Sleep apnea and cardiovascular disease: Implications for understanding erectile dysfunction

Herz

Volumn 28, Issue 4, 2003, Pages 298-303

  Arruda Olson, Adelaide M ^a   Olson, Lyle J ^a   Nehra, Ajay ^b   Somers, Virend K ^a  

^a MAYO CLINIC   (United States)

^b DEPARTMENT OF UROLOGY   (United States)

Author keywords

Cardiovascular diseases; Erectile dysfunction; Obstructive sleep apnea

Indexed keywords

CARDIOVASCULAR DISEASE; COMORBIDITY; DISEASE ASSOCIATION; ERECTILE DYSFUNCTION; HIGH RISK PATIENT; HORMONE ACTION; HUMAN; OBESITY; PATHOGENESIS; PENIS ERECTION; REVIEW; SLEEP APNEA SYNDROME; VASCULAR DISEASE;

EID: 0037592390     PISSN: 03409937     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00059-003-2482-z     Document Type: Review

References (38)

1. Lue TF. Physiology of penile erection and pathophysiology of erectile dysfunction and priapism. In: Walsh PC, Retik AB, Vaughan ED, Wein AJ, eds. Campbell's urology. Philadelphia: Saunders, 2002:1591-618.
2. Lue TF. Erectile dysfunction. N Engl J Med 2000;342:1802-13.
3. Giuliano FA, Rampin O, Benoit G, Jardin A. Neural control of penile erection. Urol Clin North Am 1995;22:747-66.
4. Saenz de Tejada I. In the physiology of erection, signposts to impotence. Contemp Urol 1992;7:52-68.
5. Andersson K-E, Wagner G. Physiology of erection. Physiol Rev 1995;75:191-236.
6. Christ GJ. The penis as a vascular organ. Urol Clin North Am 1995;22:727-45.
7. Burnett A. Nitric oxide in the penis: physiology and pathology. J Urol 1997;157:320-4.
8. Lue TF, Dahiya R. Molecular biology of erectile function and dysfunction. Mol Urol 1997;1:55-64.
9. Levine L, Lenting E. Use of nocturnal penile tumescence and rigidity in the evaluation of male erectile dysfunction. In: Melman A, ed. The urologic clinics of North America. Impotence. Philadelphia: Saunders, 1995:775-88.
10. Schmidt HS, Wise HA. Significance of impaired penile tumescence and associated polysomnographic abnormalities in the impotent patient. J Urol 1981;126:348-51.
11. Pressman MR, Diphillipo MA, Kendrick JI, Conroy K, Fry JM. Problems in the interpretation of nocturnal penile tumescence studies: disruption of sleep by occult sleep disorders. J Urol 1986; 136:595-8.
12. Bradley DT, Floras JS. Sleep apnea and heart failure. Part 1: Obstructive sleep apnea. Circulation 2003;107:1671-8.
13. Malhotra A, White DP. Obstructive sleep apnoea. Lancet 2002; 360:237-45.
14. Lattimore JL, Celermajer DS, Wilcox I. Obstructive sleep apnea and cardiovascular disease. J Am Coll Cardiol 2003;41:1429-37.
15. Ward FW. Clinical practice. Obstructive sleep apnea. N Engl J Med 2002;347:498-504.
16. Parmeggiani PL, Morrison AL. Alterations in autonomic functions during sleep. In: Loewy AD Spyer KM, eds. Central regulation of autonomic functions. New York: Oxford University Press, 1990: 367-86.
17. Crasset V, Mezzetti S, Antoine M, Linkowski P, Degaute JP, Van de Borne P. Effects of aging and cardiac denervation on heart rate variability during sleep. Circulation 2001;103:84-8.
18. Lavie P, Shlitner A, Nave R. Cardiac autonomic function during sleep in psychogenic and organic erectile dysfunction. J Sleep Res 1999;8:135-42.
19. Phillips BG, Somers VK. Neural and humoral mechanisms mediating cardiovascular responses to obstructive sleep apnea. Respir Physiol 2000;119:181-7.
20. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993;328:1230-35.
21. Young T, Gottlieb DJ. Epidemiology of obstructive sleep apnea. A population health perspective. Am J Respir Crit Care Med 2002; 165:1217-39.
22. Hirshkowitz M, Karacan I, Arcasoy MO, Acik G, Narter EM, Williams RL. Prevalence of sleep apnea in men with erectile dysfunction. Urology 1990;36:232-34.
23. Bassiri AG, Guillerminault C. Clinical features and evaluation of obstructive sleep apnea-hypopnea syndrome. In: Kriger MH, Roth T, Dement WC, eds. Principles and practice of sleep medicine. Philadelphia: Saunders, 2000:869-78.
24. Somers VK, Dyken ME, Clary MP, Abboud FM. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 1995; 96:1897-904.
25. Ziegler MG, Nelesen R, Mills P, Ancoli-Israel S, Kennedy B, Dimsdale JE. Sleep apnea, norepinephrine-release rate, and day time hypertension. Sleep 1997;20:224-31.
26. Fanfulla F, Malaguti S, Montagna T, Bruschi C, Crotti P, Casale R, Rampulla C. Erectile dysfunction in men with obstructive sleep apnea: an early sign of nerve involvement. Sleep 2000;23:775-81.
27. Mayer P, Dematteis M, Pepin JL, Wuyam B, Veale D, Vila A, Levy P. Peripheral neuropathy in sleep apnea. A tissue marker of the severity of nocturnal desaturation. Am J Respir Crit Care Med 1999;159:213-9.
28. Luboshitzky R, Herer P, Levi M, Shen-Orr Z, Lavie P. Relationship between rapid eye movement sleep and testosterone secretion in normal men. J Androl 1999;20:731-7.
29. Luboshitzky R, Zabari Z, Shen-Orr Z, Herer P, Lavie P. Disruption of the nocturnal testosterone rhythm by sleep fragmentation in normal men. J Clin Endocrinol Metab 2001;86:1134-9.
30. Luboshitzky R, Aviv A, Hefetz A, Herer P, Shen-Orr Z. Decreased pituitary-gonadal secretion in men with obstructive sleep apnea. J Clin Endocrinol Metab 2002;87:3394-8.
31. Kato M, Roberts-Thomson P, Phillips B, Haynes WG, Winnicki M, Accurso V, Somers VK. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 2000;102:2607-10.
32. Kourembanas S, Marsden PA, McQuillan LP, Faller DV. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest 1991;88:1054-7.
33. Rakugi H, Tabuchi Y, Nakamaru M, Nagano M, Higashimori K, Mikami H, Ogihara T, Suzuki N. Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia. Biochem Biophys Res Commun 1990;169:973-7.
34. Phillips B, Narkiewicz K, Pesek CA, Haynes WG, Dyken ME, Somers VK. Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens 1999;17:61-6.
35. Karacan I, Karatas M. Erectile dysfunction in sleep apnea and response to CPAP. J Sex Marital Ther 1995;21:239-47.
36. Schulz R, Schimidt D, Blum A, Lopes-Ribeiro X, Lucke C, Mayer K, Olschewski H, Seeger W, Girmminger F. Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy. Thorax 2000;55:1046-51.
37. Ip MSM, Lam B, Chan L, Zheng L,Tsang KWT, Fung PCW, Lam W. Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med 2000;162:2166-71.
38. Bremner S, Vitiello MV, Prinz PN. Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 1983;56:1278-81.