Asymmetric synthesis and biological evaluation of Danshensu derivatives as anti-myocardial ischemia drug candidates

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 9, 2009, Pages 3499-3507

  Dong, Cunnan ^a   Wang, Yang ^b   Zhu, Yi Zhun ^a  

^a Institutes of Brain Science   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Asymmetric synthesis; Danshensu derivatives; Myocardial infarction; Neonatal rat ventricular myocytes (NRVMs)

Indexed keywords

2 ACETAMIDO 3 (3,4 DIACETYLPHENYL)ACRYLIC ACID; 2 ACETAMIDO 3 (3,4 METHYLENEDIOXYPHENYL)ACRYLIC ACID; 2 ACETOXY 3 (3,4 DIACETOXYPHENYL)ACRYLIC ACID; 2 ACETOXY 3 (3,4 DIHYDROXYPHENYL)ACRYLIC ACID; 2 ACETOXY 3 (3,4 METHYLENEDIOXYPHENYL)ACRYLIC ACID; 2 ACETOXY 3 (3,4 METHYLENEDIOXYPHENYL)PROPANOIC ACID; 3 (3,4 DIHYDROXYPHENYL) 2 HYDROXYACRYLIC ACID; 3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; 3 (3,4 METHYLENEDIOXYPHENYL) 2 HYDROXYACRYLIC ACID; 3 (3,4 METHYLENEDIOXYPHENYL) 2 HYDROXYPROPANOIC ACID; CASPASE 3; METHYL 2 ACETOXY 3 (3,4 DIACETOXYPHENYL)PROPANOATE; METHYL 2 ACETOXY 3 (3,4 DIACETYLPHENYL)ACRYLATE; METHYL 2 ACETOXY 3 (3,4 METHYLENEDIOXYPHENYL) ACRYLATE; METHYL 2 ACETOXY 3 (3,4 METHYLENEDIOXYPHENYL) PROPANOATE; METHYL 2 ACETOXY 3 (3,4 METHYLENEDIOXYPHENYL)PROPANOATE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART MUSCLE ISCHEMIA; HYDROGENATION; HYPOXIA; MALE; MUSCLE CELL; NONHUMAN; PROTEIN EXPRESSION; RAT;

ANIMALS; CARDIOTONIC AGENTS; CASPASE 3; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; HEART; HUMANS; LACTATES; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIUM; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

RATTUS;

EID: 65249176910     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.065     Document Type: Article

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