Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits

European Journal of Pharmacology

Volumn 517, Issue 3, 2005, Pages 224-231

  Shukla, Nilima ^a   Jones, Robert ^a   Persad, Raj ^a   Angelini, Gianni D ^a   Jeremy, Jamie Y ^a  

^a BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

Cholesterol; Erectile dysfunction; NADPH oxidase; Superoxide

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; APOCYNIN; CARBACHOL; CYCLIC GMP; DIPHENYLIODONIUM SALT; GUANYLATE CYCLASE INHIBITOR; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; OXIDOREDUCTASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SILDENAFIL; SILDENAFIL NITRATE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG EFFECT; DRUG POTENCY; HYPERCHOLESTEROLEMIA; MALE; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RABBIT; STIMULATION;

ACETOPHENONES; ALLOPURINOL; ANIMALS; CARBACHOL; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HYPERCHOLESTEROLEMIA; MALE; MUSCLE RELAXATION; NADPH OXIDASE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE; ONIUM COMPOUNDS; OXADIAZOLES; PENIS; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; QUINOXALINES; RABBITS; ROTENONE; SUPEROXIDES; UNCOUPLING AGENTS; XANTHINE OXIDASE;

EID: 22144480608     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.05.012     Document Type: Article

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