메뉴 건너뛰기




Volumn 33, Issue 6, 2012, Pages 1186-1198

NADPH oxidase activation: A mechanism of erectile dysfunction in a rat model of sleep apnea

Author keywords

Intermittent hypoxia; Nitric oxide synthase; Reactive oxygen

Indexed keywords

APOCYNIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE;

EID: 84873598336     PISSN: 01963635     EISSN: 19394640     Source Type: Journal    
DOI: 10.2164/jandrol.112.016642     Document Type: Article
Times cited : (23)

References (57)
  • 1
    • 1642499152 scopus 로고    scopus 로고
    • Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase
    • Abramov AY, Canevari L, Duchen MR. Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci. 2004;24:565-575.
    • (2004) J Neurosci , vol.24 , pp. 565-575
    • Abramov, A.Y.1    Canevari, L.2    Duchen, M.R.3
  • 2
    • 33646371004 scopus 로고    scopus 로고
    • Role of oxidative stress in the pathophysiological mechanism of erectile dysfunction
    • Agarwal A, Nandipati KC, Sharma RK, Zippe CD, Raina R. Role of oxidative stress in the pathophysiological mechanism of erectile dysfunction. J Androl. 2006;27(3):335-347.
    • (2006) J Androl , vol.27 , Issue.3 , pp. 335-347
    • Agarwal, A.1    Nandipati, K.C.2    Sharma, R.K.3    Zippe, C.D.4    Raina, R.5
  • 3
    • 0028837352 scopus 로고
    • Physiology of penile erection
    • Andersson KE, Wagner G. Physiology of penile erection. Physiol Rev. 1995;75(1):191-236.
    • (1995) Physiol Rev , vol.75 , Issue.1 , pp. 191-236
    • Andersson, K.E.1    Wagner, G.2
  • 4
    • 0037592390 scopus 로고    scopus 로고
    • Sleep apnea and cardiovascular disease: implications for understanding erectile dysfunction
    • Arruda-Olson AM, Olson LJ, Nehra A, Somers VK. Sleep apnea and cardiovascular disease: implications for understanding erectile dysfunction. Herz. 2003;28:298-303.
    • (2003) Herz , vol.28 , pp. 298-303
    • Arruda-Olson, A.M.1    Olson, L.J.2    Nehra, A.3    Somers, V.K.4
  • 5
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology
    • Bedard K, Krause K-H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007;87: 245-313.
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.-H.2
  • 7
    • 0037404943 scopus 로고    scopus 로고
    • Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats
    • Bivalacqua TJ, Usta MF, Champion HC, Adams D, Namara DB, Abdel-Mageed AB, Kadowitz PJ, Hellstrom WJ. Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats. J Urol. 2003b;169:1911-1917.
    • (2003) J Urol , vol.169 , pp. 1911-1917
    • Bivalacqua, T.J.1    Usta, M.F.2    Champion, H.C.3    Adams, D.4    Namara, D.B.5    Abdel-Mageed, A.B.6    Kadowitz, P.J.7    Hellstrom, W.J.8
  • 8
    • 3342887762 scopus 로고    scopus 로고
    • Novel nitric oxide signaling mechanisms regulate the erectile response
    • Burnett AL. Novel nitric oxide signaling mechanisms regulate the erectile response. Int J Impot Res. 2004;16:S15-S19.
    • (2004) Int J Impot Res , vol.16
    • Burnett, A.L.1
  • 9
    • 27944499322 scopus 로고    scopus 로고
    • The nitric oxide signaling pathway in the penis
    • Burnett AL, Musicki B. The nitric oxide signaling pathway in the penis. Curr Pharm Des. 2005;11(31):3987-3994.
    • (2005) Curr Pharm Des , vol.11 , Issue.31 , pp. 3987-3994
    • Burnett, A.L.1    Musicki, B.2
  • 10
    • 33745479208 scopus 로고    scopus 로고
    • Nitric oxide/redoxbased signaling as a therapeutic target for penile disorders
    • Burnett AL, Musicki B, Jin L, Bivalacqua TJ. Nitric oxide/redoxbased signaling as a therapeutic target for penile disorders. Expert Opin Ther Target. 2006;10:445-457.
    • (2006) Expert Opin Ther Target , vol.10 , pp. 445-457
    • Burnett, A.L.1    Musicki, B.2    Jin, L.3    Bivalacqua, T.J.4
  • 11
    • 0028858786 scopus 로고
    • NO, nitrosonium ions, nitroxide ions, nitrosothiols and iron-nitrosyls in biology: a chemist's perspective
    • Butler AR, Flitney FW, Williams DL. NO, nitrosonium ions, nitroxide ions, nitrosothiols and iron-nitrosyls in biology: a chemist's perspective. Trends Pharmacol Sci. 1995;16(1):18-22.
    • (1995) Trends Pharmacol Sci , vol.16 , Issue.1 , pp. 18-22
    • Butler, A.R.1    Flitney, F.W.2    Williams, D.L.3
  • 13
    • 0030889536 scopus 로고    scopus 로고
    • Disruption of vascular signaling buy the reaction nitric oxide with superoxide: implication for cardiovascular disease
    • Darley-Usmar V, White R. Disruption of vascular signaling buy the reaction nitric oxide with superoxide: implication for cardiovascular disease. Exp Physiol. 1997;82(2):305-316.
    • (1997) Exp Physiol , vol.82 , Issue.2 , pp. 305-316
    • Darley-Usmar, V.1    White, R.2
  • 14
    • 0842270038 scopus 로고    scopus 로고
    • Oxidative stress and aging
    • Droge W. Oxidative stress and aging. Adv Exp Med Biol. 2003;543: 191-200.
    • (2003) Adv Exp Med Biol , vol.543 , pp. 191-200
    • Droge, W.1
  • 15
    • 0033067451 scopus 로고    scopus 로고
    • Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model
    • El-Sakka AI, Lin CS, Chui RM, Dahiya R, Lue TF. Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model. Int J Impot Res. 1999;11:123-132.
    • (1999) Int J Impot Res , vol.11 , pp. 123-132
    • El-Sakka, A.I.1    Lin, C.S.2    Chui, R.M.3    Dahiya, R.4    Lue, T.F.5
  • 16
    • 55149091753 scopus 로고    scopus 로고
    • Morbidity due to obstructive sleep apnea: insights from animal models
    • Farre R, Montserrat JM, Navajas D. Morbidity due to obstructive sleep apnea: insights from animal models. Curr Opin Pulm Med. 2008;14:530-536.
    • (2008) Curr Opin Pulm Med , vol.14 , pp. 530-536
    • Farre, R.1    Montserrat, J.M.2    Navajas, D.3
  • 17
    • 0038178394 scopus 로고    scopus 로고
    • Sympathetic overactivity in the etiology of hypertension of obstructive sleep apnea
    • Fletcher EC. Sympathetic overactivity in the etiology of hypertension of obstructive sleep apnea. Sleep. 2003;26:15-19.
    • (2003) Sleep , vol.26 , pp. 15-19
    • Fletcher, E.C.1
  • 18
    • 0026602427 scopus 로고
    • Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats
    • Fletcher EC, Lesske J, Qian W, Miller CC III, Unger T. Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats. Hypertension. 1992;6:555-561.
    • (1992) Hypertension , vol.6 , pp. 555-561
    • Fletcher, E.C.1    Lesske, J.2    Qian, W.3    Miller III, C.C.4    Unger, T.5
  • 20
    • 0034130955 scopus 로고    scopus 로고
    • Central neural regulation of penile erection
    • Giuliano F, Rampin O. Central neural regulation of penile erection. Biobehav Rev. 2000;2:517-533.
    • (2000) Biobehav Rev , vol.2 , pp. 517-533
    • Giuliano, F.1    Rampin, O.2
  • 21
    • 0034243414 scopus 로고    scopus 로고
    • Male sexual circuitry. Working Group for Study of Central Mechanisms in Erectile Dysfunction
    • Goldstein I. Male sexual circuitry. Working Group for Study of Central Mechanisms in Erectile Dysfunction. Sci Am. 2000;283:70-75.
    • (2000) Sci Am. , vol.283 , pp. 70-75
    • Goldstein, I.1
  • 23
    • 0034677947 scopus 로고    scopus 로고
    • NAD(P)H oxidase: role in cardiovascular biology and disease
    • Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res. 2000;86:494-501.
    • (2000) Circ Res , vol.86 , pp. 494-501
    • Griendling, K.K.1    Sorescu, D.2    Ushio-Fukai, M.3
  • 24
    • 31944444434 scopus 로고    scopus 로고
    • Increased aortic NADPH oxidase activity in rats with genetically high angiotensin-converting enzyme levels
    • Jalil JE, Perez A, Ocaranza MP, Bargetto J, Galaz A, Lavandero S. Increased aortic NADPH oxidase activity in rats with genetically high angiotensin-converting enzyme levels. Hypertension. 2005;46(6):1362-1367.
    • (2005) Hypertension , vol.46 , Issue.6 , pp. 1362-1367
    • Jalil, J.E.1    Perez, A.2    Ocaranza, M.P.3    Bargetto, J.4    Galaz, A.5    Lavandero, S.6
  • 25
    • 79952404359 scopus 로고    scopus 로고
    • Intracavernous delivery of a designed angiopoietin-1 variant rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse
    • Jin HR, Kim WJ, Song JS, Piao S, Choi MJ, Tumurbaatar M, Shin SH, Yin GN, Koh GY, Ryu JK, Suh JK. Intracavernous delivery of a designed angiopoietin-1 variant rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse. Diabetes. 2011;60:969-980.
    • (2011) Diabetes , vol.60 , pp. 969-980
    • Jin, H.R.1    Kim, W.J.2    Song, J.S.3    Piao, S.4    Choi, M.J.5    Tumurbaatar, M.6    Shin, S.H.7    Yin, G.N.8    Koh, G.Y.9    Ryu, J.K.10    Suh, J.K.11
  • 26
    • 40349113071 scopus 로고    scopus 로고
    • NADPH oxidase activation: a mechanism of hypertension-associated erectile dysfunction
    • Jin L, Lagoda G, Leite R, Webb RC, Burnett AL. NADPH oxidase activation: a mechanism of hypertension-associated erectile dysfunction. J Sex Med. 2008;5(3):544-551.
    • (2008) J Sex Med , vol.5 , Issue.3 , pp. 544-551
    • Jin, L.1    Lagoda, G.2    Leite, R.3    Webb, R.C.4    Burnett, A.L.5
  • 27
    • 33645815874 scopus 로고    scopus 로고
    • Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunction
    • Jin L, Liu T, Lagoda GA, Champion HC, Bivalacqua TJ, Burnett AL. Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunction. FASEB J. 2006;20:536-538.
    • (2006) FASEB J , vol.20 , pp. 536-538
    • Jin, L.1    Liu, T.2    Lagoda, G.A.3    Champion, H.C.4    Bivalacqua, T.J.5    Burnett, A.L.6
  • 28
    • 0024397219 scopus 로고
    • Superoxide anion is an endothelium derived contracting factor
    • Katusic ZS, Vanhoutte PM. Superoxide anion is an endothelium derived contracting factor. Am J Physiol. 1989;257(1 Pt 2):H33- H37.
    • (1989) Am J Physiol , vol.257 , Issue.1 PART. 2 , pp. 33-37
    • Katusic, Z.S.1    Vanhoutte, P.M.2
  • 29
    • 0035154347 scopus 로고    scopus 로고
    • The effect of superoxide dismutase on nitric oxidemediated and electrical field-stimulated diabetic rabbit cavernosal smooth muscle relaxation
    • Khan MA, Thompson CS, Jeremy JY, Mumtaz FH, Mikhailidis P, Morgan RJ. The effect of superoxide dismutase on nitric oxidemediated and electrical field-stimulated diabetic rabbit cavernosal smooth muscle relaxation. BJU Int. 2001a;87:98-103.
    • (2001) BJU Int , vol.87 , pp. 98-103
    • Khan, M.A.1    Thompson, C.S.2    Jeremy, J.Y.3    Mumtaz, F.H.4    Mikhailidis, P.5    Morgan, R.J.6
  • 31
    • 27644473692 scopus 로고    scopus 로고
    • Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficits
    • Kheirandish L, Row BW, Li RC, BrittianKR, Gozal D. Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficits. Sleep. 2005;28:1412-1417.
    • (2005) Sleep , vol.28 , pp. 1412-1417
    • Kheirandish, L.1    Row, B.W.2    Li, R.C.3    Brittian, K.R.4    Gozal, D.5
  • 32
    • 0041885877 scopus 로고    scopus 로고
    • Involvement of superoxide radical in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbits
    • Kim SC, Kim IK, Seo KK, Baek KJ, Lee MY. Involvement of superoxide radical in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbits. Urol Res. 1997;25:341-346.
    • (1997) Urol Res , vol.25 , pp. 341-346
    • Kim, S.C.1    Kim, I.K.2    Seo, K.K.3    Baek, K.J.4    Lee, M.Y.5
  • 33
    • 23244448247 scopus 로고    scopus 로고
    • Sildenafil inhibits the formation of superoxide and the expression of gp47phox NAD(P)H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells
    • Koupparis AJ, Jeremy JY, Muzaffar S, Persad R, Shukla N. Sildenafil inhibits the formation of superoxide and the expression of gp47phox NAD(P)H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells. BJU Int. 2005;96:423-427.
    • (2005) BJU Int , vol.96 , pp. 423-427
    • Koupparis, A.J.1    Jeremy, J.Y.2    Muzaffar, S.3    Persad, R.4    Shukla, N.5
  • 34
    • 34447498964 scopus 로고    scopus 로고
    • FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through anti-oxidative mechanims
    • LagodaGA, Jin L, Lehrfeld TJ, Liu T, Burnett AL. FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through anti-oxidative mechanims. J Sex Med. 2007;4:908-916.
    • (2007) J Sex Med , vol.4 , pp. 908-916
    • Lagoda, G.A.1    Jin, L.2    Lehrfeld, T.J.3    Liu, T.4    Burnett, A.L.5
  • 35
    • 78650779521 scopus 로고    scopus 로고
    • Chronic treatment with an oral rho-kinase inhibitor restores erection function by suppressing corporal apoptosis in diabetic rats
    • Li WJ, Park K, Paick JS, Kim SM. Chronic treatment with an oral rho-kinase inhibitor restores erection function by suppressing corporal apoptosis in diabetic rats. J Sex Med. 2010;8(2): 400-410.
    • (2010) J Sex Med , vol.8 , Issue.2 , pp. 400-410
    • Li, W.J.1    Park, K.2    Paick, J.S.3    Kim, S.M.4
  • 36
    • 75449093386 scopus 로고    scopus 로고
    • Apocynin attenuate spatial learning deficits and oxidative responses to intermittent hypoxia
    • Liu HG, Liu K, Zhou YN, Xu YJ. Apocynin attenuate spatial learning deficits and oxidative responses to intermittent hypoxia. Sleep Med. 2010;11:205-212.
    • (2010) Sleep Med , vol.11 , pp. 205-212
    • Liu, H.G.1    Liu, K.2    Zhou, Y.N.3    Xu, Y.J.4
  • 37
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method. Methods. 2001;25(4):402-408.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 38
    • 0034660235 scopus 로고    scopus 로고
    • Erectile dysfunction
    • Lue TF. Erectile dysfunction. N Engl J Med. 2000;342(24):1802-1813.
    • (2000) N Engl J Med , vol.342 , Issue.24 , pp. 1802-1813
    • Lue, T.F.1
  • 39
    • 0035460008 scopus 로고    scopus 로고
    • Neural circuitry involved in sexual function
    • McKenna KE. Neural circuitry involved in sexual function. J Spinal Cord Med. 2001;24:148-154.
    • (2001) J Spinal Cord Med , vol.24 , pp. 148-154
    • McKenna, K.E.1
  • 40
    • 77956286084 scopus 로고    scopus 로고
    • Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase
    • Musicki B, Liu T, Lagoda GA, Strong TD, Sezen SF, Johnson JM, Burnett AL. Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase. J Sex Med. 2010;7(9):3023-3032.
    • (2010) J Sex Med , vol.7 , Issue.9 , pp. 3023-3032
    • Musicki, B.1    Liu, T.2    Lagoda, G.A.3    Strong, T.D.4    Sezen, S.F.5    Johnson, J.M.6    Burnett, A.L.7
  • 41
    • 40349113064 scopus 로고    scopus 로고
    • Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysis
    • Musicki B, Liu T, Strong T, Jin L, Laughlin MH, Turk JR, Burnett AL. Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysis. J Sex Med. 2008;5:552-561.
    • (2008) J Sex Med , vol.5 , pp. 552-561
    • Musicki, B.1    Liu, T.2    Strong, T.3    Jin, L.4    Laughlin, M.H.5    Turk, J.R.6    Burnett, A.L.7
  • 42
    • 33846818459 scopus 로고    scopus 로고
    • Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury
    • Papaharalambus CA, Griendling KK. Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury. Trends Cardiovasc Med. 2007;17:48-54.
    • (2007) Trends Cardiovasc Med , vol.17 , pp. 48-54
    • Papaharalambus, C.A.1    Griendling, K.K.2
  • 43
    • 0026353632 scopus 로고
    • Nitric oxide as amediator of relaxation of the corpus cavernosumin response to nonadrenergic, noncholinergic neurotransmission
    • Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as amediator of relaxation of the corpus cavernosumin response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med. 1992;326(2):90-94.
    • (1992) N Engl J Med , vol.326 , Issue.2 , pp. 90-94
    • Rajfer, J.1    Aronson, W.J.2    Bush, P.A.3    Dorey, F.J.4    Ignarro, L.J.5
  • 44
    • 1842562373 scopus 로고    scopus 로고
    • Platelet-activating factor receptor-deficient mice are protected from experimental sleep apnea-induced learning deficits
    • Row BW, Kheirandish L, Li RC, Guo SZ, Brittian KR, Hardy M, Bazan NG, Gozal D. Platelet-activating factor receptor-deficient mice are protected from experimental sleep apnea-induced learning deficits. J Neurochem. 2004;89:189-196.
    • (2004) J Neurochem , vol.89 , pp. 189-196
    • Row, B.W.1    Kheirandish, L.2    Li, R.C.3    Guo, S.Z.4    Brittian, K.R.5    Hardy, M.6    Bazan, N.G.7    Gozal, D.8
  • 47
    • 0036591853 scopus 로고    scopus 로고
    • Protein turnover by the proteasome in aging and disease
    • Shringarpure R, Davies KJ. Protein turnover by the proteasome in aging and disease. Free Radic Biol Med. 2002;32:1084-1089.
    • (2002) Free Radic Biol Med , vol.32 , pp. 1084-1089
    • Shringarpure, R.1    Davies, K.J.2
  • 48
    • 57649219192 scopus 로고    scopus 로고
    • The administration of folic acid improves erectile function and reduces intracavernosal oxidative stress in the diabetic rabbit
    • Shukla N, Hotston M, Persad R, Angelini GD, Jeremy JY. The administration of folic acid improves erectile function and reduces intracavernosal oxidative stress in the diabetic rabbit. BJU Int. 2009;103:98-103.
    • (2009) BJU Int , vol.103 , pp. 98-103
    • Shukla, N.1    Hotston, M.2    Persad, R.3    Angelini, G.D.4    Jeremy, J.Y.5
  • 49
    • 22144480608 scopus 로고    scopus 로고
    • Effect of sildenafil citrate and a nitric oxidedonating sildenafil derivative NCX 911 on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits
    • Shukla N, Jones R, Persad R, Angelini GD, Jeremy JY. Effect of sildenafil citrate and a nitric oxidedonating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits. Eur J Pharmacol. 2005;517:224-231.
    • (2005) Eur J Pharmacol , vol.517 , pp. 224-231
    • Shukla, N.1    Jones, R.2    Persad, R.3    Angelini, G.D.4    Jeremy, J.Y.5
  • 50
    • 33646839749 scopus 로고    scopus 로고
    • Defining association between sleep apnea syndrome and erectile dysfunction
    • Teloken PE, Smith EB, Lodowsky C, Freedom T, Mulhall JP. Defining association between sleep apnea syndrome and erectile dysfunction. Urology. 2006;67:1033-1037.
    • (2006) Urology , vol.67 , pp. 1033-1037
    • Teloken, P.E.1    Smith, E.B.2    Lodowsky, C.3    Freedom, T.4    Mulhall, J.P.5
  • 52
    • 3242744596 scopus 로고    scopus 로고
    • Longterm intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions
    • Veasey SC, DavisCW, Fenik P, ZhanG, Hsu YJ, PraticoD, GowA. Longterm intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions. Sleep. 2004;27:194-201.
    • (2004) Sleep , vol.27 , pp. 194-201
    • Veasey, S.C.1    Davis, C.W.2    Fenik, P.3    Zhan, G.4    Hsu, Y.J.5    Pratico, D.6    Gow, A.7
  • 56
    • 0027462562 scopus 로고
    • The occurrence of sleep-disordered breathing among middle-aged adults
    • Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328:1230-1235.
    • (1993) N Engl J Med , vol.328 , pp. 1230-1235
    • Young, T.1    Palta, M.2    Dempsey, J.3    Skatrud, J.4    Weber, S.5    Badr, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.