Central neural regulation of penile erection

Neuroscience and Biobehavioral Reviews

Volumn 24, Issue 5, 2000, Pages 517-533

  Giuliano, F ^a   Rampin, O ^b  

^a BICÊTRE HOSPITAL   (France)

^b CEMAGREF   (France)

Author keywords

Dopamine; Genital reflexes; Lumbosacral spinal cord; Medial preoptic area; Noradrenaline; Oxytocin; Paraventricular nucleus; Penile erection; Raphe nuclei; Serotonin

Indexed keywords

ADRENALIN; APOMORPHINE; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; ENDORPHIN; MELANOCORTIN; NEUROPEPTIDE; NORADRENALIN; OXYTOCIN; SEROTONIN; YOHIMBINE;

ADRENERGIC SYSTEM; BRAIN REGION; CHOLINERGIC SYSTEM; HUMAN; INNERVATION; LUMBOSACRAL SPINE; MALE; MEDIAL PREOPTIC AREA; MOTONEURON; NEUROMODULATION; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAPHE NUCLEUS; REVIEW; SEXUAL BEHAVIOR; THALAMUS MIDLINE NUCLEUS;

ANIMALS; CENTRAL NERVOUS SYSTEM; HUMANS; MALE; PENILE ERECTION; SPINAL CORD;

EID: 0034130955     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0149-7634(00)00020-8     Document Type: Review

References (261)

1. Ackerman A.E., Lange G.M., Clemens L.G. Effects of paraventricular lesions on sex behavior and seminal emission in male rats. Physiol Behav. 63:1997;49-53.
2. Agmö A. Mating in male rabbits after anesthesia of the glans penis. Physiol Behav. 17:1976;435-437.
3. Aloi J.A., Insel T.R., Mueller E.A., Murphy D.L. Neuroendocrine and behavioral effects of m-chlorophenylpiperazine administration in rhesus monkeys. Life Sci. 34:1984;1325-1331.
4. Anderson C.R., Edwards S.L., Furness J.B., Bredt D.S., Snyder S.H. The distribution of nitric oxide synthase-containing autonomic preganglionic terminals in the rat. Brain Res. 614:1993;78-85.
5. Andersson K.E., Wagner G. Physiology of penile erection. Physiol Rev. 75:1995;191-236.
6. Andersson P.O., Bloom S.R., Mellander S. Haemodynamics of pelvic nerve induced penile erection in the dog: possible mediation by vasoactive intestinal polypeptide. J Physiol. 350:1984;209-224.
7. Andersson P.O., Björnberg J., Bloom S.R., Mellander S. Vasoactive intestinal polypeptide in relation to penile erection in the cat evoked by pelvic and by hypogastric nerve stimulation. J Urol. 138:1987;419-422.
8. Argiolas A., Gessa G.L. Central functions of oxytocin. Neurosci Biobehav Rev. 15:1991;217-231.
9. Argiolas A., Melis M.R. Neuromodulation of penile erection: an overview of the role of neurotransmitters and neuropeptides. Prog Neurobiol. 47:1995;235-255.
10. Arletti R., Calza L., Giardino L., Benelli A., Cavazzuti E., Bertolini A. Sexual impotence is associated with a reduced production of oxytocin and with an increased production of opioid peptides in the paraventricular nucleus of male rats. Neurosci Lett. 233:1997;65-68.
11. Arnold A.P., Breedlove S.M. Organizational and activational effects of sex steroid hormones on vertebrate brain and behavior: a re-analysis. Horm Behav. 19:1985;469-498.
12. Arnold A.P., Jordan C.L. Hormonal organization of neural circuits. Martini L., Ganong W.F. Frontiers in neuroendocrinology. vol 10:1988;185-214 Raven Press, New York.
13. Aston-Jones G., Shipley M.T., Grzanna R. The locus coeruleus, A5 and A7 noradrenergic cell groups. Paxinos G. The rat nervous system. 2nd ed. 1995;183-213 Academic Press, San Diego. (chap 11).
14. Bacq Z.M. Impotence of the male rodent after sympathetic denervation of the genital organs. Am J Physiol. 96:1931;321-330.
15. Bacq Z.M. Recherches sur la physiologie et la pharmacologie du système nerveux autonome. XII. Nature cholinergique et adrénergique des diverses innervations vasomotrices du pénis chez le chien. Arch Int Physiol. 11:1935;311-321.
16. Baggio G., Ferrari F. The role of dopaminergic receptors in the behavioural effects induced by lisuride in male rats. Psychopharmacology. 80:1983;38-42.
17. Bancila M., Vergé D., Rampin O., Backstrom J.R., Sanders-Bush E., McKenna K.E., Marson L., Calas A., Giuliano F. 5-hydroxytryptamine2C receptors on spinal neurons controlling penile erection in the rat. Neuroscience. 4:1999;1523-1537.
18. Bancroft J. Are the effects of androgens on male sexuality noradrenergically mediated? Some consideration of the human. Neurosci Biobehav Rev. 19:1995;325-330.
19. Barber R.P., Vaughn J.E., Roberts E. The cytoarchitecture of gabaergic neurons in rat spinal cord. Brain Res. 238:1982;305-328.
20. Barber R.P., Phelps P.E., Houser C.R., Crawford G.D., Salvaterra P.M., Vaughn J.E. The morphology and distribution of neurons containing choline acetyltransferase in the adult rat spinal cord: an immunocytochemical study. J Comp Neurol. 229:1984;329-346.
21. Baraldi M., Benassi-Benelli A. Induzione di erezioni ripetute nel ratto adulto mediante apomorfina. Riv Farmacol Ter. 6:1975;147-149.
22. Baum M.J., Everitt B.J. Increased expression of c-fos in the medial preoptic area after mating in male rats: role of afferent inputs from the medial amygdala and midbrain central temgental field. Neuroscience. 50:1992;627-646.
23. Bazzett T.J., Eaton R.C., Thompson J.T., Markowski V.P., Lumley L.A., Hull E.M. Dose dependent D2 effects on genital reflexes after MPOA injections of quinelorane and apomorphine. Life Sci. 48:1991;2309-2315.
24. Beach F.A., Levinson G. Effects of androgen on the glans penis and mating behavior of castrated male rats. J Exp Zool. 114:1950;159-171.
25. Bell C. Autonomic nervous control of reproduction: circulatory and other factors. Pharmacol Rev. 24:1972;657-736.
26. Benassi-Benelli A., Ferrari F., Pellegrini Quarantotti B. Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats. Arch Int Pharmacodyn. 242:1979;241-247.
27. Berendsen H.H.G., Gower A.J. Opiate-androgen interactions in drug-induced yawning and penile erections in the rat. Neuroendocrinology. 42:1986;185-190.
28. Berendsen H.H.G., Jenck F., Broekkamp C.L.E. Drug-induced penile erections in rats: indications of serotonin1B receptor mediation. Eur J Pharmacol. 135:1987;279-287.
29. Berendsen H.H.G., Jenck F., Broekkamp C.L.E. Involvement of 5-HT1C receptors in drug-induced penile erections in rats. Psychopharmacology. 101:1990;57-61.
30. Berendsen H.H.G., Broekkamp C.L.E., Van Delft A.M.L. Depletion of brain serotonin differently affects behaviors induced by 5HT1A, 5HT1C, and 5HT2 receptor activation in rats. Behav Neural Biol. 55:1991;214-226.
31. Berendsen H.H.G., Kester R.C.H., Peeters B.W.M.M., Broekkamp C.L.E. Modulation of 5-HT receptor subtype-mediated behaviours by corticosterone. Eur J Pharmacol. 308:1996;103-111.
32. Bernabé J., Rampin O., Giuliano F., Benoit G. Intracavernous pressure changes during reflexive penile erections in the rat. Physiol Behav. 57:1995;837-841.
33. Bernabé J., Rampin O., McKenna K.E., Giuliano F. Spinal regulation of erection by oxytocin: a pharmacological approach in the rat. Soc Neurosci Abstr. 23:1997;1520.
34. Bernabé J., Rampin O., Sachs B.D., Giuliano F. Intracavernous pressure during erection in rats: an integrative approach based on telemetric recording. Am J Physiol. 276:1999;R441-R449.
35. Bitran D., Hull E.M. Pharmacological analysis of male rat sexual behavior. Neurosci Biobehav Rev. 11:1987;365-389.
36. Bitran D., Thompson J.T., Hull E.M., Sachs B.D. Quinerolane (LY163502), a D2 dopamine receptor agonist, facilitates seminal emission, but inhibits penile erection in the rat. Pharmacol Biochem Behav. 34:1989;453-458.
37. Björklund A., Skagerberg G. Evidence for a major spinal projection from the diencephalic A11 dopamine cell group in the rat using transmitter-specific fluorescent retrograde tracing. Brain Res. 177:1979;170-175.
38. Brannigan R.E., McKenna K.E., McVary K.T. Nitric oxide synthase levels in chronic diabetic rats. Int J Impotence Res. 8:1996;123.
39. Breedlove S.M., Arnold A.P. Hormone accumulation in a sexually dimoprhic motor nucleus of the rat spinal cord. Science. 210:1980;564-566.
40. Buijs R.M., Swaab D.F., Dogterom D.F., Van Leeuwen F.W. Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Cell Tissue Res. 186:1978;423-433.
41. Burnett A.L., Saito S., Maguire M., Yamaguchi H., Chang T.S.K., Hanley D.F. Localization of nitric oxide synthase in spinal nuclei innervating pelvic ganglia. J Urol. 153:1995;212-217.
42. Carati C.J., Creed K.E., Keogh E.J. Autonomic control of penile erection in the dog. J Physiol. 384:1987;525-538.
43. Chang A.Y., Kuo T.B., Chan J.Y., Chan S.H. Concurrent elicitation of electroencephalographic desynchronization and penile erection by cocaine in the rat. Synapse. 24:1996;233-239.
44. Charlton C.G., Helke C.J. Autoradiographic localization and characterization of spinal cord substance P binding sites: high densities in sensory, autonomic, phrenic and Onuf's motor nuclei. J Neurosci. 5:1985;1635-1661.
45. Chen K.K., Chan J.Y.H., Chang L.S., Chen M.T., Chan S.H.H. Elicitation of penile erection following activation of the hippocampal formation in the rat. Neurosci Lett. 141:1992;218-222.
46. Chung K., Briner R.P., Carlton S.M., Westlund K.N. Immunohistochemical localization of seven different peptides in the human spinal cord. J Comp Neurol. 280:1989;158-170.
47. Courtois F.J., MacDougall J.C., Higher C.N.S. control of penile responses in rats: The effect of hypothalamic stimulation. Physiol Behav. 44:1988;165-171.
48. Dahlström A., Fuxe K. The distribution of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine level of bulbospinal neuron systems. Acta Physiol Scand. 247:1965;5-36.
49. Dail W.G., Walton G., Olmsted M.P. Penile erection in the rat: stimulation of the hypogastric nerve elicits increases in penile pressure after chronic interruption of hte sacral parasympathetic outflow. J Autonom Nerv Syst. 28:1989;251-258.
50. Danuser H., Thor K.B. Inhibition of central sympathetic and somatic outflow to the lower urinary tract of the cat by the alpha1 adrenergic receptor antagonist prazosin. J Urol. 153:1995;1308-1312.
51. Day H.E., Campeau S., Watson S.J. Jr, Akil H. Distribution of alpha 1a-, alpha 1b- and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord. J Chem Neuroanat. 13:1997;115-139.
52. DeGroat W.C., Booth A.M. Neural control of penile erection. Maggi C.A. The autonomic nervous system. Nervous control of the urogenital system. vol 3:1993;467-524 Harwood Academic Publishers, London. (chap 13).
53. Diederichs W., Stief C.G., Benard F., Bosch R., Lue T.F., Tanagho E.A. The sympathetic role as an antagonist of erection. Urol Res. 19:1991;123-126.
54. Dixson A.F. Genital sensory feedback and sexual behaviour in male and female marmosets (Callithrix jacchus). Physiol Behav. 37:1986;447-450.
55. Doherty P.C., Wisler P.A. Stimulatory effects of quinelorane on yawning and penile erection in the rat. Life Sciences. 54:1994;507-514.
56. Dornan W.A., Malsbury C.W. Neuropeptides and male sexual behavior. Neurosci Biobehav Rev. 13:1989;1-15.
57. Downie J.W., Bialik G.J. Evidence for a spinal site of action of clonidine on somatic and viscerosomatic reflex activity evoked on the pudendal nerve in cats. J Pharmacol Exp Ther. 246:1988;352-358.
58. Dun N.J., Dun S.L., Wu S.Y., Forstermann U., Schmidt H.H.H.W., Tseng L.F. Nitric oxide synthase immunoreactivity in the rat, mouse, cat and squirrel monkey spinal cord. Neuroscience. 54:1993;845-857.
59. Eaton R.C., Markowski V.P., Lumley A., Thompson J.T., Moses J., Hull E.M. D2 receptors in the paraventricular nucleus regulate genital responses and copulation in male rats. Pharmacol Biochem Behav. 39:1991;177-181.
60. Ernst E., Pittler M.H. Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials. J Urol. 159:1998;433-436.
61. Everitt B.J. Sexual motivation: a neural and behavioural analysis of the mechanisms underlying appetitive and consummatory responses of male rats. Neurosci Biobehav Rev. 14:1990;217-232.
62. Ferrari F., Baggio G. Influence of cimetidine, ranitidine an dimidazole on the behavioral effects of (+) N-n-propylnorapomorphine in male rats. Psychopharmacology. 85:1985;197-200.
63. Ferrari F., Giuliani D. Behavioural effects induced in rats and chicks by D2 dopamine agonists. Physiol Behav. 54:1993;695-700.
64. Ferrari F., Pelloni F., Giuliani D. Behavioural evidence that different neurochemical mechanisms underly stretching-yawning and penile erection induced in male rats by SND 919, a new selective D2 dopamine receptor agonist. Psychopharmacology. 113:1993;172-176.
65. Fritschy J.M., Lyons W.E., Mullen C.A., Kosovsky B.E., Molliver M.E., Grzanna R. Distribution of locus coeruleus axons in the rat spinal cord: a combined anterograde transport and immunohistochemical study. Brain Res. 437:1987;176-180.
66. Giuliano F., Rampin O., Bernabé J., Rousseau J.P. Neural control of penile erection in the rat. J Autonom Nerv Syst. 55:1995;36-44.
67. Giuliano F., Rampin O., Benoit G., Jardin A. Neural control of penile erection. Urol Clin North Am. 22:1995;747-766.
68. Giuliano F., Bernabé J., Brown K., Droupy S., Benoit G., Rampin O. Erectile response to hypothalamic stimulation in rats: role of peripheral nerves. Am J Physiol. 273:1997;R1990-R1997.
69. Glazer E.J., Basbaum A.I. Leucine enkephalin: localization in and axoplasmic transport by sacral parasympathetic preganglionic neurons. Science. 208:1980;1479-1481.
70. Gomez-Marrero J., Feria M., Mas M. Stimulation of opioid receptors suppresses penile erectile reflexes and seminal emission in rats. Pharmacol Biochem Behav. 31:1988;393-396.
71. Gower A.J., Berendsen H.H.G., Princen M.M., Broekkamp C.L.E. The yawning-penile erection syndrome as a model for putative dopamine autoreceptor activity. Eur J Pharmacol. 103:1984;81-89.
72. Gray G.D., Smith E.R., Davidson J.M. Hormonal regulation of penile erection in castrated male rats. Physiol Behav. 24:1980;463-468.
73. Greco B., Edwards Zumpe D., Michael R.P., Clancy A.N. Fos induced by mating or noncontact sociosexual interaction is colocalized with androgen receptors in neurons within the forebrain, midbrain and lumbosacral spinal cord of male rats. Horm Behav. 33:1998;125-138.
74. Haldeman S., Bradley W.E., Bhatia N.N., Johnson B.K. Pudendal evoked responses. Arch Neurol. 39:1982;280-283.
75. Halliday G., Harding A., Paxinos G. Serotonin and tachykinin systems. Paxinos G. The rat nervous system. 2nd ed :1995;929-974 Academic Press, San Diego. (chap 34).
76. Hancock M.B., Peveto C.A. Preganglionic neurons in the sacral spinal cord of the rat: an HRP study. Neurosci Lett. 11:1979;1-5.
77. Hancock M.B., Peveto C.A. A preganglionic autonomic nucleus in the dorsal gray commissure of the lumbar spinal cord of the rat. J Comp Neurol. 183:1979;65-72.
78. Hart B.L. Testosterone regulation of sexual reflexes in spinal male rats. Science. 155:1967;1283-1284.
79. Hart B.L. Sexual reflexes and mating behavior in the male rat. J Comp Physiol Psychol. 65:1968;453-460.
80. Hart B.L., Melese-D'Hospital P.Y. Penile mechanisms and the role of the striated penile muscles in penile reflexes. Physiol Behav. 31:1983;807-813.
81. Hart B.L., Wallach S.J.R., Melese-d'Hospital P.Y. Differences in responsiveness to testosterone of penile reflexes and copulatory behavior of male rats. Horm Behav. 17:1983;274-283.
82. Heaton J.P.W., Varrin S.J., Morales A. The characterization of a bio-assay of erectile function in a rat model. J Urol. 145:1991;1099-1102.
83. Heaton J.P.W., Varrin S.J. Metoclopramide decreases apomorphine-induced yawning and penile erection. Pharmacol Biochem Behav. 38:1991;917-920.
84. Helke C.J., Sayson S.C., Keeler J.R., Charlton C.G. Thyrotropin-releasing hormone-immunoreactive neurons project from the ventral medulla to the intermediolateral cell column: partial coexistence with serotonin. Brain Res. 381:1986;1-7.
85. Herbert J. The role of the dorsal nerves of the penis in the sexual behaviour of the male rhesus monkey. Physiol Behav. 10:1973;293-300.
86. Hermann G.E., Bresnahan J.C., Holmes G.M., Beattie M.S., Rogers R.C. Direct descending projections from the nucleus raphe obscurus to rat pudendal motoneurons. J Comp Neurol. 397:1998;458-474.
87. Hernandez-Gonzalez M., Oropeza M.V., Guevara M.A., Cervantes M., Morali G. Effects of intrathecal administration of adrenergic agonists on the frequency of copulatory pelvic thrusting of the male rat. Arch Med Res. 25:1994;419-425.
88. Hökfelt T., Phillipson O., Goldstein M. Evidence for a dopaminergic pathway in the rat descending from the A11 cell group to the spinal cord. Acta Physiol Scand. 107:1979;393-395.
89. Holmes G.M., Chapple W.D., Leipheimer R.E., Sachs B.D. Electromyographic analysis of male rat perineal muscles during copulation and reflexive erections. Physiol Behav. 49:1991;1235-1246.
90. Holmes G.M., Rogers R.C., Bresnahan J.C., Beattie M.S. Differential effects of intrathecal thyrotropin-releasing hormone (TRH) on perineal reflexes in male rats. Physiol Behav. 61:1997;57-63.
91. Holstege G., Blok B.F.M., ter Horst G.J. Brainstem systems involved in the blink reflex, feeding mechanisms, and micturition. Paxinos G. The rat nervous system. 2nd ed. 1995;257-275 Academic Press, San Diego. (chap 14).
92. Honda C.N., Perl E. Functional and morphological features of neurons in the midline region of the caudal spinal cord of the cat. Brain Res. 340:1985;285-295.
93. Honda C.N., Lee C.L. Immunohistochemistry of synaptic input and functional characterizations of neurons near the spinal central canal. Brain Res. 343:1985;120-128.
94. Honda C.N. Visceral and somatic afferent convergence onto neurons near the central canal in the sacral spinal cord of the cat. J Neurophysiol. 53:1985;1059-1078.
95. Hong Y., Weaver L.C. Distribution of immunoreactivity for enkephalin, substance P and vasoactive intestinal peptide in fibres surrounding splanchnic sympathetic preganglionic neurons in rats. Neuroscience. 57:1993;1121-1133.
96. Hubscher C.H., Johnson R.D. Responses of medullary reticular formation neurons to input from the male genitalia. J Neurophysiol. 76:1996;2474-2482.
97. Hull E.M., Eaton R.C., Markowski V.P., Moses J., Lumley L.A., Loucks J.A. Opposite influence of medial preoptic D1 and D2 receptors on genital reflexes: implication for copulation. Life Sci. 51:1993;1705-1713.
98. Hull E.M., Eaton R.C., Moses J., Lorrain D. Copulation increases dopamine activity in the medial preoptic area of male rats. Life Sci. 52:1993;935-940.
99. Hull E.M., Du J., Lorrain D.S., Matuszewich L. Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation. J Neurosci. 15:1999;7465-7471.
100. Huston J. Yawning and penile erection induced in rats by cortical spreading depression. Nature. 232:1971;274-275.
101. Jänig W., McLachlan E.M. Organization of lumbar sympathetic outflow to distal colon and pelvic organs. Physiol Rev. 67:1987;1332-1404.
102. Johansson O., Hökfelt T., Pernow B., Jeffcoate S.L., White N., Steinbusch H.W.M., Verhofstad A.A.J., Emson P.C., Spindel E. Immunohistochemical support for three putative transmitters in one neuron: Coexistence of 5-hydroxytryptamine, substance P and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord. Neuroscience. 6:1981;1857-1881.
103. Johnson R.D., Hubscher C.H. Brainstem microstimulation differentially inhibits pudendal motoneuron reflex input. NeuroReport. 9:1998;341-345.
104. Jünemann K.P., Persson-Jünemann, Lue T.F., Tanagho E.A., Alken P. Neurophysiological aspects of penile erection: the role of the sympathetic nervous system. Br J Urol. 64:1989;84-92.
105. Katagiri T., Gibson S.J., Polak J.M. Composition and central projections of the pudendal nerve in the rat investigated by combined peptide immunocytochemistry and retrograde fluorescent labeling. Brain Res. 372:1986;313-322.
106. Kawano M., Sugita O., Inagaki S., Furuyama T., Takagi H., Neuropeptide Y. innervation in the spinal nucleus of bulbocavernosus of the rat. Neurosci Lett. 152:1993;158-160.
107. Kojima M., Matsuura T., Tanaka A., Amagai T., Imanishi J., Sano Y. Characteristic distribution of noradrenergic terminals on the anterior horn motoneurons innervating the perineal striated muscles in the rat. Anat Embryol. 171:1985;267-273.
108. Kondo H., Kuramoto H., Wainer B., Yanaihara N. Evidence for the coexistence of acetylcholine and enkephalin in the sympathetic preganglionic neurons of rats. Brain Res. 335:1985;309-314.
109. Kurtz R.G., Santos R. Supraspinal influences on the penile reflexes of the male rat: a comparison of the effects of copulation, spinal transection and cortical spreading depression. Horm Behav. 12:1979;73-94.
110. Kurz E.M., Sengelaub D.R., Arnold A.P. Androgens regulate the dendritic length of mammalian motoneurons in adulthood. Science. 232:1986;395-398.
111. Lakke E.A.J.F. The projections to the spinal cord of the rat during development; a time-table of descent. Advances in anatomy embryology and cell biology. vol. 135:1997;Springer, Berlin.
112. Langley J.N., Anderson H.K. The innervation of the pelvic and adjoining viscera. J Physiol (London). 19:1895;71-130.
113. Lee R.L., Smith E.R., Mas M., Davidson J.M. Effects of intrathecal administration of 8-OH-DPAT on genital reflexes and mating behavior in male rats. Physiol Behav. 47:1990;665-669.
114. Leipheimer R.E., Sachs B.D. GABAergic regulation of penile reflexes and copulation in rats. Physiol Behav. 42:1988;351-357.
115. Liu Y.C., Salamone J.D., Sachs B.D. Impaired sexual response after lesions of the paraventricular nucleus of the hypothalamus in male rats. Behav Neurosci. 111:1997;1361-1367.
116. Liu Y.C., Salamone J.D., Sachs B.D. Lesions in medial preoptic area and bed nucleus of stria terminalis: differential effects on copulatory behavior and noncontact erection in male rats. J Neurosci. 17:1997;5245-5253.
117. Liu Y.C., Sachs B.D., Salamone J.D. Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions in nucleus accumbens. Pharmacol. Biochem Behav. 60:1998;585-592.
118. Loewy A.D., McKellar S. Serotoninergic projections from the ventral medulla to the intermediolateral cell column in the rat. Brain Res. 211:1981;146-152.
119. Loewy A.D. Raphe pallidus and raphe obscurus projections to the intermediolateral cell column in the rat. Brain Res. 222:1981;129-139.
120. Lue T.F., Umraiya M., Takamura T., Schmidt R.A., Tanagho E.A. Animal models for penile erection studies. Neurourol Urodynamics. 2:1983;225-231.
121. Lue T.F., Gleason C.A., Brock G.B., Carroll P.R., Tanagho E.A. Intraoperative electrostimulation of the cavernous nerve: technique, results and limitations. J Urol. 154:1995;1426-1428.
122. Luiten P.G.M., ter Horst G.J., Karst H., Steffens A.B. The course of paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord. Brain Res. 329:1985;374-378.
123. Lumia A.R., Sachs B.D., Meisel R.L. Sexual reflexes in male rats: restoration by ejaculation following suppression by penile sheath removal. Physiol Behav. 23:1979;273-277.
124. MacLean P.D., Ploog D.W. Cerebral representation of penile erection. J Neurophysiol. 25:1962;29-55.
125. Maeda N., Matsuoka N., Yamaguchi I. Septohippocampal cholinergic pathway and penile erections induced by dopaminergic and cholinergic stimulants. Brain Res. 537:1990;163-168.
126. Maeda N., Matsuoka N., Yamaguchi I. Role of the dopaminergic, serotoninergic and cholinergic link in the expression of penile erection in rats. Jpn J Pharmacol. 66:1994;59-66.
127. Mallick H.N., Manchanda S.K., Mohan Kumar V. Sensory modulation of the medial preoptic area neuronal activity by dorsal penile nerve stimulation in rats. J Urol. 151:1994;759-762.
128. Marlier L., Teilhac J.R., Cerruti C., Privat A. Autoradiographic mapping of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord. Brain Res. 550:1991;15-23.
129. Marson L., McKenna K.E. The identification of a brainstem site controlling spinal sexual reflexes in male rats. Brain Res. 515:1990;303-308.
130. Marson L., List M.S., McKenna K.E. Lesions of the nucleus paragigantocellularis alter ex copula penile reflexes. Brain Res. 592:1992;187-192.
131. Marson L., McKenna K.E. A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes. Exp Brain Res. 88:1992;313-320.
132. Marson L., Platt K.B., McKenna K.E. Central nervous system innervation of the penis as revealed by the transneuronal transport of pseudorabies virus. Neuroscience. 55:1993;263-280.
133. Marson L., McKenna K.E. Serotonergic neurotoxic lesions facilitate male sexual reflexes. Pharmacol Biochem Behav. 47:1994;883-888.
134. Marson L., McKenna K.E. Stimulation of the hypothalamus initiates the urethrogenital reflex in male rats. Brain Res. 638:1994;103-108.
135. Marson L., McKenna K.E. CNS cell groups involved in the control of the ischiocavernosus and bulbospongiosus muscles: a transneuronal tracing study using pseudorabies virus. J Comp Neurol. 374:1996;161-179.
136. Mas M. Neurobiological correlates of masculine sexual behavior. Neurosci Biobehav Rev. 19:1995;261-277.
137. Mas M., Zahradnik M.A., Martino V., Davidson J.M. Stimulation of spinal serotonergic receptors facilitates seminal emission and suppresses penile erectile reflexes. Brain Res. 342:1985;128-134.
138. Mathes C.W., Smith E.R., Popa B.R., Davidson J.M. Effects of intrathecal and systemic administration of buspirone on genital reflexes and mating behavior in male rats. Pharmacol Biochem Behav. 36:1990;63-68.
139. Matsumoto T., Kondo Y., Sachs B.D., Yamanouchi K. Effects of p-chlorophenylalanine on reflexive and noncontact penile erections in male rats. Physiol Behav. 61:1997;165-168.
140. Matsuoka N., Maeda N., Yamazaki M., Yamaguchi I. Brain somatostatin depletion by cysteamine attenuates the penile erection induced by serotonergic and dopaminergic, but not cholinergic, activation in rats. Brain Res. 729:1996;132-136.
141. McKenna K.E., Nadelhaft I. The organization of the pudendal nerve in the male and female rat. J Comp Neurol. 248:1986;532-549.
142. McKenna K.E., Nadelhaft I. The pudendo-pudendal reflex in male and female rats. J Autonom Nerv Syst. 27:1989;67-77.
143. McKenna K.E., Chung S.K., McVary K.T. A model for the study of sexual function in anesthetized male and female rats. Am J Physiol. 261:1991;R1276-R1285.
144. McKenna K.E. Central control of penile erection. Int J Impotence Res. 10:(Suppl. 1):1998;S25-S34.
145. Meisel R.L., O'Hanlon J.K., Sachs B.D. Differential maintenance of penile responses and copulatory behavior by gonadal hormones in castrated male rats. Horm Behav. 18:1984;56-64.
146. Meisel R.L., Sachs B.D. The physiology of male sexual behavior. Knobil E., Neill J. The physiology of reproduction. 2nd ed. 1994;3-105 Raven Press, New York. (chap 350.
147. Melis M.R., Argiolas A., Gessa G.L. Apomorphine-induced penile erection and yawning: site of action in the brain. Brain Res. 415:1987;98-104.
148. Melis M.R., Stancampiano R., Argiolas A. Hippocampal oxytocin mediates apomorphine-induced penile erection and yawning. Pharmacol Biochem Behav. 42:1992;61-66.
149. Melis M.R., Argiolas A. Dopamine and sexual behavior. Neurosci Biobehav Rev. 19:1999;19-38.
150. Micevych P.E., Coquelin A., Arnold A.P. Immunohistochemical distribution of substance P, serotonin, and methionine enkephalin in sexually dimorphic nuclei of the rat lumbar spinal cord. J Comp Neurol. 248:1986;235-244.
151. Millan M.J., Millan M.H., Czlonkowski A., Herz A. Vasopressin and oxytocin in the rat spinal cord: distribution and origins in comparison to [Met]enkephalin, dynorphin and related opioids and their irresponsiveness to stimuli modulating neurohypohyseal secretion. Neuroscience. 13:1984;179-187.
152. Millan M.J., Perrin-Monneyron S. Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors. Eur J Pharmacol. 321:1997;R11-R13.
153. Millan M.J., Peglion J.L., Lavielle G., Perrin-Monneyron S. 5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists. Eur J Pharmacol. 325:1997;9-12.
154. Mills T.M., Lewis R.W. The role of androgens in the erectile response: a 1999 perspective. Mol Urol. 3:1999;75-80.
155. Morrison S.F., Callaway J., Milner T.A., Reis D.J. Glutamate in the spinal sympathetic intermediolateral nucleus: localization by light and electron microscopy. Brain Res. 503:1989;5-15.
156. Murphy A.Z., Rizvi T.A., Ennis M., Shipley M.T. The organization of preoptic-medullary circuits in the male rat: evidence for interconnectivity of neural structures involved in reproductive behavior, antinociception and cardiovascular regulation. Neuroscience. 91:1999;1103-1116.
157. Nadelhaft I., Booth A.M. The location and morphology of preganglionic neurons and the distribution of visceral afferents from the rat pelvic nerve: a horseradish peroxidase study. J Comp Neurol. 226:1984;238-245.
158. Nadelhaft I., McKenna K.E. Sympathetic afferent and preganglionic neurons labeled by horseradish peroxidase applied to the hypogastric nerve and the sacral sympathetic chain of the rat. Soc Neurosci Abstr. 11:1985;764.
159. Nadelhaft I., McKenna K.E. Sexual dimorphism in sympathetic preganglionic neurons of the rat hypogastric nerve. J Comp Neurol. 256:1987;308-315.
160. Newton B.W., Hamill R.W., Neuropeptide Y. immunoreactivity is preferentially located in rat lumbar sexually dimorphic nuclei. Neurosci Lett. 94:1991;10-16.
161. Nouel D., Costentin J. Inhibition of apomorphine-induced yawning and penile erection by neurotensin. Peptides. 12:1991;755-759.
162. Nygren L.G., Olson L. A new major projection from locus coeruleus: the main source of noradrenergic nerve terminals in the ventral and dorsal columns of the spinal cord. Brain Res. 132:1977;85-93.
163. Oomura Y., Yoshimatsu H., Aou S. Medial preoptic and hypothalamic neuronal activity during sexual behavior of the male monkey. Brain Res. 266:1983;340-343.
164. Oomura Y., Aou S., Koyama Y., Fujita I., Yoshimatsu H. Central control of sexual behavior. Brain Res Bull. 20:1988;863-870.
165. Paredes R.G., Baum M.J. Role of the medial preoptic area/anterior hypothalamus in the control of masculine sexual behavior. Ann Rev Sex Res. 8:1997;68-101.
166. Pehek E.A., Thompson J.T., Eaton R.C., Bazzett T.J., Hull E.M. Apomorphine and haloperidol, but not domperidone, affect penile reflexes in rats. Pharmacol Biochem Behav. 31:1988;201-208.
167. Pehek E.A., Thompson J.T., Hull E.M. The effects of intrathecal administration of the dopamine agonist apomorphine on penile reflexes and copulation in the male rat. Psychopharmacology. 99:1989;304-308.
168. Pehek E.A., Thompson J.T., Hull E.M. The effects of intracranial administration of the dopamine agonits apomorphine on penile reflexes and seminal emission in the rat. Brain Res. 500:1989;325-332.
169. Peng Y., Kohno J., Shinoda K., Kawai Y., Ono K., Jiang W., Shiotani Y. Interaction between cholinergic neurons and substance P or calcitonin gene-related peptide terminals of the rat sacral intermediolateral nucleus: double immunostaining at the light and electron microscopic levels. J Comp Neurol. 285:1989;1-8.
170. Pescatori E.S., Calabro A., Artibani W., Pagano F., Triban C., Italiano G. Electrical stimulation of the dorsal nerve of the penis evokes reflex tonic erections of the penile body and reflex ejaculatory responses in the spinal rat. J Urol. 149:1993;627-632.
171. Pfaus J.G., Damsma G., Nomikos G.G., Wenkstern D.G., Blaha C.D., Phillips A.G., Fibiger H.C. Sexual behavior enhances central dopamine transmission in the male rat. Brain Res. 530:1990;345-348.
172. Pickard R.S., Powell P.H., Schofield I.S. The clinical application of dorsal penile nerve cerebral-evoked response recording in the investigation of impotence. Br J Urol. 74:1994;231-235.
173. Pleim E.T., Matochik J.A., Barfield R.J., Auerbach S.B. Correlation of dopamine release in the nucleus accumbens with masculine sexual behavior in rats. Brain Res. 524:1990;160-163.
174. Pomerantz S.M. Quinelorane (LY163502), a D2 dopamine receptor agonist, acts centrally to facilitate penile erections of male rhesus monkeys. Pharmacol Biochem Behav. 39:1991;123-128.
175. Pomerantz S.M., Hepner B.C., Wertz J.M. Serotonergic influences on male sexual behavior of rhesus monkeys: effects of serotonin agonists. Psychopharmacology. 111:1993;47-54.
176. Protais P., Windsor M., Mocaer E., Comoy E. Post-synaptic 5-HT1A receptor involvement in yawning and penile erection induced by apomorphine, physostigmine and mCPP in rats. Psychopharmacology. 120:1995;376-383.
177. Quinlan D.M., Nelson R.J., Partin A.W., Mostwin J.L., Walsh P.C. The rat as a model for the study of penile erection. J Urol. 141:1989;656-661.
178. Rajaofetra N., Passagia J.G., Marlier L., Poulat P., Pellas F., Sandillon F., Verschuere B., Gouy D., Geffard M., Privat A. Serotoninergic, noradrenergic, and peptidergic innervation of Onuf's nucleus of normal and transected spinal cords of baboons (Papio papio). J Comp Neurol. 318:1992;1-17.
179. Rajaofetra N., Poulat P., Marlier L., Geffard M., Privat A. Pre- and postnatal development of noradrenergic projections to the rat spinal cord: an immunocytochemical study. Dev Brain Res. 67:1992;237-246.
180. Rampin O., Giuliano F., Dompeyre P., Rousseau J.P. Physiological evidence of neural pathways involved in reflexogenic penile erection in the rat. Neurosci Lett. 180:1994;138-142.
181. Rampin O., Bernabé J., Rousseau J.P. Effects of the NMDA glutamatergic receptor antagonist MK-801 on reflexive erections in the rat. Soc Neurosci Abstr. 22:1996;1053.
182. Rampin O., Gougis S., Giuliano F., Rousseau J.P. Spinal Fos labeling and penile erection elicited by stimulation of the dorsal nerve of the penis in the rat. Am J Physiol. 272:1997;R1425-R1431.
183. Rampin O., Bernabé J., Giuliano F. Spinal control of penile erection. World J Urol. 15:1997;2-13.
184. Rand M.N., Breedlove S.M. Androgen alters the dendritic arbors of SNB motoneurons by acting upon their target muscles. J Neurosci. 15:1995;4408-4416.
185. Reiter M.K., Kremarik P., Freund-Mercier M.J., Stoeckel M.E., Desaulles E., Feltz P. Localization of oxytocin binding sites in the thoracic and upper lumbar spinal cord of the adult and postnatal rat: a histoautoradiographic study. Eur J Neurosci. 6:1994;98-104.
186. Ridet J.L., Sandillon F., Rajaofetra N., Geffard M., Privat A. Spinal dopaminergic system of the rat: light and electron microscopic study using an antiserum against dopamine, with particular emphasis on synaptic incidence. Brain Res. 598:1992;233-241.
187. Ridet J.L., Tamir H., Privat A. Direct immunocytochemical localization of 5-hydroxytryptamine receptors in the adult rat spinal cord: a light and electron microscopic study using an anti-idiotypic antiserum. J Neurosci Res. 38:1994;109-121.
188. Romagnono M.A., Hamill R.W. Spinal parasympathetic enkephalin fibers: patterns and projections. Brain Res. 335:1985;174-181.
189. Root W.S., Bard P. The mediation of feline erection through sympathetic pathways with some remarks on sexual behavior after deafferentation of the genitalia. Am J Physiol. 151:1947;80-90.
190. Roudet C., Mouchet P., Feuerstein C., Savasta M. Normal distribution of alpha 2-adrenoceptors in the rat spinal cord and its modification after noradrenergic denervation: a quantitative autoradiographic study. J Neurosci Res. 39:1994;319-329.
191. Roudet C., Gimenez-Ribotta M., Privat A., Feuerstein C., Savasta M. Regional study of spinal alpha 2-adrenoceptor densities after intraspinal noradrenergic-rich implants on adult rats bearing complete spinal cord transection or selective chemical noradrenergic denervation. Neurosci Lett. 208:1996;89-92.
192. Rousselot P., Papadopoulos G., Merighi A., Poulain D.A., Theodosis D.T. Oxytocinergic innervation of the rat spinal cord. Brain Res. 529:1990;178-184.
193. Sachs B.D., Garinello L.D. Interaction between penile reflexes and copulation in male rats. J Comp Physiol Psychol. 92:1978;759-767.
194. Sachs B.D., Garinello L.D. Spinal pacemaker controlling sexual reflexes in male rats. Brain Res. 171:1979;152-156.
195. Sachs B.D. Role of striated penile muscles in penile reflexes, copulation, and induction of pregnancy in the rat. J Reprod Fertil. 66:1982;433-443.
196. Sachs B.D. Potency and fertility: hormonal and mechanical causes and effects of penile actions in rats. Balthazart J., Pröve E., Gilles R. Hormones and behaviour in higher vertebrates. 1983;86-110 Springer, Berlin.
197. Sachs B.D., Leipheimer R.E. Rapid effect of testosterone on striated muscle activity in rats. Neuroendocrinology. 48:1988;453-458.
198. Sachs B.D., Bitran D. Spinal block reveals roles for brain and spinal cord in the mediation of reflexive penile erections in rats. Brain Res. 528:1990;99-108.
199. Sachs B.D., Liu Y.-C. Copulatory behavior and reflexive penile erection in rats after section of the pudendal and genitofemoral nerves. Physiol Behav. 51:1992;673-680.
200. Sachs B.D., Akasofu K., McEldowney S.S. Effects of copulation on apomorphine-induced erection in rats. Pharmacol Biochem Behav. 48:1994;423-428.
201. Sachs B.D., Akasofu K., Citron J.H., Daniels S.B., Natoli J.H. Noncontact stimulation from estrous females evokes penile erection in rats. Physiol Behav. 55:1994;1073-1079.
202. Sachs B.D. Placing erection in context: the reflexogenic-psychogenic dichotomy reconsidered. Neurosci Biobehav Rev. 19:1995;211-224.
203. Saito S., Kidd G.J., Trapp B.D., Dawson T.M., Bredt D.S., Wilson D.A., Traystman R.J., Snyder S.H., Hanley D.F. Rat spinal cord neurons contain nitric oxide synthase. Neuroscience. 59:1994;447-456.
204. Sasaki M., Arnold A.P. Androgenic regulation of denritic trees of motoneurons in the spinal nucleus of the bulbocavernosus: Reconstruction after intracellular iontophoresis of horseradish peroxidase. J Comp Neurol. 308:1991;11-27.
205. Sato Y., Wada H., Horita H., Suzuki N., Shibuya A., Adachi H., Kato R., Tsukamoto T., Kumamoto Y. Dopamine release in the medial preoptic area during male copulatory behavior in rats. Brain Res. 692:1995;66-70.
206. Sasek C.A., Seybold V.S., Elde R.P. The immunohistochemical localization of nine peptides in the sacral parasympathetic nucleus and the dorsal gray commissure in rat spinal cord. Neuroscience. 12:1984;855-873.
207. Sasek C.A., Elde R.P. Distribution of neuropeptide Y-like immunoreactivity and its relationship to FMRF-amide-like immunoreactivity in the sixth lumbar and first sacral spinal cord segments of the rat. J Neurosci. 5:1985;1729-1739.
208. Sasek C.A., Wessendorf M.W., Helke C.J. Evidence for co-existence of thyrotropin-releasing hormone, substance P and serotonin in ventral medullary neuons that project to the intermediolateral cell column in the rat. Neuroscience. 35:1990;105-119.
209. Sawchenko P.E., Swanson L.W. Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat. J Comp Neurol. 205:1982;260-272.
210. Schmidt M.H., Schmidt H.S. The ischiocavernosus and bulbospongiosus muscles in mammalian penile rigidity. Sleep. 16:1993;171-183.
211. Schmidt M.H., Valatx J.L., Sakai K., Debilly G., Jouvet M. Corpus spongiosum penis pressure and perineal muscle activity during reflexive erections in the rat. Am J Physiol. 269:1995;R904-R913.
212. Schoenen J., Lotstra F., Vierendeels G., Reznik M., Vanderhaeghen J.J., Substance P. enkephalins, somatostatin, cholecystokinin, oxytocin, and vasopressin in human spinal cord. Neurology. 35:1985;881-890.
213. Schroder H.D. Organization of the motoneurons innervating the pelvic muscles of the male rat. J Comp Neurol. 192:1980;567-587.
214. Schroder H.D. Localization of cholecystokininlike immunoreactivity in the rat spinal cord, with particular reference to the autonomic innervation of the pelvic organs. J Comp Neurol. 217:1983;176-186.
215. Schroder H.D. Somatostatin in the caudal spinal cord: an immunohistochemical study of the spinal centers involved in the innervation of pelvic organs. J Comp Neurol. 233:1984;400-414.
216. Scott-Young I.I.I., Kuhar M.J. Noradrenergic α1 and α2 receptors: light microscopic autoradiographic localization. Proc Natl Acad Sci. 77:1980;1696-1700.
217. Semans J.H., Langworthy O.R. Observations on the neurophysiology of sexual function in the male cat. J Urol. 40:1938;836-846.
218. Sengelaub D.R., Arnold A.P. Hormonal control of neuron number in sexually dimoprhic spinal nuclei of the rat: I. Testosterone-regulated death in the dorsolateral nucleus. J Comp Neurol. 280:1989;622-629.
219. Shapiro H.A. Effect of testosterone propionate on mating. Nature. 139:1937;588-589.
220. Simon P., Guardiola B., Bizot-Espiard J., Schiavi P., Costentin J. 5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists. Psychopharmacology. 108:1992;47-50.
221. Sjöstrand N.O., Klinge E. Principal mechanisms controlling penile retraction and protrusion in rabbits. Acta Physiol Scand. 106:1979;199-214.
222. Skajerberg G., Björklund A., Lindvall O., Schmidt R.H. Origin and termination of the diencephalo-spinal dopamine system in the rat. Brain Res Bull. 9:1982;237-244.
223. Skajerberg R., Björklund A. Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat. Neuroscience. 15:1985;445-480.
224. Skajerberg R., Lindvall O. Organization of diencephalic dopamine neurons projecting to the spinal cord of the rat. Brain Res. 342:1985;340-351.
225. Smith E.R., Lee R.L., Schnur S.L., Davidson J.M. Alpha2-adrenoceptor antagonists and male sexual behavior: I. Mating behavior. Physiol Behav. 41:1987;1-14.
226. Smith E.R., Lee R.L., Schnur S.L., Davidson J.M. Alpha2-adrenoceptor antagonists and male sexual behavior: II. Erectile and ejaculatory reflexes. Physiol Behav. 41:1987;15-19.
227. Smith E.R., Cetrulo E.J., Donahue J.P., Sparrow H., Davidson J.M., Hoffman B.B., Clark J.T. The inhibitory effects of propranolol on genital reflexes in male rats. Pharmacol Biochem Behav. 52:1995;541-546.
228. Smith M.S., Schambra U.B., Wilson K.H., Page S.O., Hulette C., Light A.R., Schwinn D.A. Alpha2-adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha2-adrenergic receptor subtypes at four distinct levels. Mol Brain Res. 34:1995;109-117.
229. Stancampiano R., Melis M.R., Argiolas A. Penile erection and yawning induced by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic transmission. Eur J Pharmacol. 261:1994;149-155.
230. Steers W.D., Mallory B., DeGroat W.C. Electrophysiological study of neural activity in penile nerve of the rat. Am J Physiol (Regulatory, Integrative and Comparative Physiology). 254:1988;R989-R1000.
231. Steers W.D., DeGroat W.C. Effects of m-chlorophenylpiperazine on penile and bladder function in rats. Am J Physiol (Regulatory, Integrative and Comparative Physiology). 257:1989;R1441-R1449.
232. Stefanick M.L., Smith E.R., Clark J.T., Davidson J.M. Effects of a potent dopamine receptor agonist, RDS-127, on penile reflexes and seminal emission in intact and spinally transected rats. Physiol Behav. 29:1982;973-978.
233. Stefanick M.L., Davidson J.M. Genital responses in noncopulators and rats with lesions in the medial preoptic area or midthoracic spinal cord. Physiol Behav. 41:1987;439-444.
234. Steinbusch H. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience. 6:1981;557-618.
235. Stone L.S., Broberger C., Vulchanova L., Wilcox G.L., Hökfelt T., Riedi M.S., Elde R. Differential distribution of RDS-127, on penile reflexes and seminal emission in intact and spinally transected rats α2A and α2C adrenergic receptor immunoreactivity in the rat spinal cord. J Neurosci. 18:1998;5928-5937.
236. Svenson L., Hansen S. Spinal monoaminergic modulation of masculine copulatory behavior in the rat. Brain Res. 302:1984;315-321.
237. Swanson L.W., McKellar S. The distribution of oxytocin- and neurophysin-stained fibers in the spinal cord of the rat and monkey. J Comp Neurol. 188:1979;87-106.
238. Szele F.G., Murphy D.L., Garrick N.A. Effects of fenfluramine, m-chlorophenylpiperazine, and other serotonin-related agonists and antagonists on penile erection in non-human primates. Life Sci. 43:1988;1297-1303.
239. Tang Y., Rampin O., Facchinetti P., Calas A., Giuliano F. Oxytocinergic and serotonergic innervation of identified lumbosacral nuclei controlling penile erection in the male rat. Neuroscience. 82:1998;241-254.
240. Tang Y., Rampin O., Giuliano F., Ugolini G. Spinal and brain circuits to motoneurons of the bulbospongiosus muscle: retrograde transneuronal tracing with rabies virus. J Comp Neurol. 1999;167-192.
241. Tappaz M.L., Zivin J.A., Kopin I.J. Intraspinal glutamic decarboxylase distribution after transection of the cord at the thoracic level. Brain Res. 111:1976;220-223.
242. Tashiro T., Satoda T., Matsushima R., Mizuno N. Convergence of serotonin-, enkephalin- and substance P-like immunoreactive afferent fibers on single pudendal motoneurons in Onuf's nucleus of the cat: a light microscope study combining the triple immunocytochemical staining technique with the retrograde HRP-tracing method. Brain Res. 481:1989;392-398.
243. 1B and 5-hydroxytryptamine1C/2 binding sites in the rat spinal cord. Neuroscience. 55:1993;235-252.
244. Valtschanoff J.G., Weinberg R.J., Rustioni A. NADPH diaphorase in the spinal cord of rats. J Comp Neurol. 321:1992;209-222.
245. Van Furth W.R., Wolterink G., Van Ree J.M. Regulation of masculine sexual behavior: involvement of brain opioids and dopamine. Brain Res Rev. 21:1995;162-184.
246. Vardi Y., Youdim M.B., Levin R.D., Finberg J.P. A model for the study of penile erection in the rat. Int J Impotence Res. 1:1989;11-17.
247. Véronneau-Longueville F., Rampin O., Freund-Mercier M.J., Tang Y., Calas A., Marson L., McKenna K.E., Stoeckel M.E., Benoit G., Giuliano F. Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat. Neuroscience. 93:1999;1437-1447.
248. Vizzard M.A., Erdman S.L., DeGroat W.C. Localization of NADPH-diaphorase in pelvic afferent and efferent pathways of the rat. Neurosci Lett. 152:1993;72-76.
249. Vizzard M.A., Erdman S.L., Förstermann U., DeGroat W.C. Ontogeny of nitric oxide synthase in the lumbosacral spinal cord of the neonatal rat. Dev Brain Res. 81:1994;201-217.
250. Wada T., Otsu T., Hasegawa Y., Mizuchi A., Ono H. Characterization of alpha 1-adrenoceptor subtypes in rat spinal cord. Eur J Pharmacol. 312:1996;263-266.
251. Wagner C.K., Clemens L.G. Projections of the paraventricular nucleus of the hypothalamus to the sexually dimorphic lumbosacral region of the spinal cord. Brain Res. 539:1991;254-262.
252. Warner R.K., Thompson J.T., Markowski V.P., Loucks J.A., Bazzett T.J., Eaton R.C., Hull E.M. Microinjection of the dopamine antagonist cis-flupenthixol in the MPOA impairs copulation, penile reflexes and sexual motivation in male rats. Brain Res. 540:1991;177-182.
253. Westlund K.N., Bowker R.M., Ziegler M.G., Coulter J.D. Noradrenergic projections to the spinal cord of the rat. Brain Res. 236:1983;15-31.
254. Westlund K.N., Bowker R.M., Ziegler M.G., Coulter J.D. Origins and terminations of descending noradrenergic projections to the spinal cord of monkey. Brain Res. 292:1984;1-16.
255. White J.D., Krause J.E., McKelvy J.F. In vivo biosynthesis and transport of oxytocin, vasopressin and neurophysin from the hypothalamus to the spinal cord. Neuroscience. 17:1986;133-140.
256. Wiesenfeld-Hallin J., Södersten P. Spinal opiates affect sexual behavior in rats. Nature. 309:1984;257-258.
257. Wilson C.A. Pharmacological targets for the control of male and female sexual behaviour. Riley A.J., Peet M., Wilson C. Sexual pharmacology. 1993;1-58 Clarendon Press, Oxford.
258. Wu W., Elde R., Wessendorf M.W. Organization of the serotoninergic innervation of spinal neurons in rats-III. Differential serotoninergic innervation of somatic and parasympathetic preganglionic motoneurons as determined by patterns of co-existing peptides. Neuroscience. 55:1993;223-233.
259. Yanagimoto M., Honda K., Goto Y., Negoro H. Afferents originating from the dorsal penile nerve excite oxytocin cells in the hypothalamic paraventricular nucleus of the rat. Brain Res. 733:1996;292-296.
260. Zarrindast M.R., Farahvash H. Effects of GABA-ergic drugs on penile erection induced by apomorphine in rats. Psychopharmacology. 115:1994;249-253.
261. Zeng D., Lynch K.R. Distribution of α2-adrenergic receptor mRNAs in the rat CNS. Mol Brain Res. 10:1991;219-225.