메뉴 건너뛰기




Volumn 23, Issue 1, 2008, Pages 59-66

Involvement of hepatocyte nuclear factor 4alpha in transcriptional regulation of the human pregnane x receptor gene in the human liver

Author keywords

Hepatocyte nuclear factor 4alpha (HNF4a); Human liver; Nuclear receptor; Pregnane X receptor (PXR); Transcriptional regulation

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; PREGNANE X RECEPTOR; SMALL INTERFERING RNA; HEPATOCYTE NUCLEAR FACTOR 4; STEROID RECEPTOR;

EID: 42249098584     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.23.59     Document Type: Article
Times cited : (20)

References (33)
  • 3
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • Lehmann, J. M., McKee, D. D., Watson, M. A., Willson, T. M., Moore, J. T. and Kliewer, S. A.: The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J. Clin. Invest., 102: 1016-1023 (1998).
    • (1998) J. Clin. Invest , vol.102 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3    Willson, T.M.4    Moore, J.T.5    Kliewer, S.A.6
  • 4
    • 0032702726 scopus 로고    scopus 로고
    • The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
    • Goodwin, B., Hodgson, E. and Liddle, C.: The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol. Pharmacol., 56: 1329-1339 (1999).
    • (1999) Mol. Pharmacol , vol.56 , pp. 1329-1339
    • Goodwin, B.1    Hodgson, E.2    Liddle, C.3
  • 5
    • 0034874393 scopus 로고    scopus 로고
    • Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor
    • Goodwin, B., Moore, L. B., Stoltz, C. M., McKee, D. D. and Kliewer, S. A.: Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor. Mol. Pharmacol., 60: 427-431 (2001).
    • (2001) Mol. Pharmacol , vol.60 , pp. 427-431
    • Goodwin, B.1    Moore, L.B.2    Stoltz, C.M.3    McKee, D.D.4    Kliewer, S.A.5
  • 6
    • 1642498178 scopus 로고    scopus 로고
    • Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor
    • Chen, Y., Ferguson, S. S., Negishi, M. and Goldstein, J. A.: Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J. Pharmacol. Exp. Ther., 308: 495-501 (2004).
    • (2004) J. Pharmacol. Exp. Ther , vol.308 , pp. 495-501
    • Chen, Y.1    Ferguson, S.S.2    Negishi, M.3    Goldstein, J.A.4
  • 7
    • 1042287037 scopus 로고    scopus 로고
    • The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics
    • Sugatani, J., Yamakawa, K., Tonda, E., Nishitani, S., Yoshinari, K., Degawa, M., Abe, I., Noguchi, H. and Miwa, M.: The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics. Biochem. Pharmacol., 67: 989-1000 (2004).
    • (2004) Biochem. Pharmacol , vol.67 , pp. 989-1000
    • Sugatani, J.1    Yamakawa, K.2    Tonda, E.3    Nishitani, S.4    Yoshinari, K.5    Degawa, M.6    Abe, I.7    Noguchi, H.8    Miwa, M.9
  • 8
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    • Geick, A., Eichelbaum, M. and Burk, O.: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J. Biol. Chem., 276: 14581-14587 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 9
    • 0037169551 scopus 로고    scopus 로고
    • Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
    • Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C. M., Tontonoz, P., Kliewer, S., Willson, T. M. and Edwards, P. A.: Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J. Biol. Chem., 277: 2908-2915 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 2908-2915
    • Kast, H.R.1    Goodwin, B.2    Tarr, P.T.3    Jones, S.A.4    Anisfeld, A.M.5    Stoltz, C.M.6    Tontonoz, P.7    Kliewer, S.8    Willson, T.M.9    Edwards, P.A.10
  • 10
    • 0033931266 scopus 로고    scopus 로고
    • Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor activators
    • Pascussi, J. M., Drocourt, L., Fabre, J. M., Maurel, P. and Vilarem, M. J.: Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol. Pharmacol., 58: 361-372 (2000).
    • (2000) Mol. Pharmacol , vol.58 , pp. 361-372
    • Pascussi, J.M.1    Drocourt, L.2    Fabre, J.M.3    Maurel, P.4    Vilarem, M.J.5
  • 11
    • 29944432134 scopus 로고    scopus 로고
    • Transcriptional regulation of the PXR gene: Identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR
    • Aouabdi, S., Gibson, G. and Plant, N.: Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR. Drug Metab. Dispos., 34: 138-144 (2006).
    • (2006) Drug Metab. Dispos , vol.34 , pp. 138-144
    • Aouabdi, S.1    Gibson, G.2    Plant, N.3
  • 12
    • 0025690311 scopus 로고
    • Liverenriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily
    • Sladek, F. M., Zhong, W. M., Lai, E. and Darnell, J. E. Jr.: Liverenriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev., 4: 2353-2365 (1990).
    • (1990) Genes Dev , vol.4 , pp. 2353-2365
    • Sladek, F.M.1    Zhong, W.M.2    Lai, E.3    Darnell Jr., J.E.4
  • 13
    • 0027662208 scopus 로고
    • Orphan receptor HNF-4 and liver-specific gene expression
    • Sladek, F. M.: Orphan receptor HNF-4 and liver-specific gene expression. Receptor, 3:223-232 (1993).
    • (1993) Receptor , vol.3 , pp. 223-232
    • Sladek, F.M.1
  • 14
    • 0038482452 scopus 로고    scopus 로고
    • Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development
    • Kamiya, A., Inoue, Y. and Gonzalez, F. J.: Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development. Hepatology, 37: 1375-1384 (2003).
    • (2003) Hepatology , vol.37 , pp. 1375-1384
    • Kamiya, A.1    Inoue, Y.2    Gonzalez, F.J.3
  • 16
    • 0032807743 scopus 로고    scopus 로고
    • The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue
    • Dotzlaw, H., Leygue, E., Watson, P. and Murphy, L. C.: The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue. Clin. Cancer Res., 5: 2103-2107 (1999).
    • (1999) Clin. Cancer Res , vol.5 , pp. 2103-2107
    • Dotzlaw, H.1    Leygue, E.2    Watson, P.3    Murphy, L.C.4
  • 18
    • 20044378331 scopus 로고    scopus 로고
    • 5′ Diversity of human hepatic PXR (NR1I2) transcripts and identification of the major transcription initiation site
    • Kurose, K., Koyano, S., Ikeda, S., Tohkin, M., Hasegawa, R. and Sawada, J.: 5′ Diversity of human hepatic PXR (NR1I2) transcripts and identification of the major transcription initiation site. Mol. Cell Biochem., 273: 79-85 (2005).
    • (2005) Mol. Cell Biochem , vol.273 , pp. 79-85
    • Kurose, K.1    Koyano, S.2    Ikeda, S.3    Tohkin, M.4    Hasegawa, R.5    Sawada, J.6
  • 19
    • 85047682066 scopus 로고    scopus 로고
    • NUBIScan, an in silico approach for prediction of nuclear receptor response elements
    • Podvinec, M., Kaufmann, M. R., Handschin, C. and Meyer, U. A.: NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Mol. Endocrinol., 16: 1269-1279 (2002).
    • (2002) Mol. Endocrinol , vol.16 , pp. 1269-1279
    • Podvinec, M.1    Kaufmann, M.R.2    Handschin, C.3    Meyer, U.A.4
  • 20
    • 9444219646 scopus 로고    scopus 로고
    • Synergistic role of specificity proteins and upstream stimulatory factor 1 in transactivation of the mouse carboxylesterase 2/microsomal acylcarnitine hydrolase gene promoter
    • Furihata, T., Hosokawa, M., Satoh, T. and Chiba, K.: Synergistic role of specificity proteins and upstream stimulatory factor 1 in transactivation of the mouse carboxylesterase 2/microsomal acylcarnitine hydrolase gene promoter. Biochem. J., 384: 101-110 (2004).
    • (2004) Biochem. J , vol.384 , pp. 101-110
    • Furihata, T.1    Hosokawa, M.2    Satoh, T.3    Chiba, K.4
  • 21
    • 33646779923 scopus 로고    scopus 로고
    • Involvement of hepatocyte nuclear factor 4alpha in the different expression level between CYP2C9 and CYP2C19 in the human liver
    • Kawashima, S., Kobayashi, K., Takama, K., Higuchi, T., Furihata, T., Hosokawa, M. and Chiba, K.: Involvement of hepatocyte nuclear factor 4alpha in the different expression level between CYP2C9 and CYP2C19 in the human liver. Drug Metab. Dispos., 34: 1012-1018 (2006).
    • (2006) Drug Metab. Dispos , vol.34 , pp. 1012-1018
    • Kawashima, S.1    Kobayashi, K.2    Takama, K.3    Higuchi, T.4    Furihata, T.5    Hosokawa, M.6    Chiba, K.7
  • 22
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A. and Speleman, F.: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol., 3: 1-12 (2002).
    • (2002) Genome Biol , vol.3 , pp. 1-12
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 23
    • 27144468030 scopus 로고    scopus 로고
    • Reliable gene expression measurements from degraded RNA by quantitative real-time PCR depend on short amplicons and a proper normalization
    • Antonov, J., Goldstein, D. R., Oberli, A., Baltzer, A., Pirotta, M., Fleischmann, A., Altermatt, H. J. and Jaggi. R.: Reliable gene expression measurements from degraded RNA by quantitative real-time PCR depend on short amplicons and a proper normalization. Lab. Invest., 85: 1040-1050 (2005).
    • (2005) Lab. Invest , vol.85 , pp. 1040-1050
    • Antonov, J.1    Goldstein, D.R.2    Oberli, A.3    Baltzer, A.4    Pirotta, M.5    Fleischmann, A.6    Altermatt, H.J.7    Jaggi, R.8
  • 25
    • 33644950650 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver
    • Furihata, T., Hosokawa, M., Masuda, M., Satoh, T. and Chiba, K.: Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver. Arch. Biochem. Biophys., 447: 107-117 (2006).
    • (2006) Arch. Biochem. Biophys , vol.447 , pp. 107-117
    • Furihata, T.1    Hosokawa, M.2    Masuda, M.3    Satoh, T.4    Chiba, K.5
  • 27
    • 0029865801 scopus 로고    scopus 로고
    • TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4
    • Malik, S. and Karathanasis, S. K. TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4. Mol. Cell Biol., 16: 1824-1831 (1996).
    • (1996) Mol. Cell Biol , vol.16 , pp. 1824-1831
    • Malik, S.1    Karathanasis, S.K.2
  • 28
    • 0029035904 scopus 로고
    • Transcriptional regulation of human CYP2C genes: Functional comparison of CYP2C9 and CYP2C18 promoter regions
    • Ibeanu, G. C. and Goldstein, J. A.: Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions. Biochemistry, 34: 8028-8036 (1995).
    • (1995) Biochemistry , vol.34 , pp. 8028-8036
    • Ibeanu, G.C.1    Goldstein, J.A.2
  • 29
    • 0029816947 scopus 로고    scopus 로고
    • Characterization of the human cytochrome P4502D6 promoter
    • Cairns, W., Smith, C. A. D., McLaren, A.W. and Wolf, C. R.: Characterization of the human cytochrome P4502D6 promoter. J. Biol. Chem., 271: 25269-25276 (1996).
    • (1996) J. Biol. Chem , vol.271 , pp. 25269-25276
    • Cairns, W.1    Smith, C.A.D.2    McLaren, A.W.3    Wolf, C.R.4
  • 30
    • 23944510035 scopus 로고    scopus 로고
    • The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter
    • Chen, Y., Kissling, G., Negishi, M. and Goldstein, J. A.: The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter. J. Pharmacol. Exp. Ther., 314: 1125-1133 (2005).
    • (2005) J. Pharmacol. Exp. Ther , vol.314 , pp. 1125-1133
    • Chen, Y.1    Kissling, G.2    Negishi, M.3    Goldstein, J.A.4
  • 32
    • 0030042979 scopus 로고    scopus 로고
    • Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes
    • Drewes, T., Senkel, S., Holewa, B. and Ryffel, G. U.: Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. Mol. Cell Biol., 16: 925-931 (1996).
    • (1996) Mol. Cell Biol , vol.16 , pp. 925-931
    • Drewes, T.1    Senkel, S.2    Holewa, B.3    Ryffel, G.U.4
  • 33
    • 34848824067 scopus 로고    scopus 로고
    • Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA
    • Kamiyama, Y., Matsubara, T., Yoshinari, K., Nagata, K., Kamimura, H. and Yamazoe, Y.: Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA. Drug Metab. Pharmacokinet., 22: 287-298 (2007).
    • (2007) Drug Metab. Pharmacokinet , vol.22 , pp. 287-298
    • Kamiyama, Y.1    Matsubara, T.2    Yoshinari, K.3    Nagata, K.4    Kamimura, H.5    Yamazoe, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.