Multiscale modeling framework of transdermal drug delivery

Annals of Biomedical Engineering

Volumn 37, Issue 6, 2009, Pages 1217-1229

  Rim, Jee E ^a,c   Pinsky, Peter M ^a   Van Osdol, William W ^b,d  

^a Stanford University   (United States)

^b ALZA CORPORATION   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d DURECT Corporation   (United States)

Author keywords

Fentanyl; Finite element method; Homogenization; Molecular dynamics; Multiscale; Oleic acid; Permeation enhancer

Indexed keywords

DIFFUSION COEFFICIENTS; DRUG PERMEATIONS; EFFECTIVE DIFFUSIONS; EFFECTIVE PARAMETERS; EXPERIMENTAL DATUM; FENTANYL; FINITE ELEMENT SIMULATIONS; HOMOGENEOUS MEDIUMS; HOMOGENIZATION; HOMOGENIZATION PROCEDURES; LENGTH-SCALE; MACROSCOPIC DIFFUSIONS; MESOSCOPIC; MOLECULAR-DYNAMICS SIMULATIONS; MULTI COMPONENTS; MULTI-SCALE MODELING; MULTISCALE; MULTISCALE FRAMEWORKS; PERCUTANEOUS PERMEATIONS; PERMEATION BARRIERS; PERMEATION ENHANCER; REPRODUCIBILITY; STRATUM CORNEUM; SUB-PROBLEMS; TRANSDERMAL; TRANSDERMAL DRUG DELIVERIES; UNIT CELLS;

ACIDS; ANESTHETICS; CONTROLLED DRUG DELIVERY; DIFFUSION; DYNAMICS; HOMOGENIZATION METHOD; LIPID BILAYERS; MOLECULAR DYNAMICS; OLEIC ACID; SKIN;

FINITE ELEMENT METHOD;

FENTANYL; OLEIC ACID;

ARTICLE; BIOLOGICAL MODEL; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DIFFUSION; INTRADERMAL DRUG ADMINISTRATION; LIPID BILAYER; METABOLISM; SKIN;

ADMINISTRATION, CUTANEOUS; DIFFUSION; FENTANYL; LIPID BILAYERS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; OLEIC ACID; SKIN;

EID: 67349086273     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-009-9678-1     Document Type: Article

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