Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates

Genes and Development

Volumn 14, Issue 17, 2000, Pages 2134-2139

  Sander, Maike ^a,b   Paydar, Sussan ^c   Ericson, Johan ^d,e   Briscoe, James ^d   Berber, Elizabeth ^c   German, Michael ^a   Jessell, Thomas M ^d   Rubenstein, John L R ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Karolinska Institute ^*  (United States)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Interneurons; Motor neurons; Neuronal specification; Nkx; Spinal cord

Indexed keywords

HOMEODOMAIN PROTEIN;

ANIMAL CELL; ARTICLE; CENTRAL NERVOUS SYSTEM; EMBRYO; EMBRYO DEVELOPMENT; GENE MUTATION; HOMEOBOX; INTERNEURON; MOTONEURON; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINEAGE; CELLS, CULTURED; DNA-BINDING PROTEINS; GENE TARGETING; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MOTOR NEURONS; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; PAX2 TRANSCRIPTION FACTOR; PROTEIN BIOSYNTHESIS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SPINAL CORD; STEM CELLS; TIME FACTORS; TISSUE DISTRIBUTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0033844629     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.820400     Document Type: Article

References (30)

1. Interneuron migration from basal forebrain to neocortex: Dependence on Dlx genes
2. Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
3. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
4. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
5. + interneurons that require PAX6 for their development
6. Formation and specification of ventral neuroblasts is controlled by vnd in Drosophila neurogenesis
7. Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube
8. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
9. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
10. Pax-3, a novel murine DNA binding protein expressed during early neurogenesis
11. The world according to hedgehog
12. Notochord repression of endodermal Sonic hedgehog permits pancreas development
13. Patterning the vertebrate neuraxis
14. Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing intereurons
15. Dorsoventral patterning in the Drosophila central nervous system: The vnd homeobox gene specifies ventral column identity
16. Nkx2-9 is a novel homeobox transcription factor which demarcates ventral domains in the developing mouse CNS
17. Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
18. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
19. Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development
20. Patterning of the embryonic forebrain
21. Regionalization of the prosencephalic neural plate
22. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: In situ hybridization using digoxigenin-labelled cRNA probes
23. Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons
24. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: Evidence for a transformation of the pallidum into the striatum
25. Diversity and pattern in the developing spinal cord
26. Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9
27. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
28. Gsh-1: A novel murine homeobox gene expressed in the central nervous system
29. Dorsoventral patterning in the Drosophila central nervous system: The intermediate neuroblasts defective homeobox gene specifies intermediate column identity