Comparison of skin distribution of hydrolytic activity for bioconversion of β-estradiol 17-acetate between man and several animals in vitro

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 54, Issue 2, 2002, Pages 155-160

  Hikima, Tomohiro ^a,b,d   Yamada, Kayoko ^a   Kimura, Tohru ^c   Maibach, Howard I ^b   Tojo, Kakuji ^a  

^a KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Research Center   (Japan)

^d Division of Therapeutic Systems Research   (Japan)

Author keywords

Estradiol; Estradiol 17 acetate; Hairless dog skin; Hairless mouse skin; Human skin; Hydrolytic enzyme; Rat skin; Skin distribution of metabolite

Indexed keywords

ESTRADIOL; ESTRADIOL ACETATE; HYDROLASE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; ESTRADIOL 17-ACETATE;

ADULT; AGED; ANIMAL MODEL; ARTICLE; CADAVER; CONTROLLED STUDY; DOG; DRUG HYDROLYSIS; ENZYME ACTIVITY; HISTOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MALE; MOUSE; NORMAL HUMAN; NUDE MOUSE; RAT; SKIN PENETRATION; SPECIES DIFFERENCE; ANIMAL; BIOTRANSFORMATION; COMPARATIVE STUDY; ENZYMOLOGY; FEMALE; HAIRLESS MOUSE; HYDROLYSIS; METABOLISM; MIDDLE AGED; SKIN; SKIN ABSORPTION;

ADULT; AGED; ANIMALS; BIOTRANSFORMATION; DOGS; ESTRADIOL; FEMALE; HUMANS; HYDROLYSIS; MALE; MICE; MICE, INBRED HRS; MIDDLE AGED; RATS; SKIN; SKIN ABSORPTION; SPECIES SPECIFICITY;

EID: 1842832662     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(02)00084-X     Document Type: Article

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