The administration of folic acid improves erectile function and reduces intracavernosal oxidative stress in the diabetic rabbit

BJU International

Volumn 103, Issue 1, 2009, Pages 98-103

  Shukla, Nilima ^b   Hotston, Matthew ^b   Persad, Raj ^b   Angelini, Gianni D ^b   Jeremy, Jamie Y ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

Diabetes mellitus; Erectile dysfunction; Folic acid

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; ALLOXAN; CARBACHOL; FOLIC ACID; GLUCOSE; HOMOCYSTEINE; PROSTACYCLIN; PROSTAGLANDIN F1 ALPHA; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES MELLITUS; DRUG EFFECT; ELECTROSTIMULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ERECTILE DYSFUNCTION; ERYTHROCYTE; GLUCOSE BLOOD LEVEL; NONHUMAN; OXIDATIVE STRESS; PENIS ERECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SPECTROPHOTOMETRY; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; DIABETES MELLITUS, EXPERIMENTAL; DRUG EVALUATION, PRECLINICAL; ERECTILE DYSFUNCTION; FOLIC ACID; MALE; OXIDATIVE STRESS; PENILE ERECTION; RABBITS; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 57649219192     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2008.07911.x     Document Type: Article

References (37)

1. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 1989 320 : 1025 30
2. Sullivan ME, Thompson CS, Dashwood MR et al. Nitric oxide and erection: is erectile dysfunction another manifestation of vascular disease? Cardiovasc Res 1999 43 : 658 65
3. Jeremy JY, Angelini GD, Khan M et al. Platelets, oxidant stress and erectile dysfunction: an hypothesis. Cardiovasc Res 2000 46 : 50 4
4. Rosen RC, Kostis JB. Overview of phosphodiesterase 5 inhibition in erectile dysfunction. Am J Cardiol 2003 92 : 9M 18M
5. Lau DH, Kommu S, Mumtaz FH, Morgan RJ, Thompson CS, Mikhailidis DP. The management of phosphodiesterase-5 (PDE5) inhibitor failure. Curr Vasc Pharmacol 2006 4 : 89 93
6. Kloner RA, Mullin SH, Shook T et al. Erectile dysfunction in the cardiac patient: how common and how should we treat it. J Urol 2003 170 : S46 50
7. Solomon H, Man JW, Jackson G. Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 2003 89 : 251 3
8. Barrett-Connor E. Cardiovascular risk stratification and cardiovascular risk factors associated with erectile dysfunction: assessing cardiovascular risk in men with erectile dysfunction. Clin Cardiol 2004 27 (Suppl. 1 I8 13
9. Kostis JB, Jackson G, Rosen R et al. Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference). Am J Cardiol 2005 96 : 313 21
10. Jeremy JY, Ballard S, Naylor A, Miller MA, Angelini GD. Effect of sildenafil, a type-5 cGMP phosphodiesterase inhibitor, and papaverine on cylic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro. Br J Urol 1997 79 : 958 63
11. Jeremy JY, Jones RA, Koupparis AJ, Hotston M, Persad R, Angelini GD, Shukla N. Reactive oxygen species and ecrectile dysfunction: possible role of NADPH oxidase. Int J Impot Res 2007 19 : 265 80
12. Jeremy JY, Rowe D, Emsley AM, Newby AC. Nitric oxide and the proliferation of vascular smooth muscle cells. Cardiovasc Res 1999 43 : 580 94
13. 2 mimetic, U46619, in corpus cavernosal smooth muscle cells. BJU Int 2005 96 : 423 7
14. Shukla N, Jones R, Persad R, Angelini GD, Jeremy JY. Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits. Eur J Pharmacol 2005 517 : 224 31
15. Hotston M, Jeremy JY, Bloor J, Koupparis A, Persad R, Shukla N. Sildenafil inhibits the up-regulation of type 5 phosphodiesterase elicited with nicotine and tumour necrosing factor-α in cavernosal vascular smooth muscle cells: mediation by superoxide. BJU Int 2007 99 : 612 8
16. phox expression in porcine pulmonary artery endothelial cells. Br J Pharmacol 2005 146 : 109 17
17. Jones RW, Jeremy JY, Koupparis A, Persad R, Shukla N. Cavernosal dysfunction in a rabbit model of hyperhomocysteinaemia. BJU Int 2005 95 : 125 30
18. Koupparis AJ, Jeremy J, Angelini G, Persad R, Shukla N. Penicillamine administration reverses the inhibitory effect of hyperhomocysteinaemia on endothelium-dependent relaxation in the corpus cavernosum in the rabbit. BJU Int 2006 98 : 440 4
19. Shukla N, Thompson CS, Angelini GD, Mikhailidis DP, Jeremy JY. Homocysteine enhances impairment of endothelium-dependent relaxation and guanosine cyclic monophosphate formation in aortae from diabetic rabbits. Diabetologia 2002 45 : 1325 31
20. Wald DS, Wald NJ, Morris JK, Law M. Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence. BMJ 2006 333 : 1114 7
21. Moat SJ, Madhavan A, Taylor SY et al. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2006 36 : 850 9
22. 2α, cytokines and endotoxin in the pig pulmonary artery. Br J Pharmacol 2004 141 : 488 96
23. Jeremy JY, Mikhailidis DP, Dandona P. Simulating the diabetic environment modifies in vitro prostacyclin synthesis. Diabetes 1983 32 : 217 21
24. Jeremy JY, Thompson CS, Mikhailidis DP, Dandona P. Experimental diabetes mellitus inhibits prostacyclin synthesis by the rat penis: pathological implications. Diabetologia 1985 28 : 365 8
25. Miller M, Morgan RJ, Thompson CS, Mikhailidis DP, Jeremy JY. Adenylate and guanylate cyclase activity in the penis and aorta of the diabetic rat: an in vitro study. Br J Urol 1994 74 : 106 11
26. Thompson C, Mumtaz FH, Khan M et al. The effect of sildenafil on corpus cavernosal smooth muscle relaxation and cyclic GMP formation in the diabetic rabbit. Eur J Pharmacol 2001 425 : 57 64
27. Khan MA, Thompson CS, Jeremy JY, Mumtaz FH, Mikhailidis P, Morgan RJ. The effect of superoxide dismutase on nitric oxide-mediated and electrical field-stimulated diabetic rabbit cavernosal smooth muscle relaxation. BJU Int 2001 87 : 98 103
28. Jeremy JY, Shukla N, Angelini GD et al. Sustained increases of plasma homocysteine, copper and ceruloplasmin after coronary artery bypass grafting. Ann Thorac Surg 2002 74 : 1553 7
29. phox induced by endotoxin and cytokines in pig pulmonary artery vascular smooth muscle cells and endothelial cells. Circulation 2004 110 : 1140 7
30. Muzaffar S, Jeremy JY, Angelini GD, Stuart-Smith K, Shukla N. Role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries. Thorax 2003 58 : 598 604
31. Jeremy JY, Mikhailidis DP, Dandona P. Vascular trauma and prostacyclin release. Microcirc Endothelium Lymphatics 1984 1 : 629 44
32. Jeremy JY, Mikhailidis DP, Dandona P. The rat urinary bladder produces prostacyclin as well as other prostaglandins. Prostaglandins Leukot Med 1984 16 : 235 48
33. Jeremy JY, Tsang V, Mikhailidis DP, Rogers H, Morgan RJ, Dandona P. Eicosanoid synthesis by the human urinary bladder mucosa: pathological implications. Br J Urol 1987 59 : 36 9
34. Jeremy JY, Mikhailidis DP, Dandona P. The effect of nifedipine, nimodipine and nisoldipine on agonist- and trauma-stimulated vascular prostacyclin synthesis in vitro. Naunyn Schmiedebergs Arch Pharmacol 1986 332 : 70 3
35. Morrow JD. Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans. Arterioscler Thromb Vasc Biol 2005 25 : 279 86
36. Andersson KE. Pharmacology of penile erection. Pharmacol Rev 2001 53 : 417 50
37. Shukla N, Greaves NS, Angelini GD, Jeremy JY. The administration of folic acid reduces intravascular oxidative stress in diabetic rabbits. Metabolism 2008 57 : 774 81