Inherent sex-dependent regulation of human hepatic CYP3A5

British Journal of Pharmacology

Volumn 168, Issue 4, 2013, Pages 988-1000

  Thangavel, Chellappagounder ^a,b   Boopathi, Ettickan ^a   Shapiro, Bernard H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

dexamethasone; growth hormone; hepatocyte nuclear factor; human CYP3A5; pregnane X receptor; retinoic X receptor; sexual dimorphorism

Indexed keywords

CYTOCHROME P450 3A5; DEXAMETHASONE; GROWTH HORMONE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; PREGNANE X RECEPTOR; RETINOID X RECEPTOR ALPHA; SMALL INTERFERING RNA;

ARTICLE; CELL STRAIN HEPG2; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME REGULATION; FEMALE; GENDER; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL; MALE; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN MOTIF; SEX DIFFERENCE; SOUTHERN BLOTTING; WESTERN BLOTTING;

ADULT; CYTOCHROME P-450 CYP3A; DEXAMETHASONE; DRUG SYNERGISM; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GROWTH HORMONE; HEP G2 CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; HUMANS; MALE; MIDDLE AGED; RECEPTORS, STEROID; RETINOID X RECEPTOR ALPHA; RNA, SMALL INTERFERING; SEX CHARACTERISTICS; YOUNG ADULT;

EID: 84872909732     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02222.x     Document Type: Article

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