Age-related changes in the capacity, rate, and modulation of dopamine uptake within the striatum and nucleus accumbens of Fischer 344 rats: An in vivo electrochemical study

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 2, 1999, Pages 879-887

  Hebert, Meleik A ^a   Gerhardt, Greg A ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DOPAMINE UPTAKE; DOPAMINERGIC SYSTEM; MALE; NEUROMODULATION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT;

ADRENERGIC UPTAKE INHIBITORS; AGING; ANIMALS; CITALOPRAM; CORPUS STRIATUM; DESIPRAMINE; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; ELECTROPHYSIOLOGY; MALE; NOMIFENSINE; NUCLEUS ACCUMBENS; RATS; RATS, INBRED F344; SEROTONIN UPTAKE INHIBITORS;

EID: 0032989030     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Altar CA, Marien MR and Marshall JF (1987) Time course of adaptations in DA biosynthesis, metabolism, and release following nigrostriatal lesions: Implications for behavioral recovery from brain injury. J Neurochem 48:390-399.
2. Amara SG and Kuhar MJ (1993) Neurotransmitter transporters: Recent progress. Annu Rev Neurosci 16:73-93.
3. Bannon MJ and Whitty CJ (1997) Age-related and regional differences in dopamine transporter mRNA expression in human midbrain. Neurology 48:969-977.
4. Beninger RJ (1983) The role of dopamine in locomotor activity and learning. Brain Res 287:173-196.
5. Cass WA and Gerhardt GA (1994) Direct in vivo evidence that D2 dopamine receptors can modulate dopamine uptake. Neuroscie Lett 176:259-263.
6. Cass WA and Gerhardt GA (1995) In vivo assessment of dopamine uptake in rat medial prefrontal cortex: Comparison with dorsal striatum and nucleus accumbens. J Neurochem 65:201-207.
7. Cass WA, Gerhardt GA, Zhang Z, Ovadia A and Gash DM (1995) Increased dopamine clearance in the non-lesioned striatum of rhesus monkeys with unilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) striatal lesions. Neurosci Lett 185: 52-55.
8. Cass WA, Zahniser NR, Flach KA and Gerhardt GA (1993) Clearance of exogenous dopamine in rat dorsal striatum and nucleus accumbens: Role of metabolism and effects of locally applied uptake inhibitors. J Neurochem 61:2269-2278.
9. Finch CE, Randall PK and Marshall JF (1981) Aging and basal gangliar function. Annu Rev Gerontol Geriatr 2:49-87.
10. Friedemann MN (1992) In vivo electrochemical studies of dopamine diffusion and clearance in the striatum of young and aged Fischer-344 rats. Age 15:23-28.
11. Friedemann MN and Gerhardt GA (1992) Regional effects of aging on dopaminergic function in the Fischer-344 rat. Neurobiol Aging 13:325-332.
12. Gainetdinov RR, Fumagalli F, Jones SR, Caron MG (1997) Dopamine transporter is required for in vivo MPTP neurotoxicity: Evidence from mice lacking the transporter. J Neurochem 69:1322-1325.
13. Gerhardt GA (1995) Rapid chronocoulometric measurements of norepinephrine overflow and clearance in CNS tissue, in Voltammetric Methods in Brain Systems, Neuromethods, 27 (Boulton A, Baker G and Adams RN eds) pp 117-151 Humana Press, Clifton.
14. Gerhardt GA, Cass WA, Hudson J, Henson M, Zhang Z, Ovadia A, Hoffer BJ and Gash DM (1996) In vivo electrochemical studies of dopamine overflow and clearance in the striatum of normal and MPTP-treated rhesus monkeys. J Neurochem 66:579-588.
15. Gerhardt GA and Palmer MR (1987) Characterization of the techniques of pressure ejection and microiontophoresis using in vivo electrochemistry. J Neurosci Meth 22:147-159.
16. Giros B, Jaber M, Jones SR, Wightman RM and Caron MG (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature (London) 379:606-612.
17. Goldman-Rakic PS and Brown RM (1981) Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys. Neurosci 6:177-187.
18. Hebert MA and Gerhardt GA (1998) Normal and drug-induced locomotor behavior in aging: Comparison to evoked DA release and tissue content in Fischer 344 rats. Brain Res 797:42-54.
19. Hebert MA, van Horne CG, Hoffer BJ and Gerhardt GA (1996) Functional effects of GDNF in normal rat striatum: Presynaptic studies using in vivo electrochemistry and microdialysis. J Pharmacol Exp Ther 279:1181-1190.
20. Hoffman AF and Gerhardt GA (1998) In vivo electrochemical studies of dopamine clearance in the rat substantia nigra: Effects of locally applied uptake inhibitors and unilateral 6-hydroxydopamine lesions. J Neurochem 70:179-189.
21. 3H]dopamine uptake in vitro in rat nucleus accumbens but not in striatum. Brain Res 531:338-341.
22. Izenwasser S, Werling LL and Cox BM (1990) Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex. Brain Res 520:303-309.
23. Joseph JA, Berger RE, Engel BT and Roth GS (1978) Age-related changes in the nigrostriatum: A behavioral and biochemical analysis. J Gerontol 33:643-649.
24. Kuhar MJ, Sanchez-Roa PM, Wong DF, Dannals RF, Grigoriadis DE, Lew R and Milberger M (1990) Dopamine transporter: Biochemistry, pharmacology and imaging. Eur Neural 30(Suppl 1):15-20
25. Lenhard T, Marheineke K, Lingen B, Haase W, Hammermann R, Michel H and Reilander H (1998) Characterization of the human dopamine transporter heterologously expressed in BHK-21 cells. Cell Mol Neurobiol 18:347-360.
26. Marshall JF, O'Dell SJ, Navarrete R and Rosenstein AJ (1990) Dopamine high-affinity transport site topography in rat brain: Major differences between dorsal and ventral striatum. Neurosci 37:11-21.
27. Meiergerd SM and Schenk JO (1994) Striatal transporter for dopamine: Catechol structure-activity studies and susceptibility to chemical modification. J Neurochem 62:998-1008.
28. Patel AP, Cerruti C, Vaughan RA and Kuhar MJ (1994) Developmentally regulated glycosylation of dopamine transporter. Brain Res Dev Brain Res 83:53-58.
29. Paxinos G and Watson C (1986) The Rat Brain in Stereotaxic Coordinates, Academic Press, New York.
30. Paxinos G, Watson C, Pennisi M and Topple A (1985) Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight. J Neurosci Methods 13:139-143.
31. Rose GM, Gerhardt GA, Conboy GL and Hoffer BJ (1986) Age-related alterations in monoamine release from rat striatum: An in vivo electrochemical study. Neurobiol Aging 7:77-82.
32. Schenk JO, Miller E, Rice ME and Adams RN (1983) Chronoamperometry in brain slices: Quantitative evaluations of in vivo electrochemistry. Brain Res 277:1-8.
33. Sesack SR, Hawrylak VA, Matus C, Guido MA and Levey AI (1998) Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. J Neurosci 18:2697-2708.
34. 3H]dopamine uptake in rat striatum during aging. J Neuroch 56:575-579.
35. Stamford JA, Kruk ZL, Palij P and Millar J (1988) Diffusion and uptake of dopamine in rat caudate and nucleus accumbens compared using fast cyclic voltammetry. Brain Res 448:381-385.
36. Suaud-Chagny MF, Dugast C, Chergui K, Msghina M and Gonon F (1995) Uptake of dopamine released by impulse flow in the rat mesolimbic and striatal systems in vivo. J Neurochem 65:2603-2611.
37. Uhl GR, Walther D, Mash D, Faucheux B and Javoy-Agid F (1994) Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons. Ann Neurol 35:494-498.
38. van Horne C, Hoffer BJ, Stromberg I and Gerhardt GA (1992) Clearance and diffusion of locally applied dopamine in normal and 6-hydroxydopamine-lesioned rat striatum. J Pharm Exp Ther 263:1285-1292.
39. Volkow ND, Fowler JS, Wang GJ, Logan J, Schlyer D, MacGregor R, Hitzemann R and Wolf AP (1994) Decreased dopamine transporters with age in healthy human subjects. Ann Neurol 36:237-239.
40. Zelnik N, Angel I, Paul SM and Kleinman JE (1986) Decreased density of human striatal dopamine uptake sites with age. Eur J Pharmacol 126:175-176.
41. Zigmond MJ, Acheson AL, Stachowiak MK and Stricker EM (1984) Neurochemical compensation after nigrostriatal bundle injury in an animal model of preclinical parkinsonism. Arch Neurol 41:856-861.