 2010 49 1 823 834
15. Rogers B. P., Morgan V. L., Newton A. T., Gore J. C., Assessing functional connectivity in the human brain by fMRI Magnetic Resonance Imaging 2007 25 10 1347 1357 (Pubitemid 350122908)
16. van den Heuvel M. P., Hulshoff Pol H. E., Exploring the brain network: a review on resting-state fMRI functional connectivity European Neuropsychopharmacology 2010 20 8 519 534
17. Vincent J. L., Patel G. H., Fox M. D., Snyder A. Z., Baker J. T., Van Essen D. C., Zempel J. M., Snyder L. H., Corbetta M., Raichle M. E., Intrinsic functional architecture in the anaesthetized monkey brain Nature 2007 447 7140 83 86 (Pubitemid 46685840)
18. Rilling J. K., Barks S. K., Parr L. A., Preuss T. M., Faber T. L., Pagnoni G., Bremner J. D., Votaw J. R., A comparison of resting-state brain activity in humans and chimpanzees Proceedings of the National Academy of Sciences of the United States of America 2007 104 43 17146 17151 (Pubitemid 350211005)
19. Zhang N., Rane P., Huang W., Liang Z., Kennedy D., Frazier J. A., King J., Mapping resting-state brain networks in conscious animals Journal of Neuroscience Methods 2010 189 2 186 196
20. Damaraju E., Phillips J. R., Lowe J. R., Resting-state functional connectivity differences in premature children Frontiers in Systems Neuroscience 2010 4 23
21. Smyser C. D., Inder T. E., Shimony J. S., Hill J. E., Degnan A. J., Snyder A. Z., Neil J. J., Longitudinal analysis of neural network development in preterm infants Cerebral Cortex 2010 20 12 2852 2862
22. Tomasi D., Volkow N. D., Functional connectivity density mapping Proceedings of the National Academy of Sciences of the United States of America 2010 107 21 9885 9890
23. Buckner R. L., Sepulcre J., Talukdar T., Krienen F. M., Liu H., Hedden T., Andrews-Hanna J. R., Sperling R. A., Johnson K. A., Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease Journal of Neuroscience 2009 29 6 1860 1873
24. De Luca M., Beckmann C. F., De Stefano N., Matthews P. M., Smith S. M., fMRI resting state networks define distinct modes of long-distance interactions in the human brain NeuroImage 2006 29 4 1359 1367 (Pubitemid 43184199)
25. Greicius M. D., Supekar K., Menon V., Dougherty R. F., Resting-state functional connectivity reflects structural connectivity in the default mode network Cerebral Cortex 2009 19 1 72 78
26. Skudlarski P., Jagannathan K., Calhoun V. D., Hampson M., Skudlarska B. A., Pearlson G., Measuring brain connectivity: diffusion tensor imaging validates resting state temporal correlations NeuroImage 2008 43 3 554 561
27. Teipel S. J., Bokde A. L. W., Meindl T., Amaro E., Soldner J., Reiser M. F., Herpertz S. C., Mller H. J., Hampel H., White matter microstructure underlying default mode network connectivity in the human brain NeuroImage 2010 49 3 2021 2032
28. Van Den Heuvel M., Mandl R., Luigjes J., Pol H. H., Microstructural organization of the cingulum tract and the level of default mode functional connectivity Journal of Neuroscience 2008 28 43 10844 10851
29. Van Den Heuvel M. P., Mandl R. C. W., Kahn R. S., Hulshoff Pol H. E., Functionally linked resting-state networks reflect the underlying structural connectivity architecture of the human brain Human Brain Mapping 2009 30 10 3127 3141
30. Kjaer T. W., Nowak M., Lou H. C., Reflective self-awareness and conscious states: PET evidence for a common midline parietofrontal core NeuroImage 2002 17 2 1080 1086 (Pubitemid 35317039)
31. Piolino P., Giffard-Quillon G., Desgranges B., Chételat G., Baron J. C., Eustache F., Re-experiencing old memories via hippocampus: a PET study of autobiographical memory NeuroImage 2004 22 3 1371 1383 (Pubitemid 38829225)
32. D'Argembeau A., Collette F., Van Der Linden M., Laureys S., Del Fiore G., Degueldre C., Luxen A., Salmon E., Self-referential reflective activity and its relationship with rest: a PET study NeuroImage 2005 25 2 616 624 (Pubitemid 40387344)
33. Ries M. L., Schmitz T. W., Kawahara T. N., Torgerson B. M., Trivedi M. A., Johnson S. C., Task-dependent posterior cingulate activation in mild cognitive impairment NeuroImage 2006 29 2 485 492 (Pubitemid 43063305)
34. Buckner R. L., Carroll D. C., Self-projection and the brain Trends in Cognitive Sciences 2007 11 2 49 57 (Pubitemid 46176697)
35. Schneider F., Bermpohl F., Heinzel A., Rotte M., Walter M., Tempelmann C., Wiebking C., Dobrowolny H., Heinze H. J., Northoff G., The resting brain and our self: self-relatedness modulates resting state neural activity in cortical midline structures Neuroscience 2008 157 1 120 131
36. Amodio D. M., Frith C. D., Meeting of minds: the medial frontal cortex and social cognition Nature Reviews Neuroscience 2006 7 4 268 277
37. Milner B., The medial temporal-lobe amnesic syndrome Psychiatric Clinics of North America 2005 28 3 599 611 (Pubitemid 41191136)
38. Viard A., Piolino P., Desgranges B., Chételat G., Lebreton K., Landeau B., Young A., De La Sayette V., Eustache F., Hippocampal activation for autobiographical memories over the entire lifetime in healthy aged subjects: an fMRI study Cerebral Cortex 2007 17 10 2453 2467 (Pubitemid 47517480)
39. Binder J. R., Desai R. H., Graves W. W., Conant L. L., Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies Cerebral Cortex 2009 19 12 2767 2796
40. Chambers C. D., Payne J. M., Stokes M. G., Mattingley J. B., Fast and slow parietal pathways mediate spatial attention Nature Neuroscience 2004 7 3 217 218 (Pubitemid 38280443)
41. Andreasen N. C., O'Leary D. S., Cizadlo T., Arndt S., Rezai K., Watkins G. L., Ponto L. L. B., Hichwa R. D., Remembering the past: two facets of episodic memory explored with positron emission tomography American Journal of Psychiatry 1995 152 11 1576 1585
42. Schacter D. L., Addis D. R., Buckner R. L., Remembering the past to imagine the future: the prospective brain Nature Reviews Neuroscience 2007 8 9 657 661 (Pubitemid 47283147)
43. Schacter D. L., Addis D. R., Buckner R. L., Episodic simulation of future events: concepts, data, and applications Annals of the New York Academy of Sciences 2008 1124 39 60 (Pubitemid 351506779)
44. Schilbach L., Eickhoff S. B., Rotarska-Jagiela A., Fink G. R., Vogeley K., Minds at rest? Social cognition as the default mode of cognizing and its putative relationship to the "default system" of the brain Consciousness and Cognition 2008 17 2 457 467
45. Spreng R. N., Mar R. A., Kim A. S. N., The common neural basis of autobiographical memory, prospection, navigation, theory of mind, and the default mode: a quantitative meta-analysis Journal of Cognitive Neuroscience 2009 21 3 489 510
46. Mason M. F., Norton M. I., Van Horn J. D., Wegner D. M., Grafton S. T., Macrae C. N., Wandering minds: the default network and stimulus-independent thought Science 2007 315 5810 393 395 (Pubitemid 46175523)
47. Mazoyer B., Zago L., Mellet E., Bricogne S., Etard O., Houdé O., Crivello F., Joliot M., Petit L., Tzourio-Mazoyer N., Cortical networks for working memory and executive functions sustain the conscious resting state in man Brain Research Bulletin 2001 54 3 287 298 (Pubitemid 32273621)
48. Fransson P., Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis Human Brain Mapping 2005 26 1 15 29 (Pubitemid 41232552)
49. Delamillieure P., Doucet G., Mazoyer B., Turbelin M. R., Delcroix N., Mellet E., Zago L., Crivello F., Petit L., Tzourio-Mazoyer N., Joliot M., The resting state questionnaire: an introspective questionnaire for evaluation of inner experience during the conscious resting state Brain Research Bulletin 2010 81 6 565 573
50. Shulman G. L., Corbetta M., Fiez J. A., Buckner R. L., Miezin F. M., Raichle M. E., Petersen S. E., Searching for activations that generalize over tasks Human Brain Mapping 1997 5 4 317 322 (Pubitemid 27375534)
51. Hahn B., Ross T. J., Stein E. A., Cingulate activation increases dynamically with response speed under stimulus unpredictability Cerebral Cortex 2007 17 7 1664 1671
52. Damoiseaux J. S., Beckmann C. F., Arigita E. J. S., Barkhof F., Scheltens PH., Stam C. J., Smith S. M., Rombouts S. A. R. B., Reduced resting-state brain activity in the "default network" in normal aging Cerebral Cortex 2008 18 8 1856 1864 (Pubitemid 352019901)
53. Lustig C., Snyder A. Z., Bhakta M., O'Brien K. C., McAvoy M., Raichle M. E., Morris J. C., Buckner R. L., Functional deactivations: change with age and dementia of the Alzheimer type Proceedings of the National Academy of Sciences of the United States of America 2003 100 2 14504 14509 (Pubitemid 37499266)
54. Grady C. L., Springer M. V., Hongwanishkul D., McIntosh A. R., Winocur G., Age-related changes in brain activity across the adult lifespan Journal of Cognitive Neuroscience 2006 18 2 227 241
55. Grady C. L., Protzner A. B., Kovacevic N., Strother S. C., Afshin-Pour B., Wojtowicz M., Anderson J. A. E., Churchill N., McIntosh A. R., A multivariate analysis of age-related differences in default mode and task-positive networks across multiple cognitive domains Cerebral Cortex 2010 20 6 1432 1447
56. Davis S. W., Dennis N. A., Daselaar S. M., Fleck M. S., Cabeza R., Qué PASA? the posterior-anterior shift in aging Cerebral Cortex 2008 18 5 1201 1209
57. Miller S. L., Celone K., DePeau K., Diamond E., Dickerson B. C., Rentz D., Pihlajamki M., Sperling R. A., Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation Proceedings of the National Academy of Sciences of the United States of America 2008 105 6 2181 2186 (Pubitemid 351439485)
58. Sambataro F., Murty V. P., Callicott J. H., Tan H. Y., Das S., Weinberger D. R., Mattay V. S., Age-related alterations in default mode network: impact on working memory performance Neurobiology of Aging 2010 31 5 839 852
59. Koch W., Teipel S., Mueller S., Buerger K., Bokde A. L. W., Hampel H., Coates U., Reiser M., Meindl T., Effects of aging on default mode network activity in resting state fMRI: does the method of analysis matter? NeuroImage 2010 51 1 280 287
60. Andrews-Hanna J. R., Snyder A. Z., Vincent J. L., Lustig C., Head D., Raichle M., Buckner R. L., Disruption of large-scale brain systems in advanced aging Neuron 2007 56 5 924 935 (Pubitemid 350181355)
61. Esposito F., Aragri A., Pesaresi I., Cirillo S., Tedeschi G., Marciano E., Goebel R., Di Salle F., Independent component model of the default-mode brain function: combining individual-level and population-level analyses in resting-state fMRI Magnetic Resonance Imaging 2008 26 7 905 913
62. Gould R. L., Brown R. G., Owen A. M., Bullmore E. T., Howard R. J., Task-induced deactivations during successful paired associates learning: an effect of age but not Alzheimer's disease NeuroImage 2006 31 2 818 831 (Pubitemid 43776651)
63. Guye M., Bettus G., Bartolomei F., Cozzone P. J., Graph theoretical analysis of structural and functional connectivity MRI in normal and pathological brain networks Magnetic Resonance Materials in Physics, Biology and Medicine 2010 23 5-6 409 421
64. Chételat G., Desgranges B., De la Sayette V., Viader F., Berkouk K., Landeau B., Lalevée C., Le Doze F., Dupuy B., Hannequin D., Baron J. C., Eustache F., Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment Brain 2003 126 9 1955 1967 (Pubitemid 37059435)
65. Shi F., Liu B., Zhou Y., Yu C., Jiang T., Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: meta-analyses of MRI studies Hippocampus 2009 19 11 1055 1064
66. Gili T., Cercignani M., Serra L., Perri R., Giove F., Maraviglia B., Caltagirone C., Bozzali M., Regional brain atrophy and functional disconnection across Alzheimer's disease evolution Journal of Neurology, Neurosurgery and Psychiatry 2011 82 1 58 66
67. Koch W., Teipel S., Mueller S., Benninghoff J., Wagner M., Bokde A. L. W., Hampel H., Coates U., Reiser M., Meindl T., Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer's disease. Neurobiology of Aging. In press
68. Persson J., Lind J., Larsson A., Ingvar M., Sleegers K., Van Broeckhoven C., Adolfsson R., Nilsson L. G., Nyberg L., Altered deactivation in individuals with genetic risk for Alzheimer's disease Neuropsychologia 2008 46 6 1679 1687
69. Fleisher A. S., Sherzai A., Taylor C., Langbaum J. B. S., Chen K., Buxton R. B., Resting-state BOLD networks versus task-associated functional MRI for distinguishing Alzheimer's disease risk groups NeuroImage 2009 47 4 1678 1690
70. Pihlajamki M., Sperling R. A., Functional MRI assessment of task-induced deactivation of the default mode network in Alzheimer's disease and at-risk older individuals Behavioural Neurology 2009 21 1-2 77 91
71. Filippini N., MacIntosh B. J., Hough M. G., Goodwin G. M., Frisoni G. B., Smith S. M., Matthews P. M., Beckmann C. F., Mackay C. E., Distinct patterns of brain activity in young carriers of the APOE- 4 allele Proceedings of the National Academy of Sciences of the United States of America 2009 106 17 7209 7214
72. Filippini N., Ebmeier K. P., MacIntosh B. J., Trachtenberg A. J., Frisoni G. B., Wilcock G. K., Beckmann C. F., Smith S. M., Matthews P. M., Mackay C. E., Differential effects of the APOE genotype on brain function across the lifespan NeuroImage 2011 54 1 602 610
73. Heise V., Filippini N., Ebmeier K. P., Mackay C. E., The APOE varepsilon4 allele modulates brain white matter integrity in healthy adults. Molecular Psychiatry. In press
74. Trachtenberg A. J., Filippini N., Mackay C. E., The effects of APOE- 4 on the BOLD response. Neurobiology of Aging. In press
75. Lind J., Persson J., Ingvar M., Larsson A., Cruts M., Van Broeckhoven C., Adolfsson R., Bckman L., Nilsson L. G., Petersson K. M., Nyberg L., Reduced functional brain activity response in cognitively intact apolipoprotein E 4 carriers Brain 2006 129 5 1240 1248
76. Chételat G., Desgranges B., Landeau B., Mézenge F., Poline J. B., De La Sayette V., Viader F., Eustache F., Baron J. C., Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease Brain 2008 131 1 60 71
77. Villain N., Desgranges B., Viader F., De La Sayette V., Mézenge F., Landeau B., Baron J. C., Eustache F., Chételat G., Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease Journal of Neuroscience 2008 28 24 6174 6181
78. Villain N., Fouquet M., Baron J.-C., Mézenge F., Landeau B., De La Sayette V., Viader F., Eustache F., Desgranges B., Chételat G., Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer's disease Brain 2010 133 11 3301 3314
79. Greicius M. D., Srivastava G., Reiss A. L., Menon V., Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI Proceedings of the National Academy of Sciences of the United States of America 2004 101 13 4637 4642 (Pubitemid 38437463)
80. Celone K. A., Calhoun V. D., Dickerson B. C., Atri A., Chua E. F., Miller S. L., DePeau K., Rentz D. M., Selkoe D. J., Blacker D., Albert M. S., Sperling R. A., Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis Journal of Neuroscience 2006 26 40 10222 10231 (Pubitemid 44527415)
81. Rombouts S. A. R. B., Damoiseaux J. S., Goekoop R., Barkhof F., Scheltens P., Smith S. M., Beckmann C. F., Model-free group analysis shows altered BOLD FMRI networks in dementia Human Brain Mapping 2009 30 1 256 266
82. Zhou J., Greicius M. D., Gennatas E. D., Growdon M. E., Jang J. Y., Rabinovici G. D., Kramer J. H., Weiner M., Miller B. L., Seeley W. W., Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease Brain 2010 133 5 1352 1367
83. Sorg C., Riedl V., Mhlau M., Calhoun V. D., Eichele T., Ler L., Drzezga A., Frstl H., Kurz A., Zimmer C., Wohlschlger A. M., Selective changes of resting-state networks in individuals at risk for Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2007 104 47 18760 18765 (Pubitemid 350210770)
84. Bai F., Zhang Z., Yu H., Shi Y., Yuan Y., Zhu W., Zhang X., Qian Y., Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: a combined structural and resting-state functional MRI study Neuroscience Letters 2008 438 1 111 115
85. Supekar K., Menon V., Rubin D., Musen M., Greicius M. D., Network analysis of intrinsic functional brain connectivity in Alzheimer's disease PLoS Computational Biology 2008 4 6 11
86. Qi Z., Wu X., Wang Z., Zhang N., Dong H., Yao L., Li K., Impairment and compensation coexist in amnestic MCI default mode network NeuroImage 2010 50 1 48 55
87. Xu Y., Xu G., Wu G., Antuono P., Rowe D. B., Li S. J., The phase shift index for marking functional asynchrony in Alzheimer's disease patients using fMRI Magnetic Resonance Imaging 2008 26 3 379 392
88. Li S. J., Li Z., Wu G., Zhang M. J., Franczak M., Antuono P. G., Alzheimer disease: evaluation of a functional MR imaging index as a marker Radiology 2002 225 1 253 259
89. Wang L., Zang Y., He Y., Liang M., Zhang X., Tian L., Wu T., Jiang T., Li K., Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI NeuroImage 2006 31 2 496 504 (Pubitemid 43776683)
90. Allen G., Barnard H., McColl R., Hester A. L., Fields J. A., Weiner M. F., Ringe W. K., Lipton A. M., Brooker M., McDonald E., Rubin C. D., Cullum C. M., Reduced hippocampal functional connectivity in Alzheimer disease Archives of Neurology 2007 64 10 1482 1487 (Pubitemid 47572671)
91. Zhang H. Y., Wang S. J., Xing J., Liu B., Ma Z. L., Yang M., Zhang Z. J., Teng G. J., Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer's disease Behavioural Brain Research 2009 197 1 103 108
92. Zhang H.-Y., Wang S.-J., Liu B., Ma Z.-L., Yang M., Zhang Z.-J., Teng G.-J., Resting brain connectivity: changes during the progress of Alzheimer disease Radiology 2010 256 2 598 606
93. Bosch B., Bartrés-Faz D., Rami L., Arenaza-Urquijo E. M., Fernndez-Espejo D., Junqué C., Solé-Padullés C., Snchez-Valle R., Bargall N., Falcn C., Molinuevo J. L., Cognitive reserve modulates task-induced activations and deactivations in healthy elders, amnestic mild cognitive impairment and mild Alzheimer's disease Cortex 2010 46 4 451 461
94. Bai F., Liao W., Watson D. R., Shi Y., Wang Y., Yue C., Teng Y., Wu D., Yuan Y., Jia J., Zhang Z., Abnormal whole-brain functional connection in amnestic mild cognitive impairment patients Behavioural Brain Research 2011 216 2 666 672
95. He Y., Wang L., Zang Y., Tian L., Zhang X., Li K., Jiang T., Regional coherence changes in the early stages of Alzheimer's disease: a combined structural and resting-state functional MRI study NeuroImage 2007 35 2 488 500 (Pubitemid 46400540)
96. Stern Y., What is cognitive reserve? Theory and research application of the reserve concept Journal of the International Neuropsychological Society 2002 8 3 448 460 (Pubitemid 34296102)
97. Petrella J. R., Prince S. E., Wang L., Hellegers C., Doraiswamy P. M., Prognostic value of posteromedial cortex deactivation in mild cognitive impairment PLoS ONE 2007 2 10
98. Wermke M., Sorg C., Wohlschlger A. M., Drzezga A., A new integrative model of cerebral activation, deactivation and default mode function in Alzheimer's disease European Journal of Nuclear Medicine and Molecular Imaging 2008 35 1 S12 S24
99. Sperling R. A., LaViolette P. S., O'Keefe K., O'Brien J., Rentz D. M., Pihlajamaki M., Marshall G., Hyman B. T., Selkoe D. J., Hedden T., Buckner R. L., Becker J. A., Johnson K. A., Amyloid deposition is associated with impaired default network function in older persons without dementia Neuron 2009 63 2 178 188