Positive effects of nitric oxide on left ventricular function in humans

European Heart Journal

Volumn 27, Issue 14, 2006, Pages 1699-1705

  Rassaf, Tienush ^a   Poll, Ludger W ^b   Brouzos, Paris ^a   Lauer, Thomas ^a   Totzeck, Matthias ^a   Kleinbongard, Petra ^a   Gharini, Putrika ^a   Andersen, Kjel ^b   Schulz, Rainer ^c   Heusch, Gerd ^c   Mödder, Ulrich ^b   Kelm, Malte ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Endothelium; LV function; MRI; Myocardium; Nitric oxide

Indexed keywords

DIHYDRALAZINE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE INHIBITOR; S NITROSOGLUTATHIONE; VASODILATOR AGENT;

ADULT; ARTERIAL PRESSURE; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART RATE; HEART STROKE VOLUME; HUMAN; HUMAN EXPERIMENT; HYPOTHESIS; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ADULT; HUMANS; MAGNETIC RESONANCE ANGIOGRAPHY; NITRIC OXIDE; OMEGA-N-METHYLARGININE; STROKE VOLUME; VENTRICULAR FUNCTION, LEFT;

EID: 33745778223     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehl096     Document Type: Article

References (29)

1. Grocott-Mason R, Anning P, Evans H, Lewis MJ, Shah AM. Modulation of left ventricular relaxation in isolated ejecting heart by endogenous nitric oxide. Am J Physiol Heart Circ Physiol 1994;267:H1804-H1813.
2. Brady AJB, Warren JB, Poole-Wilson PA, Williams TJ, Harding SE. Nitric oxide attenuates cardiac myocyte contraction. Am J Physiol 1993;176-182.
3. Kelm M, Schäfer S, Dahmann R, Dolu B, Perings S, Decking U, Schrader J, Strauer BE. Nitric oxide induced contractile dysfunction is related to a reduction in myocardial energy generation. Cardiovasc Res 1997;36:185-194.
4. Massion PB, Feron O, Dessy C, Balligand JL. Nitric oxide and cardiac function. 10 years after, and continuing. Circ Res 2003;93:388-398.
5. Heusch G, Post H, Michel MC, Kelm M, Schulz R. Endogenous nitric oxide and myocardial adaptation to ischemia. Circ Res 2000;87:146-152.
6. Paulus WJ, Vantrimpont PJ, Shah AM. Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Assessment by bicoronary sodium nitroprusside infusion. Circulation 1994;89:2070-2078.
7. Stamler JS, Loh E, Roddy MA, Currie KE, Creager MA. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 1994;89:2035-2044.
8. Cotton JM, Kearney MT, MacCarthy PA, Grocott-Mason RM, McClean DR, Heymes C, Richardson PJ, Shah AM. Effects of nitric oxide synthase inhibition on basal function and the force-frequency relationship in the normal and failing human heart in vivo. Circulation 2001;104:2318-2323.
9. Alfakih K, Reid S, Jones T, Sivananthan M. Assessment of ventricular function and mass by cardiac magnetic resonance imaging. Eur Radiol 2004;14:1813-1822.
10. Rademakers FE. Bringing the heart into focus: a perspective on non-invasive cardiac imaging. Acta Cardiol 2004;59(Suppl. 1):43-45.
11. Feelisch M, Rassaf T, Mnaimneh S, Singh N, Bryan NS, Jourd'heuil D, Kelm M. Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo. FASEB J 2002;16:1775-1785.
12. Rassaf T, Preik M, Kleinbongard P, Lauer T, Heiß C, Strauer BE, Feelisch M, Kelm M. Evidence for in vivo transport of bioactive nitric oxide in human plasma. J Clin Invest 2002;109:1241-1248.
13. Rassaf T, Bryan NS, Kelm M, Feelisch M. Concomitant presence of N-nitroso and S-nitroso proteins in human plasma. Free Radic Biol Med 2002;33:1590-1596.
14. Rassaf T, Feelisch M, Kelm M. Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues. Free Radic Biol Med 2004;36:413-422.
15. Rassaf T, Kleinbongard P, Preik M, Dejam A, Gharini P, Lauer T, Erokenbrecht J, Duschin A, Schulz R, Heusch G, Feelisch M, Kelm M. Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical study on the fate of NO in human blood. Circ Res 2002;91:470-477.
16. Kelm M, Preik M, Hafner D, Strauer BE. Evidence for a multifactorial process involved in the impaired flow response to nitric oxide in hypertensive patients with endothelial dysfunction. Hypertension 1996;27:346-353.
17. Thiele H, Paetsch I, Schnackenburg B, Bornstedt A, Grebe O, Wellnhofer E, Schuler G, Fleck E, Nagel E. Improved accuracy of quantitative assessment of left ventricular volume and ejection fraction by geometric models with steady-state free precession. J Cardiovasc Magn Reson 2002;4:327-339.
18. Plein S, Bloomer TN, Ridgway JP, Jones TR, Bainbridge GJ, Sivananthan MU. Steady-state free precession magnetic resonance imaging of the heart: comparison with segmented k-space gradient-echo imaging. J Magn Reson Imaging 2001;14:230-236.
19. Koch JA, Poll LW, Godehardt E, Korbmacher B, Jung G, Modder U. In vitro determination of cardiac ventricular volumes using MRI at 1.0 T in a porcine heart model. Int J Cardiovasc Imaging 2001;17:237-242.
20. Mosteller RD. Simplified calculation of body-surface area. N Engl J Med 1987;317:1089-1099.
21. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002;39:257-265.
22. Preik M, Lauer T, Heiß C, Tabery S, Strauer BE, Kelm M. Automated ultrasonic measurement of human arteries for the determination of endothelial function. Ultraschall Med 2000;21:195-198.
23. Lauer T, Preik M, Rassaf T, Strauer BE, Deussen A, Feelisch M, Kelm M. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proc Natl Acad Sci USA 2001;98:12814-12819.
24. Preckel B, Kojda G, Schlack W, Ebel D, Kottenberg K, Noack E, Thämer V. Inotropic effects of glyceryl trinitrate and spontaneous NO donors in the dog heart. Circulation 1997;96:2675-2682.
25. Kojda G, Kottenberg K, Noack E. Inhibition of nitric oxide synthase and soluble guanylate cyclase induces cardiodepressive effects in normal rat hearts. Eur J Pharmacol 1997;334:181-190.
26. Kelly RA, Balligand JL, Smith TW. Nitric oxide and cardiac function. Circ Res 1996;79:363-380.
27. Xu L, Eu JP, Meissner G, Stamler JS. Activation of cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science 1998;279:234-237.
28. Taylor AL, Ziesche S, Yancy C, Carson P, D'Agostino R, Ferdinand K, Taylor M, Adams K, Sabolinski M, Worcel M, Cohn JN. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med 2004;351:2049-2057.
29. Schulz R, Kelm M, Heusch G. Nitric oxide in myocardial ischemia/reperfusion injury. Cardiovasc Res 2004;61:402-413.