Efficient delivery of siRNA to cortical neurons using layered double hydroxide nanoparticles

Biomaterials

Volumn 31, Issue 33, 2010, Pages 8770-8779

  Wong, Yunyi ^a   Markham, Kathryn ^a   Xu, Zhi Ping ^a   Chen, Min ^a   Max Lu, Gao Qing ^a   Bartlett, Perry F ^a   Cooper, Helen M ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Central nervous system; Drug delivery; Layered double hydroxides; Nanoparticle; Neuron; SiRNA

Indexed keywords

CELL BODIES; CELL TYPES; CENTRAL NERVOUS SYSTEMS; CLATHRIN-DEPENDENT ENDOCYTOSIS; CORTICAL NEURONS; CULTURED NEURONS; DOSE-DEPENDENT; DRUG DELIVERY SYSTEM; DRUG LOADING CAPACITY; HUNTINGTON'S DISEASE; LAYERED DOUBLE HYDROXIDES; LDH NANOPARTICLE; NANOPARTICLE FORMULATION; NEURITES; NEURODEGENERATIVE; NEURODEGENERATIVE DISEASE; SIRNA; SIRNA DELIVERY; SMALL INTERFERING RNA;

CELL MEMBRANES; CYTOLOGY; DRUG DELIVERY; GENE EXPRESSION; MOLECULAR BIOLOGY; NANOPARTICLES;

RNA;

CLATHRIN; HYDROXIDE; MESSENGER RNA; NANOPARTICLE; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; BRAIN NERVE CELL; CELL MEMBRANE PERMEABILITY; CELL TYPE; CONTROLLED STUDY; CYTOPLASM; DRUG DELIVERY SYSTEM; DRUG FORMULATION; EMBRYO; ENDOCYTOSIS; GENE EXPRESSION; HUNTINGTON CHOREA; INTERNALIZATION; MOUSE; NEURITE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TECHNOLOGY;

ALUMINUM COMPOUNDS; ANIMALS; AXONS; CELL SURVIVAL; CEREBRAL CORTEX; CLATHRIN; ENDOCYTOSIS; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; GENE TRANSFER TECHNIQUES; HUMANS; HYDROXIDES; MAGNESIUM COMPOUNDS; MICE; MICE, INBRED C57BL; NANOPARTICLES; NEURONS; RNA, SMALL INTERFERING;

EID: 77957302583     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.07.077     Document Type: Article

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