The structural basis for catalysis and substrate specificity of a rhomboid protease

EMBO Journal

Volumn 29, Issue 22, 2010, Pages 3797-3809

  Vinothkumar, Kutti R ^a   Strisovsky, Kvido ^a   Andreeva, Antonina ^a   Christova, Yonka ^a   Verhelst, Steven ^b   Freeman, Matthew ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

intramembrane protease; isocoumarin; rhomboid; serine protease; substrate specificity

Indexed keywords

PROTEINASE; RHOMBOID PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; COVALENT BOND; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; PRIORITY JOURNAL;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; ENDOPEPTIDASES; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ISOCOUMARINS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI; EUKARYOTA; PROKARYOTA;

EID: 78449268297     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2010.243     Document Type: Article

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