Design and performance of a spreadsheet-based model for estimating bioavailability of chemicals from dermal exposure

Advanced Drug Delivery Reviews

Volumn 65, Issue 2, 2013, Pages 221-236

  Dancik, Yuri ^a   Miller, Matthew A ^b   Jaworska, Joanna ^a   Kasting, Gerald B ^b  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b UNIVERSITY OF CINCINNATI ACADEMIC HEALTH CENTER   (United States)

Author keywords

Corneocytes; Dermis; Lipids; Mathematical model; Stratum corneum (SC); Transdermal drug transport; Viable epidermis (VE)

Indexed keywords

CORNEOCYTES; DERMIS; STRATUM CORNEUM; TRANSDERMAL DRUGS; VIABLE EPIDERMIS (VE);

BIOCHEMISTRY; DIFFUSION; FORECASTING; LIPIDS; MATHEMATICAL MODELS; POWER QUALITY;

SPREADSHEETS;

ACECLOFENAC; ACETYLSALICYLIC ACID; BENZO[A]PYRENE; CAFFEINE; CHLORPHENOTANE; CINNAMALDEHYDE; CODEINE; COUMARIN; DICLOFENAC; FENTANYL; FLURBIPROFEN; GLYCOL; GRISEOFULVIN; HYDROMORPHONE; IBUPROFEN; INDOMETACIN; KETOPROFEN; KETOROLAC; MALATHION; MORPHINE; NARCOTIC AGENT; PARATHION; PIROXICAM; PROPRANOLOL; STEROID; SUFENTANIL; TENOXICAM; TESTOSTERONE; TRICLOSAN; UNINDEXED DRUG;

DERMIS; DIFFUSION COEFFICIENT; DRUG ABSORPTION; DRUG EXPOSURE; DRUG PENETRATION; ELECTRONIC SPREADSHEET; EPIDERMIS; IN VITRO STUDY; IN VIVO STUDY; PARTITION COEFFICIENT; PASSIVE TRANSPORT; PREDICTION; PRIORITY JOURNAL; REVIEW; SKIN; SKIN ABSORPTION; SKIN PENETRATION; SKIN PERMEABILITY; SKIN STRUCTURE; STRATUM CORNEUM; VAPOR PRESSURE;

ADMINISTRATION, CUTANEOUS; BIOLOGICAL TRANSPORT; HUMANS; MODELS, THEORETICAL; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; SKIN; SKIN ABSORPTION; SOLUBILITY;

EID: 84873526935     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2012.01.006     Document Type: Review

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