Mechanisms of atrial-selective block of Na + channels by ranolazine: II. Insights from a mathematical model

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 4, 2011, Pages

  Nesterenko, Vladislav V ^a   Zygmunt, Andrew C ^a   Rajamani, Sridharan ^b   Belardinelli, Luiz ^b   Antzelevitch, Charles ^a  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

^b GILEAD SCIENCES   (United States)

Author keywords

Antiarrhythmic drugs; Blockade; Mathematical models; Sodium channel

Indexed keywords

RANOLAZINE; SODIUM CHANNEL;

ACTION POTENTIAL; ARTICLE; BINDING SITE; CELL STRUCTURE; CHANNEL GATING; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; ELECTRIC POTENTIAL; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HYDROPHILICITY; KINETICS; MATHEMATICAL MODEL; PRIORITY JOURNAL; SODIUM CURRENT; STEADY STATE;

ACETANILIDES; ANIMALS; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART; HEART ATRIA; HEART VENTRICLES; KINETICS; MARKOV CHAINS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MYOCYTES, CARDIAC; PIPERAZINES; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 80053236179     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00243.2011     Document Type: Article

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