β-Adrenergic signaling and response to pressure overload in transgenic mice with cardiac-specific overexpression of inducible NO synthase

Nitric Oxide - Biology and Chemistry

Volumn 25, Issue 1, 2011, Pages 11-21

  Reinartz, Michael ^a   Molojavyi, Andrei ^a   Moellendorf, Sarah ^a   Hohlfeld, Thomas ^a   Heger, Jacqueline ^a,b   Gödecke, Axel ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Hypertrophy; Nitric oxide; Transgenic animal models

Indexed keywords

BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; CYCLIC GMP; DOBUTAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; BETA ADRENERGIC STIMULATION; CARDIOVASCULAR SYSTEM EXAMINATION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG RESPONSE; HEART CONDUCTION; HEART DISEASE; HEART FUNCTION; HEART HYPERTROPHY; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE CONTRACTILITY; HEART MUSCLE TENSION; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; IN VIVO STUDY; INOTROPISM; MALE; MANOMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; DISEASE MODELS, ANIMAL; HEART; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NITRIC OXIDE SYNTHASE TYPE II; REACTIVE OXYGEN SPECIES; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; VENTRICULAR PRESSURE;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 79958155919     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2011.04.001     Document Type: Article

References (47)

1. K.Y. Xu, D.L. Huso, T.M. Dawson, D.S. Bredt, L.C. Becker, Nitric oxide synthase in cardiac sarcoplasmic reticulum, Proc. Natl. Acad. Sci. USA 96 (1999) 657-662. (Pubitemid 29061264)
2. A.J. De Belder, M.W. Radomski, H.J. Why, P.J. Richardson, J.F. Martin, Myocardial calcium-independent nitric oxide synthase activity is present in dilated cardiomyopathy, myocarditis, and postpartum cardiomyopathy but not in ischaemic or valvar heart disease, Br. Heart J. 74 (1995) 426-430.
3. G.A. Haywood, P.S. Tsao, H.E. der Leyen, M.J. Mann, P.J. Keeling, P.T. Trindade, N.P. Lewis, C.D. Byrne, P.R. Rickenbacher, N.H. Bishopric, J.P. Cooke, W.J. McKenna, M.B. Fowler, Expression of inducible nitric oxide synthase in human heart failure, Circulation 93 (1996) 1087-1094. (Pubitemid 26087012)
4. G. Taimor, A. Rakow, H.M. Piper, Transcription activator protein 1 (AP-1) mediates NO-induced apoptosis of adult cardiomyocytes, FASEB J. 15 (2001) 2518-2520.
5. K.E. Loke, S.K. Laycock, S. Mital, M.S. Wolin, R. Bernstein, M. Oz, L. Addonizio, G. Kaley, T.H. Hintze, Nitric oxide modulates mitochondrial respiration in failing human heart, Circulation 100 (1999) 1291-1297. (Pubitemid 29440121)
6. J.F. Keaney Jr., J.M. Hare, J.L. Balligand, J. Loscalzo, T.W. Smith, W.S. Colucci, Inhibition of nitric oxide synthase augments myocardial contractile responses to beta-adrenergic stimulation, Am. J. Physiol. 271 (1996) H2646-H2652.
7. R. Gyurko, P. Kuhlencordt, M.C. Fishman, P.L. Huang, Modulation of mouse cardiac function in vivo by eNOS and ANP, Am. J. Physiol. Heart Circ. Physiol. 278 (2000) H971-H981. (Pubitemid 30152555)
8. A. Gödecke, T. Heinicke, A. Kamkin, I. Kiseleva, R.H. Strasser, U.K. Decking, T. Stumpe, G. Isenberg, J. Schrader, Inotropic response to beta-adrenergic receptor stimulation and anti-adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts, J. Physiol. 532 (2001) 195-204. (Pubitemid 32303282)
9. J.W. Elrod, J.J. Greer, N.S. Bryan, W. Langston, J.F. Szot, H. Gebregzlabher, S. Janssens, M. Feelisch, D.J. Lefer, Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury, Arterioscler. Thromb. Vasc. Biol. 26 (2006) 1517-1523. (Pubitemid 44288977)
10. S.P. Jones, J.J. Greer, R. van Haperen, D.J. Duncker, R. de Crom, D.J. Lefer, Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice, Proc. Natl. Acad. Sci. USA 100 (2003) 4891-4896. (Pubitemid 36457824)
11. F. Brunner, R. Maier, P. Andrew, G. Wolkart, R. Zechner, B. Mayer, Attenuation of myocardial ischemia/reperfusion injury in mice with myocyte-specific overexpression of endothelial nitric oxide synthase, Cardiovasc. Res. 57 (2003) 55-62.
12. K.C. Wollert, H. Drexler, Regulation of cardiac remodeling by nitric oxide: focus on cardiac myocyte hypertrophy and apoptosis, Heart Fail. Rev. 7 (2002) 317-325.
13. R. Holtwick, M. van Eickels, B.V. Skryabin, H.A. Baba, A. Bubikat, F. Begrow, M.D. Schneider, D.L. Garbers, M. Kuhn, Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A, J. Clin. Invest. 111 (2003) 1399-1407.
14. J. Heger, A. Gödecke, U. Flögel, M.W. Merx, A. Molojavyi, W.N. Kuhn-Velten, J. Schrader, Cardiac-specific overexpression of inducible nitric oxide synthase does not result in severe cardiac dysfunction, Circ. Res. 90 (2002) 93-99.
15. U. Flögel, M.W. Merx, A. Gödecke, U.K. Decking, J. Schrader, Myoglobin: a scavenger of bioactive NO, Proc. Natl. Acad. Sci. USA 98 (2001) 735-740. (Pubitemid 32105112)
16. J.W. Wegener, A. Gödecke, J. Schrader, H. Nawrath, Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice, Br. J. Pharmacol. 136 (2002) 415-420.
17. C. Wunderlich, U. Flögel, A. Gödecke, J. Heger, J. Schrader, Acute inhibition of myoglobin impairs contractility and energy state of iNOS-overexpressing hearts, Circ. Res. 92 (2003) 1352-1358.
18. A. Gödecke, A. Molojavyi, J. Heger, U. Flögel, Z. Ding, C. Jacoby, J. Schrader, Myoglobin protects the heart from inducible nitric-oxide synthase (iNOS)-mediated nitrosative stress, J. Biol. Chem. 278 (2003) 21761-21766.
19. U. Flögel, C. Jacoby, A. Gödecke, J. Schrader, In vivo 2D mapping of impaired murine cardiac energetics in NO-induced heart failure, Magn. Reson. Med. 57 (2007) 50-58.
20. P. Kleinbongard, A. Dejam, T. Lauer, T. Rassaf, A. Schindler, O. Picker, T. Scheeren, A. Gödecke, J. Schrader, R. Schulz, G. Heusch, G.A. Schaub, N.S. Bryan, M. Feelisch, M. Kelm, Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals, Free Radic. Biol. Med. 35 (2003) 790-796. (Pubitemid 37329482)
21. U. Flögel, A. Gödecke, L.O. Klotz, J. Schrader, Role of myoglobin in the antioxidant defense of the heart, FASEB J. 18 (2004) 1156-1158. (Pubitemid 39561555)
22. Y. Li, H. Zhu, P. Kuppusamy, V. Roubaud, J.L. Zweier, M.A. Trush, Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems, J. Biol. Chem. 273 (1998) 2015-2023.
23. M.M. Borst, R. Marquetant, W. Kubler, R.H. Strasser, Beta-blockade reduces effects of adenosine and carbachol by transregulation of inhibitory receptors and Gi proteins, Am. J. Physiol. 272 (1997) H1672-H1679.
24. B. Nürnberg, Pertussis toxin as a pharmacological tool, in: K. Aktories, I. Just (Eds.), Bacterial Protein Toxins, Springer Verlag, Berlin, Heidelberg, 2000, pp. 187-206.
25. D. Georgakopoulos, D.A. Kass, Estimation of parallel conductance by dual-frequency conductance catheter in mice, Am. J. Physiol. Heart Circ. Physiol. 279 (2000) H443-H450. (Pubitemid 30618037)
26. A.J. Brady, P.A. Poole-Wilson, S.E. Harding, J.B. Warren, Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia, Am. J. Physiol. 263 (1992) H1963-H1966.
27. U. Muller-Werdan, H. Schumann, R. Fuchs, C. Reithmann, H. Loppnow, S. Koch, U. Zimny-Arndt, C. He, D. Darmer, P. Jungblut, J. Stadler, J. Holtz, K. Werdan, Tumor necrosis factor alpha (TNF alpha) is cardiodepressant in pathophysiologically relevant concentrations without inducing inducible nitric oxide-(NO)-synthase (iNOS) or triggering serious cytotoxicity, J. Mol. Cell. Cardiol. 29 (1997) 2915-2923. (Pubitemid 27510758)
28. S.P. Jones, J.J. Greer, P.D. Ware, J. Yang, K. Walsh, D.J. Lefer, Deficiency of iNOS does not attenuate severe congestive heart failure in mice, Am. J. Physiol. Heart Circ. Physiol. 288 (2005) H365-H370. (Pubitemid 40023868)
29. Y.H. Liu, O.A. Carretero, O.H. Cingolani, T.D. Liao, Y. Sun, J. Xu, L.Y. Li, P.J. Pagano, J.J. Yang, X.P. Yang, Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction, Am. J. Physiol. Heart Circ. Physiol. 289 (2005) H2616-H2623. (Pubitemid 41698578)
30. E. Takimoto, H.C. Champion, M. Li, S. Ren, E.R. Rodriguez, B. Tavazzi, G. Lazzarino, N. Paolocci, K.L. Gabrielson, Y. Wang, D.A. Kass, Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load, J. Clin. Invest. 115 (2005) 1221-1231.
31. J.L. Balligand, R.A. Kelly, P.A. Marsden, T.W. Smith, T. Michel, Control of cardiac muscle cell function by an endogenous nitric oxide signaling system, Proc. Natl. Acad. Sci. USA 90 (1993) 347-351. (Pubitemid 23010307)
32. E.A. Ashley, C.E. Sears, S.M. Bryant, H.C. Watkins, B. Casadei, Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes, Circulation 105 (2002) 3011-3016. (Pubitemid 34693835)
33. L.A. Barouch, R.W. Harrison, M.W. Skaf, G.O. Rosas, T.P. Cappola, Z.A. Kobeissi, I.A. Hobai, C.A. Lemmon, A.L. Burnett, B. O'Rourke, E.R. Rodriguez, P.L. Huang, J.A. Lima, D.E. Berkowitz, J.M. Hare, Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms, Nature 416 (2002) 337-339.
34. A. Gödecke, On the impact of NO-globin interactions in the cardiovascular system, Cardiovasc. Res. 69 (2006) 309-317.
35. L. Xu, J.P. Eu, G. Meissner, J.S. Stamler, Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation, Science 279 (1998) 234-237. (Pubitemid 28103882)
36. M.T. Ziolo, H. Katoh, D.M. Bers, Expression of inducible nitric oxide synthase depresses beta-adrenergic-stimulated calcium release from the sarcoplasmic reticulum in intact ventricular myocytes, Circulation 104 (2001) 2961-2966. (Pubitemid 33139110)
37. J.L. Balligand, Regulation of cardiac beta-adrenergic response by nitric oxide, Cardiovasc. Res. 43 (1999) 607-620.
38. E.K. Joe, A.E. Schussheim, D. Longrois, T. Maki, R.A. Kelly, T.W. Smith, J.L. Balligand, Regulation of cardiac myocyte contractile function by inducible nitric oxide synthase (iNOS): mechanisms of contractile depression by nitric oxide, J. Mol. Cell. Cardiol. 30 (1998) 303-315. (Pubitemid 28116310)
39. P. Schwarz, R. Diem, N.J. Dun, U. Forstermann, Endogenous and exogenous nitric oxide inhibits norepinephrine release from rat heart sympathetic nerves, Circ. Res. 77 (1995) 841-848.
40. S. Yoo, S.H. Lee, B.H. Choi, J.B. Yeom, W.K. Ho, Y.E. Earm, Dual effect of nitric oxide on the hyperpolarization-activated inward current (I(f)) in sino-atrial node cells of the rabbit, J. Mol. Cell. Cardiol. 30 (1998) 2729-2738. (Pubitemid 29017512)
41. G.Y. Oudit, M.A. Crackower, U. Eriksson, R. Sarao, I. Kozieradzki, T. Sasaki, J. Irie-Sasaki, D. Gidrewicz, V.O. Rybin, T. Wada, S.F. Steinberg, P.H. Backx, J.M. Penninger, Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure, Circulation 108 (2003) 2147-2152. (Pubitemid 37337593)
42. M. Brede, F. Wiesmann, R. Jahns, K. Hadamek, C. Arnolt, S. Neubauer, M.J. Lohse, L. Hein, Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure, Circulation 106 (2002) 2491-2496. (Pubitemid 35278807)
43. K.C. Wollert, B. Fiedler, S. Gambaryan, A. Smolenski, J. Heineke, E. Butt, C. Trautwein, S.M. Lohmann, H. Drexler, Gene transfer of cGMP-dependent protein kinase I enhances the antihypertrophic effects of nitric oxide in cardiomyocytes, Hypertension 39 (2002) 87-92. (Pubitemid 34098094)
44. H.A. Rockman, R.S. Ross, A.N. Harris, K.U. Knowlton, M.E. Steinhelper, L.J. Field, J. Ross Jr., K.R. Chien, Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy, Proc. Natl. Acad. Sci. USA 88 (1991) 8277-8281. (Pubitemid 21915339)
45. A. Bubikat, L.J. De Windt, B. Zetsche, L. Fabritz, H. Sickler, D. Eckardt, A. Gödecke, H.A. Baba, M. Kuhn, Local atrial natriuretic peptide signaling prevents hypertensive cardiac hypertrophy in endothelial nitric-oxide synthase-deficient mice, J. Biol. Chem. 280 (2005) 21594-21599.
46. H. Drexler, S. Kastner, A. Strobel, R. Studer, O.E. Brodde, G. Hasenfuss, Expression, activity and functional significance of inducible nitric oxide synthase in the failing human heart, J. Am. Coll. Cardiol. 32 (1998) 955-963.
47. M.T. Ziolo, L.S. Maier, V. Piacentino III, J. Bossuyt, S.R. Houser, D.M. Bers, Myocyte nitric oxide synthase 2 contributes to blunted beta-adrenergic response in failing human hearts by decreasing Ca2+ transients, Circulation 109 (2004) 1886-1891. (Pubitemid 38509124)