Antiapoptotic effect of novel compound from Herba leonuri- Leonurine (SCM-198): A mechanism through inhibition of mitochondria dysfunction in H9c2 cells

Current Pharmaceutical Biotechnology

Volumn 11, Issue 8, 2010, Pages 895-905

  Liu, Xin Hua ^a   Pan, Li Long ^a   Gong, Qi Hai ^a   Zhu, Yi Zhun ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

c Jun N terminal kinase 1 2; Cytochrome c; Hydrogen peroxide; Leonurine; Mitochondria; Reactive oxygen species

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CYTOCHROME C; HYDROGEN PEROXIDE; LEONURINE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE 1; ADPRT PROTEIN, RAT; DRUG DERIVATIVE; GALLIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 9; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEROXIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL STIMULATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; HERBA LEONURI; HYPOXIA; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PREMEDICATION; RAT; ANIMAL; CELL LINE; CELL SURVIVAL; DRUG EFFECT; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PHYTOTHERAPY;

RATTUS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE; CELL SURVIVAL; CYTOCHROMES C; DNA FRAGMENTATION; GALLIC ACID; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PEROXIDES; PHYTOTHERAPY; POLY(ADP-RIBOSE) POLYMERASES; RATS; REACTIVE OXYGEN SPECIES;

EID: 79955879118     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920110793262015     Document Type: Article

References (41)

1. Sawyer, D.B.; Siwik, D.A.; Xiao, L.; Pimentel, D.R.; Singh, K.; Colucci, W.S. Role of oxidative stress in myocardial hypertrophy and failure. J. Mol. Cell Cardiol., 2002, 34. 379-388.
2. Clerk, A.; Cole, S.M.; Cullingford, T.E.; Harrison, J.G.; Jormakka. M.; Valks, D.M. Regulation of cardiac myocyte cell death. Pharmacol. Ther., 2003, 97. 223-261.
3. MacLellan, W.R.; Schneider, M.D. Death by design. Programmed cell death in cardiovascular biology and disease. Circ. Res., 1997, 81. 137-144.
4. Leist, M.; Jaattela, M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell. Biol., 2001, 2. 589-598.
5. Wang, Z. The expanding role of mitochondria in apoptosis. Genes Dev., 2001, 15. 2922-2933.
6. Crompton, M. The mitochondrial permeability transition pore and its role in cell death. Biochem. J., 1999, 341. 233-249.
7. Scheubel, R.J.; Bartling, B.; Simm, A.; Silber, R.E.; Drogari, K.; Darmer, D.; Holtz, J. Apoptotic pathway activation from mitochondria and death receptors without caspase-3 cleavage in failing human myocardium. J. Am. Coll. Cardiol., 2002, 39. 481-488.
8. Armstrong, S.C. Anti-oxidants and apoptosis: attenuation of doxorubicin induced cardiomyopathy by carvedilol. J. Mol. Cell Cardiol., 2004, 37. 817-821.
9. Kim, J.K.; Pedram, A.; Razandi, M.; Levin, E.R. Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms. J. Biol. Chem., 2006, 281. 6760-6767.
10. Kong, Y.C.; Yeung, H.W.; Cheung, Y.M.; Hwang, J.C.; Chan, Y.W.; Law, Y.P.; Ng, K.H.; Yeung, C.H. Isolation of the uterotonic principle from Leonurus artemisia, the Chinese motherwort. Am. J. Chin. Med., 1976, 4. 373-382.
11. Hu, S. A contribution to our knowledge of Leonurus L., i-mu-ts'ao, the Chinese motherwort. Am. J. Chin. Med., 1976, 4. 219-237.
12. Wang, Z.S.; Li, D.W.; Xia, W.J.; Qiu, H.Q.; Zhu, L.Y. The therapeutic effect of Herba leonuri in the treatment of coronary myocardial ischemia. J. Trad. Chin. Med., 1988, 8. 103-106.
13. Sun, J.; Huang, S.H.; Zhu, Y.C.; Matthew, W.; Wang, M.J.; Benny, K.H.; Zhu, Y.Z. Anti-oxidative stress effects of Herba leonuri on ischemic rat hearts. Life Sci., 2005, 76. 3043-3056.
14. Chen, C.X.; Kwan, C.Y. Endothelium-independent vasorelaxation by leonurine, a plant alkaloid purified from Chinese motherwort. Life Sci., 2001, 68. 953-960.
15. Liu, X.H.; Xin, H.; Hou, A.J.; Zhu, Y.Z. Protective effects of leonurine in neonatal rat hypoxic cardiomyocytes and rat infracted heart. Clin. Exp. Pharmacol. Physiol., 2009, 36, 696-703.
16. Liu, X.H.; Chen, P.F.; Pan, L.L.; Zhu, Y.Z. 4-Guanidino-n-butyl syringate (leonurine) protects H9c2 rat centricular cells from hypoxia-induced apoptosis. J. Cardiovas. Pharmacol., 2009, 54. 437-444.
17. Xin, H.; Liu, X.H.; Zhu, Y.Z. Herba leonurine attenuates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells. Eur. J. Pharmacol., 2009, 612(1-3), 75-79.
18. Chen, G.; Zhang, J.X.; Ye, J.N. Determination of puerarin, daidzein and rutin in Pueraria lobata (Wild.) Ohwi by capillary electrophoresis with electrochemical detection. J. Chromatogr. A, 2001, 923. 255-262.
19. 2-induced apoptosis. FEBS J., 2008, 275. 3136-3144.
20. Nishimura, G.; Proske, R.J.; Doyama, H.; Higuchi, M. Regulation of apoptosis by respiration: cytochrome c release by respiratory substrates. FEBS Lett., 2001, 505. 399-404.
21. von Harsdorf, R.; Li, P.F.; Dietz, R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation, 1999, 99. 2934-2941.
22. Adams, J.W.; Pagel, A.L.; Means, C.K.; Oksenberg, D.; Armstrong, R.C.; Brown, J.H. Cardiomyocyte apoptosis induced by Gδq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway. Circ. Res., 2000, 87. 1180-1187.
23. Xie, P.; Guo, S.B.; Fan, Y.N.; Zhang, H.; Gu, D.F.; Li, H.H. Atrogin-1/MAFbx enhances simulated ischemia/reperfusioninduced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation. J. Biol. Chem. 2009, 284. 5488-5496.
24. Fu, H.Y.; Minamino, T.; Tsukamoto, O.; Sawada, T.; Asai, M.; Kato, H.; Asano, Y.; Fujita, M.; Takashima, S.; Hori, M.; Kitakaze, M. Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition. Cardiovasc. Res. 2008, 79. 600-610.
25. Ekhterae, D.; Lin, Z.; Lundberg, M.S.; Crow, M.T.; Brosius, F.C.; Núñez, G. ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Circ. Res. 1999, 85. e70-e77.
26. Park, C.; So, H.S.; Shin, C.H.; Baek, S.H.; Moon, B.S.; Shin, S.H.; Lee, H.S.; Lee, D.W.; Park, R. Quercetin protects the hydrogen peroxide-induced apoptosis via inhibition of mitochondrial dysfunction in H9c2 cardiomyoblast cells. Biochem. Pharmacol. 2003, 66. 1287-1295.
27. 2-induced apoptosis through AKT signaling. Biochem. Biophys. Res. Commun. 2007, 359. 685-690.
28. Morihira, M.; Hasebe, N.; Baljinnyam, E.; Sumitomo, K.; Matsusaka, T.; Izawa, K.; Fujino, T.; Fukuzawa, J.; Kikuchi, K. Ischemic preconditioning enhances scavenging activity of reactive oxygen species and diminishes transmural difference of infarct size. Am. J. Physiol. Heart. Circ. Physiol. 2006, 290. H577-583.
29. Khan, M.; Mohan, I.K.; Kutala, V.K.; Kumbala, D.; Kuppusamy, P. Cardioprotection by sulfaphenazole, a cytochrome p450 inhibitor: mitigation of ischemia-reperfusion injury by scavenging of reactive oxygen species. J. Pharmacol. Exp. Ther. 2007, 323. 813-821.
30. Matsukawa, J.; Matsuzawa, A.; Takeda, K.; Ichijo, H. The ASK1-MAP kinase cascades in mammalian stress response. J. Biol. Chem. 2004, 136. 261-265.
31. Yang, Y.; Cheng, J.Z.; Singhal, S.S.; Saini, M.; Pandya, U.; Awasthi, S.; Awasthi, Y.C. Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase-3 activation. J. Biol. Chem. 2001, 276. 19220-19230.
32. Turner, N.A.; Xia, F.; Azhar, G.; Zhang, X.; Liu, L.; Wei, J.Y. Oxidative stress induces DNA fragmentation and caspase activation via the c-Jun NH2-terminal kinase pathway in H9c2 cardiac muscle cells. J. Mol. Cell. Cardiol. 1998, 30. 1789-1801.
33. Kim, B.J.; Ryu, S.W.; Song, B.J. JNK-and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J. Biol. Chem. 2006, 281. 21256-21265.
34. Kim, H.J.; Lee, K.W.; Kim, M.S.; Lee, H.J. Piceatannol attenuates hydrogen-peroxide-and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK. J. Nutr. Biochem. 2008, 19, 459-466.
35. Xie, P.; Guo, S.; Fan, Y.; Zhang, H.; Gu, D.; Li, H. Atrogin-1/MAFbx enhances simulated ischemia/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation. J. Biol. Chem. 2009, 284. 5488-5496.
36. Ho, F.M.; Liu, S.H.; Liau, C.S.; Huang, P.J.; Lin-Shiau, S.Y. High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal kinase and caspase-3. Circulation. 2000, 101, 2618-2624.
37. Park, H.S.; Kim, M.S.; Huh, S.H.; Park, J.; Chung, J.; Kang, S.S.; Choi, E.J. Akt (Protein Kinase B) negatively regulates SEK1 by means of protein phosphorylation. J. Biol. Chem. 2002, 277. 2573-2578.
38. Petrosillo, G.; Ruggiero, F.M.; Paradies, G. Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria. FASEB J., 2003, 17, 2202-2208.
39. Fliss, H.; Gattinger, D. Apoptosis in ischemic and reperfused rat myocardium. Circ. Res. 1996, 79. 949-956.
40. Aikawa, R.; Komuro, I.; Yamazaki, T.; Zou, Y.; Kudoh, S.; Tanaka, M.; Shiokima, I.; Hiroi, Y.; Yazaki, Y. Oxidative stress activates extracellular signal-regulated kinases through src and ras in cultured cardiac myocytes of neonatal rats. J. Clin. Invest. 1997, 100, 1813-1821.
41. Singla, D.K.; McDonald, D.E. Factors released from embryonic stem cells inhibit apoptosis of H9c2 cells. Am. J. Physiol. Heart Circ. Physiol. 2007, 293. H1590-H1595.