S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuated tumor necrosis factor-α-induced inflammatory signaling and dysfunction in endothelial cells

International Journal of Cardiology

Volumn 155, Issue 2, 2012, Pages 327-332

  Pan, Li Long ^a   Liu, Xin Hua ^a   Zheng, Hong Ming ^a   Yang, He Bei ^a   Gong, Qi Hai ^a   Zhu, Yi Zhun ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Adhesion molecules; Hydrogen sulfide; Inflammation; Reactive oxygen species; S propargyl cysteine

Indexed keywords

ANTIINFLAMMATORY AGENT; HYDROGEN SULFIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; REACTIVE OXYGEN METABOLITE; S PROPARGYL CYSTEINE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; ZYZ 802;

CELL ACTIVATION; CELL ADHESION; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE CONTROL; DRUG EFFICACY; DRUG SYNTHESIS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INFLAMMATION; LETTER; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

EID: 84862811071     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2011.12.059     Document Type: Article

References (19)

1. R. Ross Atherosclerosis-an inflammatory disease N Engl J Med 340 1999 115 126
2. P. Libby Inflammation in atherosclerosis Nature 420 2002 868 874
3. M.F. Nageh, E.T. Sandberg, and K.R. Marotti Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice Arterioscler Thromb Vasc Biol 17 1997 1517 1520
4. G.A. Benavides, G.L. Squadrito, and R.W. Mills Hydrogen sulfide mediates the vasoactivity of garlic Proc Natl Acad Sci USA 104 2007 17977 17982
5. S.C. Chuah, P.K. Moore, and Y.Z. Zhu S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway Am J Physiol Heart Circ Physiol 293 2007 H2693 H2701
6. L. Li, P. Rose, and P.K. Moore Hydrogen sulfide and cell signaling Annu Rev Pharmacol Toxicol 51 2011 169 187
7. W. Zhao, J. Zhang, Y. Lu, and R. Wang The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener EMBO J 20 2001 6008 6016
8. L.L. Pan, X.H. Liu, Q.H. Gong, D. Wu, and Y.Z. Zhu Hydrogen sulfide attenuated tumor necrosis factor-α-induced inflammatory signaling and dysfunction in vascular endothelial cells PLoS One 6 2011 e19766
9. Y. Wang, X. Zhao, and H. Jin Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice Arterioscler Thromb Vasc Biol 29 2009 173 179
10. Y. Gao, X. Yao, and Y. Zhang The protective role of hydrogen sulfide in myocardial ischemia-reperfusion-induced injury in diabetic rats Int J Cardiol 152 2011 177 183
11. Q. Wang, H.R. Liu, Q. Mu, P. Rose, and Y.Z. Zhu S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway J Cardiovasc Pharmacol 54 2009 139 146
12. Q. Wang, X.L. Wang, H.R. Liu, P. Rose, and Y.Z. Zhu Protective effects of cysteine analogues on acute myocardial ischemia: novel modulators of endogenous H(2)S production Antioxid Redox Signal 12 2010 1155 1165
13. L.L. Pan, X.H. Liu, Q.H. Gong, and Y.Z. Zhu S-propargyl-cysteine (SPRC) attenuated lipopolysaccharide-induced inflammatory response in H9c2 cells involved in a hydrogen sulfide-dependent mechanism Amino Acids 41 2011 205 215
14. Q.H. Gong, Q. Wang, L.L. Pan, X.H. Liu, H. Xin, and Y.Z. Zhu S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: involvement of TNF signaling and NF-κB pathway in rats Brain Behav Immun 25 2011 110 119
15. J.S. Kang, S.K. Park, K.H. Yang, and H.M. Kim Silymarin inhibits TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells FEBS Lett 550 2003 89 93
16. Q.H. Gong, L.L. Pan, X.H. Liu, Q. Wang, H. Huang, and Y.Z. Zhu S-propargyl-cysteine (ZYZ-802), a sulphur-containing amino acid, attenuates beta-amyloid-induced cognitive deficits and pro-inflammatory response: involvement of ERK1/2 and NF-κB pathway in rats Amino Acids 40 2011 601 610
17. A. Pirillo, P. Uboldi, C. Bolego, H. Kuhn, and A.L. Catapano The 15-lipoxygenase-modified high density lipoproteins 3 fail to inhibit the TNF-α-induced inflammatory response in human endothelial cells J Immunol 181 2008 2821 2830
18. G. Yang, L. Wu, and B. Jiang H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gamma-lyase Science 322 2008 587 590
19. R. Wang Is H2S a stinky remedy for atherosclerosis? Arterioscler Thromb Vasc Biol 29 2009 156 157