Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 4, 2013, Pages 1018-1029

  Peuchmaur, Marine ^a,c   Lacour, Marie Agnès ^a,d   Sévalle, Jean ^b,e   Lisowski, Vincent ^a   Touati Jallabe, Youness ^a   Rodier, Fabien ^a,f   Martinez, Jean ^a   Checler, Frédéric ^b   Hernandez, Jean François ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c Laboratoire de Pharmacochimie   (France)

^d UNIVERSITÉ DE MONTPELLIER   (France)

^e UNIVERSITY OF TORONTO   (Canada)

^f AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

Secretase; Alzheimer's disease; Amyloid peptide; Isocoumarin; Serine proteases

Indexed keywords

3 ALKOXY 7 AMINO 4 CHLOROISOCOUMARIN; 4 CHLORO 3 METHOXY 7 (NONYLAMINO)ISOCOUMARIN [4 CHLORO 3 METHOXY 7 (NONYLAMINO) 1H 2 BENZOPYRAN 1 ONE]; 4 CHLORO 3 METHOXY 7 [(1 NAPHTHALENYLMETHYL)AMINO]ISOCOUMARIN [4 CHLORO 3 METHOXY 7 [(2 NITROPHENYLMETHYL)AMINO] 1H 2 BENZOPYRAN 1 ONE]; 4 CHLORO 3 METHOXY 7 [(2 NITROPHENYLMETHYL)AMINO]ISOCOUMARIN [4 CHLORO 3 METHOXY 7 [(2 NITROPHENYLMETHYL)AMINO] 1H 2 BENZOPYRAN 1 ONE]; 4 CHLORO 3 METHOXY 7 [(3 METHYLBUTYL)AMINO]ISOCOUMARIN [4 CHLORO 3 METHOXY 7 [(3 METHYLBUTYL)AMINO] 1H 2 BENZOPYRAN 1 ONE]; 4 CHLORO 7 (ETHYLAMINO) 3 METHOXYISOCOUMARIN [4 CHLORO 7 (ETHYLAMINO) 3 METHOXY 1H 2 BENZOPYRAN 1 ONE]; 4 CHLORO 7 (ISOBUTYLAMINO) 3 METHOXYISOCOUMARIN [4 CHLORO 7 (ISOBUTYLAMINO) 3 METHOXY 1H 2 BENZOPYRAN 1 ONE]; 7 (4 CARBOXYBUTYRAMIDO) 4 CHLORO 3 METHOXYISOCOUMARIN [5 [(4 CHLORO 3 METHOXY 1 OXO 1H 2 BENZOPYRAN 7 YL)AMINO] 5 OXOPENTANOIC ACID]; 7 (ACETYLAMINO) 4 CHLORO 3 METHOXYISOCOUMARIN [N (4 CHLORO 3 METHOXY 1 OXO 1H 2 BENZOPYRAN 7 YL)ACETAMIDE]; 7 (OCTANOYLAMINO) 4 CHLORO 3 METHOXYISOCOUMARIN [N (4 CHLORO 3 METHOXY 1 OXO 1H 2 BENZOPYRAN 7 YL)OCTANAMIDE]; 7 (PENTAFLUOROPROPIONYLAMINO) 4 CHLORO 3 METHOXYISOCOUMARIN [N (4 CHLORO 3 METHOXY 1 OXO 1H 2 BENZOPYRAN 7 YL) 2,2,3,3 PENTAFLUOROPROPIONAMIDE]; 7 (PIVALOYLAMINO) 4 CHLORO 3 METHOXYISOCOUMARIN [N (4 CHLORO 3 METHOXY 1 OXO 1H 2 BENZOPYRAN 7 YL)PIVALAMIDE]; 7 [[(ALLYLOXY)CARBONYL]AMINO] 4 CHLORO 3 METHOXYISOCOUMARIN[ALLYL (4 CHLORO 3 METHOXY 1 OXO 1H 2 BENZOPYRAN 7 YL)CARBAMATE]; 7 [[(ETHYLOXYY)CARBONYL]AMINO] 4 CHLORO 3 METHOXYISOCOUMARIN[ETHYL (4 CHLORO 3 METHOXY 1 OXO 1H 2 BENZOPYRAN 7 YL)CARBAMATE]; [[(9 FLUORENYLMETHOXY)CARBONYL]AMINO] 4 CHLORO 3 METHOXYISOCOUMARIN[9 FLUORENYLMETHYL (4 CHLORO 3 METHOXY 1 OXO 1H 2 BENZOPYRAN 7 YL)CARBAMATE]; [[(ADAMANTYLOXY)CARBONYL]AMINO] 4 CHLORO 3 METHOXYISOCOUMARIN[ADAMANTYL (4 CHLORO 3 METHOXY 1 OXO 1H 2 BENZOPYRAN 7 YL)CARBAMATE]; [[(BENZYLOXY)CARBONYL]AMINO] 4 CHLORO 3 METHOXYISOCOUMARIN[PHENYLMETHYL (4 CHLORO 3 METHOXY 1 OXO 1H 2 BENZOPYRAN 7 YL)CARBAMATE]; ALKYL GROUP; AMYLOID PRECURSOR PROTEIN; BORONIC ACID DERIVATIVE; BORTEZOMIB; GAMMA SECRETASE; HYDROLASE; ISOCOUMARIN DERIVATIVE; PEPTIDE DERIVATIVE; SERINE HYDROLASE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; URETHAN;

ARTICLE; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; PROTEIN CLEAVAGE; PROTEIN PROTEIN INTERACTION;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; BORONIC ACIDS; HEK293 CELLS; HUMANS; ISOCOUMARINS; SERINE PROTEASES; TRANSFECTION;

EID: 84873287179     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.11.045     Document Type: Article

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