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Volumn 7, Issue 9, 2010, Pages 3023-3032

Hypercholesterolemia-Induced Erectile Dysfunction: Endothelial Nitric Oxide Synthase (eNOS) Uncoupling in the Mouse Penis by NAD(P)H Oxidase

Author keywords

Hypercholesterolemia; LDLR null mouse; Nitric oxide; Oxidative stress

Indexed keywords

4 HYDROXYNONENAL; APOCYNIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEIN P47; PROTEIN P67; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; VASODILATOR STIMULATED PHOSPHOPROTEIN;

EID: 77956286084     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2010.01880.x     Document Type: Article
Times cited : (92)

References (57)
  • 1
    • 0027958541 scopus 로고
    • Experimental hypercholesterolemia in rabbits induces cavernosal atherosclerosis with endothelial and smooth muscle cell dysfunction
    • Kim JH, Klyachkin ML, Svendsen E, Davies MG, Hagen PO, Carson CC. Experimental hypercholesterolemia in rabbits induces cavernosal atherosclerosis with endothelial and smooth muscle cell dysfunction. J Urol 1994, 151:198-205.
    • (1994) J Urol , vol.151 , pp. 198-205
    • Kim, J.H.1    Klyachkin, M.L.2    Svendsen, E.3    Davies, M.G.4    Hagen, P.O.5    Carson, C.C.6
  • 2
    • 0041885877 scopus 로고    scopus 로고
    • Involvement of superoxide radical in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbits
    • Kim SC, Kim IK, Seo KK, Baek KJ, Lee MY. Involvement of superoxide radical in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbits. Urol Res 1997, 25:341-6.
    • (1997) Urol Res , vol.25 , pp. 341-346
    • Kim, S.C.1    Kim, I.K.2    Seo, K.K.3    Baek, K.J.4    Lee, M.Y.5
  • 3
    • 0034042184 scopus 로고    scopus 로고
    • The effects of isolated lipoproteins and triglyceride, combined oxidized low density lipoprotein (LDL) plus triglyceride, and combined oxidized LDL plus high density lipoprotein on the contractile and relaxation response of rabbit cavernous smooth muscle
    • suppl
    • Kim SC, Seo KK, Kim HW, Lee MY. The effects of isolated lipoproteins and triglyceride, combined oxidized low density lipoprotein (LDL) plus triglyceride, and combined oxidized LDL plus high density lipoprotein on the contractile and relaxation response of rabbit cavernous smooth muscle. Int J Androl 2000, 23(2):26-9. suppl
    • (2000) Int J Androl , vol.23 , Issue.2 , pp. 26-29
    • Kim, S.C.1    Seo, K.K.2    Kim, H.W.3    Lee, M.Y.4
  • 4
    • 0025942457 scopus 로고
    • Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle
    • Azadzoi KM, Saenz de Tejada I. Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle. J Urol 1991, 146:238-40.
    • (1991) J Urol , vol.146 , pp. 238-240
    • Azadzoi, K.M.1    Saenz de Tejada, I.2
  • 6
    • 0345621621 scopus 로고    scopus 로고
    • Involvement of endothelial nitric oxide synthase in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbit
    • Seo KK, Yun HY, Kim H, Kim SC. Involvement of endothelial nitric oxide synthase in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbit. J Androl 1999, 20:298-306.
    • (1999) J Androl , vol.20 , pp. 298-306
    • Seo, K.K.1    Yun, H.Y.2    Kim, H.3    Kim, S.C.4
  • 7
    • 0343807449 scopus 로고    scopus 로고
    • Effect of experimental hypercholesterolemia on cavernosal structures
    • Yesilli C, Yaman O, Anafarta K. Effect of experimental hypercholesterolemia on cavernosal structures. Urology 2001, 57:1184-8.
    • (2001) Urology , vol.57 , pp. 1184-1188
    • Yesilli, C.1    Yaman, O.2    Anafarta, K.3
  • 8
    • 0037376430 scopus 로고    scopus 로고
    • The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyper-lipidemia
    • Gholami SS, Rogers R, Chang J, Ho HC, Grazziottin T, Lin CS, Lue TF. The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyper-lipidemia. J Urol 2003, 169:1577-81.
    • (2003) J Urol , vol.169 , pp. 1577-1581
    • Gholami, S.S.1    Rogers, R.2    Chang, J.3    Ho, H.C.4    Grazziottin, T.5    Lin, C.S.6    Lue, T.F.7
  • 9
    • 0032426699 scopus 로고    scopus 로고
    • Cavernosal expandability is an erectile tissue mechanical property which predicts trabecular histology in an animal model of vasculogenic erectile dysfunction
    • Nehra A, Azadzoi KM, Moreland RB, Pabby A, Siroky MB, Krane RJ, Robert J, Goldstein I, Udelson D. Cavernosal expandability is an erectile tissue mechanical property which predicts trabecular histology in an animal model of vasculogenic erectile dysfunction. J Urol 1998, 159:2229-36.
    • (1998) J Urol , vol.159 , pp. 2229-2236
    • Nehra, A.1    Azadzoi, K.M.2    Moreland, R.B.3    Pabby, A.4    Siroky, M.B.5    Krane, R.J.6    Robert, J.7    Goldstein, I.8    Udelson, D.9
  • 11
    • 33750447627 scopus 로고    scopus 로고
    • Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model
    • Park K, Kim SW, Rhu KS, Paick JS. Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model. J Sex Med 2006, 3:996-1003.
    • (2006) J Sex Med , vol.3 , pp. 996-1003
    • Park, K.1    Kim, S.W.2    Rhu, K.S.3    Paick, J.S.4
  • 12
    • 28544434300 scopus 로고    scopus 로고
    • Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues
    • Xie D, Kontos CD, Donatucci CF, Annex BH. Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues. J Sex Med 2005, 2:634-40.
    • (2005) J Sex Med , vol.2 , pp. 634-640
    • Xie, D.1    Kontos, C.D.2    Donatucci, C.F.3    Annex, B.H.4
  • 13
    • 0032325399 scopus 로고    scopus 로고
    • Mechanisms of ischemia-induced cavernosal smooth muscle relaxation impairment in a rabbit model of vasculogenic erectile dysfunction
    • Azadzoi KM, Goldstein I, Siroky MB, Traish AM, Krane RJ, Saenz de Tejada I. Mechanisms of ischemia-induced cavernosal smooth muscle relaxation impairment in a rabbit model of vasculogenic erectile dysfunction. J Urol 1998, 160:2216-22.
    • (1998) J Urol , vol.160 , pp. 2216-2222
    • Azadzoi, K.M.1    Goldstein, I.2    Siroky, M.B.3    Traish, A.M.4    Krane, R.J.5    Saenz de Tejada, I.6
  • 14
    • 33645508745 scopus 로고    scopus 로고
    • Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia
    • Ryu JK, Cho CH, Shin HY, Song SU, Oh SM, Lee M, Piao S, Han JY, Kim IH, Koh GY, Suh JK. Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia. Mol Ther 2006, 13:705-15.
    • (2006) Mol Ther , vol.13 , pp. 705-715
    • Ryu, J.K.1    Cho, C.H.2    Shin, H.Y.3    Song, S.U.4    Oh, S.M.5    Lee, M.6    Piao, S.7    Han, J.Y.8    Kim, I.H.9    Koh, G.Y.10    Suh, J.K.11
  • 15
    • 33744523020 scopus 로고    scopus 로고
    • Downregulation of angiogenic factors and their downstream target molecules affects the deterioration of erectile function in a rat model of hypercholesterolemia
    • Ryu JK, Shin HY, Song SU, Oh SM, Piao S, Han JY, Park KW, Suh JK. Downregulation of angiogenic factors and their downstream target molecules affects the deterioration of erectile function in a rat model of hypercholesterolemia. Urology 2006, 67:1329-34.
    • (2006) Urology , vol.67 , pp. 1329-1334
    • Ryu, J.K.1    Shin, H.Y.2    Song, S.U.3    Oh, S.M.4    Piao, S.5    Han, J.Y.6    Park, K.W.7    Suh, J.K.8
  • 16
    • 57549099686 scopus 로고    scopus 로고
    • Improvement of endothelial function of the corpus cavernosum in apolipoprotein E knockout mice treated with irbesartan
    • Baumhäkel M, Custodis F, Schlimmer N, Laufs U, Böhm M. Improvement of endothelial function of the corpus cavernosum in apolipoprotein E knockout mice treated with irbesartan. J Pharmacol Exp Ther 2008, 327:692-8.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 692-698
    • Baumhäkel, M.1    Custodis, F.2    Schlimmer, N.3    Laufs, U.4    Böhm, M.5
  • 17
    • 0033782396 scopus 로고    scopus 로고
    • Effect of a Chinese herbal medicine mixture on a rat model of hypercholesterolemic erectile dysfunction
    • Bakircioglu ME, Hsu K, El-Sakka A, Sievert KD, Lin CS, Lue TF. Effect of a Chinese herbal medicine mixture on a rat model of hypercholesterolemic erectile dysfunction. J Urol 2000, 164:1798-801.
    • (2000) J Urol , vol.164 , pp. 1798-1801
    • Bakircioglu, M.E.1    Hsu, K.2    El-Sakka, A.3    Sievert, K.D.4    Lin, C.S.5    Lue, T.F.6
  • 18
    • 40349113064 scopus 로고    scopus 로고
    • Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: A molecular analysis
    • Musicki B, Liu T, Strong T, Jin L, Laughlin MH, Turk JR, Burnett AL. Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: A molecular analysis. J Sex Med 2008, 5:552-61.
    • (2008) J Sex Med , vol.5 , pp. 552-561
    • Musicki, B.1    Liu, T.2    Strong, T.3    Jin, L.4    Laughlin, M.H.5    Turk, J.R.6    Burnett, A.L.7
  • 19
    • 22144480608 scopus 로고    scopus 로고
    • Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hyper-cholesterolaemic rabbits
    • Shukla N, Jones R, Persad R, Angelini GD, Jeremy JY. Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hyper-cholesterolaemic rabbits. Eur J Pharmacol 2005, 517:224-31.
    • (2005) Eur J Pharmacol , vol.517 , pp. 224-231
    • Shukla, N.1    Jones, R.2    Persad, R.3    Angelini, G.D.4    Jeremy, J.Y.5
  • 20
    • 60749126367 scopus 로고    scopus 로고
    • Regulation of NADPH oxidase in vascular endothelium: The role of phospholipases, protein kinases, and cytoskeletal proteins
    • Pendyala S, Usatyuk P, Gorshkova IA, Garcia JG, Natarajan V. Regulation of NADPH oxidase in vascular endothelium: The role of phospholipases, protein kinases, and cytoskeletal proteins. Antioxid Redox Signal 2009, 11:2008-231.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2008-2231
    • Pendyala, S.1    Usatyuk, P.2    Gorshkova, I.A.3    Garcia, J.G.4    Natarajan, V.5
  • 21
    • 8644277006 scopus 로고    scopus 로고
    • Reactive oxygen species in vascular biology: Implications in hypertension
    • Touyz RM, Schiffrin EL. Reactive oxygen species in vascular biology: Implications in hypertension. Histochem Cell Biol 2004, 122:339-52.
    • (2004) Histochem Cell Biol , vol.122 , pp. 339-352
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 22
    • 67349165856 scopus 로고    scopus 로고
    • Molecular genetics of atherosclerosis
    • Roy H, Bhardwaj S, Yla-Herttuala S. Molecular genetics of atherosclerosis. Hum Genet 2009, 125:467-91.
    • (2009) Hum Genet , vol.125 , pp. 467-491
    • Roy, H.1    Bhardwaj, S.2    Yla-Herttuala, S.3
  • 24
    • 23244448247 scopus 로고    scopus 로고
    • Sildenafil inhibits the formation of superoxide and the expression of gp47phox NAD(P)H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells
    • Koupparis AJ, Jeremy JY, Muzaffar S, Persad R, Shukla N. Sildenafil inhibits the formation of superoxide and the expression of gp47phox NAD(P)H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells. BJU Int 2005, 96:423-7.
    • (2005) BJU Int , vol.96 , pp. 423-427
    • Koupparis, A.J.1    Jeremy, J.Y.2    Muzaffar, S.3    Persad, R.4    Shukla, N.5
  • 25
    • 65549108325 scopus 로고    scopus 로고
    • Effect of hydrogen sulphide-donating sildenafil (ACS6) on erectile function and oxidative stress in rabbit isolated corpus cavernosum and in hypertensive rats
    • Shukla N, Rossoni G, Hotston M, Sparatore A, Del Soldato P, Tazzari V, Persad R, Angelini GD, Jeremy JY. Effect of hydrogen sulphide-donating sildenafil (ACS6) on erectile function and oxidative stress in rabbit isolated corpus cavernosum and in hypertensive rats. BJU Int 2009, 103:1522-99.
    • (2009) BJU Int , vol.103 , pp. 1522-1599
    • Shukla, N.1    Rossoni, G.2    Hotston, M.3    Sparatore, A.4    Del Soldato, P.5    Tazzari, V.6    Persad, R.7    Angelini, G.D.8    Jeremy, J.Y.9
  • 26
    • 34548092966 scopus 로고    scopus 로고
    • Effects of 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41-2272) on smooth muscle tone, soluble guanylyl cyclase activity, and NADPH oxidase activity/expression in corpus cavernosum from wild-type, neuronal, and endothelial nitric-oxide synthase null mice
    • Teixeira CE, Priviero FB, Webb RC. Effects of 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41-2272) on smooth muscle tone, soluble guanylyl cyclase activity, and NADPH oxidase activity/expression in corpus cavernosum from wild-type, neuronal, and endothelial nitric-oxide synthase null mice. Pharmacol Exp Ther 2007, 322:1093-102.
    • (2007) Pharmacol Exp Ther , vol.322 , pp. 1093-1102
    • Teixeira, C.E.1    Priviero, F.B.2    Webb, R.C.3
  • 27
    • 40349113071 scopus 로고    scopus 로고
    • NADPH oxidase activation: A mechanism of hypertension-associated erectile dysfunction
    • Jin L, Lagoda G, Leite R, Webb RC, Burnett AL. NADPH oxidase activation: A mechanism of hypertension-associated erectile dysfunction. J Sex Med 2008, 5:544-51.
    • (2008) J Sex Med , vol.5 , pp. 544-551
    • Jin, L.1    Lagoda, G.2    Leite, R.3    Webb, R.C.4    Burnett, A.L.5
  • 28
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular disease: From marvel to menace
    • Forstermann U, Munzel T. Endothelial nitric oxide synthase in vascular disease: From marvel to menace. Circulation 2006, 113:1708-14.
    • (2006) Circulation , vol.113 , pp. 1708-1714
    • Forstermann, U.1    Munzel, T.2
  • 29
    • 0036182797 scopus 로고    scopus 로고
    • Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia
    • Fukuda Y, Teragawa H, Matsuda K, Yamagata T, Matsuura H, Chayama K. Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia. Heart 2002, 87:264-9.
    • (2002) Heart , vol.87 , pp. 264-269
    • Fukuda, Y.1    Teragawa, H.2    Matsuda, K.3    Yamagata, T.4    Matsuura, H.5    Chayama, K.6
  • 31
    • 1542344000 scopus 로고    scopus 로고
    • Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice
    • Alp NJ, McAteer MA, Khoo J, Choudhury RP, Channon KM. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 2004, 24:445-50.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 445-450
    • Alp, N.J.1    McAteer, M.A.2    Khoo, J.3    Choudhury, R.P.4    Channon, K.M.5
  • 32
    • 34247220499 scopus 로고    scopus 로고
    • Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice
    • Hattori Y, Hattori S, Wang X, Satoh H, Nakanishi N, Kasai K. Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice. Arterioscler Thromb Vasc Biol 2007, 27:865-70.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 865-870
    • Hattori, Y.1    Hattori, S.2    Wang, X.3    Satoh, H.4    Nakanishi, N.5    Kasai, K.6
  • 33
    • 0027026881 scopus 로고
    • Molecular genetics of the LDL receptor gene in familial hypercholesterolemia
    • Hobbs HH, Brown MS, Goldstein JL. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Hum Mutat 1992, 1:445-66.
    • (1992) Hum Mutat , vol.1 , pp. 445-466
    • Hobbs, H.H.1    Brown, M.S.2    Goldstein, J.L.3
  • 34
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer R, Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 1993, 92:883-93.
    • (1993) J Clin Invest , vol.92 , pp. 883-893
    • Ishibashi, S.1    Brown, M.S.2    Goldstein, J.L.3    Gerard, R.D.4    Hammer, R.5    Herz, J.6
  • 35
    • 0037154287 scopus 로고    scopus 로고
    • Oral administration of an Apo A-I mimetic peptide synthesized from d-amino acids dramatically reduces atherosclerosis in mice independent of plasma cholesterol
    • Navab M, Anantharamaiah GM, Hama S, Garber DW, Chaddha M, Hough G, Lallone R, Fogelman AM. Oral administration of an Apo A-I mimetic peptide synthesized from d-amino acids dramatically reduces atherosclerosis in mice independent of plasma cholesterol. Circulation 2002, 105:290-2.
    • (2002) Circulation , vol.105 , pp. 290-292
    • Navab, M.1    Anantharamaiah, G.M.2    Hama, S.3    Garber, D.W.4    Chaddha, M.5    Hough, G.6    Lallone, R.7    Fogelman, A.M.8
  • 37
    • 0742271502 scopus 로고    scopus 로고
    • Phosphorylated endothelial nitric oxide synthase mediates vascular endothelial growth factor-induced penile erection
    • Musicki B, Palese MA, Crone JK, Burnett AL. Phosphorylated endothelial nitric oxide synthase mediates vascular endothelial growth factor-induced penile erection. Biol Reprod 2004, 70:282-9.
    • (2004) Biol Reprod , vol.70 , pp. 282-289
    • Musicki, B.1    Palese, M.A.2    Crone, J.K.3    Burnett, A.L.4
  • 39
    • 25144453937 scopus 로고    scopus 로고
    • NADPH oxidase and endothelial cell function
    • Ray R, Shah AM. NADPH oxidase and endothelial cell function. Clin Sci (Lond) 2005, 109:217-26.
    • (2005) Clin Sci (Lond) , vol.109 , pp. 217-226
    • Ray, R.1    Shah, A.M.2
  • 41
    • 57249095767 scopus 로고    scopus 로고
    • Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions
    • Catala A. Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions. Chem Phys Lipids 2009, 157:1-11.
    • (2009) Chem Phys Lipids , vol.157 , pp. 1-11
    • Catala, A.1
  • 42
    • 0034711470 scopus 로고    scopus 로고
    • Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction
    • Oelze M, Mollnau H, Hoffmann N, Warnholtz A, Bodenschatz M, Smolenski A, Walter U, Skatchkov M, Meinertz T, Münzel T. Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction. Circ Res 2000, 87:999-1005.
    • (2000) Circ Res , vol.87 , pp. 999-1005
    • Oelze, M.1    Mollnau, H.2    Hoffmann, N.3    Warnholtz, A.4    Bodenschatz, M.5    Smolenski, A.6    Walter, U.7    Skatchkov, M.8    Meinertz, T.9    Münzel, T.10
  • 43
    • 0035860241 scopus 로고    scopus 로고
    • Age-related decrease of protein kinase G activation in vascular smooth muscle cells
    • Lin CS, Liu X, Tu R, Chow S, Lue TF. Age-related decrease of protein kinase G activation in vascular smooth muscle cells. Biochem Biophys Res Commun 2001, 287:244-8.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 244-248
    • Lin, C.S.1    Liu, X.2    Tu, R.3    Chow, S.4    Lue, T.F.5
  • 44
    • 0038168385 scopus 로고    scopus 로고
    • Systemic basic fibroblast growth factor induces favorable histological changes in the corpus cavernosum of hypercholesterolemic rabbits
    • Dai Q, Silverstein AD, Davies MG, Hagen PO, Donatucci CF, Annex BH. Systemic basic fibroblast growth factor induces favorable histological changes in the corpus cavernosum of hypercholesterolemic rabbits. J Urol 2003, 170:664-8.
    • (2003) J Urol , vol.170 , pp. 664-668
    • Dai, Q.1    Silverstein, A.D.2    Davies, M.G.3    Hagen, P.O.4    Donatucci, C.F.5    Annex, B.H.6
  • 48
    • 0034640107 scopus 로고    scopus 로고
    • Vascular superoxide production by NAD(P)H oxidase: Association with endothelial dysfunction and clinical risk factors
    • Guzik TJ, West NEJ, Black E, McDonald D, Ratnatunga C, Pillai R, Channon KM. Vascular superoxide production by NAD(P)H oxidase: Association with endothelial dysfunction and clinical risk factors. Circ Res 2000, 86:E85-E90.
    • (2000) Circ Res , vol.86
    • Guzik, T.J.1    West, N.E.J.2    Black, E.3    McDonald, D.4    Ratnatunga, C.5    Pillai, R.6    Channon, K.M.7
  • 53
    • 0037031892 scopus 로고    scopus 로고
    • Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase
    • Zou MH, Hou XY, Shi CM, Nagata D, Walsh K, Cohen RA. Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase. J Biol Chem 2002, 277:32552-7.
    • (2002) J Biol Chem , vol.277 , pp. 32552-32557
    • Zou, M.H.1    Hou, X.Y.2    Shi, C.M.3    Nagata, D.4    Walsh, K.5    Cohen, R.A.6
  • 55
    • 13444262357 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: Regulator of endothelial nitric oxide synthase in vascular disease
    • Channon KM. Tetrahydrobiopterin: Regulator of endothelial nitric oxide synthase in vascular disease. Trends Cardiovasc Med 2004, 14:323-7.
    • (2004) Trends Cardiovasc Med , vol.14 , pp. 323-327
    • Channon, K.M.1
  • 56
    • 34447536457 scopus 로고    scopus 로고
    • Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
    • Schmidt TS, Alp NJ. Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease. Clin Sci (Lond) 2007, 113:47-63.
    • (2007) Clin Sci (Lond) , vol.113 , pp. 47-63
    • Schmidt, T.S.1    Alp, N.J.2
  • 57
    • 73449114562 scopus 로고    scopus 로고
    • Differential effects of activation of liver X receptor on plasma lipid homeostasis in wild-type and lipoprotein clearance-deficient mice
    • Peng D, Hiipakka RA, Xie JT, Reardon CA, Getz GS, Liao S. Differential effects of activation of liver X receptor on plasma lipid homeostasis in wild-type and lipoprotein clearance-deficient mice. Atherosclerosis 2010, 208:126-33.
    • (2010) Atherosclerosis , vol.208 , pp. 126-133
    • Peng, D.1    Hiipakka, R.A.2    Xie, J.T.3    Reardon, C.A.4    Getz, G.S.5    Liao, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.