SiRNA delivery to CNS cells using a membrane translocation peptide

Bioconjugate Chemistry

Volumn 21, Issue 5, 2010, Pages 803-806

  Ifediba, Marytheresa A ^b,c,d   Medarova, Zdravka ^b   Ng, Shu Wing ^c   Yang, Junzheng ^c   Moore, Anna ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD UNIVERSITY   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CYTOLOGY; ENDOTHELIAL CELLS; PEPTIDES; RNA;

ENDOTHELIAL-CELLS; FLUORESCENT PROBES; GENE SILENCING; IN-VITRO; ISCHEMIC STROKES; MEMBRANE TRANSLOCATION; PATHOLOGICAL CONDITIONS; RNA INTERFERENCE; SMALL INTERFERING RNA; VITRO CHARACTERIZATION;

PROBES;

FLUORESCENT DYE; MEMBRANE PROTEIN; MEMBRANE TRANSOLOCATION PEPTIDE; MESSENGER RNA; NUCLEASE; POLYARGININE; PROTEIN; PROTEIN C SRC; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CENTRAL NERVOUS SYSTEM; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; GENE DELIVERY SYSTEM; IN VITRO STUDY; MOUSE; NERVE CELL; NONHUMAN; PROTEIN DEGRADATION; RNA INTERFERENCE;

EID: 77952579169     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc900488e     Document Type: Article

References (20)

1. Castanotto, D. and Rossi, J. J. (2009) The promises and pitfalls of RNA-interference-based therapeutics Nature 457, 426-33
2. Vives, E., Brodin, P., and Lebleu, B. (1997) A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus J. Biol. Chem. 272, 16010-7
3. Derossi, D., Joliot, A. H., Chassaing, G., and Prochiantz, A. (1994) The third helix of the Antennapedia homeodomain translocates through biological membranes J. Biol. Chem. 269, 10444-50
4. Schwarze, S. R., Ho, A., Vocero-Akbani, A., and Dowdy, S. F. (1999) In vivo protein transduction: delivery of a biologically active protein into the mouse Science 285, 1569-72
5. Torchilin, V. P., Levchenko, T. S., Rammohan, R., Volodina, N., Papahadjopoulos-Sternberg, B., and DSouza, G. G. (2003) Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes Proc. Natl. Acad. Sci. U.S.A. 100, 1972-7
6. Lewin, M., Carlesso, N., Tung, C. H., Tang, X. W., Cory, D., Scadden, D. T., and Weissleder, R. (2000) Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells Nat. Biotechnol. 18, 410-4
7. Kumar, P., Wu, H., McBride, J. L., Jung, K. E., Kim, M. H., Davidson, B. L., Lee, S. K., Shankar, P., and Manjunath, N. (2007) Transvascular delivery of small interfering RNA to the central nervous system Nature 448, 39-43
8. Pham, W., Kircher, M. F., Weissleder, R., and Tung, C. H. (2004) Enhancing membrane permeability by fatty acylation of oligoarginine peptides ChemBioChem 5, 1148-51
9. Kumar, M., Medarova, Z., Pantazopoulos, P., Dai, G., and Moore, A. (2010) Novel membrane permeable contrast agent for brain tumor detection by MRI. Magn. Reson. Med. 63, 617-624.
10. Medarova, Z., Pham, W., Farrar, C., Petkova, V., and Moore, A. (2007) In vivo imaging of siRNA delivery and silencing in tumors Nat. Med. 13, 372-7
11. Pham, W., Zhao, B. Q., Lo, E. H., Medarova, Z., Rosen, B., and Moore, A. (2005) Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging Neuroimage 28, 287-92
12. Lipton, P. (1999) Ischemic cell death in brain neurons Physiol. Rev. 79, 1431-568
13. Korematsu, K., Goto, S., Nagahiro, S., and Ushio, Y. (1994) Microglial response to transient focal cerebral ischemia: an immunocytochemical study on the rat cerebral cortex using anti-phosphotyrosine antibody J. Cereb. Blood Flow Metab. 14, 825-30
14. Paul, R., Zhang, Z. G., Eliceiri, B. P., Jiang, Q., Boccia, A. D., Zhang, R. L., Chopp, M., and Cheresh, D. A. (2001) Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke Nat. Med. 7, 222-7
15. Braasch, D. A., Jensen, S., Liu, Y., Kaur, K., Arar, K., White, M. A., and Corey, D. R. (2003) RNA interference in mammalian cells by chemically-modified RNA Biochemistry 42, 7967-75
16. Soutschek, J., Akinc, A., Bramlage, B., Charisse, K., Constien, R., Donoghue, M., Elbashir, S., Geick, A., Hadwiger, P., Harborth, J., John, M., Kesavan, V., Lavine, G., Pandey, R. K., Racie, T., Rajeev, K. G., Rohl, I., Toudjarska, I., Wang, G., Wuschko, S., Bumcrot, D., Koteliansky, V., Limmer, S., Manoharan, M., and Vornlocher, H. P. (2004) Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs Nature 432, 173-8
17. Saar, K., Lindgren, M., Hansen, M., Eiriksdottir, E., Jiang, Y., Rosenthal-Aizman, K., Sassian, M., and Langel, U. (2005) Cell-penetrating peptides: a comparative membrane toxicity study Anal. Biochem. 345, 55-65
18. Simeoni, F., Morris, M. C., Heitz, F., and Divita, G. (2003) Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells Nucleic Acids Res. 31, 2717-24
19. Kim, W. J., Christensen, L. V., Jo, S., Yockman, J. W., Jeong, J. H., Kim, Y. H., and Kim, S. W. (2006) Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma Mol. Ther. 14, 343-50
20. Lundberg, P., El-Andaloussi, S., Sutlu, T., Johansson, H., and Langel, U. (2007) Delivery of short interfering RNA using endosomolytic cell-penetrating peptides Faseb J. 21, 2664-71