Effect of soy protein and isoflavones on blood pressure and endothelial cytokines: A 6-month randomized controlled trial among postmenopausal women

Journal of Hypertension

Volumn 31, Issue 2, 2013, Pages 384-392

  Liu, Zhao Min ^a   Ho, Suzanne C ^a   Chen, Yu Ming ^b   Woo, Jean ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

adhesion molecules; blood pressure; isoflavones; soy protein

Indexed keywords

CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; ISOFLAVONE DERIVATIVE; MILK PROTEIN; SOYBEAN PROTEIN;

ADULT; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL FUNCTION; CHINESE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ENDOTHELIUM; FEMALE; HUMAN; HYPERGLYCEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MOLECULE; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PHYSICAL ACTIVITY; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION;

EID: 84872874053     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32835c0905     Document Type: Article

References (39)

1. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42:1206-1252.
2. Arnoldi A, editor. Isoflavones and coronary heart disease. In Functional foods, cardiovascular disease and diabetes. Cambridge: Woodhead Publishing Ltd.; 2004.
3. Nestel P. Isoflavones: their effects on cardiovascular risk and functions. Curr Opin Lipidol 2003; 14:3-8; Epub 2003/01/25. doi: 10.1097/01.mol.0000052844.26236.9c.
4. Valsecchi AE, Franchi S, Panerai AE, Rossi A, Sacerdote P, Colleoni M. The soy isoflavone genistein reverses oxidative and inflammatory state, neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model. Eur J Pharmacol 650:694-702.
5. Li J, Xie ZZ, Tang YB. Genistein prevents myocardial hypertrophy in 2-kidney 1-clip renal hypertensive rats by restoring eNOS pathway. Pharmacology 86:240-248.
6. Je HD, Sohn UD. Inhibitory effect of genistein on agonist-induced modulation of vascular contractility. Mol Cells 2009; 27:191-198.
7. Wu J, Ding X. Hypotensive and physiological effect of angiotensin converting enzyme inhibitory peptides derived from soy protein on spontaneously hypertensive rats. J Agric Food Chem 2001; 49:501-506.
8. Yang G, Shu XO, Jin F, Zhang X, Li HL, Li Q, et al. Longitudinal study of soy food intake and blood pressure among middle-aged and elderly Chinese women. Am J Clin Nutr 2005; 81:1012-1017.
9. Nagata C, Shimizu H, Takami R, Hayashi M, Takeda N, Yasuda K. Association of blood pressure with intake of soy products and other food groups in Japanese men and women. Prev Med 2003; 36:692-697.
10. Kokubo Y, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S. Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I. Circulation 2007; 116:2553-2562.
11. Cuevas AM, Irribarra VL, Castillo OA, Yantez MD, Germain AM. Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women. Eur J Clin Nutr 57:889-894.
12. Welty FK, Lee KS, Lew NS, Zhou JR. Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women. Arch Intern Med 2007; 167:1060-1067.
13. Nasca MM, Zhou JR, Welty FK. Effect of soy nuts on adhesion molecules and markers of inflammation in hypertensive and normotensive postmenopausal women. Am J Cardiol 2008; 102: 84-86.
14. Rivas M, Garay RP, Escanero JF, Cia P Jr, Cia P, Alda JO. Soy milk lowers blood pressure in men and women with mild to moderate essential hypertension. J Nutr 2002; 132:1900-1902.
15. He J, Gu D, Wu X, Chen J, Duan X, Chen J, et al. Effect of soybean protein on blood pressure: a randomized, controlled trial. Ann Intern Med 2005; 143:1-9.
16. Puska P, Korpelainen V, Hoie LH, Skovlund E, Smerud KT. Isolated soya protein with standardised levels of isoflavones, cotyledon soya fibres and soya phospholipids improves plasma lipids in hypercholesterolaemia: a double-blind, placebo-controlled trial of a yoghurt formulation. Br J Nutr 2004; 91:393-401.
17. Kreijkamp-Kaspers S, Kok L, Bots ML, Grobbee DE, Lampe JW, Van Der Schouw YT. Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women. Am J Clin Nutr 2005; 81:189-195.
18. Androulakis E, Tousoulis D, Papageorgiou N, Latsios G, Siasos G, Tsioufis C, et al. Inflammation in hypertension: current therapeutic approaches. Curr Pharmaceut Design 2011; 17:4121-4131.
19. Pate M, Damarla V, Chi DS, Negi S, Krishnaswamy G. Endothelial cell biology: role in the inflammatory response. Adv Clin Chem 2010; 52:109-130.
20. Rajtar-Ciosek A, Huras H, Krzysiek J, Reron A, Wilczak M, Jach R. Beneficial influence of postmenopausal estrogen therapy on serum adhesion molecules is independent of the route and dose of administration. Neuroendocrinol Lett 2011; 32:340-344.
21. Chacko BK, Chandler RT, Mundhekar A, Khoo N, Pruitt HM, Kucik DF, et al. Revealing anti-inflammatory mechanisms of soy isoflavones by flow: modulation of leukocyte-endothelial cell interactions. Am J Physiol Heart Circ Physiol 2005; 289:H908-H915.
22. May MJ, Wheeler-Jones CP, Pearson JD. Effects of protein tyrosine kinase inhibitors on cytokine-induced adhesion molecule expression by human umbilical vein endothelial cells. Br J Pharmacol 1996; 118:1761-1771.
23. Andrade CM, Sa MF, Toloi MR. Effects of phytoestrogens derived from soy bean on expression of adhesion molecules on HUVEC. Climacteric J Int Menopause Soc 2012; 15:186-194.
24. Liu ZM, Chen YM, Ho SC, Ho YP, Woo J. Effects of soy protein and isoflavones on glycemic control and insulin sensitivity: a 6-mo double-blind, randomized, placebo-controlled trial in postmenopausal Chinese women with prediabetes or untreated early diabetes. Am J Clin Nutr 2010; 91:1394-1401.
25. Liu XX, Li SH, Chen JZ, Sun K, Wang XJ, Wang XG, et al. Effect of soy isoflavones on blood pressure: A meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis 2012; 22:463-470.
26. Morgan TO, Anderson AI, MacInnis RJ. ACE inhibitors, beta-blockers, calcium blockers, and diuretics for the control of systolic hypertension. Am J Hypertens 2001; 14:241-247.
27. Whelton PK, He J, Appel LJ, Cutler JA, Havas S, Kotchen TA, et al. Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education Program. JAMA 2002; 288:1882-1888.
28. Beavers KM, Jonnalagadda SS, Messina MJ. Soy consumption, adhesion molecules, and pro-inflammatory cytokines: a brief review of the literature. Nutr Rev 2009; 67:213-221.
29. Atteritano M, Marini H, Minutoli L, Polito F, Bitto A, Altavilla D, et al. Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2007; 92:3068-3075.
30. Colacurci N, Chiantera A, Fornaro F, de Novellis V, Manzella D, Arciello A, et al. Effects of soy isoflavones on endothelial function in healthy postmenopausal women. Menopause 2005; 12:299-307.
31. Azadbakht L, Kimiagar M, Mehrabi Y, Esmaillzadeh A, Hu FB, Willett WC. Soy consumption, markers of inflammation, and endothelial function: a cross-over study in postmenopausal women with the metabolic syndrome. Diabetes Care 2007; 30:967-973.
32. Nikander E, Metsa-Heikkila M, Tiitinen A, Ylikorkala O. Evidence of a lack of effect of a phytoestrogen regimen on the levels of C-reactive protein, E-selectin, and nitrate in postmenopausal women. J Clin Endocrinol Metab 2003; 88:5180-5185.
33. Hall WL, Vafeiadou K, Hallund J, Bugel S, Koebnick C, Reimann M, et al. Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production. Am J Clin Nutr 2005; 82:1260-1268; quiz 365-6.
34. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329:2002-2012.
35. Iritani N, Sugimoto T, Fukuda H, Komiya M, Ikeda H. Dietary soybean protein increases insulin receptor gene expression in Wistar fatty rats when dietary polyunsaturated fatty acid level is low. J Nutr 1997; 127:1077-1083.
36. Ferrannini E, Buzzigoli G, Bonadonna R, Giorico MA, Oleggini M, Graziadei L, et al. Insulin resistance in essential hypertension. N Engl J Med 1987; 317:350-357.
37. Cederroth CR, Nef S. Soy, phytoestrogens and metabolism: a review. Mol Cell Endocrinol 2009; 304:30-42.
38. Miura K, Dyer AR, Greenland P, Daviglus ML, Hill M, Liu K, et al. Pulse pressure compared with other blood pressure indexes in the prediction of 25-year cardiovascular and all-cause mortality rates: The Chicago Heart Association Detection Project in Industry Study. Hypertension 2001; 38:232-237.
39. Muthyala RS, Ju YH, Sheng S, Williams LD, Doerge DR, Katzenellenbogen BS, et al. Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R-and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem 2004; 12:1559-1567.