Role of oxidative stress in the pathophysiological mechanism of erectile dysfunction

Journal of Andrology

Volumn 27, Issue 3, 2006, Pages 335-347

  Agarwal, Ashok ^a,b   Nandipati, Kalyana C ^a   Sharma, Rakesh K ^a   Zippe, Craig D ^a   Raina, Rupesh ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALPHA TOCOPHEROL; ANGIOTENSIN II; ANTIOXIDANT; ARGININE; BINDING PROTEIN; CARBON MONOXIDE; CAROTENOID; CATALASE; FLAVONOID; INDUCIBLE NITRIC OXIDE SYNTHASE; LINOLENIC ACID; N ACETYLGLUCOSAMINE; NCX 4050; NEUROTRANSMITTER; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; PHOSPHODIESTERASE V INHIBITOR; PROBUCOL; PROTEIN KINASE C; SILDENAFIL; SILDENAFIL NITRATE; SUPEROXIDE; TADALAFIL; THIOCTIC ACID; TRANSITION ELEMENT; UNCLASSIFIED DRUG; VARDENAFIL;

AGING; CARDIOVASCULAR RISK; DIABETES MELLITUS; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENTIATION; ERECTILE DYSFUNCTION; GENE THERAPY; GENE TRANSFER; GLYCATION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; NONHUMAN; OXIDATIVE STRESS; PENIS ERECTION; PENIS INJURY; PEYRONIE DISEASE; PREVALENCE; PRIAPISM; PRIORITY JOURNAL; REVIEW; RISK FACTOR; VASOCONSTRICTION;

ANIMALS; ANTIOXIDANTS; DIABETES COMPLICATIONS; EUROPE; GENE THERAPY; HUMANS; HYPERHOMOCYSTEINEMIA; HYPERTENSION; IMPOTENCE; JAPAN; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; PEROXYNITROUS ACID; PREVALENCE; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; SUPEROXIDES; UNITED STATES;

EID: 33646371004     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.2164/jandrol.05136     Document Type: Review

References (113)

1. Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J. 2001;357:593-615.
2. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A. 1993;90:7915-7922.
3. Andersson KE, Garcia Pascual A, Persson K, Forman A, Tottrup A. Electrically-induced, nerve-mediated relaxation of rabbit urethra involves nitric oxide. J Urol. 1992;147:253-259.
4. Baylis C, Vallance P. Nitric oxide and blood pressure: effects of nitric oxide deficiency. Current Opin Nephrol Hypert. 1996;5:80-88.
5. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol. 1996;271:1424-1437.
6. -• and improves erectile function in aged rats. Am J Physiol Heart Circ Physiol. 2003;284:1408-1421.
7. Bivalacqua TJ, Champion HC, Hellstrom WJ, Kadowitz PJ. Pharmacotherapy for erectile dysfunction. Trends Pharmacol Sci. 2000;21:484-489.
8. Bivalacqua TJ, Hellstrom WJ, Kadowitz PJ, Champion HC. Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction. Biochem Biophys Res Commun. 2001;283:923-927.
9. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA. 1995;274:1049-1057.
10. Burchardt M, Burchardt T, Baer L, Kiss AJ, Pawar RV, Shabsigh A, de la Taille A, Hayek OR, Shabsigh R. Hypertension is associated with severe erectile dysfunction. J Urol. 2000;164:1188-1191.
11. Burnett AL. Nitric oxide in the penis: physiology and pathology. J Urol. 1997;157:320-324.
12. Burnett AL, Kramer MF, Becker RE, Musicki B. Dysregulation of endothelial nitric oxide synthase phosphorylation mechanisms in diabetes associated erectile dysfunction. In: 30th Annual meeting of American Society of Andrology, March 30-April 5, 2005; Seattle, Wash.
13. Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH. Nitric oxide: a physiologic mediator of penile erection. Science. 1992;257:401-403.
14. Burnett AL, Maguire MP, Chamness SL, Ricker DD, Takeda M, Lepor H, Chang TS. Characterization and localization of nitric oxide synthase in the human prostate. Urology. 1995;45:435-439.
15. Burnett AL, Ricker DD, Chamness SL, Maguire MP, Crone JK, Bredt DS, Snyder SH, Chang TS. Localization of nitric oxide synthase in the reproductive organs of the male rat. Biol Reprod. 1995;52:1-7.
16. Burnett AL, Tillman SL, Chang TS, Epstein JI, Lowenstein CJ, Bredt DS, Snyder SH, Walsh PC. Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis. J Urol. 1993;150:73-76.
17. Calignano A, Whittle BJ, Di Rosa M, Moncada S. Involvement of endogenous nitric oxide in the regulation of rat intestinal motility in vivo. Eur J Pharmacol. 1992;229:273-276.
18. Carrier S, Nagaraju P, Morgan DM, Baba K, Nunes L, Lue TF. Age decreases nitric oxide synthase-containing nerve fibers in the rat penis. J Urol. 1997;157:1088-1092.
19. Champion HC, Bivalacqua TJ, Hyman AL, Ignarro LJ, Hellstrom WJ, Kadowitz PJ. Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Proc Natl Acad Sci USA. 1999;96:11648-11652.
20. De Young L, Yu D, Bateman RM, Brock GB. Oxidative stress and antioxidant therapy: their impact in diabetes-associated erectile dysfunction. J Androl. 2004;25:830-836.
21. De Young L, Yu D, Freeman D, Brock GB. Effect of PDE5 inhibition combined with free oxygen radical scavenger therapy on erectile function in a diabetic animal model. Int J Impot Res. 2003;15:347-354.
22. Ding Y, Gonick HC, Vaziri ND, Liang K, Wei L. Lead-induced hypertension. III. Increased hydroxyl radical production. Am J Hypertens. 2001;14:169-173.
23. Ding Y, Vaziri ND, Gonick HC. Lead-induced hypertension. II. Response to sequential infusions of L-arginine, superoxide dismutase, and nitroprusside. Environ Res. 1998;76:107-113.
24. Dobrian AD, Davies MJ, Schriver SD, Lauterio TJ, Prewitt RL. Oxidative stress in a rat model of obesity-induced hypertension. Hypertension. 2001;37:554-560.
25. Dobrian AD, Schriver SD, Lynch T, Prewitt RL. Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity. Am J Physiol Renal Physiol. 2003;285:F619-F628.
26. Escrig A, Marin R, Abreu P, Gonzalez-Mora JL, Mas M. Changes in mating behavior, erectile function, and nitric oxide levels in penile corpora cavernosa in streptozotocin-diabetic rats. Biol Reprod. 2002;66:185-189.
27. Esterbauer H, Dieber-Rotheneder M, Striegl G, Waeg G. Role of vitamin E in preventing the oxidation of low-density lipoprotein. Am J Clin Nutr. 1991;53:314-321.
28. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994;151:54-61.
29. Ferrara N, Abete P, Ambrosio G, Landino P, Caccese P, Cirillo P, Oradei A, Littarru GP, Chiariello M, Rengo F. Protective role of chronic ubiquinone administration on acute Cardiac oxidative stress. J Pharmacol Exp Therapy. 1995;274:858-865.
30. Filippi S, Crescioli C, Vannelli GB, Fazzini A, Natali A, Riffaud JP, Maggi M, Ledda F. Effects of NCX 4050, a new NO donor, in rabbit and human corpus cavernosum. Int J Androl. 2003;26:101-108.
31. Finberg JP, Levy S, Vardi Y. Inhibition of nerve stimulation-induced vasodilatation in corpora cavernosa of the pithed rat by blockade of nitric oxide synthase. Brit J Pharmacol. 1993;108:1038-1042.
32. Ganz MB, Seftel A. Glucose-induced changes in protein kinase C and nitric oxide are prevented by vitamin E. Am J Physiol Endocrinol Metab. 2000;278:146-152.
33. Garban H, Vernet D, Freedman A, Rajfer J, Gonzalez-Cadavid N. Effect of aging on nitric oxide-mediated penile erection in rats. Am J Physiol. 1995;268:H467-H475.
34. Gonick HC, Ding Y, Bondy SC, Ni Z, Vaziri ND. Lead-induced hypertension: interplay of nitric oxide and reactive oxygen species. Hypertension. 1997;30:1487-1492.
35. Gur S, Ozturk B, Karahan ST. Impaired endothelium-dependent and neurogenic relaxation of corpus cavernosum from diabetic rats: improvement with L-arginine. Urol Res. 2000;28:14-19.
36. Haas CA, Seftel AD, Razmjouei K, Ganz MB, Hampel N, Ferguson K. Erectile dysfunction in aging: upregulation of endothelial nitric oxide synthase. Urology. 1998;51:516-522.
37. Heaton JP, Morales A, Owen J, Saunders FW, Fenemore J. Topical glyceryltrinitrate causes measurable penile arterial dilation in impotent men. J Urol. 1990;143:729-731.
38. Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM. The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int. 2002;62:1524-1538.
39. Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RA, Warnholtz A, Meinertz T, Griendling K, Harrison DG, Forstermann U, Munzel T. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res. 2001;88:14-22.
40. Holmquist F, Stief CG, Jonas U, Andersson KE. Effects of the nitric oxide synthase inhibitor NG-nitro-L-arginine on the erectile response to cavernous nerve stimulation in the rabbit. Acta Physiolog Scand. 1991;143:299-304.
41. Huang PL, Dawson TM, Bredt DS, Snyder SH, Fishman MC. Targeted disruption of the neuronal nitric oxide synthase gene. Cell. 1993;75:1273-1286.
42. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995;77:239-242.
43. Ignarro LJ, Bush PA, Buga GM, Wood KS, Fukuto JM, Rajfer J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophy Res Commun. 1990;170:843-850.
44. Islam KN, Devaraj S, Jialal I. alpha-Tocopherol enrichment of monocytes decreases agonist induced adhesion to human endothelial cells. Circulation. 1998;98:2255-2261.
45. Jeremy JY, Angelini GD, Khan M, Mikhailidis DP, Morgan RJ, Thompson CS, Bruckdorfer KR, Naseem KM. Platelets, oxidant stress and erectile dysfunction: an hypothesis. Cardiovasc Res. 2000;46:50-54.
46. Jevtich MJ, Khawand NY, Vidic B. Clinical significance of ultrastructural findings in the corpora cavernosa of normal and impotent men. J Urol. 1990;143:289-293.
47. Jones RW, Jeremy JY, Koupparis A, Persad R, Shukla N. Cavernosal dysfunction in a rabbit model of hyperhomocysteinaemia. BJU Int. 2005;95:125-130.
48. Jones RW, Rees RW, Minhas S, Ralph D, Persad RA, Jeremy JY. Oxygen free radicals and the penis. Expert Opin Pharm. 2002;3:889-897.
49. Kaiser FE, Viosca SP, Morley JE, Mooradian AD, Davis SS, Korenman SG. Impotence and aging: clinical and hormonal factors. J Am Geriatr Soc. 1988;36:511-519.
50. Kalsi JS, Kell PD, Cellek S, Ralph DJ. NCX-911, a novel nitric oxide-releasing PDE5 inhibitor relaxes rabbit corpus cavernosum in the absence of endogenous nitric oxide. Int J Impot Res. 2004;16:195-200.
51. Katusic ZS, Vanhoutte PM. Superoxide anion is an endothelium-derived contracting factor. Am J Physiol. 1989;257:33-37.
52. Keegan A, Cotter MA, Cameron NE. Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats. Diabetologia. 1999;42:343-350.
53. Keegan A, Walbank H, Cotter MA, Cameron NE. Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta. Diabetologia. 1995;38:1475-1478.
54. Kim N, Azadzoi KM, Goldstein I, Saenz de Tejada I. A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. J Clin Invest. 1991;88:112-118.
55. Khan MA, Thompson CS, Mumtaz FH, Mikhailidis DP, Morgan RJ, Bruckdorfer RK, Naseem KM. The effect of nitric oxide and peroxynitrite on rabbit cavernosal smooth muscle relaxation. World J Urol. 2001;19:220-224.
56. Kim JH, Klyachkin ML, Svendsen E, Davies MG, Hagen PO, Carson CC3rd. Experimental hypercholesterolemia in rabbits induces cavernosal atherosclerosis with endothelial and smooth muscle cell dysfunction. J Urol. 1994;151:198-205.
57. Kim SC, Kim IK, Seo KK, Baek KJ, Lee MY. Involvement of superoxide radical in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbits. Urol Res. 1997;25:341-346.
58. Knispel HH, Goessl C, Beckmann R. Basal and acetylcholine-stimulated nitric oxide formation mediates relaxation of rabbit cavernous smooth muscle. J Urol. 1991;146:1429-1433.
59. Kojda G, Harrison D. Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Rex. 1999;43:562-571.
60. Laight DW, Carrier MJ, Anggard EE. Antioxidants, diabetes and endothelial dysfunction. Cardiovasc Res. 2000;47:457-464.
61. Langenstroer P, Pieper GM. Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals. Am J Physiol. 1992;263:257-265.
62. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA. 1999;281:537-544.
63. Maas R, Schwedhelm E, Albsmeier J, Boger RH. The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function. Vasc Med. 2002;7:213-225.
64. Mannino DM, Klevens RM, Flanders WD. Cigarette smoking: an independent risk factor for impotence? Am J Epidemiol. 1994;140:1003-1008.
65. Martin-Morales A, Sanchez-Cruz JJ, Saenz de Tejada I, Rodriguez-Vela L, Jimenez-Cruz JF, Burgos-Rodriguez R. Prevalence and independent risk factors for erectile dysfunction in Spain: results of the Epidemiologia de la Disfuncion Erectil Masculina Study. J Urol. 2001;166:569-574.
66. McDowell IF, Lang D. Homocysteine and endothelial dysfunction: a link with cardiovascular disease. J Nutr. 2000;130:369-372.
67. Melman A, Gingell JC. The epidemiology and pathophysiology of erectile dysfunction. J Urol. 1999;161:5-11.
68. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991;43:109-142.
69. Mori M, Gotoh T. Regulation of nitric oxide production by arginine metabolic enzymes. Biochem Biophysic Res Commun. 2000;275:715-719.
70. Mullarkey CJ, Edelstein D, Brownlee M. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. Biochem Biophys Res Commun. 1990;173:932-939.
71. Newman HF, Marcus H. Erectile dysfunction in diabetes and hypertension. Urology. 1985;26:135-137.
72. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA. 1993;270:83-90.
73. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L arginine. Nature. 1988;333:664-666.
74. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987;327:524-526.
75. Pickard RS, Powell PH, Zar MA. The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve-evoked relaxation of human cavernosal smooth muscle. Brit J Pharmacol. 1991;104:755-759.
76. Rajasekaran M, Hellstrom WJ, Sikka SC. Nitric oxide induces oxidative stress and mediates cytotoxicity to human cavernosal cells in culture. J Androl. 2001;22:34-39.
77. Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. New Engl J Med. 1992;326:90-94.
78. Reckelhoff JF, Romero JC. Role of oxidative stress in angiotensin-induced hypertension. Am J Physiol. 2003;284:R893-R912.
79. Rendell MS, Rajfer J, Wicker PA, Smith MD. Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. Sildenafil Diabetes Study Group. JAMA. 1999;281:421-426.
80. Romero JC, Reckelhoff JF. Role of angiotensin and oxidative stress in essential hypertension. Hypertension. 1999;34:943-949.
81. Ruiz-Ortega M, Ortis A. Angiotensin II and reactive oxygen species. Antioxid Redox Signal. 2005;7:1258-1260.
82. Russo C, Olivieri O, Girelli D, Faccini G, Zenari ML, Lombardi S, Corrocher R. Anti-oxidant status and lipid peroxidation in patients with essential hypertension. J Hypert. 1998;16:1267-1271.
83. Ryu JK, Kim DJ, Lee T, Kang YS, Yoon SM, Suh JK. The role of free radical in the pathogenesis of impotence in streptozotocin-induced diabetic rats. Yonsei Med J. 2003;44:236-241.
84. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med. 1989;320:1025-1030.
85. Sagar S, Kallo IJ, Kaul N, Ganguly NK, Sharma BK. Oxygen free radicals in essential hypertension. Mol Cell Biochem. 1992;111:103-108.
86. Saldeen T, Li D, Mehta JL. Differential effects of alpha- and gamma-tocopherol on low-density lipoprotein oxidation, superoxide activity, platelet aggregation and arterial thrombogenesis. J Am College Cardiol. 1999;34:1208-1215.
87. Schnackenberg CG, Welch WJ, Wilcox CS. Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide. Hypertension. 1998;32:59-64.
88. Schoneich C. Reactive oxygen species and biological aging: a mechanistic approach. Exp Gerontol. 1999;34:19-34.
89. Seftel AD, Viola KA, Kasner SE, Ganz MB. Nitric oxide relaxes rabbit corpus cavernosum smooth muscle via a potassium-conductive pathway. Biochem Biophys Res Commun. 1996;219:382-387.
90. Shuttleworth CW, Sanders KM, Keef KD. Inhibition of nitric oxide synthesis reveals non cholinergic excitatory neurotransmission in the canine proximal colon. Brit J Pharmacol. 1993;109:739-747.
91. Sikka S, Zeng X, Hellstrom WJ. Redox signaling mechanisms and apoptotic response in human cavernosa under oxidative stress. In: 30th Annual Meeting of American Society of Andrology, March 30-April 5, 2005; Seattle, Wash. Abstract 94.
92. Solstad K, Davidsen M. Sexual behaviour and attitudes of Danish middle-aged men methodological considerations. Maturitas. 1993;17:139-149.
93. Soma M, Nakayama T, Kanmatsuse K. Nitric oxide synthase gene polymorphism and its influence on cardiovascular disease. Current Opin Nephrol Hypert. 1999;8:83-87.
94. Sommer F, Engelmann UH. What are the long term effects on erectile function of taking sildenafil on a daily basis [abstract 1192]? J Urol. 2004;171:375.
95. Spector KR, Boyle M. The prevalence and perceived aetiology of male sexual problems in a non-clinical sample. Br J Med Psychol. 1986;59:351-358.
96. Swei A, Lacy F, DeLano FA, Schmid-Schonbein GW. Oxidative stress in the Dahl hypertensive rat. Hypertension. 1997;30:1628-1633.
97. Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A, Salvetti A. Age-related reduction of NO availability and oxidative stress in humans. Hypertension. 2001;38:274-279.
98. Tenhunen R, Marver HS, Schmid R. Microsomal heme oxygenase. Characterization of the enzyme. J Biol Chem. 1969;244:388-394.
99. Tepel M, Echelmeyer M, Orie NN, Zidek W. Increased intracellular reactive oxygen species in patients with end-stage renal failure: effect of hemodialysis. Kidney Int. 2000;58:867-872.
100. Thirlby RC, Pearson PJ. Nitric oxide is (or is not) everywhere! Gastroent. 1993;104:658-659.
101. Trigo-Rocha F, Aronson WJ, Hohenfellner M, Ignarro LJ, Rajfer J, Lue TF. Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs. Amer J Physiol. 1993;264:H419-H422.
102. Ushiyama M, Morita T, Kuramochi T, Yagi S, Katayama S. Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide. Hypertens Res. 2004;27:253-261.
103. Vaziri ND, Ding Y, Ni Z, Gonick HC. Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: effect of lazaroid therapy. Kidney Int. 1997;52:1042-1046.
104. Vaziri ND, Liang K, Ding Y. Increased nitric oxide inactivation by reactive oxygen species in lead-induced hypertension. Kidney Int. 1999;56:1492-1498.
105. Vaziri ND, Wang XQ, Oveisi F, Rad B. Induction of oxidative stress by glutathione depletion causes severe hypertension in normal rats. Hypertension. 2000;36:142-146.
106. Warnholtz A, Nickenig G, Schulz E, Macharzina R, Brasen JH, Skatchkov M, Heitzer T, Stasch JP, Griendling KK, Harrison DG, Bohm M, Meinertz T, Munzel T. Increased NADH oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. Circulation. 1999;99:2027-2033.
107. Wei M, Macera CA, Davis DR, Hornung CA, Nankin HR, Blair SN. Total cholesterol and high density lipoprotein cholesterol as important predictors of erectile dysfunction. Am J Epidemiol. 1994;140:930-937.
108. Wink DA, Feelisch M, Fukuto J, Chistodoulou D, Jourd'heuil D, Grisham MB, Vodovotz Y, Cook JA, Krishna M, DeGraff WG, Kim S, Gamson J, Mitchell JB. The cytotoxicity of nitroxyl: possible implications for the pathophysiological role of NO. Arch Biochem Biophys. 1998;351:66-74.
109. Xiao S, Wagner L, Mahaney J, Baylis C. Uremic levels of urea inhibit L-arginine transport in cultured endothelial cells. Am J Physiol Renal Physiol. 2001;280:989-995.
110. Yasunari K, Maeda K, Nakamura M, Yoshikawa J. Oxidative stress in leukocytes is a possible link between blood pressure, blood glucose, and C-reacting protein. Hypertension. 2002;39:777-780.
111. Zalba G, Beaumont J, San Jose G, Fortuno A, Fortuno MA, Diez J. Vascular oxidant stress: molecular mechanisms and pathophysiological implications. J Physiol Biochem. 2000;56:57-64.
112. Zeiher AM, Drexler H, Saurbier B, Just H. Endothelium-mediated coronary blood flow modulation in humans: effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest. 1993;92:652-662.
113. Zou M, Martin C, Ullrich V. Tyrosine nitration as a mechanism of selective inactivation of prostacyclin synthase by peroxynitrite. Biol Chem. 1997;378:707-713.