-
1
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
-
DOI 10.1038/35888
-
Fire A, Xu S, Montgomery MK, et al: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391:806-811, 1998 (Pubitemid 28099681)
-
(1998)
Nature
, vol.391
, Issue.6669
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
2
-
-
0027751663
-
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
-
DOI 10.1016/0092-8674(93)90529-Y
-
Lee RC, Feinbaum RL, Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843-854, 1993 (Pubitemid 24014542)
-
(1993)
Cell
, vol.75
, Issue.5
, pp. 843-854
-
-
Lee, R.C.1
Feinbaum, R.L.2
Ambros, V.3
-
3
-
-
58449134534
-
Small silencing RNAs: An expanding universe
-
Ghildiyal M, Zamore PD: Small silencing RNAs: An expanding universe. Nat Rev Genet 10: 94-108, 2009
-
(2009)
Nat Rev Genet
, vol.10
, pp. 94-108
-
-
Ghildiyal, M.1
Zamore, P.D.2
-
4
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116:281-297, 2004
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
5
-
-
4644309196
-
The functions of animal microRNAs
-
Ambros V: The functions of animal microRNAs. Nature 431:350-355, 2004
-
(2004)
Nature
, vol.431
, pp. 350-355
-
-
Ambros, V.1
-
6
-
-
60149095444
-
Most mammalian mRNAs are conserved targets of microRNAs
-
Friedman RC, Farh KK, Burge CB, et al: Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19:92-105, 2009
-
(2009)
Genome Res
, vol.19
, pp. 92-105
-
-
Friedman, R.C.1
Farh, K.K.2
Burge, C.B.3
-
7
-
-
20944450160
-
Combinatorial microRNA target predictions
-
DOI 10.1038/ng1536
-
Krek A, Grün D, Poy MN, et al: Combinatorial microRNA target predictions. Nat Genet 37:495-500, 2005 (Pubitemid 40617277)
-
(2005)
Nature Genetics
, vol.37
, Issue.5
, pp. 495-500
-
-
Krek, A.1
Grun, D.2
Poy, M.N.3
Wolf, R.4
Rosenberg, L.5
Epstein, E.J.6
MacMenamin, P.7
Da, P.I.8
Gunsalus, K.C.9
Stoffel, M.10
Rajewsky, N.11
-
8
-
-
34547463506
-
Let-7 expression defines two differentiation stages of cancer
-
DOI 10.1073/pnas.0704372104
-
Shell S, Park SM, Radjabi AR, et al: Let-7 expression defines two differentiation stages of cancer. Proc Natl Acad Sci U S A 104:11400-11405, 2007 (Pubitemid 47175152)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.27
, pp. 11400-11405
-
-
Shell, S.1
Park, S.-M.2
Radjabi, A.R.3
Schickel, R.4
Kistner, E.O.5
Jewell, D.A.6
Feig, C.7
Lengyel, E.8
Peter, M.E.9
-
9
-
-
20444460289
-
MicroRNA expression profiles classify human cancers
-
DOI 10.1038/nature03702
-
Lu J, Getz G, Miska EA, et al: MicroRNA expression profiles classify human cancers. Nature 435:834-838, 2005 (Pubitemid 40839735)
-
(2005)
Nature
, vol.435
, Issue.7043
, pp. 834-838
-
-
Lu, J.1
Getz, G.2
Miska, E.A.3
Alvarez-Saavedra, E.4
Lamb, J.5
Peck, D.6
Sweet-Cordero, A.7
Ebert, B.L.8
Mak, R.H.9
Ferrando, A.A.10
Downing, J.R.11
Jacks, T.12
Horvitz, H.R.13
Golub, T.R.14
-
10
-
-
33144490646
-
A microRNA expression signature of human solid tumors defines cancer gene targets
-
DOI 10.1073/pnas.0510565103
-
Volinia S, Calin GA, Liu CG, et al: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 103:2257-2261, 2006 (Pubitemid 43271657)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.7
, pp. 2257-2261
-
-
Volinia, S.1
Calin, G.A.2
Liu, C.-G.3
Ambs, S.4
Cimmino, A.5
Petrocca, F.6
Visone, R.7
Iorio, M.8
Roldo, C.9
Ferracin, M.10
Prueitt, R.L.11
Yanaihara, N.12
Lanza, G.13
Scarpa, A.14
Vecchione, A.15
Negrini, M.16
Harris, C.C.17
Croce, C.M.18
-
11
-
-
41849114566
-
MicroRNAs accurately identify cancer tissue origin
-
DOI 10.1038/nbt1392, PII NBT1392
-
Rosenfeld N, Aharonov R, Meiri E, et al: MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol 26:462-469, 2008 (Pubitemid 351501813)
-
(2008)
Nature Biotechnology
, vol.26
, Issue.4
, pp. 462-469
-
-
Rosenfeld, N.1
Aharonov, R.2
Meiri, E.3
Rosenwald, S.4
Spector, Y.5
Zepeniuk, M.6
Benjamin, H.7
Shabes, N.8
Tabak, S.9
Levy, A.10
Lebanony, D.11
Goren, Y.12
Silberschein, E.13
Targan, N.14
Ben-Ari, A.15
Gilad, S.16
Sion-Vardy, N.17
Tobar, A.18
Feinmesser, M.19
Kharenko, O.20
Nativ, O.21
Nass, D.22
Perelman, M.23
Yosepovich, A.24
Shalmon, B.25
Polak-Charcon, S.26
Fridman, E.27
Avniel, A.28
Bentwich, I.29
Bentwich, Z.30
Cohen, D.31
Chajut, A.32
Barshack, I.33
more..
-
12
-
-
34548746977
-
MicroRNA signatures in human ovarian cancer
-
DOI 10.1158/0008-5472.CAN-07-1936
-
Iorio MV, Visone R, Di Leva G, et al: MicroRNA signatures in human ovarian cancer. Cancer Res 67:8699-8707, 2007 (Pubitemid 47437445)
-
(2007)
Cancer Research
, vol.67
, Issue.18
, pp. 8699-8707
-
-
Iorio, M.V.1
Visone, R.2
Di, L.G.3
Donati, V.4
Petrocca, F.5
Casalini, P.6
Taccioli, C.7
Volinia, S.8
Liu, C.-G.9
Alder, H.10
Calin, G.A.11
Menard, S.12
Croce, C.M.13
-
13
-
-
27244434788
-
A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
-
DOI 10.1056/NEJMoa050995
-
Calin GA, Ferracin M, Cimmino A, et al: A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 353:1793-1801, 2005 (Pubitemid 41549891)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.17
, pp. 1793-1801
-
-
Calin, G.A.1
Ferracin, M.2
Cimmino, A.3
Di, L.G.4
Shimizu, M.5
Wojcik, S.E.6
Iorio, M.V.7
Visone, R.8
Sever, N.I.9
Fabbri, M.10
Iuliano, R.11
Palumbo, T.12
Pichiorri, F.13
Roldo, C.14
Garzon, R.15
Sevignani, C.16
Rassenti, L.17
Alder, H.18
Volinia, S.19
Liu, C.-G.20
Kipps, T.J.21
Negrini, M.22
Croce, C.M.23
more..
-
14
-
-
60149084560
-
MicroRNAs and cancer: Short RNAs go a long way
-
Ventura A, Jacks T: MicroRNAs and cancer: Short RNAs go a long way. Cell 136:586-591, 2009
-
(2009)
Cell
, vol.136
, pp. 586-591
-
-
Ventura, A.1
Jacks, T.2
-
15
-
-
33748302836
-
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster
-
DOI 10.1038/ng1855, PII NG1855
-
Dews M, Homayouni A, Yu D, et al: Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet 38:1060-1065, 2006 (Pubitemid 44325933)
-
(2006)
Nature Genetics
, vol.38
, Issue.9
, pp. 1060-1065
-
-
Dews, M.1
Homayouni, A.2
Yu, D.3
Murphy, D.4
Sevignani, C.5
Wentzel, E.6
Furth, E.E.7
Lee, W.M.8
Enders, G.H.9
Mendell, J.T.10
Thomas-Tikhonenko, A.11
-
16
-
-
63049085576
-
MicroRNAs: The micro steering wheel of tumour metastases
-
Nicoloso MS, Spizzo R, Shimizu M, et al: MicroRNAs: The micro steering wheel of tumour metastases. Nat Rev Cancer 9:293-302, 2009
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 293-302
-
-
Nicoloso, M.S.1
Spizzo, R.2
Shimizu, M.3
-
17
-
-
66449095667
-
A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis
-
Valastyan S, Reinhardt F, Benaich N, et al: A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell 137:1032-1046, 2009
-
(2009)
Cell
, vol.137
, pp. 1032-1046
-
-
Valastyan, S.1
Reinhardt, F.2
Benaich, N.3
-
18
-
-
38049115129
-
Endogenous human microRNAs that suppress breast cancer metastasis
-
Tavazoie SF, Alarcón C, Oskarsson T, et al: Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451:147-152, 2008
-
(2008)
Nature
, vol.451
, pp. 147-152
-
-
Tavazoie, S.F.1
Alarcón, C.2
Oskarsson, T.3
-
19
-
-
41849092209
-
MicroRNAs in malignant progression
-
Ma L, Weinberg RA: MicroRNAs in malignant progression. Cell Cycle 7:570-572, 2008 (Pubitemid 351498993)
-
(2008)
Cell Cycle
, vol.7
, Issue.5
, pp. 570-572
-
-
Ma, L.1
Weinberg, R.A.2
-
20
-
-
18744396337
-
Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
-
DOI 10.1073/pnas.242606799
-
Calin GA, Dumitru CD, Shimizu M, et al: Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 99:15524-15529, 2002 (Pubitemid 35403967)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.24
, pp. 15524-15529
-
-
Calin, G.A.1
Dumitru, C.D.2
Shimizu, M.3
Bichi, R.4
Zupo, S.5
Noch, E.6
Aldler, H.7
Rattan, S.8
Keating, M.9
Rai, K.10
Rassenti, L.11
Kipps, T.12
Negrini, M.13
Bullrich, F.14
Croce, C.M.15
-
21
-
-
73649116987
-
The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia
-
Klein U, Lia M, Crespo M, et al: The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 17:28-40, 2010
-
(2010)
Cancer Cell
, vol.17
, pp. 28-40
-
-
Klein, U.1
Lia, M.2
Crespo, M.3
-
22
-
-
34250013672
-
Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice
-
DOI 10.1182/blood-2007-02-071225
-
Raveche ES, Salerno E, Scaglione BJ, et al: Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood 109:5079-5086, 2007 (Pubitemid 46890521)
-
(2007)
Blood
, vol.109
, Issue.12
, pp. 5079-5086
-
-
Raveche, E.S.1
Salerno, E.2
Scaglione, B.J.3
Manohar, V.4
Abbasi, F.5
Lin, Y.-C.6
Fredrickson, T.7
Landgraf, P.8
Ramachandra, S.9
Huppi, K.10
Toro, J.R.11
Zenger, V.E.12
Metcalf, R.A.13
Marti, G.E.14
-
23
-
-
25444520537
-
MiR-15 and miR-16 induce apoptosis by targeting BCL2
-
DOI 10.1073/pnas.0506654102
-
Cimmino A, Calin GA, Fabbri M, et al: miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A 102:13944-13949, 2005 (Pubitemid 41377683)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.39
, pp. 13944-13949
-
-
Cimmino, A.1
Calin, G.A.2
Fabbri, M.3
Iorio, M.V.4
Ferracin, M.5
Shimizu, M.6
Wojcik, S.E.7
Aqeilan, R.I.8
Zupo, S.9
Dono, M.10
Rassenti, L.11
Alder, H.12
Volinia, S.13
Liu, C.-G.14
Kipps, T.J.15
Negrini, M.16
Croce, C.M.17
-
24
-
-
12144290519
-
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
-
DOI 10.1073/pnas.0307323101
-
Calin GA, Sevignani C, Dumitru CD, et al: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A 101:2999-3004, 2004 (Pubitemid 38327724)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.9
, pp. 2999-3004
-
-
Calin, G.A.1
Sevignani, C.2
Dumitru, C.D.3
Hyslop, T.4
Noch, E.5
Yendamuri, S.6
Shimizu, M.7
Rattan, S.8
Bullrich, F.9
Negrini, M.10
Croce, C.M.11
-
25
-
-
47949100595
-
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
-
Newman MA, Thomson JM, Hammond SM: Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA 14: 1539-1549, 2008
-
(2008)
RNA
, vol.14
, pp. 1539-1549
-
-
Newman, M.A.1
Thomson, J.M.2
Hammond, S.M.3
-
26
-
-
40849108663
-
Selective blockade of microRNA processing by Lin28
-
DOI 10.1126/science.1154040
-
Viswanathan SR, Daley GQ, Gregory RI: Selective blockade of microRNA processing by Lin28. Science 320:97-100, 2008 (Pubitemid 351490762)
-
(2008)
Science
, vol.320
, Issue.5872
, pp. 97-100
-
-
Viswanathan, S.R.1
Daley, G.Q.2
Gregory, R.I.3
-
27
-
-
70349820140
-
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells
-
Hagan JP, Piskounova E, Gregory RI: Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol 16:1021-1025, 2009
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 1021-1025
-
-
Hagan, J.P.1
Piskounova, E.2
Gregory, R.I.3
-
28
-
-
68749102148
-
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation
-
Heo I, Joo C, Kim YK, et al: TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 138:696-708, 2009
-
(2009)
Cell
, vol.138
, pp. 696-708
-
-
Heo, I.1
Joo, C.2
Kim, Y.K.3
-
29
-
-
70349810911
-
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
-
Lehrbach NJ, Armisen J, Lightfoot HL, et al: LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat Struct Mol Biol 16:1016-1020, 2009
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 1016-1020
-
-
Lehrbach, N.J.1
Armisen, J.2
Lightfoot, H.L.3
-
30
-
-
39849095077
-
E2F1-Regulated MicroRNAs Impair TGFbeta-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer
-
DOI 10.1016/j.ccr.2008.02.013, PII S1535610808000494
-
Petrocca F, Visone R, Onelli MR, et al: E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 13:272-286, 2008 (Pubitemid 351318375)
-
(2008)
Cancer Cell
, vol.13
, Issue.3
, pp. 272-286
-
-
Petrocca, F.1
Visone, R.2
Onelli, M.R.3
Shah, M.H.4
Nicoloso, M.S.5
De, M.I.6
Iliopoulos, D.7
Pilozzi, E.8
Liu, C.-G.9
Negrini, M.10
Cavazzini, L.11
Volinia, S.12
Alder, H.13
Ruco, L.P.14
Baldassarre, G.15
Croce, C.M.16
Vecchione, A.17
-
31
-
-
34249817549
-
Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis
-
DOI 10.1016/j.molcel.2007.05.010, PII S1097276507003103
-
Chang TC, Wentzel EA, Kent OA, et al: Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 26:745-752, 2007 (Pubitemid 46856245)
-
(2007)
Molecular Cell
, vol.26
, Issue.5
, pp. 745-752
-
-
Chang, T.-C.1
Wentzel, E.A.2
Kent, O.A.3
Ramachandran, K.4
Mullendore, M.5
Lee, K.6
Feldmann, G.7
Yamakuchi, M.8
Ferlito, M.9
Lowenstein, C.J.10
Arking, D.11
Beer, M.A.12
Maitra, A.13
Mendell, J.T.14
-
32
-
-
20444479428
-
C-Myc-regulated microRNAs modulate E2F1 expression
-
DOI 10.1038/nature03677
-
O'Donnell KA, Wentzel EA, Zeller KI, et al: c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435:839-843, 2005 (Pubitemid 40839736)
-
(2005)
Nature
, vol.435
, Issue.7043
, pp. 839-843
-
-
O'Donnell, K.A.1
Wentzel, E.A.2
Zeller, K.I.3
Dang, C.V.4
Mendell, J.T.5
-
33
-
-
69949098536
-
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3′UTR microRNA recognition elements
-
Lal A, Navarro F, Maher CA, et al: miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3′UTR microRNA recognition elements. Mol Cell 35:610-625, 2009
-
(2009)
Mol Cell
, vol.35
, pp. 610-625
-
-
Lal, A.1
Navarro, F.2
Maher, C.A.3
-
34
-
-
34047264639
-
Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors
-
DOI 10.1074/jbc.C600252200
-
Woods K, Thomson JM, Hammond SM: Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem 282:2130-2134, 2007 (Pubitemid 47076737)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.4
, pp. 2130-2134
-
-
Woods, K.1
Thomson, J.M.2
Hammond, S.M.3
-
35
-
-
33744805399
-
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
-
DOI 10.1016/j.ccr.2006.04.020, PII S1535610806001437
-
Saito Y, Liang G, Egger G, et al: Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9:435-443, 2006 (Pubitemid 43832188)
-
(2006)
Cancer Cell
, vol.9
, Issue.6
, pp. 435-443
-
-
Saito, Y.1
Liang, G.2
Egger, G.3
Friedman, J.M.4
Chuang, J.C.5
Coetzee, G.A.6
Jones, P.A.7
-
36
-
-
62349141187
-
Dicer and Drosha in ovarian cancer
-
author reply 1151
-
Köbel M, Gilks CB, Huntsman DG: Dicer and Drosha in ovarian cancer. N Engl J Med 360:1150-1151; author reply 1151, 2009
-
(2009)
N Engl J Med
, vol.360
, pp. 1150-1151
-
-
Köbel, M.1
Gilks, C.B.2
Huntsman, D.G.3
-
37
-
-
68949131095
-
A role for Lin28 in primordial germ-cell development and germ-cell malignancy
-
West JA, Viswanathan SR, Yabuuchi A, et al: A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature 460:909-913, 2009
-
(2009)
Nature
, vol.460
, pp. 909-913
-
-
West, J.A.1
Viswanathan, S.R.2
Yabuuchi, A.3
-
38
-
-
68749113985
-
Widespread shortening of 3′UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells
-
Mayr C, Bartel DP: Widespread shortening of 3′UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell 138:673-684, 2009
-
(2009)
Cell
, vol.138
, pp. 673-684
-
-
Mayr, C.1
Bartel, D.P.2
-
39
-
-
33947431322
-
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation
-
DOI 10.1126/science.1137999
-
Mayr C, Hemann MT, Bartel DP: Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 315:1576-1579, 2007 (Pubitemid 46449474)
-
(2007)
Science
, vol.315
, Issue.5818
, pp. 1576-1579
-
-
Mayr, C.1
Hemann, M.T.2
Bartel, D.P.3
-
40
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
DOI 10.1038/35078107
-
Elbashir SM, Harborth J, Lendeckel W, et al: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498, 2001 (Pubitemid 32494397)
-
(2001)
Nature
, vol.411
, Issue.6836
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
41
-
-
4644223259
-
Mechanisms of gene silencing by double-stranded RNA
-
DOI 10.1038/nature02873
-
Meister G, Tuschl T: Mechanisms of gene silencing by double-stranded RNA. Nature 431:343-349, 2004 (Pubitemid 39265674)
-
(2004)
Nature
, vol.431
, Issue.7006
, pp. 343-349
-
-
Meister, G.1
Tuschl, T.2
-
42
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
DOI 10.1038/nbt831
-
Jackson AL, Bartz SR, Schelter J, et al: Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 21:635-637, 2003 (Pubitemid 36638089)
-
(2003)
Nature Biotechnology
, vol.21
, Issue.6
, pp. 635-637
-
-
Jackson, A.L.1
Bartz, S.R.2
Schelter, J.3
Kobayashi, S.V.4
Burchard, J.5
Mao, M.6
Li, B.7
Cavet, G.8
Linsley, P.S.9
-
43
-
-
42649103333
-
Does the understanding of immune activation by RNA predict the design of safe siRNAs?
-
Sioud M: Does the understanding of immune activation by RNA predict the design of safe siRNAs? Front Biosci 13:4379-4392, 2008
-
(2008)
Front Biosci
, vol.13
, pp. 4379-4392
-
-
Sioud, M.1
-
44
-
-
33646049347
-
Innate sensing of self and non-self RNAs by Toll-like receptors
-
Sioud M: Innate sensing of self and non-self RNAs by Toll-like receptors. Trends Mol Med 12: 167-176, 2006
-
(2006)
Trends Mol Med
, vol.12
, pp. 167-176
-
-
Sioud, M.1
-
45
-
-
0042972933
-
Activation of the interferon system by short-interfering RNAs
-
DOI 10.1038/ncb1038
-
Sledz CA, Holko M, de Veer MJ, et al: Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 5:834-839, 2003 (Pubitemid 37087172)
-
(2003)
Nature Cell Biology
, vol.5
, Issue.9
, pp. 834-839
-
-
Sledz, C.A.1
Holko, M.2
De, V.M.J.3
Silverman, R.H.4
Williams, B.R.G.5
-
46
-
-
41649115210
-
Sequence- And target-independent angiogenesis suppression by siRNA via TLR3
-
DOI 10.1038/nature06765, PII NATURE06765
-
Kleinman ME, Yamada K, Takeda A, et al: Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 452:591-597, 2008 (Pubitemid 351483358)
-
(2008)
Nature
, vol.452
, Issue.7187
, pp. 591-597
-
-
Kleinman, M.E.1
Yamada, K.2
Takeda, A.3
Chandrasekaran, V.4
Nozaki, M.5
Baffi, J.Z.6
Albuquerque, R.J.C.7
Yamasaki, S.8
Itaya, M.9
Pan, Y.10
Appukuttan, B.11
Gibbs, D.12
Yang, Z.13
Kariko, K.14
Ambati, B.K.15
Wilgus, T.A.16
DiPietro, L.A.17
Sakurai, E.18
Zhang, K.19
Smith, J.R.20
Taylor, E.W.21
Ambati, J.22
more..
-
47
-
-
20144389695
-
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
-
DOI 10.1038/nm1191
-
Hornung V, Guenthner-Biller M, Bourquin C, et al: Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 11:263-270, 2005 (Pubitemid 40460553)
-
(2005)
Nature Medicine
, vol.11
, Issue.3
, pp. 263-270
-
-
Hornung, V.1
Guenthner-Biller, M.2
Bourquin, C.3
Ablasser, A.4
Schlee, M.5
Uematsu, S.6
Noronha, A.7
Manoharan, M.8
Akira, S.9
De, F.A.10
Endres, S.11
Hartmann, G.12
-
48
-
-
55549114663
-
5′-Triphosphate-siRNA: Turning gene silencing and Rig-I activation against melanoma
-
Poeck H, Besch R, Maihoefer C, et al: 5′-Triphosphate-siRNA: Turning gene silencing and Rig-I activation against melanoma. Nat Med 14: 1256-1263, 2008
-
(2008)
Nat Med
, vol.14
, pp. 1256-1263
-
-
Poeck, H.1
Besch, R.2
Maihoefer, C.3
-
49
-
-
36849078711
-
Let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells
-
DOI 10.1016/j.cell.2007.10.054, PII S0092867407014171
-
Yu F, Yao H, Zhu P, et al: Let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131:1109-1123, 2007 (Pubitemid 350235025)
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1109-1123
-
-
Yu, F.1
Yao, H.2
Zhu, P.3
Zhang, X.4
Pan, Q.5
Gong, C.6
Huang, Y.7
Hu, X.8
Su, F.9
Lieberman, J.10
Song, E.11
-
50
-
-
42049092138
-
Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest
-
Sun F, Fu H, Liu Q, et al: Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest. FEBS Lett 582:1564-1568, 2008
-
(2008)
FEBS Lett
, vol.582
, pp. 1564-1568
-
-
Sun, F.1
Fu, H.2
Liu, Q.3
-
52
-
-
70349256065
-
miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53
-
Navarro F, Gutman D, Meire E, et al: miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53. Blood 114:2181-2192, 2009
-
(2009)
Blood
, vol.114
, pp. 2181-2192
-
-
Navarro, F.1
Gutman, D.2
Meire, E.3
-
53
-
-
66449136951
-
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
-
Kota J, Chivukula RR, O'Donnell KA, et al: Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137: 1005-1017, 2009
-
(2009)
Cell
, vol.137
, pp. 1005-1017
-
-
Kota, J.1
Chivukula, R.R.2
O'Donnell, K.A.3
-
54
-
-
34250851115
-
A microRNA component of the p53 tumour suppressor network
-
DOI 10.1038/nature05939, PII NATURE05939
-
He L, He X, Lim LP, et al: A microRNA component of the p53 tumour suppressor network. Nature 447:1130-1134, 2007 (Pubitemid 47014436)
-
(2007)
Nature
, vol.447
, Issue.7148
, pp. 1130-1134
-
-
He, L.1
He, X.2
Lim, L.P.3
De, S.E.4
Xuan, Z.5
Liang, Y.6
Xue, W.7
Zender, L.8
Magnus, J.9
Ridzon, D.10
Jackson, A.L.11
Linsley, P.S.12
Chen, C.13
Lowe, S.W.14
Cleary, M.A.15
Hannon, G.J.16
-
55
-
-
34249822779
-
Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis
-
DOI 10.1016/j.molcel.2007.05.017, PII S1097276507003188
-
Raver-Shapira N, Marciano E, Meiri E, et al: Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 26:731-743, 2007 (Pubitemid 46856247)
-
(2007)
Molecular Cell
, vol.26
, Issue.5
, pp. 731-743
-
-
Raver-Shapira, N.1
Marciano, E.2
Meiri, E.3
Spector, Y.4
Rosenfeld, N.5
Moskovits, N.6
Bentwich, Z.7
Oren, M.8
-
56
-
-
66149157349
-
miR-24- mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells
-
Lal A, Pan Y, Navarro F, et al: miR-24- mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Nat Struct Mol Biol 16:492-498, 2009
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 492-498
-
-
Lal, A.1
Pan, Y.2
Navarro, F.3
-
57
-
-
37049019490
-
MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy
-
DOI 10.1158/0008-5472.CAN-07-2858
-
Weidhaas JB, Babar I, Nallur SM, et al: MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Cancer Res 67:11111-11116, 2007 (Pubitemid 350248533)
-
(2007)
Cancer Research
, vol.67
, Issue.23
, pp. 11111-11116
-
-
Weidhaas, J.B.1
Babar, I.2
Nallur, S.M.3
Trang, P.4
Roush, S.5
Boehm, M.6
Gillespie, E.7
Slack, F.J.8
-
58
-
-
65549110908
-
miR-34a as part of the resistance network in chronic lymphocytic leukemia
-
Zenz T, Mohr J, Eldering E, et al: miR-34a as part of the resistance network in chronic lymphocytic leukemia. Blood 113:3801-3808, 2009
-
(2009)
Blood
, vol.113
, pp. 3801-3808
-
-
Zenz, T.1
Mohr, J.2
Eldering, E.3
-
59
-
-
41649114199
-
Suppression of non-small cell lung tumor development by the let-7 microRNA family
-
DOI 10.1073/pnas.0712321105
-
Kumar MS, Erkeland SJ, Pester RE, et al: Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A 105:3903-3908, 2008 (Pubitemid 351723497)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.10
, pp. 3903-3908
-
-
Kumar, M.S.1
Erkeland, S.J.2
Pester, R.E.3
Chen, C.Y.4
Ebert, M.S.5
Sharp, P.A.6
Jacks, T.7
-
60
-
-
42049103216
-
The let-7 microRNA reduces tumor growth in mouse models of lung cancer
-
Esquela-Kerscher A, Trang P, Wiggins JF, et al: The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle 7:759-764, 2008 (Pubitemid 351520040)
-
(2008)
Cell Cycle
, vol.7
, Issue.6
, pp. 759-764
-
-
Esquela-Kerscher, A.1
Trang, P.2
Wiggins, J.F.3
Patrawala, L.4
Cheng, A.5
Ford, L.6
Weidhaas, J.B.7
Brown, D.8
Bader, A.G.9
Slack, F.J.10
-
61
-
-
39749163245
-
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
-
DOI 10.1038/ni1575, PII NI1575
-
Xiao C, Srinivasan L, Calado DP, et al: Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol 9:405-414, 2008 (Pubitemid 351405110)
-
(2008)
Nature Immunology
, vol.9
, Issue.4
, pp. 405-414
-
-
Xiao, C.1
Srinivasan, L.2
Calado, D.P.3
Patterson, H.C.4
Zhang, B.5
Wang, J.6
Henderson, J.M.7
Kutok, J.L.8
Rajewsky, K.9
-
62
-
-
39749101294
-
Dicer Ablation Affects Antibody Diversity and Cell Survival in the B Lymphocyte Lineage
-
DOI 10.1016/j.cell.2008.02.020, PII S0092867408002687
-
Koralov SB, Muljo SA, Galler GR, et al: Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell 132:860-874, 2008 (Pubitemid 351312808)
-
(2008)
Cell
, vol.132
, Issue.5
, pp. 860-874
-
-
Koralov, S.B.1
Muljo, S.A.2
Galler, G.R.3
Krek, A.4
Chakraborty, T.5
Kanellopoulou, C.6
Jensen, K.7
Cobb, B.S.8
Merkenschlager, M.9
Rajewsky, N.10
Rajewsky, K.11
-
63
-
-
33646471662
-
Pre-B cell proliferation and lymphoblastic leukemia/highgrade lymphoma in E(mu)-miR155 transgenic mice
-
Costinean S, Zanesi N, Pekarsky Y, et al: Pre-B cell proliferation and lymphoblastic leukemia/highgrade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci U S A 103:7024-7029, 2006
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 7024-7029
-
-
Costinean, S.1
Zanesi, N.2
Pekarsky, Y.3
-
64
-
-
67650486013
-
Locked nucleic acid as a novel class of therapeutic agents
-
Veedu RN, Wengel J: Locked nucleic acid as a novel class of therapeutic agents. RNA Biol 6:321-323, 2009
-
(2009)
RNA Biol
, vol.6
, pp. 321-323
-
-
Veedu, R.N.1
Wengel, J.2
-
65
-
-
42249093319
-
LNA-mediated microRNA silencing in non-human primates
-
DOI 10.1038/nature06783, PII NATURE06783
-
Elmén J, Lindow M, Schütz S, et al: LNA-mediated microRNA silencing in non-human primates. Nature 452:896-899, 2008 (Pubitemid 351550859)
-
(2008)
Nature
, vol.452
, Issue.7189
, pp. 896-899
-
-
Elmen, J.1
Lindow, M.2
Schutz, S.3
Lawrence, M.4
Petri, A.5
Obad, S.6
Lindholm, M.7
Hedtjarn, M.8
Hansen, H.F.9
Berger, U.10
Gullans, S.11
Kearney, P.12
Sarnow, P.13
Straarup, E.M.14
Kauppinen, S.15
-
66
-
-
65849111219
-
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
-
Scholl C, Fröhling S, Dunn IF, et al: Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 137:821-834, 2009
-
(2009)
Cell
, vol.137
, pp. 821-834
-
-
Scholl, C.1
Fröhling, S.2
Dunn, I.F.3
-
67
-
-
73349135374
-
RNAi nanoparticles in the service of personalized medicine
-
Lond
-
Kedmi R, Peer D: RNAi nanoparticles in the service of personalized medicine. Nanomedicine (Lond) 4:853-855, 2009
-
(2009)
Nanomedicine
, vol.4
, pp. 853-855
-
-
Kedmi, R.1
Peer, D.2
-
68
-
-
34447559636
-
Interfering with disease: A progress report on siRNA-based therapeutics
-
DOI 10.1038/nrd2310, PII NRD2310
-
de Fougerolles A, Vornlocher HP, Maraganore J, et al: Interfering with disease: A progress report on siRNA-based therapeutics. Nat Rev Drug Discov 6:443-453, 2007 (Pubitemid 47064567)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.6
, pp. 443-453
-
-
De, F.A.1
Vornlocher, H.-P.2
Maraganore, J.3
Lieberman, J.4
-
70
-
-
39549117983
-
Delivery vehicles for small interfering RNA in vivo
-
de Fougerolles AR: Delivery vehicles for small interfering RNA in vivo. Hum Gene Ther 19:125-132, 2008
-
(2008)
Hum Gene Ther
, vol.19
, pp. 125-132
-
-
De Fougerolles, A.R.1
-
71
-
-
28444469246
-
Silencing of microRNAs in vivo with 'antagomirs'
-
Krützfeldt J, Rajewsky N, Braich R, et al: Silencing of microRNAs in vivo with 'antagomirs'. Nature 438:685-689, 2005
-
(2005)
Nature
, vol.438
, pp. 685-689
-
-
Krützfeldt, J.1
Rajewsky, N.2
Braich, R.3
-
72
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann TS, Lee AC, Akinc A, et al: RNAi-mediated gene silencing in non-human primates. Nature 441:111-114, 2006
-
(2006)
Nature
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.2
Akinc, A.3
-
73
-
-
58249094519
-
Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene
-
Wu Y, Navarro F, Lal A, et al: Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell Host Microbe 5:84-94, 2009
-
(2009)
Cell Host Microbe
, vol.5
, pp. 84-94
-
-
Wu, Y.1
Navarro, F.2
Lal, A.3
-
74
-
-
30144434185
-
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
-
DOI 10.1038/nature04263
-
Palliser D, Chowdhury D, Wang QY, et al: An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 439:89-94, 2006 (Pubitemid 43053634)
-
(2006)
Nature
, vol.439
, Issue.7072
, pp. 89-94
-
-
Palliser, D.1
Chowdhury, D.2
Wang, Q.-Y.3
Lee, S.J.4
Bronson, R.T.5
Knipe, D.M.6
Lieberman, J.7
-
75
-
-
35148815670
-
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
-
DOI 10.1038/nbt1339, PII NBT1339
-
Wolfrum C, Shi S, Jayaprakash KN, et al: Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nat Biotechnol 25:1149-1157, 2007 (Pubitemid 47538115)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.10
, pp. 1149-1157
-
-
Wolfrum, C.1
Shi, S.2
Jayaprakash, K.N.3
Jayaraman, M.4
Wang, G.5
Pandey, R.K.6
Rajeev, K.G.7
Nakayama, T.8
Charrise, K.9
Ndungo, E.M.10
Zimmermann, T.11
Koteliansky, V.12
Manoharan, M.13
Stoffel, M.14
-
76
-
-
67249128859
-
The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: From concept to clinic
-
Davis ME: The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: From concept to clinic. Mol Pharm 6:659-668, 2009
-
(2009)
Mol Pharm
, vol.6
, pp. 659-668
-
-
Davis, M.E.1
-
77
-
-
39549120024
-
Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles
-
DOI 10.1002/bit.21668
-
Bartlett DW, Davis ME: Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles. Biotechnol Bioeng 99:975-985, 2008 (Pubitemid 351316639)
-
(2008)
Biotechnology and Bioengineering
, vol.99
, Issue.4
, pp. 975-985
-
-
Bartlett, D.W.1
Davis, M.E.2
-
78
-
-
77951132901
-
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
-
Davis ME, Zuckerman JE, Choi CH, et al: Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 464:1067-1070, 2010
-
(2010)
Nature
, vol.464
, pp. 1067-1070
-
-
Davis, M.E.1
Zuckerman, J.E.2
Choi, C.H.3
-
79
-
-
56249131779
-
A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth
-
Greenberger LM, Horak ID, Filpula D, et al: A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth. Mol Cancer Ther 7:3598-3608, 2008
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3598-3608
-
-
Greenberger, L.M.1
Horak, I.D.2
Filpula, D.3
-
80
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
DOI 10.1038/nbt1122
-
Morrissey DV, Lockridge JA, Shaw L, et al: Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat Biotechnol 23: 1002-1007, 2005 (Pubitemid 41114035)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.8
, pp. 1002-1007
-
-
Morrissey, D.V.1
Lockridge, J.A.2
Shaw, L.3
Blanchard, K.4
Jensen, K.5
Breen, W.6
Hartsough, K.7
Machemer, L.8
Radka, S.9
Jadhav, V.10
Vaish, N.11
Zinnen, S.12
Vargeese, C.13
Bowman, K.14
Shaffer, C.S.15
Jeffs, L.B.16
Judge, A.17
MacLachlan, I.18
Polisky, B.19
|