Atrial-selective inhibition of sodium-channel current by Wenxin Keli is effective in suppressing atrial fibrillation

Heart Rhythm

Volumn 9, Issue 1, 2012, Pages 125-131

  Burashnikov, Alexander ^a   Petroski, Alyssa ^a   Hu, Dan ^a   Barajas Martinez, Hector ^a   Antzelevitch, Charles ^a  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

Author keywords

Antiarrhythmic drugs; Arrhythmias; Atrial fibrillation; Electrophysiology; Pharmacology

Indexed keywords

ACETYLCHOLINE; CHINESE DRUG; SODIUM CHANNEL NAV1.5; UNCLASSIFIED DRUG; WENXIN KELI;

ARTICLE; CELL STRAIN HEK293; CHINESE HERB; CORONARY ARTERY PERFORATION; DEPRESSION; ELECTROCARDIOGRAM; ELECTROPHYSIOLOGY; HEART ATRIUM CONDUCTION; HEART ATRIUM FIBRILLATION; HEART EXCITATION; HEART MUSCLE REFRACTORY PERIOD; HEART REPOLARIZATION; HEART RIGHT VENTRICLE FUNCTION; HUMAN; HUMAN TISSUE; MEMBRANE POTENTIAL; NERVE CONDUCTION; P WAVE; PRIORITY JOURNAL; QRS COMPLEX; STEADY STATE;

ACTION POTENTIALS; ANIMALS; ATRIAL FIBRILLATION; DOGS; DRUGS, CHINESE HERBAL; ELECTROPHYSIOLOGICAL PHENOMENA; HEART ATRIA; HEK293 CELLS; HUMANS; MEMBRANE POTENTIALS; SODIUM CHANNEL BLOCKERS;

EID: 84555213111     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2011.08.027     Document Type: Article

References (31)

1. V. Fuster, L.E. Ryden, D.S. Cannom 2011 ACCF/AHA/HRS Focused Updates Incorporated Into the ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: a Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society J Am Coll Cardiol 57 2011 e101 e198
2. S. Nattel, L. Carlsson Innovative approaches to anti-arrhythmic drug therapy Nat Rev Drug Discov 5 2006 1034 1049 (Pubitemid 44835130)
3. A. Burashnikov, J.M. Di Diego, A.C. Zygmunt, L. Belardinelli, C. Antzelevitch Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine Circulation 116 2007 1449 1457 (Pubitemid 47480635)
4. A. Burashnikov, J.M. Di Diego, S. Sicouri Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation Heart Rhythm 5 2008 1735 1742
5. A. Burashnikov, C. Antzelevitch Atrial-selective sodium channel block for the treatment of atrial fibrillation Expert Opin Emerg Drugs 14 2009 233 249
6. A. Burashnikov, A.C. Zygmunt, J.M. Di Diego AZD1305 exerts atrial-predominant electrophysiological actions and is effective in suppressing atrial fibrillation and preventing its re-induction in the dog J Cardiovasc Pharmacol 56 2010 80 90
7. A. Burashnikov, C. Antzelevitch New development in atrial antiarrhythmic drug therapy Nat Rev Cardiol 7 2010 139 148
8. A. Burashnikov, S. Sicouri, J.M. Di Diego, L. Belardinelli, C. Antzelevitch Synergistic effect of the combination of dronedarone and ranolazine to suppress atrial fibrillation J Am Coll Cardiol 56 2010 1216 1224
9. K. Kumar, B.D. Nearing, M. Carvas Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart J Cardiovasc Electrophysiol 20 2009 796 802
10. C. Antzelevitch, A. Burashnikov Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation J Electrocardiol 42 2009 543 548
11. D. Hu, S. Viskin, A. Oliva Novel mutation in the SCN5A gene associated with arrhythmic storm development during acute myocardial infarction Heart Rhythm 4 2007 1072 1080 (Pubitemid 47163734)
12. Zygmunt AC, Nesterenko VV, Rajamani S, et al. Mechanisms of atrial-selective block of sodium channel by ranolazine I. Experimental analysis of the use-dependent block. Am J Physiol Heart Circ Physiol. In press.
13. A. Burashnikov, C. Antzelevitch Role of repolarization restitution in the development of coarse and fine atrial fibrillation in the isolated canine right atria J Cardiovasc Electrophysiol 16 2005 639 645 (Pubitemid 40807656)
14. + current similar to Kv1.5 cloned channel currents Circ Res 73 1993 1061 1076 (Pubitemid 23340202)
15. Kur promote atrial fibrillation? Heart Rhythm 5 2008 1304 1309
16. U. Ravens, E. Wettwer Ultra-rapid delayed rectifier channels: molecular basis and therapeutic implications Cardiovasc Res 89 2011 843 851
17. S.V. Pandit, S. Zlochiver, D. Filgueiras-Rama Targeting atrio-ventricular differences in ion channel properties for terminating acute atrial fibrillation in pigs Cardiovasc Res 89 2011 843 851
18. S. Sicouri, A. Glass, L. Belardinelli, C. Antzelevitch Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations Heart Rhythm 5 2008 1019 1026
19. S. Sicouri, L. Belardinelli, L. Carlsson, C. Antzelevitch Potent antiarrhythmic effects of chronic amiodarone in canine pulmonary vein sleeve preparations J Cardiovasc Electrophysiol 20 2009 803 810
20. A. Burashnikov, C. Antzelevitch Atrial-selective sodium channel blockers: do they exist? J Cardiovasc Pharmacol 52 2008 121 128
21. P. Zimetbaum Amiodarone for atrial fibrillation N Engl J Med 356 2007 935 941
22. D.K. Murdock, M. Kersten, J. Kaliebe, G. Larrian The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: a reveiw of experience with implications for possible "pill in the pocket" approach to atrial fibrillation Indian Pacing Electrophysiol J 9 2009 260 267
23. R.H. Miles, D.K. Murdock Ranolazine verses amiodarone for prophylaxis against atrial fibrillation following coronary artery bypass surgery Heart Rhythm 7 2010 S258
24. D.K. Murdock, J.A. Reiffel, J. Kaliebe, G. Larrian The conversion of paroxysmal or initial onset atrial fibrillation with oral ranolazine: implications for a new "pill-in-pocket" approach in structural heart disease J Atr Fibrillation 2 2010 705 710
25. J.C. Geller, K. Egstrup, P. Kulakowski Rapid conversion of persistent atrial fibrillation to sinus rhythm by intravenous AZD7009 J Clin Pharmacol 49 2009 312 322
26. S. Sicouri, A. Burashnikov, L. Belardinelli, C. Antzelevitch Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria Circ Arrhythm Electrophysiol 3 2010 88 95
27. Y.W. Liu, J.H. Guo, P. Zhang, C. Li The effects of nardostachys chinensis beta 1 extract on the sodium current and transient outward potassium current of rat ventricular myocytes Chin J Cardiac Paceing Electrophysiol 23 2009 533 535
28. Q.Z. Tang Effect of Nardostachys chinensis Batal extract on sodium and L-type calcium channels of rabbit ventricular myocytes Chin J Cardiol 32 2004 267 270
29. Q.Z. Tang The effect of NcBe from Buchangwenxin on potassium channels in single rabbit ventricular myocytes Chin Physician Tribune 9 2008 56 57
30. X.X. Sun, Y.P. Lan, F. Liu Granules: its effects on the electrophysiological characteristics of left ventricle with acute myocardial ischemia J Shaanxi Coll Trad Chin Med 30 2007 51 53
31. S.Y. Huang, S.R. Xie, C.Y. Huang, P. Leng Antiarrhythmic effect of Saponine of leaf Panax Notoginseng J Dalian Univ 22 2001 82 84