Modelling dermal drug distribution after topical application in human

Pharmaceutical Research

Volumn 28, Issue 9, 2011, Pages 2119-2129

  Anissimov, Yuri G ^a   Roberts, Michael Stephen ^b,c  

^a GRIFFITH UNIVERSITY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Dermal drug distribution; Modelling; Percutaneous penetration; Topical drug delivery

Indexed keywords

DESOXIMETASONE; ECONAZOLE; HYDROCORTISONE; METHOXSALEN; RETINOIC ACID; TRIAMCINOLONE ACETONIDE;

ARTICLE; CONTROLLED STUDY; DERMIS; DRUG ADMINISTRATION ROUTE; DRUG BINDING; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG TISSUE LEVEL; DRUG TRANSPORT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MATHEMATICAL MODEL; PRIORITY JOURNAL; SKIN BIOPSY; SKIN PENETRATION; TISSUE DISTRIBUTION; TOPICAL TREATMENT;

ADMINISTRATION, TOPICAL; BIOLOGICAL TRANSPORT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; SKIN; SKIN ABSORPTION; SOLUBILITY; SOLUTIONS; TISSUE DISTRIBUTION;

EID: 80054734878     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0437-2     Document Type: Article

References (24)

1. Schaefer H, Stuttgen G. Absolute concentrations of an antimycotic agent, econazole, in the human skin after local application. Arzneimittelforschung. 1976;26:432-5.
2. Schaefer H, Zesch A. Penetration of vitamin A acid into human skin. Acta Derm Venereol Suppl (Stockh). 1975;74:50-5.
3. Zesch A, Schaefer H. Penetration of radioactive hydrocortisone in human skin from various ointment bases. II. In vivo-experiments (author's transl). Arch Dermatol Forsch. 1975;252:245-56.
4. Schaefer H, Zesch A, Stuttgen G. Penetration, permeation, and absorption of triamcinolone acetonide in normal and psoriatic skin. Arch Dermatol Res. 1977;258:241-9. (Pubitemid 8108461)
5. Schaefer H, Stuttgen G, Zesch A, Schalla W, Gazith J. Quantitative determination of percutaneous absorption of radiolabeled drugs in vitro and in vivo by human skin. Curr Probl Dermatol. 1978;7:80-94.
6. Singh P, Roberts MS. Effects of vasoconstriction on dermal pharmacokinetics and local tissue distribution of compounds. J Pharm Sci. 1994;83:783-91. (Pubitemid 24233750)
7. Singh P, Roberts MS. Blood-flow measurements in skin and underlying tissues by microsphere method-application to dermal pharmacokinetics of polar nonelectrolytes. J Pharm Sci. 1993;82:873-9. (Pubitemid 23317247)
8. Gupta E, Wientjes MG, Au JL. Penetration kinetics of 2', 3'-dideoxyinosine in dermis is described by the distributed model. Pharm Res. 1995;12:108-12.
9. Cross SE, Roberts MS. Defining a model to predict the distribution of topically applied growth factors and other solutes in excisional full-thickness wounds. J Invest Dermatol. 1999;112:36-41. (Pubitemid 29024703)
10. Kretsos K, Kasting GB, Nitsche JM. Distributed diffusionclearance model for transient drug distribution within the skin. J Pharm Sci. 2004;93:2820.
11. Kretsos K, Kasting GB. A geometrical model of dermal capillary clearance. Math Biosci. 2007;208:430-53. (Pubitemid 47101854)
12. Kretsos K, Miller MA, Zamora-Estrada G, Kasting GB. Partitioning, diffusivity and clearance of skin permeants in mammalian dermis. Int J Pharm. 2008;346:64-79. (Pubitemid 350101993)
13. Dedrick RL, Flessner MF, Collins JM, Schultz JS. Is the peritoneum a membrane? ASAIO J. 1982;1-8. (Pubitemid 13169235)
14. Danckwerts PV. Continuous flow systems: distribution of residence times. Chem Eng Sci. 1953;2:1-13.
15. Roberts MS, Rowland M. A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations. J Pharmacokinet Biopharm. 1986;14:227-60. (Pubitemid 16028174)
16. Anissimov YG, Roberts MS. Diffusion modeling of percutaneous absorption kinetics: 4. Effects of a slow equilibration process within stratum corneum on absorption and desorption kinetics. J Pharm Sci. 2009;98:772-81.
17. Anissimov YG, Roberts MS. Diffusion modeling of percutaneous absorption kinetics: 1. Effects of flow rate, receptor sampling rate and viable epidermal resistance for a constant donor concentration. J Pharm Sci. 1999;88:1201-9. (Pubitemid 29526307)
18. Wilke CR, Chang P. Correlation of diffusion coefficients in dilute solutions. Aiche J. 1955;1:264-70.
19. Cross SE, Roberts MS. Dermal blood flow, lymphatics, and binding as determinates of topical absorption, clearance and distribution. In: Riviere JE, editor. Dermal absorption models in toxicology and pharmacology. Boca Raton: CRC Press; 2006. p. 251-82.
20. Roberts MS, Rowland M. Hepatic elimination-dispersion model. J Pharm Sci. 1985;74:585-7.
21. Cross SE, Anderson C, Roberts MS. Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies. Br J Clin Pharmacol. 1998;46:29-35. (Pubitemid 28308421)
22. Cevc G, Vierl U. Spatial distribution of cutaneous microvasculature and local drug clearance after drug application on the skin. J Control Release. 2007;118:18-26. (Pubitemid 46283095)
23. Anissimov YG, Bracken AJ, Roberts MS. Interconnected-tubes model of hepatic elimination. J Theor Biol. 1997;188:89-101. (Pubitemid 27421297)
24. Leu AJ, Husmann MJ, Held T, Frisullo R, Hoffmann U, Franzeck UK. Measurement of the lymphatic clearance of the human skin using a fluorescent tracer. J Vasc Res. 2001;38:423-31. (Pubitemid 34701455)