An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress

Aging Cell

Volumn 11, Issue 3, 2012, Pages 520-529

  Pascucci, Barbara ^a,b   Lemma, Tiziana ^b   Iorio, Egidio ^b   Giovannini, Sara ^b   Vaz, Bruno ^a   Iavarone, Ivano ^b   Calcagnile, Angelo ^b   Narciso, Laura ^b   Degan, Paolo ^c   Podo, Franca ^b   Roginskya, Vera ^d,e   Janjic, Bratislav M ^e   Van Houten, Bennett ^d,e   Stefanini, Miria ^a   Dogliotti, Eugenia ^b   D'Errico, Mariarosaria ^b  

^a CNR   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Cockayne syndrome; DNA oxidation; Mitochondrial alteration; Oxidative metabolism; Oxidative phosphorylation; ROS levels

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTIOXIDANT; CHOLINE; REACTIVE OXYGEN METABOLITE;

ARTICLE; COCKAYNE SYNDROME; DNA DAMAGE; ENERGY METABOLISM; FIBROBLAST; GENE MUTATION; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPERSENSITIVITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; OSMOREGULATION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN METABOLISM; REDOX STRESS;

AGING, PREMATURE; COCKAYNE SYNDROME; DNA DAMAGE; DNA REPAIR; FIBROBLASTS; HUMANS; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS;

EID: 84860883265     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2012.00815.x     Document Type: Article

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