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Volumn , Issue , 2009, Pages 449-460

Pulmonary Endothelium and Pulmonary Hypertension

Author keywords

Associated diseases of PAH (APAH); Chronic obstructive pulmonary diseases (COPDs); EC pathobiology novel concepts in pulmonary hypertension; Endothelium role in pulmonary hypertension and IPAH; Exuberant EC proliferation and misguided angiogenesis in pulmonary hypertension; HIV associated pulmonary hypertension; Human herpesvirus (HHV) 8 and proliferative switch of pulmonary ECs; Pulmonary endothelium and pulmonary hypertension; Vascular progenitor cells in pulmonary arteries

Indexed keywords


EID: 84873692204     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470747490.ch27     Document Type: Chapter
Times cited : (2)

References (98)
  • 1
    • 22044445561 scopus 로고    scopus 로고
    • Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment
    • Wright, J.L., Levy, R.D., and Churg, A. (2005) Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment. Thorax, 60, 605-9.
    • (2005) Thorax , vol.60 , pp. 605-609
    • Wright, J.L.1    Levy, R.D.2    Churg, A.3
  • 4
    • 0027200632 scopus 로고    scopus 로고
    • Primary pulmonary hypertension
    • Rubin, L.J. (1998) Primary pulmonary hypertension. Chest, 104, 236-50.
    • (1998) Chest , vol.104 , pp. 236-250
    • Rubin, L.J.1
  • 6
    • 0026751075 scopus 로고
    • Endothelial dysfunction in pulmonary hypertension
    • Loscalzo, J. (1992) Endothelial dysfunction in pulmonary hypertension. The New England Journal of Medicine, 327, 70-75.
    • (1992) The New England Journal of Medicine , vol.327 , pp. 70-75
    • Loscalzo, J.1
  • 7
    • 1642453778 scopus 로고    scopus 로고
    • Endothelial dysfunction in pulmonary hypertension
    • Budhiraja, R., Tuder, R.M., and Hassoun, P.M. (2004) Endothelial dysfunction in pulmonary hypertension. Circulation, 109, 159-65.
    • (2004) Circulation , vol.109 , pp. 159-165
    • Budhiraja, R.1    Tuder, R.M.2    Hassoun, P.M.3
  • 11
    • 70449228209 scopus 로고
    • The pathology of pulmonary hypertensive disease. A description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal changes
    • Heath, D. and Edwards, J.E. (1958) The pathology of pulmonary hypertensive disease. A description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal changes. Circulation, 18, 533-47.
    • (1958) Circulation , vol.18 , pp. 533-547
    • Heath, D.1    Edwards, J.E.2
  • 13
    • 0022359912 scopus 로고
    • Comparison of primary plexogenic arteriopathy in adults and children. A morphometric study in 40 patients
    • Yamaki, S. and Wagenvoort, C.A. (1985) Comparison of primary plexogenic arteriopathy in adults and children. A morphometric study in 40 patients. British Heart Journal, 54, 428-34.
    • (1985) British Heart Journal , vol.54 , pp. 428-434
    • Yamaki, S.1    Wagenvoort, C.A.2
  • 14
    • 0028282859 scopus 로고
    • Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension
    • Tuder, R.M., Groves, B.M., Badesch, D.B., and Voelkel, N.F. (1994) Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. American Journal of Pathology, 144, 275-85.
    • (1994) American Journal of Pathology , vol.144 , pp. 275-285
    • Tuder, R.M.1    Groves, B.M.2    Badesch, D.B.3    Voelkel, N.F.4
  • 15
    • 0030987082 scopus 로고    scopus 로고
    • Pathogenesis and evolution of plexi-form lesions in pulmonary hypertension associated with scleroderma and human immunodeficiency virus infection
    • Cool, C.D., Kennedy, D., Voelkel, N.F., and Tuder, R.M. (1997) Pathogenesis and evolution of plexi-form lesions in pulmonary hypertension associated with scleroderma and human immunodeficiency virus infection. Human Pathology, 28, 434-42.
    • (1997) Human Pathology , vol.28 , pp. 434-442
    • Cool, C.D.1    Kennedy, D.2    Voelkel, N.F.3    Tuder, R.M.4
  • 16
    • 0032777126 scopus 로고    scopus 로고
    • Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell specific markers: evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth
    • Cool, C.D., Stewart, J.S., Werahera, P. et al. (1999) Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell specific markers: evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth. American Journal of Pathology, 155, 411-19.
    • (1999) American Journal of Pathology , vol.155 , pp. 411-419
    • Cool, C.D.1    Stewart, J.S.2    Werahera, P.3
  • 17
    • 0032031727 scopus 로고    scopus 로고
    • Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension
    • Lee, S.D., Shroyer, K.R., Markham, N.E. et al. (1998) Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension. The Journal of Clinical Investigation, 101, 927-34.
    • (1998) The Journal of Clinical Investigation , vol.101 , pp. 927-934
    • Lee, S.D.1    Shroyer, K.R.2    Markham, N.E.3
  • 19
    • 0031830047 scopus 로고    scopus 로고
    • Histopathology of pulmonary hypertension
    • Tuder, R.M., Lee, S.D., and Cool, C.D. (1998) Histopathology of pulmonary hypertension. Chest, 114, 1S-6S.
    • (1998) Chest , vol.114
    • Tuder, R.M.1    Lee, S.D.2    Cool, C.D.3
  • 20
    • 0031671780 scopus 로고    scopus 로고
    • Primary pulmonary hypertension between inflammation and cancer
    • Voelkel, N.F., Cool, C.D., Lee, S.D. et al. (1999) Primary pulmonary hypertension between inflammation and cancer. Chest, 114, 225S-230S.
    • (1999) Chest , vol.114
    • Voelkel, N.F.1    Cool, C.D.2    Lee, S.D.3
  • 22
    • 0003057825 scopus 로고    scopus 로고
    • Mutational analysis of endothelial cell TGF-β receptor type II in plexiform lesions of patients with primary pulmonary hypertension
    • Yeager, M.E., Voelkel, N.F., and Tuder, R.M. (1999) Mutational analysis of endothelial cell TGF-β receptor type II in plexiform lesions of patients with primary pulmonary hypertension. Circulation, 100, I-587.
    • (1999) Circulation , vol.100
    • Yeager, M.E.1    Voelkel, N.F.2    Tuder, R.M.3
  • 23
    • 0035910729 scopus 로고    scopus 로고
    • Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension
    • Yeager, M.E., Halley, G.R., Golpon, H.A. et al. (2001) Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension. Circulation Research, 88, e8-e11.
    • (2001) Circulation Research , vol.88
    • Yeager, M.E.1    Halley, G.R.2    Golpon, H.A.3
  • 24
    • 0033838125 scopus 로고    scopus 로고
    • Familial primary pulmonary hypertension (gene PPH1) Is caused by mutations in the bone morphogenetic protein receptor-II gene
    • Deng, Z., Morse, J.H., Slager, S.L. et al. (2000) Familial primary pulmonary hypertension (gene PPH1) Is caused by mutations in the bone morphogenetic protein receptor-II gene. American Journal of Human Genetics, 67, 737-44.
    • (2000) American Journal of Human Genetics , vol.67 , pp. 737-744
    • Deng, Z.1    Morse, J.H.2    Slager, S.L.3
  • 25
    • 0033817459 scopus 로고    scopus 로고
    • Heterozygous germline mutations in BMPR2 encoding a TGF-B receptor cause familiar pulmonary hypertension
    • Lane, K.B., Machado, R.D., Pauciulo, M.W. et al. (2000) Heterozygous germline mutations in BMPR2 encoding a TGF-B receptor cause familiar pulmonary hypertension. Nature Genetics, 26, 81-84.
    • (2000) Nature Genetics , vol.26 , pp. 81-84
    • Lane, K.B.1    Machado, R.D.2    Pauciulo, M.W.3
  • 27
    • 0142061009 scopus 로고    scopus 로고
    • Circulating endothelial cells in pulmonary hypertension
    • Bull, T.M., Golpon, H., Hebbel, R.P. et al. (2003) Circulating endothelial cells in pulmonary hypertension. Thrombosis and Haemostasis, 90, 688-703.
    • (2003) Thrombosis and Haemostasis , vol.90 , pp. 688-703
    • Bull, T.M.1    Golpon, H.2    Hebbel, R.P.3
  • 28
    • 0035077330 scopus 로고    scopus 로고
    • Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema
    • Kasahara, Y., Tuder, R.M., Cool, C.D. et al. (2001) Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. American Journal of Respiratory and Critical Care Medicine, 163, 737-44.
    • (2001) American Journal of Respiratory and Critical Care Medicine , vol.163 , pp. 737-744
    • Kasahara, Y.1    Tuder, R.M.2    Cool, C.D.3
  • 29
    • 21744460365 scopus 로고    scopus 로고
    • Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells
    • Sakao, S., Taraseviciene-Stewart, L., Lee, J.D. et al. (2005) Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells. The FASEB Journal, 19, 1178-180.
    • (2005) The FASEB Journal , vol.19 , pp. 1178-1180
    • Sakao, S.1    Taraseviciene-Stewart, L.2    Lee, J.D.3
  • 30
    • 0035130107 scopus 로고    scopus 로고
    • Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
    • Taraseviciene-Stewart, L., Kasahara, Y., Alger, L. et al. (2001) Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. The FASEB Journal, 15, 427-38.
    • (2001) The FASEB Journal , vol.15 , pp. 427-438
    • Taraseviciene-Stewart, L.1    Kasahara, Y.2    Alger, L.3
  • 31
    • 0034772039 scopus 로고    scopus 로고
    • Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angio-genesis
    • Tuder, R.M., Chacon, M., Alger, L.A. et al. (2001) Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angio-genesis. Journal of Pathology, 195, 367-74.
    • (2001) Journal of Pathology , vol.195 , pp. 367-374
    • Tuder, R.M.1    Chacon, M.2    Alger, L.A.3
  • 32
    • 13444309082 scopus 로고    scopus 로고
    • Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension
    • Machado, R.D., James, V., Southwood, M. et al. (2005) Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension. Circulation, 111, 607-13.
    • (2005) Circulation , vol.111 , pp. 607-613
    • Machado, R.D.1    James, V.2    Southwood, M.3
  • 33
    • 0037046175 scopus 로고    scopus 로고
    • Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
    • Atkinson, C., Stewart, S., Upton, P.D. et al. (2002) Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation, 105, 1672-78.
    • (2002) Circulation , vol.105 , pp. 1672-1678
    • Atkinson, C.1    Stewart, S.2    Upton, P.D.3
  • 34
    • 35248893990 scopus 로고    scopus 로고
    • Phenotypic heterogeneity in lung capillary and extra-alveolar endothelial cells. Increased extra-alveolar endothelial permeability is sufficient to decrease compliance
    • Lowe, K., Alvarez, D., King, J., and Stevens, T. (2007) Phenotypic heterogeneity in lung capillary and extra-alveolar endothelial cells. Increased extra-alveolar endothelial permeability is sufficient to decrease compliance. The Journal ofSurgical Research, 143, 70-77.
    • (2007) The Journal ofSurgical Research , vol.143 , pp. 70-77
    • Lowe, K.1    Alvarez, D.2    King, J.3    Stevens, T.4
  • 35
    • 85048262809 scopus 로고    scopus 로고
    • Pulmonary circulation and pulmonary hypertension
    • in, 1st edn (ed. W.C. Aird), Taylor & Francis, Boca Raton, FL
    • Stevens, T., Kasper, M., Cool, C., and Voelkel, N.F. (2005) Pulmonary circulation and pulmonary hypertension, in Endothelial Cells in Health and Disease, 1st edn (ed. W.C. Aird), Taylor & Francis, Boca Raton, FL, pp. 417-38.
    • (2005) Endothelial Cells in Health and Disease , pp. 417-438
    • Stevens, T.1    Kasper, M.2    Cool, C.3    Voelkel, N.F.4
  • 36
    • 7244242362 scopus 로고    scopus 로고
    • Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood
    • Ingram, D.A., Mead, L.E., Tanaka, H. et al. (2004) Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood, 104, 2752-60.
    • (2004) Blood , vol.104 , pp. 2752-2760
    • Ingram, D.A.1    Mead, L.E.2    Tanaka, H.3
  • 37
    • 33847348148 scopus 로고    scopus 로고
    • Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
    • Yoder, M.C., Mead, L.E., Prater, D. et al. (2007) Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood, 109, 1801-9.
    • (2007) Blood , vol.109 , pp. 1801-1809
    • Yoder, M.C.1    Mead, L.E.2    Prater, D.3
  • 38
    • 9444220218 scopus 로고    scopus 로고
    • Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension
    • Xu, W., Kaneko, F.T., Zheng, S. et al. (2004) Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. The FASEB Journal, 18, 1746-48.
    • (2004) The FASEB Journal , vol.18 , pp. 1746-1748
    • Xu, W.1    Kaneko, F.T.2    Zheng, S.3
  • 40
    • 0034721758 scopus 로고    scopus 로고
    • Vascular endothelial growth factor activates STAT proteins in aortic endothelial cells
    • Bartoli, M., Gu, X., Tsai, N.T. et al. (2000) Vascular endothelial growth factor activates STAT proteins in aortic endothelial cells. The Journal of Biological Chemistry, 275, 33189-92.
    • (2000) The Journal of Biological Chemistry , vol.275 , pp. 33189-33192
    • Bartoli, M.1    Gu, X.2    Tsai, N.T.3
  • 41
    • 85047695527 scopus 로고    scopus 로고
    • Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
    • Niu, G., Wright, K.L., Huang, M. et al. (2002) Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene, 21, 2000-8.
    • (2002) Oncogene , vol.21 , pp. 2000-2008
    • Niu, G.1    Wright, K.L.2    Huang, M.3
  • 42
    • 0038407916 scopus 로고    scopus 로고
    • Inhibition of STAT3 prevents neointima formation by inhibiting proliferation and promoting apoptosis of neointimal smooth muscle cells
    • Shibata, R., Kai, H., Seki, Y. et al. (2003) Inhibition of STAT3 prevents neointima formation by inhibiting proliferation and promoting apoptosis of neointimal smooth muscle cells. Human Gene Therapy, 14, 601-10.
    • (2003) Human Gene Therapy , vol.14 , pp. 601-610
    • Shibata, R.1    Kai, H.2    Seki, Y.3
  • 43
    • 0141960055 scopus 로고    scopus 로고
    • Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation
    • Yahata, Y., Shirakata, Y., Tokumaru, S. et al. (2003) Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation. The Journal of Biological Chemistry, 278, 40026-31.
    • (2003) The Journal of Biological Chemistry , vol.278 , pp. 40026-40031
    • Yahata, Y.1    Shirakata, Y.2    Tokumaru, S.3
  • 46
    • 41549154142 scopus 로고    scopus 로고
    • Cytoplasmic provenance of STAT3 and PY-STAT3 in endolysosomal compartments in pulmonary arterial endothelial and smooth muscle cells: implications in PAH
    • Mukhopadhyay, S., Shah, M., Xu, F. et al. (2007) Cytoplasmic provenance of STAT3 and PY-STAT3 in endolysosomal compartments in pulmonary arterial endothelial and smooth muscle cells: implications in PAH. American Journal of Physiology: Lung Cellular and Molecular Physiology, 294, L449-68.
    • (2007) American Journal of Physiology: Lung Cellular and Molecular Physiology , vol.294
    • Mukhopadhyay, S.1    Shah, M.2    Xu, F.3
  • 47
    • 40449086880 scopus 로고    scopus 로고
    • Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension
    • Asosingh, K., Aldred, M.A., Vasanji, A. et al. (2008) Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension. American Journal of Pathology, 172, 615-27.
    • (2008) American Journal of Pathology , vol.172 , pp. 615-627
    • Asosingh, K.1    Aldred, M.A.2    Vasanji, A.3
  • 48
    • 0032491187 scopus 로고    scopus 로고
    • Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension
    • Yuan, J.X., Aldinger, A.M., Juhaszova, M. et al. (1998) Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension. Circulation, 98, 1400-6.
    • (1998) Circulation , vol.98 , pp. 1400-1406
    • Yuan, J.X.1    Aldinger, A.M.2    Juhaszova, M.3
  • 50
    • 20444483234 scopus 로고    scopus 로고
    • Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension
    • McMurtry, M.S., Archer, S.L., Altieri, D.C., Bonnet, S. et al. (2005) Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. The Journal of Clinical Investigation, 115, 1479-91.
    • (2005) The Journal of Clinical Investigation , vol.115 , pp. 1479-1491
    • McMurtry, M.S.1    Archer, S.L.2    Altieri, D.C.3    Bonnet, S.4
  • 51
    • 6344257102 scopus 로고    scopus 로고
    • Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
    • McMurtry, M.S., Bonnet, S., Wu, X. et al. (2004) Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circulation Research, 95, 830-40.
    • (2004) Circulation Research , vol.95 , pp. 830-840
    • McMurtry, M.S.1    Bonnet, S.2    Wu, X.3
  • 52
    • 33745155785 scopus 로고    scopus 로고
    • v channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats-similarities to human pulmonary arterial hypertension
    • v channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats-similarities to human pulmonary arterial hypertension. Circulation, 113, 2630-41.
    • (2006) Circulation , vol.113 , pp. 2630-2641
    • Michelakis, E.D.1    Porter, C.J.2    Bonnet, S.3
  • 53
    • 0034727717 scopus 로고    scopus 로고
    • Primary pulmonary hypertension: a vascular biology and translational research "work in progress"
    • Archer, S. and Rich, S. (2000) Primary pulmonary hypertension: a vascular biology and translational research "work in progress". Circulation, 102, 2781-91.
    • (2000) Circulation , vol.102 , pp. 2781-2791
    • Archer, S.1    Rich, S.2
  • 54
    • 0036370646 scopus 로고    scopus 로고
    • Effects of low doses of inhaled nitric oxide combined with oxygen for the evaluation of pulmonary vascular reactivity in patients with pulmonary hypertension
    • Azeka, E., Costa, A.J. Jr., Kajita, L. et al. (2002) Effects of low doses of inhaled nitric oxide combined with oxygen for the evaluation of pulmonary vascular reactivity in patients with pulmonary hypertension. Pediatric Cardiology, 23, 20-26.
    • (2002) Pediatric Cardiology , vol.23 , pp. 20-26
    • Azeka, E.1    Costa Jr., A.J.2    Kajita, L.3
  • 55
    • 0036791014 scopus 로고    scopus 로고
    • Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice
    • Champion, H.C., Bivalacqua, T.J., Greenberg, S.S. et al. (2002) Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 99, 13248-53.
    • (2002) Proceedings of the National Academy of Sciences of the United States of America , vol.99 , pp. 13248-13253
    • Champion, H.C.1    Bivalacqua, T.J.2    Greenberg, S.S.3
  • 56
    • 0031054463 scopus 로고    scopus 로고
    • Nitric oxide synthase: role in the genesis of vascular disease
    • Cooke, J.P. and Dzau, V.J. (1997) Nitric oxide synthase: role in the genesis of vascular disease. Annual Review ofMedicine, 48, 489-509.
    • (1997) Annual Review ofMedicine , vol.48 , pp. 489-509
    • Cooke, J.P.1    Dzau, V.J.2
  • 57
    • 0027326007 scopus 로고
    • Nitric oxide-mediated vasorelaxation
    • Ignarro, L.J. (1993) Nitric oxide-mediated vasorelaxation. Thrombosis and Haemostasis, 70, 148-51.
    • (1993) Thrombosis and Haemostasis , vol.70 , pp. 148-151
    • Ignarro, L.J.1
  • 58
    • 0036875930 scopus 로고    scopus 로고
    • Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension
    • Jeffery, T.K. and Morrell, N.W. (2002) Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension. Progress in Cardiovascular Diseases, 45, 173-202.
    • (2002) Progress in Cardiovascular Diseases , vol.45 , pp. 173-202
    • Jeffery, T.K.1    Morrell, N.W.2
  • 59
  • 60
    • 0032957595 scopus 로고    scopus 로고
    • Nitric oxide: discovery and impact on clinical medicine
    • Moncada, S. (1999) Nitric oxide: discovery and impact on clinical medicine. Journal of the Royal Society of Medicine, 92, 164-69.
    • (1999) Journal of the Royal Society of Medicine , vol.92 , pp. 164-169
    • Moncada, S.1
  • 62
    • 0035722661 scopus 로고    scopus 로고
    • High levels of nitric oxide in individuals with pulmonary hypertension receiving epoprostenol therapy
    • Ozkan, M., Dweik, R.A., Laskowski, D. et al. (2001) High levels of nitric oxide in individuals with pulmonary hypertension receiving epoprostenol therapy. Lung, 179, 233-43.
    • (2001) Lung , vol.179 , pp. 233-243
    • Ozkan, M.1    Dweik, R.A.2    Laskowski, D.3
  • 63
    • 0037113188 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase (NOS) deficiency affects energy metabolism pattern in murine oxidative skeletal muscle
    • Momken, I., Fortin, D., Serrurier, B. et al. (2002) Endothelial nitric oxide synthase (NOS) deficiency affects energy metabolism pattern in murine oxidative skeletal muscle. The Biochemical Journal, 368, 341-47.
    • (2002) The Biochemical Journal , vol.368 , pp. 341-347
    • Momken, I.1    Fortin, D.2    Serrurier, B.3
  • 64
    • 0347579845 scopus 로고    scopus 로고
    • Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
    • Nisoli, E., Clementi, E., Paolucci, C. et al. (2003) Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science, 299, 896-99.
    • (2003) Science , vol.299 , pp. 896-899
    • Nisoli, E.1    Clementi, E.2    Paolucci, C.3
  • 66
    • 0000129458 scopus 로고    scopus 로고
    • The pulmonary circulation of mice with either homozygous or heterozygous disruption of endothelial nitric oxide synthase is hyperresponsive to chronic mild hypoxia
    • Fagan, K.A., Fouty, B.W., Tyler, R.C. et al. (1998) The pulmonary circulation of mice with either homozygous or heterozygous disruption of endothelial nitric oxide synthase is hyperresponsive to chronic mild hypoxia. The Journal of Clinical Investigation, 1-3, 291-99.
    • (1998) The Journal of Clinical Investigation , vol.1-3 , pp. 291-299
    • Fagan, K.A.1    Fouty, B.W.2    Tyler, R.C.3
  • 67
    • 3042721626 scopus 로고    scopus 로고
    • Investigation of proton conductance in liver mitochondria of broilers with pulmonary hypertension syndrome
    • Cawthon, D., Iqbal, M., Brand, J. et al. (2004) Investigation of proton conductance in liver mitochondria of broilers with pulmonary hypertension syndrome. Poultry Science, 83, 259-65.
    • (2004) Poultry Science , vol.83 , pp. 259-265
    • Cawthon, D.1    Iqbal, M.2    Brand, J.3
  • 68
    • 0035320648 scopus 로고    scopus 로고
    • Lung mitochondrial dysfunction in pulmonary hypertension syndrome. I. Site-specific defects in the electron transport chain
    • Iqbal, M., Cawthon, D., Wideman, R.F., and Bottje, W.G. Jr. (2001) Lung mitochondrial dysfunction in pulmonary hypertension syndrome. I. Site-specific defects in the electron transport chain. Poultry Science, 80, 485-95.
    • (2001) Poultry Science , vol.80 , pp. 485-495
    • Iqbal, M.1    Cawthon, D.2    Wideman, R.F.3    Bottje Jr., W.G.4
  • 69
    • 0037080541 scopus 로고    scopus 로고
    • Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels
    • Michelakis, E.D., McMurtry, M.S., Wu, X.C. et al. (2002) Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation, 105, 244-50.
    • (2002) Circulation , vol.105 , pp. 244-250
    • Michelakis, E.D.1    McMurtry, M.S.2    Wu, X.C.3
  • 72
    • 0017153683 scopus 로고
    • Aerobic glycolysis during lymphocyte proliferation
    • Wang, T., Marquardt, C., and Foker, J. (1976) Aerobic glycolysis during lymphocyte proliferation. Nature, 261, 702-5.
    • (1976) Nature , vol.261 , pp. 702-705
    • Wang, T.1    Marquardt, C.2    Foker, J.3
  • 73
    • 33745155785 scopus 로고    scopus 로고
    • An abnormal mitochondrial-hypoxia inducible factor-1 alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats-Similarities to human pulmonary arterial hypertension
    • Bonnet, S., Michelakis, E.D., Porter, C.J., ndrade-Navarro, M.A.,, Thebaud, B., Bonnet, S., Haromy, A., Harry, G., Moudgil, R., McMurtry, S., Weir, E.K. and Archer, S.L. (2006) An abnormal mitochondrial-hypoxia inducible factor-1 alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats-Similarities to human pulmonary arterial hypertension. Circulation, 113, 2630-2641.
    • (2006) Circulation , vol.113 , pp. 2630-2641
    • Bonnet, S.1    Michelakis, E.D.2    Porter, C.J.3    Ndrade-Navarro, M.A.4    Thebaud, B.5    Bonnet, S.6    Haromy, A.7    Harry, G.8    Moudgil, R.9    McMurtry, S.10    Weir, E.K.11    Archer, S.L.12
  • 74
    • 0025329710 scopus 로고
    • The histopathology of 36 cases of plexogenic pulmonary arteriopathy
    • Caslin, A.W., Heath, D., Madden, B. et al. (1990) The histopathology of 36 cases of plexogenic pulmonary arteriopathy. Histopathology, 16, 9-19.
    • (1990) Histopathology , vol.16 , pp. 9-19
    • Caslin, A.W.1    Heath, D.2    Madden, B.3
  • 75
    • 33144471139 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage
    • Frid, M.G., Brunetti, J.A., Burke, D.L. et al. (2006) Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. American Journal of Pathology, 168, 659-69.
    • (2006) American Journal of Pathology , vol.168 , pp. 659-669
    • Frid, M.G.1    Brunetti, J.A.2    Burke, D.L.3
  • 76
    • 0018747729 scopus 로고
    • Electron microscopy of the plexiform lesion
    • Smith, P. and Heath, D. (1979) Electron microscopy of the plexiform lesion. Thorax, 34, 177-86.
    • (1979) Thorax , vol.34 , pp. 177-186
    • Smith, P.1    Heath, D.2
  • 77
    • 33749345684 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
    • Stenmark, K.R., Fagan, K.A., and Frid, M.G. (2006) Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circulation Research, 99, 675-91.
    • (2006) Circulation Research , vol.99 , pp. 675-691
    • Stenmark, K.R.1    Fagan, K.A.2    Frid, M.G.3
  • 79
    • 0034658662 scopus 로고    scopus 로고
    • In vitro differentiation of endothelial cells from AC133-positive progenitor cells
    • Gehling, U.M., Ergun, S., Schumacher, U. et al. (2000) In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood, 95, 3106-12.
    • (2000) Blood , vol.95 , pp. 3106-3112
    • Gehling, U.M.1    Ergun, S.2    Schumacher, U.3
  • 80
    • 0141541729 scopus 로고    scopus 로고
    • Myoendothelial differentiation of human umbilical cord blood-derived stem cells in ischemic limb tissues
    • Pesce, M., Orlandi, A., Iachininoto, M.G. et al. (2003) Myoendothelial differentiation of human umbilical cord blood-derived stem cells in ischemic limb tissues. Circulation Research, 93, e51-e62.
    • (2003) Circulation Research , vol.93
    • Pesce, M.1    Orlandi, A.2    Iachininoto, M.G.3
  • 81
    • 34249704141 scopus 로고    scopus 로고
    • Working hypothesis to redefine endothelial progenitor cells
    • Prater, D.N., Case, J., Ingram, D.A., and Yoder, M.C. (2007) Working hypothesis to redefine endothelial progenitor cells. Leukemia, 21, 1141-49.
    • (2007) Leukemia , vol.21 , pp. 1141-1149
    • Prater, D.N.1    Case, J.2    Ingram, D.A.3    Yoder, M.C.4
  • 82
    • 1042291152 scopus 로고    scopus 로고
    • Characterization of two types of endothelial progenitor cells and their different contributions to neovasculo-genesis
    • Hur, J., Yoon, C.H., Kim, H.S. et al. (2004) Characterization of two types of endothelial progenitor cells and their different contributions to neovasculo-genesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 288-93.
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , pp. 288-293
    • Hur, J.1    Yoon, C.H.2    Kim, H.S.3
  • 83
    • 4043184065 scopus 로고    scopus 로고
    • Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
    • Ceradini, D.J., Kulkarni, A.R., Callaghan, M.J. et al. (2004) Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nature Medicine, 10, 858-64.
    • (2004) Nature Medicine , vol.10 , pp. 858-864
    • Ceradini, D.J.1    Kulkarni, A.R.2    Callaghan, M.J.3
  • 85
    • 19844374754 scopus 로고    scopus 로고
    • Bone marrow-derived cells contribute to pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension
    • Hayashida, K., Fujita, J., Miyake, Y. et al. (2005) Bone marrow-derived cells contribute to pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension. Chest, 127, 1793-98.
    • (2005) Chest , vol.127 , pp. 1793-1798
    • Hayashida, K.1    Fujita, J.2    Miyake, Y.3
  • 86
    • 34147120072 scopus 로고    scopus 로고
    • Mechanisms underlying the impairment of ischemia-induced neovascularization in matrix metalloproteinase 2-deficient mice
    • Cheng, X.W., Kuzuya, M., Nakamura, K. et al. (2007) Mechanisms underlying the impairment of ischemia-induced neovascularization in matrix metalloproteinase 2-deficient mice. Circulation Research, 100, 904-13.
    • (2007) Circulation Research , vol.100 , pp. 904-913
    • Cheng, X.W.1    Kuzuya, M.2    Nakamura, K.3
  • 87
    • 33644865928 scopus 로고    scopus 로고
    • Bone mor phogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension
    • Teichert-Kuliszewska, K., Kutryk, M.J., Kuliszewski, M.A. et al. (2006) Bone mor phogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension. Circulation Research, 98, 209-17.
    • (2006) Circulation Research , vol.98 , pp. 209-217
    • Teichert-Kuliszewska, K.1    Kutryk, M.J.2    Kuliszewski, M.A.3
  • 89
    • 33646201514 scopus 로고    scopus 로고
    • Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia
    • Eddahibi, S., Guignabert, C., Barlier-Mur, A.M. et al. (2006) Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia. Circulation, 113, 1857-64.
    • (2006) Circulation , vol.113 , pp. 1857-1864
    • Eddahibi, S.1    Guignabert, C.2    Barlier-Mur, A.M.3
  • 90
    • 0034776773 scopus 로고    scopus 로고
    • Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension
    • Eddahibi, S., Humbert, M., Fadel, E. et al. (2001) Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension. The Journal of Clinical Investigation, 108, 1141-50.
    • (2001) The Journal of Clinical Investigation , vol.108 , pp. 1141-1150
    • Eddahibi, S.1    Humbert, M.2    Fadel, E.3
  • 91
    • 33646429236 scopus 로고    scopus 로고
    • The human herpesvirus 8 chemokine receptor vG-PCR triggers autonomous proliferation of endothelial cells
    • Grisotto, M.G., Garin, A., Martin, A.P. et al. (2006) The human herpesvirus 8 chemokine receptor vG-PCR triggers autonomous proliferation of endothelial cells. The Journal of Clinical Investigation, 116, 1264-73.
    • (2006) The Journal of Clinical Investigation , vol.116 , pp. 1264-1273
    • Grisotto, M.G.1    Garin, A.2    Martin, A.P.3
  • 92
    • 0141679188 scopus 로고    scopus 로고
    • Expression of human herpesvirus 8 in primary pulmonary hypertension
    • Cool, C.D., Rai, M.D., Yeager, M.E. et al. (2003) Expression of human herpesvirus 8 in primary pulmonary hypertension. The New England Journal of Medicine, 349, 1113-22.
    • (2003) The New England Journal of Medicine , vol.349 , pp. 1113-1122
    • Cool, C.D.1    Rai, M.D.2    Yeager, M.E.3
  • 93
    • 15844384870 scopus 로고    scopus 로고
    • Kaposi sarcoma-associated herpesvirus and primary and secondary pulmonary hypertension
    • Laney, A.S., De, M., Peters, J.S. et al. (2005) Kaposi sarcoma-associated herpesvirus and primary and secondary pulmonary hypertension. Chest, 127, 762-67.
    • (2005) Chest , vol.127 , pp. 762-767
    • Laney, A.S.1    De, M.2    Peters, J.S.3
  • 95
    • 39149131039 scopus 로고    scopus 로고
    • Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin
    • Spiekerkoetter, E., Alvira, C.M., Kim, Y.M. et al. (2008) Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin. American Journal of Physiology: Lung Cellular and Molecular Physiology, 294, L276-89.
    • (2008) American Journal of Physiology: Lung Cellular and Molecular Physiology , vol.294
    • Spiekerkoetter, E.1    Alvira, C.M.2    Kim, Y.M.3
  • 98
    • 40749109217 scopus 로고    scopus 로고
    • Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension
    • Moreno-Vinasco, L., Gomberg-Maitland, M., Maitland, M.L. et al. (2008) Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension. Physiological Genomics, 33, 278-91.
    • (2008) Physiological Genomics , vol.33 , pp. 278-291
    • Moreno-Vinasco, L.1    Gomberg-Maitland, M.2    Maitland, M.L.3


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