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Volumn 108, Issue 2, 2013, Pages

Endothelial NOS (NOS3) impairs myocardial function in developing sepsis

Author keywords

Nitric oxide; NOS3; Sepsis; Septic cardiomyopathy

Indexed keywords

CATECHOLAMINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRATE; NITRITE; NOS3 PROTEIN, MOUSE;

EID: 84873393773     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-013-0330-8     Document Type: Article
Times cited : (37)

References (76)
  • 1
    • 0037588986 scopus 로고    scopus 로고
    • The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
    • DOI 10.1182/blood-2002-06-1887
    • Aird WC (2003) The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101:3765-3777. doi:10.1182/blood-2002-06-1887 (Pubitemid 36857845)
    • (2003) Blood , vol.101 , Issue.10 , pp. 3765-3777
    • Aird, W.C.1
  • 2
    • 64749090979 scopus 로고    scopus 로고
    • ENOS activation by physical forces: From short-term regulation of contraction to chronic remodeling of cardiovascular tissues
    • doi:10.1152/physrev.00042.2007
    • Balligand JL, Feron O, Dessy C (2009) eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues. Physiol Rev 89:481-534. doi:10.1152/physrev.00042.2007
    • (2009) Physiol Rev , vol.89 , pp. 481-534
    • Balligand, J.L.1    Feron, O.2    Dessy, C.3
  • 3
    • 77955970985 scopus 로고    scopus 로고
    • Nos3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis
    • doi:10.1097/SHK.0b013e3181cdc327
    • Bougaki M, Searles RJ, Kida K, Yu J, Buys ES, Ichinose F (2010) Nos3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis. Shock 34:281-290. doi:10.1097/SHK.0b013e3181cdc327
    • (2010) Shock , vol.34 , pp. 281-290
    • Bougaki, M.1    Searles, R.J.2    Kida, K.3    Yu, J.4    Buys, E.S.5    Ichinose, F.6
  • 4
    • 0035909940 scopus 로고    scopus 로고
    • Myocardial contractile function and heart rate in mice with myocyte-specific overexpression of endothelial nitric oxide synthase
    • Brunner F, Andrew P, Wölkert G, Zechner R, Mayer B (2001) Myocardial contractile function and heart rate in mice with myocyte-specific overexpression of endothelial nitric oxide synthase. Circulation 104:3097-3102. doi:10.1161/hc5001.101966 (Pubitemid 34014064)
    • (2001) Circulation , vol.104 , Issue.25 , pp. 3097-3102
    • Brunner, F.1    Andrew, P.2    Wolkart, G.3    Zechner, R.4    Mayer, B.5
  • 5
    • 0034835936 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition as therapy for sepsis: A decade of promise
    • doi:10.1089/109629601750469410
    • Cobb JP (2001) Nitric oxide synthase inhibition as therapy for sepsis: a decade of promise. Surg Infect 2:93-100. doi:10.1089/ 109629601750469410
    • (2001) Surg Infect , vol.2 , pp. 93-100
    • Cobb, J.P.1
  • 6
    • 0032863627 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice
    • DOI 10.1016/S0039-6060(99)70189-3
    • Cobb JP, Hotchkiss R, Swanson PE et al (1999) Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice. Surgery 126:438-442. pii: N9c41cb98N2a1153cc (Pubitemid 29382815)
    • (1999) Surgery , vol.126 , Issue.2 , pp. 438-442
    • Cobb, J.P.1    Hotchkiss, R.S.2    Swanson, P.E.3    Chang, K.4    Qiu, Y.5    Laubach, V.E.6    Karl, I.E.7    Buchman, T.G.8
  • 7
    • 15444369648 scopus 로고    scopus 로고
    • Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: A pro-inflammatory role for eNOS-derived no in vivo
    • DOI 10.1074/jbc.M411991200
    • Connelly L, Madhani M, Hobbs AJ (2005) Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knockout mice: a pro-inflammatory role for eNOS-derived no in vivo. J Biol Chem 280:10040-10046. doi:10.1074/jbc. M411991200 (Pubitemid 40395855)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.11 , pp. 10040-10046
    • Connelly, L.1    Madhani, M.2    Hobbs, A.J.3
  • 8
    • 0036892344 scopus 로고    scopus 로고
    • Clinical review: Myocardial depression in sepsis and septic shock
    • DOI 10.1186/cc1822
    • Court O, Kumar A, Parrillo JE, Kumar A (2002) Clinical review: myocardial depression in sepsis and septic shock. Crit Care 6:500-508. doi:10.1186/cc1822 (Pubitemid 35414581)
    • (2002) Critical Care , vol.6 , Issue.6 , pp. 500-508
    • Court, O.1    Kumar, A.2    Parrillo, J.E.3    Kumar, A.4
  • 9
    • 79951972996 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis
    • doi:10.1371/journal.pone. 0017260
    • Davis JS, Darcy CJ, Yeo TW, Jones C, McNeil YR, Stephens DP, Celermajer DS, Anstey NM (2011) Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis. PLoS ONE 6:e17260-e17260. doi:10.1371/journal.pone. 0017260
    • (2011) PLoS ONE , vol.6
    • Davis, J.S.1    Darcy, C.J.2    Yeo, T.W.3    Jones, C.4    McNeil, Y.R.5    Stephens, D.P.6    Celermajer, D.S.7    Anstey, N.M.8
  • 10
    • 44449101531 scopus 로고    scopus 로고
    • Distribution of NOS isoforms in a porcine endotoxin shock model
    • DOI 10.1097/SHK.0b013e3181598b77, PII 0002438220080600000009
    • Doursout MF, Oguchi T, Fischer UM, Liang Y, Chelly B, Hartley CJ, Chelly JE (2008) Distribution of NOS isoforms in a porcine endotoxin shock model. Shock 29:692-702. doi:10.1097/SHK. 0b013e3181598b77 (Pubitemid 351769932)
    • (2008) Shock , vol.29 , Issue.6 , pp. 692-702
    • Doursout, M.-F.1    Oguchi, T.2    Fischer, U.M.3    Liang, Y.4    Chelly, B.5    Hartley, C.J.6    Chelly, J.E.7
  • 12
    • 44649115085 scopus 로고    scopus 로고
    • Molecular events in the cardiomyopathy of sepsis
    • DOI 10.2119/2007-00130.Flierl
    • Flierl MA, Rittirsch D, Huber-Lang MS, Sarma JV, Ward PA (2008) Molecular events in the cardiomyopathy of sepsis. Mol Med 14:327-336. doi:10.2119/2007-00130.Flierl (Pubitemid 351785706)
    • (2008) Molecular Medicine , vol.14 , Issue.5-6 , pp. 327-336
    • Flierl, M.A.1    Rittirsch, D.2    Huber-Lang, M.S.3    Sarma, J.V.4    Ward, P.A.5
  • 13
    • 0033119242 scopus 로고    scopus 로고
    • Contribution of NO to ischemia-reperfusion injury in the saline-perfused heart: A study in endothelial NO synthase knockout mice
    • DOI 10.1006/jmcc.1998.0921
    • Flögel U, Decking UK, Gödecke A, Schrader J (1999) Contribution of NO to ischemia-reperfusion injury in the saline-perfused heart: a study in endothelial NO synthase knockout mice. J Mol Cell Cardiol 31:827-836. doi:10.1006/jmcc.1998.0921 (Pubitemid 29201552)
    • (1999) Journal of Molecular and Cellular Cardiology , vol.31 , Issue.4 , pp. 827-836
    • Flogel, U.1    Decking, U.K.M.2    Godecke, A.3    Schrader, J.4
  • 14
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular disease: From marvel to menace
    • doi:10.1161/CIRCULATIONAHA.105.602532
    • Förstermann U, Münzel T (2006) Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113:1708-1714. doi:10.1161/CIRCULATIONAHA.105.602532
    • (2006) Circulation , vol.113 , pp. 1708-1714
    • Förstermann, U.1    Münzel, T.2
  • 15
    • 84856734532 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor 2 signaling limits ß-adrenergic receptor-mediated cardiac hypertrophy in vivo
    • doi:10.1007/s00395-011-0196-6
    • Garlie JB, Hamid T, Gu Y, Ismahil MA, Chandrasekar B, Prabhu SD (2011) Tumor necrosis factor receptor 2 signaling limits ß-adrenergic receptor-mediated cardiac hypertrophy in vivo. Basic Res Cardiol 106:1193-1205. doi:10.1007/s00395-011-0196-6
    • (2011) Basic Res Cardiol , vol.106 , pp. 1193-1205
    • Garlie, J.B.1    Hamid, T.2    Gu, Y.3    Ismahil, M.A.4    Chandrasekar, B.5    Prabhu, S.D.6
  • 17
    • 0035310422 scopus 로고    scopus 로고
    • Inotropic response to β-adrenergic receptor stimulation and anti-adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts
    • DOI 10.1111/j.1469-7793.2001.0195g.x
    • Godecke A, Heinicke T, Kamkin A, Kiseleva I, Strasser RH, Decking UK, Stumpe T, Isenberg G, Schrader J (2001) Inotropic response to beta-adrenergic receptor stimulation and anti-adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts. J Physiol 532:195-204. doi:10.1111/j.1469-7793. 2001.0195g.x (Pubitemid 32303282)
    • (2001) Journal of Physiology , vol.532 , Issue.1 , pp. 195-204
    • Godecke, A.1    Heinicke, T.2    Kamkin, A.3    Kiseleva, I.4    Strasser, R.H.5    Decking, U.K.M.6    Stumpe, T.7    Isenberg, G.8    Schrader, J.9
  • 19
    • 84857029526 scopus 로고    scopus 로고
    • Identification of inducible nitric oxide synthase in peripheral blood cells as a mediator of myocardial ischemia/reperfusion injury
    • doi:10.1007/s00395-012-0253-9
    • Guo Y, Sanganalmath SK, Wu W, Zhu X, Huang Y, Tan W, Ildstad ST, Li Q, Bolli R (2012) Identification of inducible nitric oxide synthase in peripheral blood cells as a mediator of myocardial ischemia/reperfusion injury. Basic Res Cardiol 107:253. doi:10.1007/s00395-012-0253-9
    • (2012) Basic Res Cardiol , vol.107 , pp. 253
    • Guo, Y.1    Sanganalmath, S.K.2    Wu, W.3    Zhu, X.4    Huang, Y.5    Tan, W.6    Ildstad, S.T.7    Li, Q.8    Bolli, R.9
  • 21
    • 57049138339 scopus 로고    scopus 로고
    • Role of endothelial nitric oxide synthase-derived nitric oxide in activation and dysfunction of cerebrovascular endothelial cells during early onsets of sepsis
    • doi:10.1152/ajpheart.00476.2008
    • Handa O, Stephen J, Cepinskas G (2008) Role of endothelial nitric oxide synthase-derived nitric oxide in activation and dysfunction of cerebrovascular endothelial cells during early onsets of sepsis. Am J Physiol Heart Circ Physiol 295:H1712-H1719. doi:10.1152/ajpheart.00476.2008
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Handa, O.1    Stephen, J.2    Cepinskas, G.3
  • 22
    • 14644423890 scopus 로고    scopus 로고
    • NO/redox disequilibrium in the failing heart and cardiovascular system
    • DOI 10.1172/JCI200524459
    • Hare JM, Stamler J (2005) NO/redox disequilibrium in the failing heart and cardiovascular system. J Clin Invest 115:509-517. doi:10.1172/JCI24459 (Pubitemid 40322220)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.3 , pp. 509-517
    • Hare, J.M.1    Stamler, J.S.2
  • 23
    • 22944444837 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition in sepsis? Lessons learned from large-animal studies
    • DOI 10.1213/01.ANE.0000177117.80058.4D
    • Hauser B, Bracht H, Matejovic M, Radermacher P, Venkatesh B (2005) Nitric oxide synthase inhibition in sepsis? Lessons learned from large-animal studies. Anesth Analg 101:488-498. doi: 10.1213/01.ANE.0000177117.80058.4D (Pubitemid 41045235)
    • (2005) Anesthesia and Analgesia , vol.101 , Issue.2 , pp. 488-498
    • Hauser, B.1    Bracht, H.2    Matejovic, M.3    Radermacher, P.4    Venkatesh, B.5
  • 24
    • 70350575360 scopus 로고    scopus 로고
    • Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury
    • doi:10.1038/ nrneph.2009.155
    • Heemskerk S, Masereeuw R, Russel FG, Pickkers P (2009) Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury. Nat Rev Nephrol 5:629-640. doi:10.1038/ nrneph.2009.155
    • (2009) Nat Rev Nephrol , vol.5 , pp. 629-640
    • Heemskerk, S.1    Masereeuw, R.2    Russel, F.G.3    Pickkers, P.4
  • 26
    • 52049111565 scopus 로고    scopus 로고
    • Reductive gas-phase chemiluminescence and flow injection analysis for measurement of the nitric oxide pool in biological matrices
    • doi:10.1016/ S0076-6879(08)01216-0
    • Hendgen-Cotta U, Grau M, Rassaf T, Kelm M, Kleinbongard P (2008) Reductive gas-phase chemiluminescence and flow injection analysis for measurement of the nitric oxide pool in biological matrices. Methods Enzymol 441:295-315. doi:10.1016/ S0076-6879(08)01216-0
    • (2008) Methods Enzymol , vol.441 , pp. 295-315
    • Hendgen-Cotta, U.1    Grau, M.2    Rassaf, T.3    Kelm, M.4    Kleinbongard, P.5
  • 27
    • 0034698063 scopus 로고    scopus 로고
    • Endogenous nitric oxide and myocardial adaptation to ischemia
    • Heusch G, Post H, Michel MC, Kelm M, Schulz R (2000) Endogenous nitric oxide and myocardial adaptation to ischemia. Circ Res 87:146-152. doi:10.1161/01.RES.87.2.146 (Pubitemid 30616911)
    • (2000) Circulation Research , vol.87 , Issue.2 , pp. 146-152
    • Heusch, G.1    Post, H.2    Michel, M.C.3    Kelm, M.4    Schulz, R.5
  • 28
    • 77955734986 scopus 로고    scopus 로고
    • Characteristics of plasma NOx levels in severe sepsis: High interindividual variability and correlation with illness severity, but lack of correlation with cortisol levels
    • doi:10.1111/j.1365- 2265.2010.03817.x
    • Ho JT, Chapman MJ, O'Conner S, Lam S, Edwards J, Ludbrook G, Lewis JG, Torpy DJ (2010) Characteristics of plasma NOx levels in severe sepsis: high interindividual variability and correlation with illness severity, but lack of correlation with cortisol levels. Clin Endocrinol (Oxf) 73:413-420. doi:10.1111/j.1365- 2265.2010.03817.x
    • (2010) Clin Endocrinol (Oxf) , vol.73 , pp. 413-420
    • Ho, J.T.1    Chapman, M.J.2    O'Conner, S.3    Lam, S.4    Edwards, J.5    Ludbrook, G.6    Lewis, J.G.7    Torpy, D.J.8
  • 29
    • 0034647013 scopus 로고    scopus 로고
    • Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase
    • doi:10.1161/01.RES.86.7.774
    • Hollenberg SM, Broussard M, Osman J, Parrillo JE (2000) Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase. Circ Res 86:774-778. doi:10.1161/01.RES.86.7.774
    • (2000) Circ Res , vol.86 , pp. 774-778
    • Hollenberg, S.M.1    Broussard, M.2    Osman, J.3    Parrillo, J.E.4
  • 30
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • DOI 10.1056/NEJMra021333
    • Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348:138-150. doi:10.1056/NEJMra021333 (Pubitemid 36056721)
    • (2003) New England Journal of Medicine , vol.348 , Issue.2 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 32
    • 3042658752 scopus 로고    scopus 로고
    • Selective inducible nitric oxide inhibition can restore hemodynamics, but does not improve neurological dysfunction in experimentally-induced septic shock in rats
    • Kadoi Y, Goto F (2004) Selective inducible nitric oxide inhibition can restore hemodynamics, but does not improve neurological dysfunction in experimentally-induced septic shock in rats. Anesth Analg 99:212-220. doi:10.1213/01ANE.0000118111.94913.22 (Pubitemid 38808193)
    • (2004) Anesthesia and Analgesia , vol.99 , Issue.1 , pp. 212-220
    • Kadoi, Y.1    Goto, F.2
  • 33
    • 0031281447 scopus 로고    scopus 로고
    • Nitric oxide induced contractile dysfunction is related to a reduction in myocardial energy generation
    • DOI 10.1016/S0008-6363(97)00149-1, PII S0008636397001491
    • Kelm M, Schäfer S, Dahmann R, Dolu B, Perings S, Decking U, Schrader J, Strauer BE (1997) Nitric oxide induced contractile dysfunction is related to a reduction in myocardial energy generation. Cardiovasc Res 36:185-194. doi:10.1016/S0008-6363 (97)00149-1 (Pubitemid 27527343)
    • (1997) Cardiovascular Research , vol.36 , Issue.2 , pp. 185-194
    • Kelm, M.1    Schafer, S.2    Dahmann, R.3    Dolu, B.4    Perings, S.5    Decking, U.K.M.6    Schrader, J.7    Strauer, B.E.8
  • 35
    • 0034984296 scopus 로고    scopus 로고
    • Myocardial dysfunction in septic shock: Part I. Clinical manifestation of cardiovascular dysfunction
    • DOI 10.1053/jcan.2001.22317
    • Kumar A, Haery C, Parrillo JE (2001) Myocardial dysfunction in septic shock: part I. Clinical manifestation of cardiovascular dysfunction. J Cardiothorac Vasc Anesth 15:364-376. doi: 10.1053/jcan.2001.22317 (Pubitemid 32553389)
    • (2001) Journal of Cardiothoracic and Vascular Anesthesia , vol.15 , Issue.3 , pp. 364-376
    • Kumar, A.1    Haery, C.2    Parrillo, J.E.3
  • 39
    • 77956188993 scopus 로고    scopus 로고
    • Thrombopoietin modulates cardiac contractility in vitro and contributes to myocardial depressing activity of septic shock serum
    • doi:10.1007/s00395-010-0103-6
    • Lupia E, Spatola T, Cuccurullo A, Bosco O, Mariano F, Pucci A, Ramella R, Alloatti G, Montrucchio G (2010) Thrombopoietin modulates cardiac contractility in vitro and contributes to myocardial depressing activity of septic shock serum. Basic Res Cardiol 105:609-620. doi:10.1007/s00395-010-0103-6
    • (2010) Basic Res Cardiol , vol.105 , pp. 609-620
    • Lupia, E.1    Spatola, T.2    Cuccurullo, A.3    Bosco, O.4    Mariano, F.5    Pucci, A.6    Ramella, R.7    Alloatti, G.8    Montrucchio, G.9
  • 41
    • 33847729386 scopus 로고    scopus 로고
    • Beneficial effects of statins on the microcirculation during sepsis: The role of nitric oxide
    • DOI 10.1093/bja/ael358
    • McGown CC, Brookes ZL (2007) Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide. Br J Anaesth 98:163-175. doi:10.1093/bja/aeI358 (Pubitemid 47071995)
    • (2007) British Journal of Anaesthesia , vol.98 , Issue.2 , pp. 163-175
    • McGown, C.C.1    Brookes, Z.L.S.2
  • 43
    • 21844463540 scopus 로고    scopus 로고
    • Statin treatment after onset of sepsis in a murine model improves survival
    • DOI 10.1161/CIRCULATIONAHA.104.502195
    • Merx MW, Liehn EA, Graf J, van de Sandt A, Schaltenbrand M, Schrader J, Hanrath P, Weber C (2005) Statin treatment after onset of sepsis in a murine model improves survival. Circulation 112:117-124. doi:10.1161/CIRCULATIONAHA. 104.502195 (Pubitemid 40962577)
    • (2005) Circulation , vol.112 , Issue.1 , pp. 117-124
    • Merx, M.W.1    Liehn, E.A.2    Graf, J.3    Van De Sandt, A.4    Schaltenbrand, M.5    Schrader, J.6    Hanrath, P.7    Weber, C.8
  • 44
    • 2642553075 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis
    • DOI 10.1161/01.CIR.0000129774.09737.5B
    • Merx MW, Liehn EA, Janssens U, Lütticken R, Schrader J, Hanrath P, Weber C (2004) HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis. Circulation 109:2560-2565. doi:10.1161/01.CIR.0000129 774.09737.5B (Pubitemid 38720557)
    • (2004) Circulation , vol.109 , Issue.21 , pp. 2560-2565
    • Merx, M.W.1    Liehn, E.A.2    Janssens, U.3    Lutticken, R.4    Schrader, J.5    Hanrath, P.6    Weber, C.7
  • 45
    • 34547918870 scopus 로고    scopus 로고
    • Sepsis and the heart
    • DOI 10.1161/CIRCULATIONAHA.106.678359, PII 0000301720070814000018
    • Merx MW, Weber C (2007) Sepsis and the heart. Circulation 116:793-802. doi:10.1161/CIRCULATIONAHA.106.678359 (Pubitemid 47255997)
    • (2007) Circulation , vol.116 , Issue.7 , pp. 793-802
    • Merx, M.W.1    Weber, C.2
  • 46
    • 79957803333 scopus 로고    scopus 로고
    • Mitochondrial complex i and NAD(P)H oxidase are major sources of exacerbated oxidative stress in pressure-overloaded ischemic-reperfused hearts
    • doi:10.1007/s00395-011-0150-7
    • Mozaffari MS, Baban B, Liu JY, Abebe W, Sullivan JC, El-Marakby A (2011) Mitochondrial complex I and NAD(P)H oxidase are major sources of exacerbated oxidative stress in pressure-overloaded ischemic-reperfused hearts. Basic Res Cardiol 106:287-297. doi:10.1007/s00395-011-0150-7
    • (2011) Basic Res Cardiol , vol.106 , pp. 287-297
    • Mozaffari, M.S.1    Baban, B.2    Liu, J.Y.3    Abebe, W.4    Sullivan, J.C.5    El-Marakby, A.6
  • 47
    • 0036439715 scopus 로고    scopus 로고
    • Measuring end products of nitric oxide in vivo
    • DOI 10.1016/S0076-6879(02)59173-4
    • Nussler AK, Bruckner UB, Vogt J, Radermacher P (2002) Measuring end products of nitric oxide in vivo. Methods Enyzmol 359:75-83. doi:10.1016/S0076-6879(02)59173-4 (Pubitemid 35387011)
    • (2002) Methods in Enzymology , vol.359 , pp. 75-83
    • Nussler, A.K.1    Bruckner, U.B.2    Vogt, J.3    Radermacher, P.4
  • 48
    • 0027920980 scopus 로고
    • Mechanisms of disease: Pathogenetic mechanisms of septic shock
    • DOI 10.1056/NEJM199305203282008
    • Parrillo JE (1993) Pathogenetic mechanisms of septic shock. N Engl J Med 328:1471-1477. doi:10.1056/NEJM199305203282008 (Pubitemid 23143850)
    • (1993) New England Journal of Medicine , vol.328 , Issue.20 , pp. 1471-1477
    • Parrillo, J.E.1
  • 49
    • 0035658477 scopus 로고    scopus 로고
    • No involvement of nitric oxide in the limitation of beta -adrenergic inotropic responsiveness during ischemia
    • Post H, Schulz R, Gres P, Heusch G (2001) No involvement of nitric oxide in the limitation of beta -adrenergic inotropic responsiveness during ischemia. Am J Physiol Heart Circ Physiol 281:H2392-H2397
    • (2001) Am J Physiol Heart Circ Physiol , vol.281
    • Post, H.1    Schulz, R.2    Gres, P.3    Heusch, G.4
  • 50
    • 0035707122 scopus 로고    scopus 로고
    • Time course of inducible nitric oxide synthase activity following endotoxin administration in dogs
    • DOI 10.1006/niox.2001.0342
    • Preiser JC, Zhang H, Vray B, Hrabak A, Vincent JL (2001) Time course of inducible nitric oxide synthase activity following endotoxin administration in dogs. Nitric Oxide 5:208-211. doi: 10.1006/niox.2001.0342 (Pubitemid 34142744)
    • (2001) Nitric Oxide - Biology and Chemistry , vol.5 , Issue.2 , pp. 208-211
    • Preiser, J.-C.1    Zhang, H.2    Vray, B.3    Hrabak, A.4    Vincent, J.-L.5
  • 51
    • 0036890053 scopus 로고    scopus 로고
    • Concomitant presence of N-nitroso and S-nitroso proteins in human plasma
    • DOI 10.1016/S0891-5849(02)01183-8, PII S0891584902011838
    • Rassaf T, Bryan NS, Kelm M, Feelisch M (2002) Concomitant presence of N-nitroso and S-nitroso proteins in human plasma. Free Radic Biol Med 33:1590-1596. doi:10.1016/S0891-5849 (02)01183-8 (Pubitemid 35355729)
    • (2002) Free Radical Biology and Medicine , vol.33 , Issue.11 , pp. 1590-1596
    • Rassaf, T.1    Bryan, N.S.2    Kelm, M.3    Feelisch, M.4
  • 52
    • 1242351238 scopus 로고    scopus 로고
    • Circulating no pool: Assessment of nitrite and nitroso species in blood and tissues
    • DOI 10.1016/j.freeradbiomed.2003.11.011
    • Rassaf T, Feelisch M, Kelm M (2004) Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues. Free Radic Biol Med 36:413-422. doi:10.1016/j.freeradbiomed.2003. 11.011 (Pubitemid 38224513)
    • (2004) Free Radical Biology and Medicine , vol.36 , Issue.4 , pp. 413-422
    • Rassaf, T.1    Feelisch, M.2    Kelm, M.3
  • 54
    • 79958155919 scopus 로고    scopus 로고
    • ß-Adrenergic signaling and response to pressure overload in transgenic mice with cardiac-specific overexpression of inducible NO synthase
    • doi: 10.1016/j.niox.2011.04.001
    • Reinartz M, Molojavyi A, Moellendorf S, Hohlfeld T, Heger J, Gödecke A (2011) ß-Adrenergic signaling and response to pressure overload in transgenic mice with cardiac-specific overexpression of inducible NO synthase. Nitric Oxide 25:11-21. doi: 10.1016/j.niox.2011.04.001
    • (2011) Nitric Oxide , vol.25 , pp. 11-21
    • Reinartz, M.1    Molojavyi, A.2    Moellendorf, S.3    Hohlfeld, T.4    Heger, J.5    Gödecke, A.6
  • 55
    • 47749137764 scopus 로고    scopus 로고
    • Nitrosative stress leads to protein glutathiolation, increased S-nitrosation and up-regulation of peroxiredoxins in the heart
    • Reinartz M, Ding Z, Flögel U, Gödecke A, Schrader J (2008) Nitrosative stress leads to protein glutathiolation, increased S-nitrosation and up-regulation of peroxiredoxins in the heart. J Biol Chem 283:17440-17449
    • (2008) J Biol Chem , vol.283 , pp. 17440-17449
    • Reinartz, M.1    Ding, Z.2    Flögel, U.3    Gödecke, A.4    Schrader, J.5
  • 56
    • 34249326963 scopus 로고    scopus 로고
    • Mechanisms of sepsis-induced cardiac dysfunction
    • doi:10.1097/01. CCM.0000266683.64081.02
    • Rudiger A, Singer M (2007) Mechanisms of sepsis-induced cardiac dysfunction. Crit Care Med 35:1599-1608. doi:10.1097/01. CCM.0000266683.64081.02
    • (2007) Crit Care Med , vol.35 , pp. 1599-1608
    • Rudiger, A.1    Singer, M.2
  • 57
    • 0030989581 scopus 로고    scopus 로고
    • Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency
    • Schulz R, Dodge KL, Lopaschuk GD, Clanachan AS (1997) Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency. Am J Physiol 272:H1212-H1219
    • (1997) Am J Physiol , vol.272
    • Schulz, R.1    Dodge, K.L.2    Lopaschuk, G.D.3    Clanachan, A.S.4
  • 58
    • 1142285456 scopus 로고    scopus 로고
    • Nitric oxide in myocardial ischemia/reperfusion injury
    • DOI 10.1016/j.cardiores.2003.09.019
    • Schulz R, Kelm M, Heusch G (2004) Nitric oxide in myocardial ischemia/reperfusion injury. Cardiovasc Res 61:402-413. doi: 10.1016/j.cardiores.2003.09.019 (Pubitemid 38210147)
    • (2004) Cardiovascular Research , vol.61 , Issue.3 , pp. 402-413
    • Schulz, R.1    Kelm, M.2    Heusch, G.3
  • 59
    • 80054704273 scopus 로고    scopus 로고
    • NADPH oxidases in cardiovascular disease: Insights from in vivo models and clinical studies
    • doi:10.1007/s00395- 011-0190-z
    • Sirker A, Zhang M, Shah AM (2011) NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies. Basic Res Cardiol 106:735-747. doi:10.1007/s00395- 011-0190-z
    • (2011) Basic Res Cardiol , vol.106 , pp. 735-747
    • Sirker, A.1    Zhang, M.2    Shah, A.M.3
  • 60
    • 79961087496 scopus 로고    scopus 로고
    • Disruption of COX-2 and eNOS does not confer protection from cardiovascular failure in lipopolysaccharide-treated conscious mice and isolated vascular rings
    • doi:10.1152/ajpregu.00823.2010
    • Staehr M, Madsen K, Vanhoutte PM, Hansen PB, Jensen BL (2011) Disruption of COX-2 and eNOS does not confer protection from cardiovascular failure in lipopolysaccharide-treated conscious mice and isolated vascular rings. Am J Physiol Regul Integr Comp Physiol 301:R412-R420. doi:10.1152/ajpregu.00823.2010
    • (2011) Am J Physiol Regul Integr Comp Physiol , vol.301
    • Staehr, M.1    Madsen, K.2    Vanhoutte, P.M.3    Hansen, P.B.4    Jensen, B.L.5
  • 61
    • 0032211062 scopus 로고    scopus 로고
    • Increased expression of constitutive nitric oxide synthase III, but not inducible nitric oxide synthase II, in human heart failure
    • DOI 10.1016/S0735-1097(98)00399-4, PII S0735109798003994
    • Stein B, Eschenhagen T, Rüdiger J, Scholz H, Förstermann U, Gath I (1998) Increased expression of constitutive nitric oxide synthase III, but not inducible nitric oxide synthase II, in human heart failure. J Am Coll Cardiol 32:1179-1186. doi:10.1016/ S0735-1097(98)00399-4 (Pubitemid 28522371)
    • (1998) Journal of the American College of Cardiology , vol.32 , Issue.5 , pp. 1179-1186
    • Stein, B.1    Eschenhagen, T.2    Rudiger, J.3    Scholz, H.4    Forstermann, U.5    Gath, I.6
  • 62
    • 0035126821 scopus 로고    scopus 로고
    • Selective iNOS inhibition prevents hypotension in septic rats while preserving endothelium-dependent vasodilation
    • Strunk V, Hahnenkamp K, Schneuing M, Fischer LG, Rich GF (2001) Selective iNOS inhibition prevents hypotension in septic rats while preserving endothelium-dependent vasodilation. Anesth Analg 92:681-687 (Pubitemid 32185112)
    • (2001) Anesthesia and Analgesia , vol.92 , Issue.3 , pp. 681-687
    • Strunk, V.1    Hahnenkamp, K.2    Schneuing, M.3    Fischer, L.G.4    Rich, G.F.5
  • 64
    • 33644869495 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms underlying LPS-associated myocyte impairment
    • doi:10.1152/ajpheart.00701. 2005
    • Tavener SA, Kubes P (2006) Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol 290:H800-H806. doi:10.1152/ajpheart.00701. 2005
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Tavener, S.A.1    Kubes, P.2
  • 65
    • 79951648994 scopus 로고    scopus 로고
    • Nitrotyrosine impairs angiogenesis and uncouples eNOS activity of pulmonary artery endothelial cells isolated from developing sheep lungs
    • Teng RJ, Wu TJ, Bisig CG, Eis A, Pritchard KA, Konduri GG (2011) Nitrotyrosine impairs angiogenesis and uncouples eNOS activity of pulmonary artery endothelial cells isolated from developing sheep lungs. Pediatr Res 69:112-117
    • (2011) Pediatr Res , vol.69 , pp. 112-117
    • Teng, R.J.1    Wu, T.J.2    Bisig, C.G.3    Eis, A.4    Pritchard, K.A.5    Konduri, G.G.6
  • 66
    • 0037134405 scopus 로고    scopus 로고
    • Myocardial dysfunction with coronary microembolization: Signal transduction through a sequence of nitric oxide, tumor necrosis factor-α, and sphingosine
    • DOI 10.1161/01.RES.0000014451.75415.36
    • Thielmann M, Dörge H, Martin C, Belosjorow S, Schwanke U, van de Sand A, Konietzka I, Büchert A, Krüger A, Schulz R, Heusch G (2002) Myocardial dysfunction with coronary microembolization: signal transduction through a sequence of nitric oxide, tumor necrosis factor-a, and sphingosine. Circ Res 90:807-813. doi:10.1161/01.RES.0000014451.75415.36 (Pubitemid 34633897)
    • (2002) Circulation Research , vol.90 , Issue.7 , pp. 807-813
    • Thielmann, M.1    Dorge, H.2    Martin, C.3    Belosjorow, S.4    Schwanke, U.5    Van De Sand, A.6    Konietzka, I.7    Buchert, A.8    Kruger, A.9    Schulz, R.10    Heusch, G.11
  • 68
    • 72449194215 scopus 로고    scopus 로고
    • Transcriptional and posttranscriptional regulators of biglycan in cardiac fibroblasts
    • doi:10.1007/s00395-009-0049-0058
    • Tiede K, Melchior-Becker A, Fischer JW (2010) Transcriptional and posttranscriptional regulators of biglycan in cardiac fibroblasts. Basic Res Cardiol 105:99-108. doi:10.1007/s00395-009- 0049-8
    • (2010) Basic Res Cardiol , vol.105 , pp. 99-108
    • Tiede, K.1    Melchior-Becker, A.2    Fischer, J.W.3
  • 70
    • 42749083110 scopus 로고    scopus 로고
    • Detection of basal NO production in rat tissues using iron-dithiocarbamate complexes
    • doi:10.1016/j.niox. 2008.02.003
    • van Faassen EE, Koeners MP, Joles JA, Vanin AF (2008) Detection of basal NO production in rat tissues using iron-dithiocarbamate complexes. Nitric Oxide 18:279-286. doi:10.1016/j.niox. 2008.02.003
    • (2008) Nitric Oxide , vol.18 , pp. 279-286
    • Van Faassen, E.E.1    Koeners, M.P.2    Joles, J.A.3    Vanin, A.F.4
  • 71
    • 33751424161 scopus 로고    scopus 로고
    • Reduction enhances yields of nitric oxide trapping by iron-diethyldithiocarbamate complex in biological systems
    • DOI 10.1016/j.niox.2006.06.009, PII S1089860306003636
    • Vanin AF, Bevers LM, Mikoyan VD, Poltorakov AP, Kubrina LN, Van Faassen E (2007) Reduction enhances yields of nitric oxide trapping by iron-diethyldithiocarbamate complex in biological systems. Nitric Oxide 16:71-81. doi:10.1016/j.niox.2006. 06.009 (Pubitemid 44820885)
    • (2007) Nitric Oxide - Biology and Chemistry , vol.16 , Issue.1 , pp. 71-81
    • Vanin, A.F.1    Bevers, L.M.2    Mikoyan, V.D.3    Poltorakov, A.P.4    Kubrina, L.N.5    Van Faassen, E.6
  • 72
    • 14844286922 scopus 로고    scopus 로고
    • Autoregulatory role of endothelium-derived nitric oxide (NO) on lipopolysaccharide-induced vascular inducible NO synthase expression and function
    • DOI 10.1074/jbc.M411317200
    • Vo PA, Lad B, Tomlinson JAP, Francis S, Ahluwalia A (2005) Autoregulatory role of endothelium-derived nitric oxide (NO) on Lipopolysaccharide-induced vascular inducible NO synthase expression and function. J Biol Chem 280:7236-7243 (Pubitemid 40341281)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.8 , pp. 7236-7243
    • Vo, P.A.1    Lad, B.2    Tomlinson, J.A.P.3    Francis, S.4    Ahluwalia, A.5
  • 74
    • 77649123845 scopus 로고    scopus 로고
    • Nitric oxide and calcium signaling regulate myocardial tumor necrosis factor-alpha expression and cardiac function in sepsis
    • doi:10.1139/Y09-097
    • Zhang T, Feng Q (2010) Nitric oxide and calcium signaling regulate myocardial tumor necrosis factor-alpha expression and cardiac function in sepsis. Can J Physiol Pharmacol 88:92-104. doi:10.1139/Y09-097
    • (2010) Can J Physiol Pharmacol , vol.88 , pp. 92-104
    • Zhang, T.1    Feng, Q.2
  • 75
    • 84857014229 scopus 로고    scopus 로고
    • Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/ mTOR signaling in endotoxemia
    • doi:10.1007/s00395-012-0254-8
    • Zhang T, Lu X, Li J, Chidiac P, Sims SM, Feng Q (2012) Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/ mTOR signaling in endotoxemia. Basic Res Cardiol 107:254. doi:10.1007/s00395-012-0254-8
    • (2012) Basic Res Cardiol , vol.107 , pp. 254
    • Zhang, T.1    Lu, X.2    Li, J.3    Chidiac, P.4    Sims, S.M.5    Feng, Q.6
  • 76
    • 84859037766 scopus 로고    scopus 로고
    • A novel pathway of NADPH oxidase/ vascular peroxidase 1 in mediating oxidative injury following ischemia-reperfusion
    • doi:10.1007/ s00395-012-0266-0274
    • Zhang YS, He L, Liu B, Li NS, Luo XJ, Hu CP, Ma QL, Zhang GG, Li YJ, Peng J (2012) A novel pathway of NADPH oxidase/ vascular peroxidase 1 in mediating oxidative injury following ischemia-reperfusion. Basic Res Cardiol 107:266. doi:10.1007/ s00395-012-0266-4
    • (2012) Basic Res Cardiol , vol.107 , pp. 266
    • Zhang, Y.S.1    He, L.2    Liu, B.3    Li, N.S.4    Luo, X.J.5    Hu, C.P.6    Ma, Q.L.7    Zhang, G.G.8    Li, Y.J.9    Peng, J.10


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