A novel compound derived from danshensu inhibits apoptosis via upregulation of heme oxygenase-1 expression in SH-SY5Y cells

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 4, 2013, Pages 2861-2871

  Pan, Li Long ^a   Liu, Xin Hua ^a   Jia, Yao Ling ^a   Wu, Dan ^a   Xiong, Qing Hui ^a   Gong, Qi Hai ^a   Wang, Yang ^a   Zhu, Yi Zhun ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; Danshensu cysteine derivative; Heme oxygenase 1; Neurodegenerative disorder

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; [4 [2 ACETOXY 3 (BENZYLTHIO) 1 METHOXY 1 OXOPROPAN 2 YLAMINO] 3 OXOPROPYL] 1,2 PHENYLENE DIACETATE; CARBON MONOXIDE; CASPASE 3; HEME OXYGENASE 1; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME REGULATION; ENZYME RELEASE; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SH SY5Y CELL LINE; TUMOR CELL LINE; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DRUGS, CHINESE HERBAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEME OXYGENASE-1; HUMANS; HYDROGEN PEROXIDE; LACTATES; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHENYLACETATES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; UP-REGULATION;

EID: 84873714426     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.01.008     Document Type: Article

References (35)

1. A. Fukuhara, M. Yamada, K. Fujimori, Y. Miyamoto, T. Kusumoto, H. Nakajima, and T. Inui Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death Biochem. J. 443 2012 75 84
2. Q.H. Gong, X.R. Shi, Z.Y. Hong, L.L. Pan, X.H. Liu, and Y.Z. Zhu A new hope for neurodegeneration: possible role of hydrogen sulfide J. Alzheimers Dis. 24 Suppl. 2 2011 173 182
3. J.K. Andersen Oxidative stress in neurodegeneration: cause or consequence? Nat. Med. 10 2004 S18 S25 (Suppl.)
4. Z.Z. Chong, F. Li, and K. Maiese Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease Prog. Neurobiol. 75 2005 207 246
5. A. Asaithambi, A. Kanthasamy, H. Saminathan, V. Anantharam, and A.G. Kanthasamy Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration Mol. Neurodegener. 6 2011 43
6. S.W. Ryter, J. Alam, and A.M. Choi Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications Physiol. Rev. 86 2006 583 650
7. M. Noda, Y. Doi, J. Liang, J. Kawanokuchi, Y. Sonobe, H. Takeuchi, T. Mizuno, and A. Suzumura Fractalkine attenuates excito-neurotoxicity via microglial clearance of damaged neurons and antioxidant enzyme heme oxygenase-1 expression J. Biol. Chem. 286 2011 2308 2319
8. S.Y. Hung, H.C. Liou, K.H. Kang, R.M. Wu, C.C. Wen, and W.M. Fu Overexpression of heme oxygenase-1 protects dopaminergic neurons against 1-methyl-4-phenylpyridinium-induced neurotoxicity Mol. Pharmacol. 74 2008 1564 1575
9. M.L. Dallas, J.P. Boyle, C.J. Milligan, R. Sayer, T.L. Kerrigan, C. McKinstry, P. Lu, J. Mankouri, M. Harris, J.L. Scragg, H.A. Pearson, and C. Peers Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1 FASEB J. 25 2011 1519 1530
10. G. Scapagnini, S. Vasto, N.G. Abraham, C. Caruso, D. Zella, and G. Fabio Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders Mol. Neurobiol. 44 2011 192 201
11. E. Parada, J. Egea, A. Romero, L. del Barrio, A.G. Garcia, and M.G. Lopez Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via alpha7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway Free Radic. Biol. Med. 49 2010 1815 1821
12. J.W. Kim, M.H. Li, J.H. Jang, H.K. Na, N.Y. Song, C. Lee, J.A. Johnson, and Y.J. Surh 15-Deoxy-Delta(12,14)-prostaglandin J(2) rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2 Biochem. Pharmacol. 76 2008 1577 1589
13. M.H. Li, J.M. Chen, Y. Peng, Q. Wu, and P.G. Xiao Investigation of Danshen and related medicinal plants in China J. Ethnopharmacol. 120 2008 419 426
14. Y. Zhou, W. Li, L. Xu, and L. Chen In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid beta-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors Environ. Toxicol. Pharmacol. 31 2011 443 452
15. T. Wang, F. Fu, B. Han, L. Zhang, and X. Zhang Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation J. Neuroimmunol. 245 2012 79 86
16. C. Dong, Y. Wang, and Y.Z. Zhu Asymmetric synthesis and biological evaluation of Danshensu derivatives as anti-myocardial ischemia drug candidates Bioorg. Med. Chem. 17 2009 3499 3507
17. Q.H. Gong, Q. Wang, L.L. Pan, X.H. Liu, H. Xin, and Y.Z. Zhu S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: involvement of TNF signaling and NF-kappaB pathway in rats Brain Behav. Immun. 25 2011 110 119
18. Q.H. Gong, L.L. Pan, X.H. Liu, Q. Wang, H. Huang, and Y.Z. Zhu S-propargyl-cysteine (ZYZ-802), a sulphur-containing amino acid, attenuates beta-amyloid-induced cognitive deficits and pro-inflammatory response: involvement of ERK1/2 and NF-kappaB pathway in rats Amino Acids 40 2011 601 610
19. L.L. Pan, X.H. Liu, H.M. Zheng, H.B. Yang, Q.H. Gong, and Y.Z. Zhu S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuated tumor necrosis factor-alpha-induced inflammatory signaling and dysfunction in endothelial cells Int. J. Cardiol. 155 2012 327 332
20. Q. Wang, X.L. Wang, H.R. Liu, P. Rose, and Y.Z. Zhu Protective effects of cysteine analogues on acute myocardial ischemia: novel modulators of endogenous H(2)S production Antioxid. Redox Signal. 12 2010 1155 1165
21. Y. Jia, X. Dong, P. Zhou, X. Liu, L. Pan, H. Xin, Y.Z. Zhu, and Y. Wang The synthesis and biological evaluation of novel Danshensu-cysteine analog conjugates as cardiovascular-protective agents Eur. J. Med. Chem. 55 2012 176 187
22. X.H. Liu, L.L. Pan, Q.H. Gong, and Y.Z. Zhu Antiapoptotic effect of novel compound from Herba leonuri - leonurine (SCM-198): a mechanism through inhibition of mitochondria dysfunction in H9c2 cells Curr. Pharm. Biotechnol. 11 2010 895 905
23. B. Pascucci, T. Lemma, E. Iorio, S. Giovannini, B. Vaz, I. Iavarone, A. Calcagnile, L. Narciso, P. Degan, F. Podo, V. Roginskya, B.M. Janjic, B. Van Houten, M. Stefanini, E. Dogliotti, and M. D'Errico An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress Aging Cell 11 2012 520 529
24. Y.M. Ha, M.Y. Kim, M.K. Park, Y.S. Lee, Y.M. Kim, H.J. Kim, J.H. Lee, and K.C. Chang Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways Apoptosis 17 2012 463 474
25. B. Liu, Z. Jian, Q. Li, K. Li, Z. Wang, L. Liu, L. Tang, X. Yi, H. Wang, C. Li, and T. Gao Baicalein protects Human melanocytes from H(2)O(2)-induced apoptosis via inhibiting mitochondria-dependent caspase activation and the p38 MAPK pathway Free Radic. Biol. Med. 53 2012 183 193
26. A. Das, N.L. Banik, and S.K. Ray Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to flavonoids Int. J. Cancer 119 2006 2575 2585
27. J. Kuroda, T. Ago, S. Matsushima, P. Zhai, M.D. Schneider, and J. Sadoshima NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart Proc. Natl. Acad. Sci. U. S. A. 107 2010 15565 15570
28. D.F. Dai, T. Chen, H. Szeto, M. Nieves-Cintron, V. Kutyavin, L.F. Santana, and P.S. Rabinovitch Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy J. Am. Coll. Cardiol. 58 2011 73 82
29. Y. Kitamura, T. Ota, Y. Matsuoka, I. Tooyama, H. Kimura, S. Shimohama, Y. Nomura, P.J. Gebicke-Haerter, and T. Taniguchi Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells Glia 25 1999 154 164
30. R. Pazdro, and J.R. Burgess Differential effects of alpha-tocopherol and N-acetyl-cysteine on advanced glycation end product-induced oxidative damage and neurite degeneration in SH-SY5Y cells Biochim. Biophys. Acta 1822 2012 550 556
31. E.K. Kim, and E.J. Choi Pathological roles of MAPK signaling pathways in human diseases Biochim. Biophys. Acta 1802 2010 396 405
32. B.G. Park, C.I. Yoo, H.T. Kim, C.H. Kwon, and Y.K. Kim Role of mitogen-activated protein kinases in hydrogen peroxide-induced cell death in osteoblastic cells Toxicology 215 2005 115 125
33. Z.S. Xu, X.Y. Wang, D.M. Xiao, L.F. Hu, M. Lu, Z.Y. Wu, and J.S. Bian Hydrogen sulfide protects MC3T3-E1 osteoblastic cells against H2O2-induced oxidative damage-implications for the treatment of osteoporosis Free Radic. Biol. Med. 50 2011 1314 1323
34. F. Zhang, S. Wang, M. Zhang, Z. Weng, P. Li, Y. Gan, L. Zhang, G. Cao, Y. Gao, R.K. Leak, M.B. Sporn, and J. Chen Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury Stroke 43 2012 1390 1397
35. B.J. Wu, K. Chen, P.J. Barter, and K.A. Rye Niacin inhibits vascular inflammation via the induction of heme oxygenase-1 Circulation 125 2012 150 158