-
2
-
-
28244477646
-
Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at Rizzoli Institute, Italy
-
Bacci G, Longhi A, Fagioli F, et al. Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at Rizzoli Institute, Italy. Eur J Cancer 2005; 41: 2836-45.
-
(2005)
Eur J Cancer
, vol.41
, pp. 2836-2845
-
-
Bacci, G.1
Longhi, A.2
Fagioli, F.3
-
4
-
-
0028061444
-
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region
-
Moi P, Chan K, Asunis I, et al. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci USA 1994; 91: 9926-30.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9926-9930
-
-
Moi, P.1
Chan, K.2
Asunis, I.3
-
5
-
-
59849113546
-
Molecular mechanisms of Nrf2-mediated antioxidant response
-
Li W, Kong AN. Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog 2009; 48: 91-104.
-
(2009)
Mol Carcinog
, vol.48
, pp. 91-104
-
-
Li, W.1
Kong, A.N.2
-
7
-
-
77649272110
-
A systems biology perspective on Nrf2- mediated antioxidant response
-
Zhang Q, Pi J, Woods CG, et al. A systems biology perspective on Nrf2- mediated antioxidant response. Toxicol Appl Pharmacol 2010; 244: 84-97.
-
(2010)
Toxicol Appl Pharmacol
, vol.244
, pp. 84-97
-
-
Zhang, Q.1
Pi, J.2
Woods, C.G.3
-
8
-
-
0036007313
-
Role of NRF2 in protection against hyperoxic lung injury in mice
-
Cho HY, Jedlicka AE, Reddy SP, et al. Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol 2002; 26: 175- 82.
-
(2002)
Am J Respir Cell Mol Biol
, vol.26
, pp. 175-182
-
-
Cho, H.Y.1
Jedlicka, A.E.2
Reddy, S.P.3
-
9
-
-
77951199503
-
The protective role of Nrf2 in streptozotocininduced diabetic nephropathy
-
Jiang T, Huang Z, Lin Y, et al. The protective role of Nrf2 in streptozotocininduced diabetic nephropathy. Diabetes 2010; 59: 850-60.
-
(2010)
Diabetes
, vol.59
, pp. 850-860
-
-
Jiang, T.1
Huang, Z.2
Lin, Y.3
-
10
-
-
33847050801
-
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
-
Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 2007; 47: 89-116.
-
(2007)
Annu Rev Pharmacol Toxicol
, vol.47
, pp. 89-116
-
-
Kensler, T.W.1
Wakabayashi, N.2
Biswal, S.3
-
11
-
-
22344438250
-
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
-
Rangasamy T, Guo J, Mitzner WA, et al. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med 2005; 202: 47-59.
-
(2005)
J Exp Med
, vol.202
, pp. 47-59
-
-
Rangasamy, T.1
Guo, J.2
Mitzner, W.A.3
-
12
-
-
27844612530
-
Nrf2 as a target for cancer chemoprevention
-
Yu X, Kensler T. Nrf2 as a target for cancer chemoprevention. Mutat Res 2005; 591: 93-102.
-
(2005)
Mutat Res
, vol.591
, pp. 93-102
-
-
Yu, X.1
Kensler, T.2
-
13
-
-
4644328941
-
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
-
Iida K, Itoh K, Kumagai Y, et al. Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res 2004; 64: 6424-31.
-
(2004)
Cancer Res
, vol.64
, pp. 6424-6431
-
-
Iida, K.1
Itoh, K.2
Kumagai, Y.3
-
14
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the aminoterminal Neh2 domain
-
Itoh K, Wakabayashi N, Katoh Y, et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the aminoterminal Neh2 domain. Genes Dev 1999; 13: 76-86.
-
(1999)
Genes Dev
, vol.13
, pp. 76-86
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
-
15
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
Kobayashi A, Kang MI, Okawa H, et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 2004; 24: 7130-9.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7130-7139
-
-
Kobayashi, A.1
Kang, M.I.2
Okawa, H.3
-
17
-
-
46949099638
-
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
-
Wang XJ, Sun Z, Villeneuve NF, et al. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis 2008; 29: 1235-43.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1235-1243
-
-
Wang, X.J.1
Sun, Z.2
Villeneuve, N.F.3
-
18
-
-
33748255958
-
Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas
-
Stacy DR, Ely K, Massion PP, et al. Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas. Head Neck 2006; 28: 813-8.
-
(2006)
Head Neck
, vol.28
, pp. 813-818
-
-
Stacy, D.R.1
Ely, K.2
Massion, P.P.3
-
19
-
-
51649130168
-
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
-
Shibata T, Ohta T, Tong KI, et al. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc Natl Acad Sci USA 2008; 105: 13568-73.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 13568-13573
-
-
Shibata, T.1
Ohta, T.2
Tong, K.I.3
-
20
-
-
53049105119
-
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
-
Shibata T, Kokubu A, Gotoh M, et al. Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology 2008; 135: 1358-68.
-
(2008)
Gastroenterology
, vol.135
, pp. 1358-1368
-
-
Shibata, T.1
Kokubu, A.2
Gotoh, M.3
-
21
-
-
77954351631
-
High levels of Nrf2 determine chemoresistance in type II endometrial cancer
-
Jiang T, Chen N, Zhao F, et al. High levels of Nrf2 determine chemoresistance in type II endometrial cancer. Cancer Res 2010; 70: 5486-96.
-
(2010)
Cancer Res
, vol.70
, pp. 5486-5496
-
-
Jiang, T.1
Chen, N.2
Zhao, F.3
-
22
-
-
76649089973
-
Loss of Kelch-like ECHassociated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth
-
Zhang P, Singh A, Yegnasubramanian S, et al. Loss of Kelch-like ECHassociated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth. Mol Cancer Ther 2010; 9: 336-46.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 336-346
-
-
Zhang, P.1
Singh, A.2
Yegnasubramanian, S.3
-
23
-
-
76749106638
-
Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
-
Kim YR, Oh JE, Kim MS, et al. Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin. J Pathol 2010; 220: 446-51.
-
(2010)
J Pathol
, vol.220
, pp. 446-451
-
-
Kim, Y.R.1
Oh, J.E.2
Kim, M.S.3
-
24
-
-
34548577395
-
A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity
-
Nioi P, Nguyen T. A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity. Biochem Biophys Res Commun 2007; 362: 816-21.
-
(2007)
Biochem Biophys Res Commun
, vol.362
, pp. 816-821
-
-
Nioi, P.1
Nguyen, T.2
-
25
-
-
33344456501
-
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
-
Padmanabhan B, Tong KI, Ohta T, et al. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell 2006; 21: 689-700.
-
(2006)
Mol Cell
, vol.21
, pp. 689-700
-
-
Padmanabhan, B.1
Tong, K.I.2
Ohta, T.3
-
26
-
-
33750885385
-
Dysfunctional KEAP1- NRF2 interaction in non-small-cell lung cancer
-
Singh A, Misra V, Thimmulappa RK, et al. Dysfunctional KEAP1- NRF2 interaction in non-small-cell lung cancer. PLoS Med 2006; 3: e420.
-
(2006)
PLoS Med
, vol.3
-
-
Singh, A.1
Misra, V.2
Thimmulappa, R.K.3
-
27
-
-
38149003106
-
Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to cancer cell resistance
-
Cho JM, Manandhar S, Lee HR, et al. Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: implication to cancer cell resistance. Cancer Lett 2008; 260: 96-108.
-
(2008)
Cancer Lett
, vol.260
, pp. 96-108
-
-
Cho, J.M.1
Manandhar, S.2
Lee, H.R.3
-
28
-
-
78049370987
-
Oxidative stress, inflammation, and cancer: How are they linked?
-
Reuter S, Gupta SC, Chaturvedi MM, et al. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med 2010; 49: 1603-16.
-
(2010)
Free Radic Biol Med
, vol.49
, pp. 1603-1616
-
-
Reuter, S.1
Gupta, S.C.2
Chaturvedi, M.M.3
-
29
-
-
54249087596
-
RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy
-
Singh A, Boldin-Adamsky S, Thimmulappa RK, et al. RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res 2008; 68: 7975-84.
-
(2008)
Cancer Res
, vol.68
, pp. 7975-7984
-
-
Singh, A.1
Boldin-Adamsky, S.2
Thimmulappa, R.K.3
-
30
-
-
0020609447
-
Determination of the degree of morphological regression following chemotherapy in malignant bone tumors. (German.)
-
Salzer-Kuntschik M, Brand G, Delling G. Determination of the degree of morphological regression following chemotherapy in malignant bone tumors. (German.). Pathologe 1983; 4: 135-41.
-
(1983)
Pathologe
, vol.4
, pp. 135-141
-
-
Salzer-Kuntschik, M.1
Brand, G.2
Delling, G.3
-
31
-
-
15244356847
-
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
-
Rangasamy T, Cho CY, Thimmulappa RK, et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 2004; 114: 1248-59.
-
(2004)
J Clin Invest
, vol.114
, pp. 1248-1259
-
-
Rangasamy, T.1
Cho, C.Y.2
Thimmulappa, R.K.3
-
32
-
-
0037106099
-
Identification of Nrf2- regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
-
Thimmulappa RK, Mai KH, Srisuma S, et al. Identification of Nrf2- regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 2002; 62: 5196-203.
-
(2002)
Cancer Res
, vol.62
, pp. 5196-5203
-
-
Thimmulappa, R.K.1
Mai, K.H.2
Srisuma, S.3
-
33
-
-
0242329881
-
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
-
Wakabayashi N, Itoh K, Wakabayashi J, et al. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet 2003; 35: 238-45.
-
(2003)
Nat Genet
, vol.35
, pp. 238-245
-
-
Wakabayashi, N.1
Itoh, K.2
Wakabayashi, J.3
-
34
-
-
77958113395
-
Correlation of Nrf2, HO-1, and MRP3 in gallbladder cancer and their relationships to clinicopathologic features and survival
-
Wang J, Zhang M, Zhang L, et al. Correlation of Nrf2, HO-1, and MRP3 in gallbladder cancer and their relationships to clinicopathologic features and survival. J Surg Res 2010; 164: e99-105.
-
(2010)
J Surg Res
, vol.164
-
-
Wang, J.1
Zhang, M.2
Zhang, L.3
-
35
-
-
79959614990
-
The role of NF-E2-related factor 2 in predicting chemoresistance and prognosis in advanced non-small-cell lung cancer
-
Yang H, Wang W, Zhang Y, et al. The role of NF-E2-related factor 2 in predicting chemoresistance and prognosis in advanced non-small-cell lung cancer. Clin Lung Cancer 2011; 12: 166-71.
-
(2011)
Clin Lung Cancer
, vol.12
, pp. 166-171
-
-
Yang, H.1
Wang, W.2
Zhang, Y.3
-
36
-
-
79960958309
-
Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer
-
Konstantinopoulos PA, Spentzos D, Fountzilas E, et al. Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer. Cancer Res 2011; 71: 5081-9.
-
(2011)
Cancer Res
, vol.71
, pp. 5081-5089
-
-
Konstantinopoulos, P.A.1
Spentzos, D.2
Fountzilas, E.3
-
37
-
-
1942530423
-
Conventional osteosarcoma
-
Fletcher CDM, Unni KK, Mertens F, editors. Lyon: IARC Press
-
Raymond AK, Ayala AG, Knuutila S. Conventional osteosarcoma. In: Fletcher CDM, Unni KK, Mertens F, editors.World Health Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press, 2002; 264-270.
-
(2002)
World Health Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone
, pp. 264-270
-
-
Raymond, A.K.1
Ayala, A.G.2
Knuutila, S.3
-
38
-
-
0142013132
-
Telangiectatic osteosarcoma
-
Fletcher CDM, Unni KK, Mertens F, editors. Lyon: IARC Press
-
Matsuno T, Okada K, Knuutila S. Telangiectatic osteosarcoma. In: Fletcher CDM, Unni KK, Mertens F, editors. World Health Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press, 2002; 271-272.
-
(2002)
World Health Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone
, pp. 271-272
-
-
Matsuno, T.1
Okada, K.2
Knuutila, S.3
-
39
-
-
75649151996
-
Prognostic factors in the survival of patients diagnosed with primary non-metastatic osteosarcoma with a poor response to neoadjuvant chemotherapy
-
Bispo RZ Jr, Camargo OP. Prognostic factors in the survival of patients diagnosed with primary non-metastatic osteosarcoma with a poor response to neoadjuvant chemotherapy. Clinics (Sao Paulo) 2009; 64: 1177-86.
-
(2009)
Clinics (Sao Paulo)
, vol.64
, pp. 1177-1186
-
-
Bispo Jr., R.Z.1
Camargo, O.P.2
-
40
-
-
2442478364
-
Antisense RNA down-regulation of bcl-2 expression in DU145 prostate cancer cells does not diminish the cytostatic effects of G3139 (Oblimersen)
-
Raffo A, Lai JC, Stein CA, et al. Antisense RNA down-regulation of bcl-2 expression in DU145 prostate cancer cells does not diminish the cytostatic effects of G3139 (Oblimersen). Clin Cancer Res 2004; 10: 3195-206.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3195-3206
-
-
Raffo, A.1
Lai, J.C.2
Stein, C.A.3
-
41
-
-
66149168685
-
Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer
-
Homma S, Ishii Y, Morishima Y, et al. Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res 2009; 15: 3423-32.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3423-3432
-
-
Homma, S.1
Ishii, Y.2
Morishima, Y.3
|