Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome

Circulation

Volumn 96, Issue 6, 1997, Pages 2038-2047

  Shimizu, Wataru ^a   Antzelevitch, Charles ^a  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

Author keywords

Arrhythmia; Electrophysiology; Long QT syndrome; Pharmacology; Torsade de pointes

Indexed keywords

MEXILETINE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SOTALOL;

ANIMAL CELL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFICACY; ELECTROCARDIOGRAM; ENDOCARDIUM; EPICARDIUM; HEART LEFT VENTRICLE; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; LONG QT SYNDROME; NONHUMAN; PRIORITY JOURNAL; PURKINJE FIBER; T WAVE; TORSADE DES POINTES;

EID: 0030819433     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.96.6.2038     Document Type: Article

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