Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat

Brain Research

Volumn 967, Issue 1-2, 2003, Pages 306-310

  Albeck, Dave ^a   Mesches, Michael H ^b,c   Juthberg, Sonya ^d   Browning, Michael ^b   Bickford, Paula C ^e,f   Rose, Gregory M ^g   Granholm, A Ch ^h  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c VA MRS   (United States)

^d UMEÅ UNIVERSITY   (Sweden)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f Department of Neurosurgery   (United States)

^g Memory Pharmaceuticals Corporation   (United States)

^h MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Basal forebrain; Cholinergic neuron; Hippocampus; Nerve growth factor

Indexed keywords

NERVE GROWTH FACTOR;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; CHOLINERGIC NERVE CELL; COGNITIVE DEFECT; CONTROLLED STUDY; FOREBRAIN; MALE; MENTAL TASK; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; SPATIAL MEMORY;

EID: 0037470724     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(03)02272-8     Document Type: Article

References (44)

1. Albeck D.S., Bäckman C., Veng L., Friden P., Rose G.M., Granholm A.-C. Acute application of NGF increases the firing rate of aged rat basal forebrain neurons. Eur. J. Neurosci. 11:1999;2291-2304.
2. Alberch J., Pérez-Navarro E., Arenas E., Marsal J. Involvement of Nerve Growth Factor and its receptor in the regulation of the cholinergic function in aged rats. J. Neurochem. 57:1991;1483-1487.
3. Bäckman C., Rose G.M., Bartus R.T., Hoffer B.J., Mufson E.J., Granholm A.-C. Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors. J. Comp. Neurol. 387:1997;1-11.
4. Bäckman C., Rose G.M., Hoffer B.J., Henry M.A., Bartus R.T., Friden P., Granholm A.-C. Systemic administration of Nerve Growth Factor conjugate reverses age related cognitive dysfunction and prevents cholinergic neuron atrophy. J. Neurosci. 16:1996;5437-5442.
5. Bartus R.T., Dean R.L., Beer B., Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science. 217:1982;408-417.
6. Blochl A., Thoenen H. Characterization of nerve growth factor release from hippocampal neurons: evidence for a constitutive and an unconventional sodium-dependent regulated pathway. Eur. J. Neurosci. 7:1995;1220-1227.
7. Cooper J.D., Lindholm D., Sofroniew M.V. Reduced transport of [125I]nerve growth factor by cholinergic neurons and down-regulated TrkA expression in the medial septum of aged rats. Neuroscience. 62:(3):1994;625-629.
8. Crutcher K.A., Weingartner J. Hippocampal NGF levels are not reduced in the aged Fischer 344 rat. Neurobiol. Aging. 12:(5):1991;449-454.
9. De Lacalle S., Cooper J.D., Svendsen C.N., Dunnett S.B., Sofroniew M.V. Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats. Neuroscience. 75:(1):1996;19-27.
10. Fahnestock M., Michalski B., Xu B., Coughlin M.D. The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Mol. Cell. Neurosci. 18:(2):2001;210-220.
11. Fischer W., Wictorin K., Björklund A., Williams L.R., Varon S., Gage F.H. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature. 329:1987;65-68.
12. Fischer W., Chen K.S., Gage F.H., Björklund A. Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging. Neurobiol. Aging. 13:1991;9-23.
13. Friden P., Walus L.R., Watson P., Doctrow S.R., Kozarich J.W., Bäckman C., Bergman H., Hoffer B.J., Bloom F., Granholm A.-C. Blood-brain barrier penetration and in vivo activity of an NGF conjugate. Science. 259:1993;373-377.
14. Gallagher M., Burwell R., Burchinal M. Severity of spatial learning impairment in aging. Development of a learning index for performance in the Morris Water Maze. Behav. Neurosci. 107:1993;618-626.
15. Granholm A.-Ch., Bäckman C., Bloom F., Ebendal T., Gerhardt G., Hoffer B., Mackerlova L., Olson L., Söderström S., Walus L.R., Friden P.M. NGF and anti-transferrin receptor antibody conjugate: short and long term effects on survival of cholinergic neurons in intraocular septal transplants. J. Pharm. Exp. Ther. 268:(1):1994;448-459.
16. Granholm A.-C., Albeck D.S., Bäckman C., Curtis M., Ebendal T., Friden P., Henry M.A., Hoffer B.J., Kordower J., Rose G.M., Söderstrom S., Bartus R.T. A non-invasive system for delivering Neural Growth Factors across the blood-brain barrier. Rev. Neurosci. 9:1998;31-55.
17. Granholm A.-C. Loss of cholinergic phenotype in basal forebrain coiNON-IMPdes with cognitive decline in a mouse model of Down's Syndrome. Exp. Neurol. 161:2000;647-663.
18. Gustilo M.C., Markowska A.L., Breckler S.J., Fleischman C.A., Price D.L., Koliatsos V.E. Evidence that nerve growth factor influences recent memory through structural changes in septohippocampal cholinergic neurons. J. Comp. Neurol. 405:1999;491-507.
19. Hefti F. Neurotrophic factor therapy for nervous system degenerative diseases. J. Neurobiol. 25:(11):1994;1418-1435.
20. Hellweg R., Fischer W., Hock C., Gage F.H., Bjorklund A., Thoenen H. Nerve growth factor levels and choline acetyltransferase activity in the brain of aged rats with spatial memory impairments. Brain Res. 537:(1/2):1990;123-130.
21. Henriksson B.G., Soderstrom S., Gower A.J., Ebendal T., Winblad B., Mohammed A.H. Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats. Behav. Brain Res. 48:(1):1992;15-20.
22. Katoh-Semba R., Semba R., Takeuchi I.K., Kato K. Age-related changes in BDNF, NGF and NT-3 with age in the brain. Neurosci. Res. 3:1998;227-234.
23. Kelly A., Maguire C., Lynch M.A. Deficits in nerve growth factor release and tyrosine receptor kinase phosphorylation are associated with age-related impairment in long-term potentiation in the dentate gyrus. Neuroscience. 95:(2):2000;359-365.
24. Koh S., Loy R. Age-related loss of nerve growth factor sensitivity in rat basal forebrain neurons. Brain Res. 440:(2):1988;396-401.
25. Kordower J., Charles V., Bayer R., Bartus R.T., Putney S., Walus L.R., Friden P. Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington's disease. Neurobiology. 91:1994;9077-9080.
26. Kromer L.F. Nerve growth factor treatment after brain injury prevents neuronal death. Science. 235:1987;214-216.
27. Larkfors L., Ebendal T., Whittemore S.R., Persson H., Hoffer B., Olson L. Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain. Brain Res. 427:(1):1987;55-60.
28. Liao G.S., Li X.B., Zhang C.Y., Shu Y.Y., Tang S.X. Pharmacological actions of nerve growth factor-transferrin conjugate on the central nervous system. J. Nat. Toxins. 2001:(4):2001;291-297.
29. Markowska A.L., Koliatsos V.E., Breckler S.J., Price D.L., Olton D.S. Human nerve growth factor improves spatial memory in aged but not in young rats. J. Neurosci. 14:1994;4815-4824.
30. Mufson E.J., Conner J.M., Kordower J. Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis. NeuroReport. 6:1995;1063-1066.
31. Nishizuka M., Katoh-Semba R., Eto K., Arai Y., Iizuka R., Kato K. Age and sex related differences in the nerve growth factor distribution in the rat brain. Brain Res. Bull. 27:(5):1991;685-688.
32. Ohnishi K., Tomimoto H., Akiguchi I., Seriu N., Kawamata T., Nakamura S., Kimura J., Nishio T., Higuchi K., Hosokawa M. Age-related decrease of nerve growth factor-like immunoreactivity in the basal forebrain of senescence-accelerated mice. Acta Neuropathol. (Berl.). 90:(1):1995;11-16.
33. Pellymounter M.A., Cullen M.J., Baker M.B., Gollub M., Wellman C. The effects of intrahippocampal BDNF and NGF on spatial learning in aged Long Evans rats. Mol. Chem. Neuropathol. 29:1996;211-226.
34. Pham T.M., Ickes B., Albeck D., Soderstrom S., Granholm A.-C., Mohammed A.H. Changes in brain NGF levels and NGF receptors in rats exposed to environmental enrichment for one year. Neuroscience. 94:(1):1999;279-286.
35. Santucci A.C., Kanof P.D., Haroutunian V. Transient enhancement of cholinergic neurochemical markers induced by NGF in aged F344 rats. Dementia. 6:(4):1995;179-184.
36. Scali C., Casamenti R., Pazzagli M., Bartolini L., Pepeu G. Nerve growth factor increases extracellular acetylcholine levels in the parietal cortex and hippocampus of aged rats and restores object recognition. Neurosci. Lett. 170:1994;117-120.
37. Scott S.A., Mufson E.J., Weingartner J.A., Skau K.A., Crutcher K.A. Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J. Neurosci. 15:(9):1995;6213-6221.
38. Smith D.E., Roberts J., Gage F.H., Tuszynski M.H. Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. Proc. Natl. Acad. Sci. USA. 96:1999;10893-10898.
39. Sugaya K., Greene R., Personett D., Robbins M., Kent C., Bryan D., Skiba E., Gallagher M., McKinney M. Septo-hippocampal cholinergic and neurotrophin markers in age-induced cognitive decline. Neurobiol. Aging. 19:(4):1998;351-361.
40. Svendsen C.N., Sofroniew M.V. Do central nervous system neurons require target-derived neurotrophic support for survival throughout adult life and aging? Perspect. Dev. Neurobiol. 3:(2):1996;133-142.
41. Taglialatela G., Robinson R., Gegg M., Perez-Polo J.R. Nerve growth factor, central nervous system apoptosis, and adrenocortical activity in aged Fischer-344/brown Norway F1 hybrid rats. Brain Res. Bull. 43:(2):1997;229-233.
42. Thoenen H., Edgar D. Neurotrophic factors. Science. 229:1985;238-242.
43. Williams L.R. Exogenous NGF stimulates choline acetyltransferase activity in aging Fisher 344 male rats. Neurobiol. Aging. 12:(1):1991;39-46.
44. Yuen E.C., Howe C.L., Holtzman D.M., Mobley W.C. Nerve growth factor and the neurotrophic factor hypothesis. Brain Dev. 18:(5):1996;362-368.