메뉴 건너뛰기




Volumn 41, Issue 4, 2005, Pages 624-634

Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells

Author keywords

Apoptosis; hTERC; hTERT; Prostate cancer; Telomerase

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MESSENGER RNA; PHOSPHOROTHIOIC ACID; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

EID: 14344265993     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2004.12.002     Document Type: Article
Times cited : (81)

References (38)
  • 1
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • E.H. Blackburn Structure and function of telomeres Nature 350 1991 569 573
    • (1991) Nature , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 2
    • 0015844590 scopus 로고
    • A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
    • A.M. Olovnikov A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon J Theor Biol 41 1973 181 190
    • (1973) J Theor Biol , vol.41 , pp. 181-190
    • Olovnikov, A.M.1
  • 3
    • 0029096515 scopus 로고
    • The RNA component of human telomerase
    • J. Feng, W.D. Funk, and S.S. Wang The RNA component of human telomerase Science 269 1995 1236 1241
    • (1995) Science , vol.269 , pp. 1236-1241
    • Feng, J.1    Funk, W.D.2    Wang, S.S.3
  • 4
    • 0030668722 scopus 로고    scopus 로고
    • Human telomerase contains evolutionarily conserved catalytic and structural subunits
    • L. Harrington, W. Zhou, and T. McPhail Human telomerase contains evolutionarily conserved catalytic and structural subunits Genes Dev 11 1997 3109 3115
    • (1997) Genes Dev , vol.11 , pp. 3109-3115
    • Harrington, L.1    Zhou, W.2    McPhail, T.3
  • 5
    • 0031036350 scopus 로고    scopus 로고
    • A mammalian telomerase-associated protein
    • L. Harrington, T. McPhail, and V. Mar A mammalian telomerase-associated protein Science 275 1997 973 977
    • (1997) Science , vol.275 , pp. 973-977
    • Harrington, L.1    McPhail, T.2    Mar, V.3
  • 6
    • 0030067487 scopus 로고    scopus 로고
    • Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues
    • A.A. Avilion, A.A. Piatyszek, and J. Gupta Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues Cancer Res 56 1996 645 650
    • (1996) Cancer Res , vol.56 , pp. 645-650
    • Avilion, A.A.1    Piatyszek, A.A.2    Gupta, J.3
  • 7
    • 0037687623 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres, telomerase, and cancer
    • R.R. Reddel Alternative lengthening of telomeres, telomerase, and cancer Cancer Lett 194 2003 155 162
    • (2003) Cancer Lett , vol.194 , pp. 155-162
    • Reddel, R.R.1
  • 8
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • N.W. Kim, M.A. Piatyszek, and K.R. Prowse Specific association of human telomerase activity with immortal cells and cancer Science 266 1994 2011 2015
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3
  • 9
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • W.E. Wright, M.A. Piatyszek, and W.E. Rainey Telomerase activity in human germline and embryonic tissues and cells Dev Genet 18 1996 173 179
    • (1996) Dev Genet , vol.18 , pp. 173-179
    • Wright, W.E.1    Piatyszek, M.A.2    Rainey, W.E.3
  • 10
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • J.W. Shay, and S. Bacchetti A survey of telomerase activity in human cancer Eur J Cancer 33 1997 787 791
    • (1997) Eur J Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 11
    • 0036348269 scopus 로고    scopus 로고
    • Targeting human telomerase by antisense oligonucleotides and ribozymes
    • M. Folini, M. Pennati, and N. Zaffaroni Targeting human telomerase by antisense oligonucleotides and ribozymes Curr Med Chem Anti-Cancer Agents 2 2002 605 612
    • (2002) Curr Med Chem Anti-Cancer Agents , vol.2 , pp. 605-612
    • Folini, M.1    Pennati, M.2    Zaffaroni, N.3
  • 12
    • 0035171612 scopus 로고    scopus 로고
    • Telomerase and cancer: Time to move from a promising target to a clinical reality
    • W.N. Keith, T.R.J. Evans, and R.M. Glasspool Telomerase and cancer: time to move from a promising target to a clinical reality J Pathol 195 2001 404 414
    • (2001) J Pathol , vol.195 , pp. 404-414
    • Keith, W.N.1    Evans, T.R.J.2    Glasspool, R.M.3
  • 13
    • 0037148329 scopus 로고    scopus 로고
    • Telomerase inhibition, oligonucleotides, and clinical trials
    • D.R. Corey Telomerase inhibition, oligonucleotides, and clinical trials Oncogene 21 2002 631 637
    • (2002) Oncogene , vol.21 , pp. 631-637
    • Corey, D.R.1
  • 14
    • 0034597794 scopus 로고    scopus 로고
    • Telomere states and cell fates
    • E.H. Blackburn Telomere states and cell fates Nature 408 2000 53 56
    • (2000) Nature , vol.408 , pp. 53-56
    • Blackburn, E.H.1
  • 15
    • 0034775290 scopus 로고    scopus 로고
    • Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells
    • G. Saretzki, A. Ludwig, and T. von Zglinicki Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells Cancer Gene Ther 8 2001 827 834
    • (2001) Cancer Gene Ther , vol.8 , pp. 827-834
    • Saretzki, G.1    Ludwig, A.2    Von Zglinicki, T.3
  • 16
    • 0141791288 scopus 로고    scopus 로고
    • Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells
    • K. Kraemer, S. Fuessel, and U. Schmidt Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells Clin Cancer Res 9 2003 3794 3800
    • (2003) Clin Cancer Res , vol.9 , pp. 3794-3800
    • Kraemer, K.1    Fuessel, S.2    Schmidt, U.3
  • 17
    • 85047697807 scopus 로고    scopus 로고
    • TERT regulates cell survival independent of telomerase enzymatic activity
    • Y. Cao, H. Li, and S. Deb TERT regulates cell survival independent of telomerase enzymatic activity Oncogene 21 2002 3130 3138
    • (2002) Oncogene , vol.21 , pp. 3130-3138
    • Cao, Y.1    Li, H.2    Deb, S.3
  • 18
    • 0027494237 scopus 로고
    • P53 oncogene mutations in three human prostate cancer cell lines
    • A.G. Carroll, H.J. Voeller, and L. Sugars p53 oncogene mutations in three human prostate cancer cell lines Prostate 23 1993 123 134
    • (1993) Prostate , vol.23 , pp. 123-134
    • Carroll, A.G.1    Voeller, H.J.2    Sugars, L.3
  • 19
    • 0033151591 scopus 로고    scopus 로고
    • The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes
    • R.H. Vonderheide, W.C. Hahn, and J.L. Schultze The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes Immunity 10 1999 673 679
    • (1999) Immunity , vol.10 , pp. 673-679
    • Vonderheide, R.H.1    Hahn, W.C.2    Schultze, J.L.3
  • 20
    • 0029867408 scopus 로고    scopus 로고
    • Inhibition of human telomerase activity by peptide nucleic acids
    • J.C. Norton, M.A. Piatyszek, and W.E. Wright Inhibition of human telomerase activity by peptide nucleic acids Nat Biotechnol 14 1996 615 619
    • (1996) Nat Biotechnol , vol.14 , pp. 615-619
    • Norton, J.C.1    Piatyszek, M.A.2    Wright, W.E.3
  • 21
    • 0034184999 scopus 로고    scopus 로고
    • Telomerase activity and telomere length in human ovarian cancer and melanoma cell lines: Correlation with sensitivity to DNA damaging agents
    • R. Villa, M. Folini, and P. Perego Telomerase activity and telomere length in human ovarian cancer and melanoma cell lines: correlation with sensitivity to DNA damaging agents Int J Oncol 16 2000 995 1002
    • (2000) Int J Oncol , vol.16 , pp. 995-1002
    • Villa, R.1    Folini, M.2    Perego, P.3
  • 22
    • 0035045477 scopus 로고    scopus 로고
    • Telomerase activation, cellular immortalization and cancer
    • W.C. Hahn, and M. Meyerson Telomerase activation, cellular immortalization and cancer Ann Med 2 2001 123 1299
    • (2001) Ann Med , vol.2 , pp. 123-1299
    • Hahn, W.C.1    Meyerson, M.2
  • 23
    • 0033229856 scopus 로고    scopus 로고
    • Telomerase as a possible target for anticancer therapy
    • C. Autexier Telomerase as a possible target for anticancer therapy Chem Biol 6 1999 299 303
    • (1999) Chem Biol , vol.6 , pp. 299-303
    • Autexier, C.1
  • 24
    • 0037820395 scopus 로고    scopus 로고
    • Approaches for the inhibition of human telomerase based on the use of peptide nucleic acids and hammerhead ribozymes
    • N. Zaffaroni, R. Villa, and M. Pennati Approaches for the inhibition of human telomerase based on the use of peptide nucleic acids and hammerhead ribozymes Mini Rev Med Chem 3 2003 51 60
    • (2003) Mini Rev Med Chem , vol.3 , pp. 51-60
    • Zaffaroni, N.1    Villa, R.2    Pennati, M.3
  • 25
    • 0035262502 scopus 로고    scopus 로고
    • Telomerase: Biology and phase I trials
    • L.R. Kelland Telomerase: biology and phase I trials Lancet Oncol 2 2001 95 102
    • (2001) Lancet Oncol , vol.2 , pp. 95-102
    • Kelland, L.R.1
  • 27
    • 3843059093 scopus 로고    scopus 로고
    • Oligomer-mediated modulation of hTERT alternative splicing induces telomerase inhibition and cell growth decline in prostate cancer cells
    • C. Brambilla, M. Folini, and P. Gandellini Oligomer-mediated modulation of hTERT alternative splicing induces telomerase inhibition and cell growth decline in prostate cancer cells Cell Mol Life Sci 61 2004 1764 1774
    • (2004) Cell Mol Life Sci , vol.61 , pp. 1764-1774
    • Brambilla, C.1    Folini, M.2    Gandellini, P.3
  • 28
    • 0032530136 scopus 로고    scopus 로고
    • Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts
    • G.A. Ulaner, J.-.F. Hu, and T.H. Vu Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts Cancer Res 58 1998 4168 4172
    • (1998) Cancer Res , vol.58 , pp. 4168-4172
    • Ulaner, G.A.1    Hu -., J.F.2    Vu, T.H.3
  • 29
    • 0033988011 scopus 로고    scopus 로고
    • Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium
    • G.A. Ulaner, J.F. Hu, and T.H. Vu Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium Int J Cancer 85 2000 330 335
    • (2000) Int J Cancer , vol.85 , pp. 330-335
    • Ulaner, G.A.1    Hu, J.F.2    Vu, T.H.3
  • 30
    • 0034989980 scopus 로고    scopus 로고
    • Possible regulation of telomerase activity by transcription and alternative splicing of telomerase reverse transcriptase in human melanoma
    • R. Villa, C. Della Porta, and M. Folini Possible regulation of telomerase activity by transcription and alternative splicing of telomerase reverse transcriptase in human melanoma J Invest Dermatol 116 2001 867 873
    • (2001) J Invest Dermatol , vol.116 , pp. 867-873
    • Villa, R.1    Della Porta, C.2    Folini, M.3
  • 31
    • 0036724354 scopus 로고    scopus 로고
    • Transcription and alternative splicing of telomerase reverse transcriptase in benign and malignant breast tumours and in adjacent mammary glandular tissues: Implications for telomerase activity
    • N. Zaffaroni, C. Della Porta, and R. Villa Transcription and alternative splicing of telomerase reverse transcriptase in benign and malignant breast tumours and in adjacent mammary glandular tissues: implications for telomerase activity J Pathol 198 2002 37 46
    • (2002) J Pathol , vol.198 , pp. 37-46
    • Zaffaroni, N.1    Della Porta, C.2    Villa, R.3
  • 32
    • 0034352944 scopus 로고    scopus 로고
    • The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity
    • L.M. Colgin, C. Wilkinson, and A. Englezou The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity Neoplasia 2 2000 426 432
    • (2000) Neoplasia , vol.2 , pp. 426-432
    • Colgin, L.M.1    Wilkinson, C.2    Englezou, A.3
  • 33
    • 0034523665 scopus 로고    scopus 로고
    • An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity
    • X. Yi, D.M. White, and D.L. Aisner An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity Neoplasia 2 2000 433 440
    • (2000) Neoplasia , vol.2 , pp. 433-440
    • Yi, X.1    White, D.M.2    Aisner, D.L.3
  • 34
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • J.D. Griffith, L. Comeau, and S. Rosenfield Mammalian telomeres end in a large duplex loop Cell 97 1999 503 514
    • (1999) Cell , vol.97 , pp. 503-514
    • Griffith, J.D.1    Comeau, L.2    Rosenfield, S.3
  • 35
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • T. de Lange Protection of mammalian telomeres Oncogene 21 2002 532 540
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 36
    • 0037148270 scopus 로고    scopus 로고
    • New ways not to make ends meet: Telomerase, DNA damage proteins and heterochromatin
    • S.W.L. Chan, and E. Blackburn New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin Oncogene 21 2002 553 563
    • (2002) Oncogene , vol.21 , pp. 553-563
    • Chan, S.W.L.1    Blackburn, E.2
  • 37
    • 0038159280 scopus 로고    scopus 로고
    • Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase
    • M. Folini, K. Berg, and E. Millo Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase Cancer Res 63 2003 3490 3494
    • (2003) Cancer Res , vol.63 , pp. 3490-3494
    • Folini, M.1    Berg, K.2    Millo, E.3
  • 38
    • 0037427086 scopus 로고    scopus 로고
    • HTERT associates with human telomeres and enhances genomic stability and DNA repair
    • G.G. Sharma, A. Gupta, and H. Wang hTERT associates with human telomeres and enhances genomic stability and DNA repair Oncogene 22 2003 131 146
    • (2003) Oncogene , vol.22 , pp. 131-146
    • Sharma, G.G.1    Gupta, A.2    Wang, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.