-
1
-
-
4544241811
-
Tolerance, not immunity, crucially depends on IL-2
-
Malek, T. R., and A. L. Bayer. 2004. Tolerance, not immunity, crucially depends on IL-2. Nat. Rev. Immunol. 4: 665-674.
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 665-674
-
-
Malek, T.R.1
Bayer, A.L.2
-
2
-
-
15544384475
-
Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period
-
Bayer, A. L., A. Yu, D. Adeegbe, and T. R. Malek. 2005. Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period. J. Exp. Med. 201: 769-777.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 769-777
-
-
Bayer, A.L.1
Yu, A.2
Adeegbe, D.3
Malek, T.R.4
-
3
-
-
33947667310
-
Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells
-
Bayer, A. L., A. Yu, and T. R. Malek. 2007. Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells. J. Immunol. 178: 4062-4071.
-
(2007)
J. Immunol.
, vol.178
, pp. 4062-4071
-
-
Bayer, A.L.1
Yu, A.2
Malek, T.R.3
-
4
-
-
41949097030
-
The biology of interleukin-2
-
Malek, T. R. 2008. The biology of interleukin-2. Annu. Rev. Immunol. 26: 453-479.
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 453-479
-
-
Malek, T.R.1
-
5
-
-
27544481941
-
A function for interleukin 2 in Foxp3-expressing regulatory T cells
-
Fontenot, J. D., J. P. Rasmussen, M. A. Gavin, and A. Y. Rudensky. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6: 1142-1151.
-
(2005)
Nat. Immunol.
, vol.6
, pp. 1142-1151
-
-
Fontenot, J.D.1
Rasmussen, J.P.2
Gavin, M.A.3
Rudensky, A.Y.4
-
6
-
-
15444374646
-
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
-
Setoguchi, R., S. Hori, T. Takahashi, and S. Sakaguchi. 2005. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201: 723-735.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 723-735
-
-
Setoguchi, R.1
Hori, S.2
Takahashi, T.3
Sakaguchi, S.4
-
7
-
-
0025899598
-
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
-
Schorle, H., T. Holtschke, T. Hünig, A. Schimpl, and I. Horak. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352: 621-624.
-
(1991)
Nature
, vol.352
, pp. 621-624
-
-
Schorle, H.1
Holtschke, T.2
Hünig, T.3
Schimpl, A.4
Horak, I.5
-
8
-
-
0029028363
-
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β
-
Suzuki, H., T. M. Kündig, C. Furlonger, A. Wakeham, E. Timms, T. Matsuyama, R. Schmits, J. J. Simard, P. S. Ohashi, H. Griesser, et al. 1995. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor b. Science 268: 1472-1476.
-
(1995)
Science
, vol.268
, pp. 1472-1476
-
-
Suzuki, H.1
Kündig, T.M.2
Furlonger, C.3
Wakeham, A.4
Timms, E.5
Matsuyama, T.6
Schmits, R.7
Simard, J.J.8
Ohashi, P.S.9
Griesser, H.10
-
9
-
-
0028784289
-
Interleukin-2 receptor a chain regulates the size and content of the peripheral lymphoid compartment
-
Willerford, D. M., J. Chen, J. A. Ferry, L. Davidson, A. Ma, and F. W. Alt. 1995. Interleukin-2 receptor a chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3: 521-530.
-
(1995)
Immunity
, vol.3
, pp. 521-530
-
-
Willerford, D.M.1
Chen, J.2
Ferry, J.A.3
Davidson, L.4
Ma, A.5
Alt, F.W.6
-
10
-
-
0027369395
-
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
-
Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261.
-
(1993)
Cell
, vol.75
, pp. 253-261
-
-
Sadlack, B.1
Merz, H.2
Schorle, H.3
Schimpl, A.4
Feller, A.C.5
Horak, I.6
-
11
-
-
0036669298
-
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
-
Malek, T. R., A. Yu, V. Vincek, P. Scibelli, and L. Kong. 2002. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17: 167-178.
-
(2002)
Immunity
, vol.17
, pp. 167-178
-
-
Malek, T.R.1
Yu, A.2
Vincek, V.3
Scibelli, P.4
Kong, L.5
-
13
-
-
67650928182
-
+ regulatory T cells
-
+ regulatory T cells. Proc. Natl. Acad. Sci. USA 106: 11673-11678.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 11673-11678
-
-
Von Allmen, C.E.1
Schmitz, N.2
Bauer, M.3
Hinton, H.J.4
Kurrer, M.O.5
Buser, R.B.6
Gwerder, M.7
Muntwiler, S.8
Sparwasser, T.9
Beerli, R.R.10
Bachmann, M.F.11
-
17
-
-
60149085254
-
A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells
-
Yu, A., L. Zhu, N. H. Altman, and T. R. Malek. 2009. A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. Immunity 30: 204-217.
-
(2009)
Immunity
, vol.30
, pp. 204-217
-
-
Yu, A.1
Zhu, L.2
Altman, N.H.3
Malek, T.R.4
-
18
-
-
37849009964
-
A two-step process for thymic regulatory T cell development
-
Lio, C. W., and C. S. Hsieh. 2008. A two-step process for thymic regulatory T cell development. Immunity 28: 100-111.
-
(2008)
Immunity
, vol.28
, pp. 100-111
-
-
Lio, C.W.1
Hsieh, C.S.2
-
19
-
-
37849008688
-
Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire
-
Burchill, M. A., J. Yang, K. B. Vang, J. J. Moon, H. H. Chu, C. W. Lio, A. L. Vegoe, C. S. Hsieh, M. K. Jenkins, and M. A. Farrar. 2008. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 28: 112-121.
-
(2008)
Immunity
, vol.28
, pp. 112-121
-
-
Burchill, M.A.1
Yang, J.2
Vang, K.B.3
Moon, J.J.4
Chu, H.H.5
Lio, C.W.6
Vegoe, A.L.7
Hsieh, C.S.8
Jenkins, M.K.9
Farrar, M.A.10
-
20
-
-
79251547354
-
A major role for Bim in regulatory T cell homeostasis
-
Chougnet, C. A., P. Tripathi, C. S. Lages, J. Raynor, A. Sholl, P. Fink, D. R. Plas, and D. A. Hildeman. 2011. A major role for Bim in regulatory T cell homeostasis. J. Immunol. 186: 156-163.
-
(2011)
J. Immunol.
, vol.186
, pp. 156-163
-
-
Chougnet, C.A.1
Tripathi, P.2
Lages, C.S.3
Raynor, J.4
Sholl, A.5
Fink, P.6
Plas, D.R.7
Hildeman, D.A.8
-
21
-
-
78650668123
-
Cutting edge: Mechanisms of IL-2-dependent maintenance of functional regulatory T cells
-
Barron, L., H. Dooms, K. K. Hoyer, W. Kuswanto, J. Hofmann, W. E. O'Gorman, and A. K. Abbas. 2010. Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells. J. Immunol. 185: 6426-6430.
-
(2010)
J. Immunol.
, vol.185
, pp. 6426-6430
-
-
Barron, L.1
Dooms, H.2
Hoyer, K.K.3
Kuswanto, W.4
Hofmann, J.5
O'Gorman, W.E.6
Abbas, A.K.7
-
23
-
-
15244354286
-
Regulatory T cell lineage specification by the forkhead transcription factor foxp3
-
Fontenot, J. D., J. P. Rasmussen, L. M. Williams, J. L. Dooley, A. G. Farr, and A. Y. Rudensky. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22: 329-341.
-
(2005)
Immunity
, vol.22
, pp. 329-341
-
-
Fontenot, J.D.1
Rasmussen, J.P.2
Williams, L.M.3
Dooley, J.L.4
Farr, A.G.5
Rudensky, A.Y.6
-
24
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
25
-
-
33847125247
-
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
-
Wan, Y. Y., and R. A. Flavell. 2007. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445: 766-770.
-
(2007)
Nature
, vol.445
, pp. 766-770
-
-
Wan, Y.Y.1
Flavell, R.A.2
-
26
-
-
34247271308
-
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
-
Williams, L. M., and A. Y. Rudensky. 2007. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat. Immunol. 8: 277-284.
-
(2007)
Nat. Immunol.
, vol.8
, pp. 277-284
-
-
Williams, L.M.1
Rudensky, A.Y.2
-
27
-
-
0029054455
-
Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation
-
Miyazaki, T., Z. J. Liu, A. Kawahara, Y. Minami, K. Yamada, Y. Tsujimoto, E. L. Barsoumian, R. M. Permutter, and T. Taniguchi. 1995. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81: 223-231.
-
(1995)
Cell
, vol.81
, pp. 223-231
-
-
Miyazaki, T.1
Liu, Z.J.2
Kawahara, A.3
Minami, Y.4
Yamada, K.5
Tsujimoto, Y.6
Barsoumian, E.L.7
Permutter, R.M.8
Taniguchi, T.9
-
28
-
-
0026017971
-
Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis
-
Lenardo, M. J. 1991. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature 353: 858-861.
-
(1991)
Nature
, vol.353
, pp. 858-861
-
-
Lenardo, M.J.1
-
29
-
-
0021875442
-
Interleukin 2 upregulates expression of its receptor on a T cell clone
-
Malek, T. R., and J. D. Ashwell. 1985. Interleukin 2 upregulates expression of its receptor on a T cell clone. J. Exp. Med. 161: 1575-1580.
-
(1985)
J. Exp. Med.
, vol.161
, pp. 1575-1580
-
-
Malek, T.R.1
Ashwell, J.D.2
-
30
-
-
33947162110
-
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
-
Laurence, A., C. M. Tato, T. S. Davidson, Y. Kanno, Z. Chen, Z. Yao, R. B. Blank, F. Meylan, R. Siegel, L. Hennighausen, et al. 2007. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26: 371-381.
-
(2007)
Immunity
, vol.26
, pp. 371-381
-
-
Laurence, A.1
Tato, C.M.2
Davidson, T.S.3
Kanno, Y.4
Chen, Z.5
Yao, Z.6
Blank, R.B.7
Meylan, F.8
Siegel, R.9
Hennighausen, L.10
-
31
-
-
65549136983
-
+ T regulatory cell-mediated suppression
-
+ T regulatory cell-mediated suppression. Immunity 30: 636-645.
-
(2009)
Immunity
, vol.30
, pp. 636-645
-
-
Shevach, E.M.1
-
32
-
-
25844504653
-
Developmental regulation of Foxp3 expression during ontogeny
-
Fontenot, J. D., J. L. Dooley, A. G. Farr, and A. Y. Rudensky. 2005. Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 202: 901-906.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 901-906
-
-
Fontenot, J.D.1
Dooley, J.L.2
Farr, A.G.3
Rudensky, A.Y.4
-
33
-
-
17044430217
-
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter
-
Wan, Y. Y., and R. A. Flavell. 2005. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl. Acad. Sci. USA 102: 5126-5131.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 5126-5131
-
-
Wan, Y.Y.1
Flavell, R.A.2
-
34
-
-
84861424521
-
An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes
-
Darce, J., D. Rudra, L. Li, J. Nishio, D. Cipolletta, A. Y. Rudensky, D. Mathis, and C. Benoist. 2012. An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity 36: 731-741.
-
(2012)
Immunity
, vol.36
, pp. 731-741
-
-
Darce, J.1
Rudra, D.2
Li, L.3
Nishio, J.4
Cipolletta, D.5
Rudensky, A.Y.6
Mathis, D.7
Benoist, C.8
-
35
-
-
84861451140
-
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency
-
Bettini, M. L., F. Pan, M. Bettini, D. Finkelstein, J. E. Rehg, S. Floess, B. D. Bell, S. F. Ziegler, J. Huehn, D. M. Pardoll, and D. A. Vignali. 2012. Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity 36: 717-730.
-
(2012)
Immunity
, vol.36
, pp. 717-730
-
-
Bettini, M.L.1
Pan, F.2
Bettini, M.3
Finkelstein, D.4
Rehg, J.E.5
Floess, S.6
Bell, B.D.7
Ziegler, S.F.8
Huehn, J.9
Pardoll, D.M.10
Vignali, D.A.11
-
36
-
-
35448967862
-
Interleukin-2 receptor signaling in regulatory T cell development and homeostasis
-
Burchill, M. A., J. Yang, K. B. Vang, and M. A. Farrar. 2007. Interleukin-2 receptor signaling in regulatory T cell development and homeostasis. Immunol. Lett. 114: 1-8.
-
(2007)
Immunol. Lett.
, vol.114
, pp. 1-8
-
-
Burchill, M.A.1
Yang, J.2
Vang, K.B.3
Farrar, M.A.4
-
37
-
-
33846016948
-
Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation
-
Chen, C., E. A. Rowell, R. M. Thomas, W. W. Hancock, and A. D. Wells. 2006. Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. J. Biol. Chem. 281: 36828-36834.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 36828-36834
-
-
Chen, C.1
Rowell, E.A.2
Thomas, R.M.3
Hancock, W.W.4
Wells, A.D.5
-
38
-
-
0031006856
-
Bcl-2 modulates telomerase activity
-
Mandal, M., and R. Kumar. 1997. Bcl-2 modulates telomerase activity. J. Biol. Chem. 272: 14183-14187.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14183-14187
-
-
Mandal, M.1
Kumar, R.2
-
39
-
-
79954559096
-
T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells
-
Cheng, G., A. Yu, and T. R.Malek. 2011. T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells. Immunol. Rev. 241: 63-76.
-
(2011)
Immunol. Rev.
, vol.241
, pp. 63-76
-
-
Cheng, G.1
Yu, A.2
Malek, T.R.3
-
40
-
-
84857416489
-
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
-
Miyao, T., S. Floess, R. Setoguchi, H. Luche, H. J. Fehling, H. Waldmann, J. Huehn, and S. Hori. 2012. Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 36: 262-275.
-
(2012)
Immunity
, vol.36
, pp. 262-275
-
-
Miyao, T.1
Floess, S.2
Setoguchi, R.3
Luche, H.4
Fehling, H.J.5
Waldmann, H.6
Huehn, J.7
Hori, S.8
|