Contribution of late sodium current (INa-L) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents

Heart Rhythm

Volumn 8, Issue 5, 2011, Pages 762-769

  Guo, Donglin ^a   Lian, Jianfang ^a,d   Liu, Tengxian ^a   Cox, Robert ^a   Margulies, Kenneth B ^b   Kowey, Peter R ^a,c   Yan, Gan Xin ^a,c,e  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d Blood Center of Ningbo   (China)

^e Main Line Health Heart Center   (United States)

Author keywords

Action potential duration; Delayed rectifier potassium current; I Kr block; Late sodium current; Rate adaptation; Reverse use dependence

Indexed keywords

CALCIUM CHANNEL L TYPE; DELAYED RECTIFIER POTASSIUM CHANNEL; DOFETILIDE; SODIUM CHANNEL; TETRODOTOXIN;

ADAPTATION; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; QT INTERVAL; RABBIT; SODIUM CURRENT; VOLTAGE CLAMP;

ANIMALS; CARDIOVASCULAR AGENTS; HEART CONDUCTION SYSTEM; HEART RATE; RABBITS; SODIUM; SODIUM CHANNELS; VENTRICULAR FUNCTION;

EID: 79955373381     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2010.12.026     Document Type: Article

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