Inhibitory effect of genistein on agonist-induced modulation of vascular contractility

Molecules and Cells

Volumn 27, Issue 2, 2009, Pages 191-198

  Je, Hyun Dong ^a   Sohn, Uy Dong ^b  

^a Catholic University of Daegu   (South Korea)

^b Chung Ang University   (South Korea)

Author keywords

Ca2+ activated K+ channels; Fluoride; MYPT1; Rho kinase; Thromboxane A2 mimetic; Tyrosine kinase; Vasodilation

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; DAIDZEIN; FLUORIDE; GENISTEIN; IBERIOTOXIN; MYOSIN LIGHT CHAIN PHOSPHATASE; MYOSIN LIGHT CHAIN PHOSPHATASE 1; PHENYLEPHRINE; PHORBOL ESTER; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; THREONINE; THROMBOXANE A2; UNCLASSIFIED DRUG; CALCIUM ACTIVATED POTASSIUM CHANNEL; CARCINOGEN; CARDIOTONIC AGENT; FLUORIDE SODIUM; ISOFLAVONE DERIVATIVE; PEPTIDE; PHOSPHOPROTEIN PHOSPHATASE 1; PHYTOESTROGEN; POTASSIUM CHANNEL BLOCKING AGENT; PPP1R12A PROTEIN, RAT; TOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM; MALE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SMOOTH MUSCLE CONTRACTILITY; VASCULAR SMOOTH MUSCLE; VASODILATATION; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; MUSCLE CONTRACTION; PHOSPHORYLATION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; AORTA; BLOTTING, WESTERN; CARCINOGENS; CARDIOTONIC AGENTS; GENISTEIN; ISOFLAVONES; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; PEPTIDES; PHENYLEPHRINE; PHORBOL ESTERS; PHOSPHORYLATION; PHYTOESTROGENS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; POTASSIUM CHLORIDE; PROTEIN PHOSPHATASE 1; RATS; RATS, SPRAGUE-DAWLEY; RHOA GTP-BINDING PROTEIN; SODIUM FLUORIDE; THROMBOXANE A2; TOXINS, BIOLOGICAL;

EID: 66149126071     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10059-009-0052-9     Document Type: Article

References (56)

1. T. Akiyama J. Ishida S. Nakagawa H. Ogawara S. Watanabe N. Itoh M. Shibuya Y. Fukami 1987 Genistein, a specific inhibitor of tyrosine-specific protein kinases J. Biol. Chem. 262 5592 5595 3106339 1:CAS:528: DyaL2sXktF2rurk%3D
2. J.W. Anderson B.W. Johnstone M.E. Cook-Newell 1995 Meta-analysis of the effects of soy protein intake on serum lipids N. Engl. J. Med. 333 276 282 7596371 10.1056/NEJM199508033330502 1:CAS:528:DyaK2MXntlKht74%3D
3. M. Amano M. Ito K. Kimura Y. Fukata K. Chihara T. Nakano Y. Matsuura K. Kaibuchi 1996 Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase) J. Biol. Chem. 271 20246 20249 8702756 10.1074/jbc.271.34.20246 1:CAS:528:DyaK28Xlt1ygt7Y%3D (Pubitemid 26281788)
4. M.S. Anthony 2002 Phytoestrogens and cardiovascular disease: Where's the meat? Arterioscler. Thromb. Vasc. Bio. 22 1245 1247 10.1161/01.ATV.0000027188. 24963.EA 1:CAS:528:DC%2BD38Xmt12jtbc%3D (Pubitemid 34875729)
5. J. Bigay P. Deterre C. Pfister M. Chabre 1985 Fluoroaluminates activate transducin-GDP by mimicking the gamma-phosphate of GTP in its binding site FEBS Lett. 191 181 185 3863758 10.1016/0014-5793(85)80004-1 1:CAS:528: DyaL2MXmtV2htrg%3D (Pubitemid 16230666)
6. P.F. Blackmore J.H. Exton 1986 Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate J. Biol. Chem. 261 11056 11063 2426266 1:CAS:528: DyaL28Xlt1Oqt7w%3D
7. T.G. Cachero A.D. Morielli E.G. Peralta 1998 The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel Cell 93 1077 1085 9635436 10.1016/S0092-8674(00)81212-X 1:CAS:528:DyaK1cXjvFKqsbo%3D (Pubitemid 28280800)
8. M. Chabre 1990 Aluminofluoride and beryllofluoride complexes: a new phosphate analogs in enzymology Trends Biochem. Sci. 15 6 10 2180149 10.1016/0968-0004(90)90117-T 1:CAS:528:DyaK3cXhslCnsbk%3D
9. S. Cockeroft J.A. Taylor 1987 Fluoroalurninates mimic guanosine 5′-[gamma-thio]triphosphate in activating the polyphosphoinositide phosphodiesterase of hepatocyte membranes. Role for the guanine nucleotide regulatory protein Gp in signal transduction Biochem. J. 241 409 414
10. M.J. Davis X. Wu T.R. Nurkiewicz J. Kawasaki P. Gui M.A. Hill E. Wilson 2001 Regulation of ion channels by protein tyrosine phosphorylation Am. J. Physiol. 281 H1835 H1862 1:CAS:528:DC%2BD3MXosFyls7w%3D
11. K.B. Delclos T.J. Bucci L.G. Lomax J.R. Latendresse A. Warbritton C.C. Weis R.R. Newbold 2001 Effects of dietary genistein exposure during development on male and female CD (Sprague-Dawley) rats Reprod Toxicol 15 647 663 11738518 10.1016/S0890-6238(01)00177-0 1:CAS:528:DC%2BD3MXovVChu7Y%3D (Pubitemid 34002939)
12. 2+-independent smooth muscle contraction: a novel function for integrin-linked kinase J. Biol. Chem. 276 16365 16373 11278951 10.1074/jbc.M011634200 1:CAS:528:DC%2BD3MXjvFakurY%3D
13. G. Edwards A. Weston 1995 Pharmacology of the potassium channel openers Cardiovasc. Drugs Ther. 9 185 193 7647022 10.1007/BF00878465
14. H.M. Finn A.J. Ridley 1996 Rho stimulates tyrosine phosphorylation of focal adhesion kinase p130 and paxillin J. Cell. Sci. 109 1133 1141
15. A.G. Gilman 1984 Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase J. Clin. Invest. 73 1 4 6140270 10.1172/JCI111179 1:CAS:528:DyaL2cXps1Ortg%3D%3D
16. C.Y. Hsieh R.C. Santell S.Z. Haslam W.G. Helferich 1998 Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo Cancer Res. 58 3833 3838 9731492 1:CAS:528:DyaK1cXlvVyru74%3D
17. J.M. Hodgson K.D. Croft L.B. Puddey T.A. Mori L.J. Beilin 1996 Soybean isoflavonoids and their metabolic products inhibit in vitro lipoprotein oxidation in serum J. Nutr. Biochem. 7 664 669 10.1016/S0955-2863(96)00133-7 1:CAS:528:DyaK28XnsFajsLk%3D (Pubitemid 27019422)
18. S.B. Jeon F. Jin J.I. Kim S.H. Kim K. Suk S.C. Chae J.E. Jun W.H. Park I.K. Kim 2006 A role for Rho kinase in vascular contraction evoked by sodium fluoride Biochem. Biophys. Res. Commun. 343 27 33 16527249 10.1016/j.bbrc.2006. 02.120 1:CAS:528:DC%2BD28XivVOjs7s%3D
19. S.V. Jones 2003 Role of the small GTPase Rho in modulation of the inwardly rectifying potassium channel Kir2.1 Mol. Pharmacol. 64 987 993 14500755 10.1124/mol.64.4.987 1:CAS:528:DC%2BD3sXnslGru7Y%3D (Pubitemid 37153067)
20. Y. Kanaho J. Moss M. Vaughan 1985 Mechanism of inhibition of transducin GTPase activity by fluoride and aluminum J. Biol. Chem. 260 11493 11497 2995338 1:CAS:528:DyaL2MXlsFKgsLg%3D (Pubitemid 16252143)
21. T. Kitazawa M. Masuo A.P. Somlyo 1991 Proteinmediated inhibition of myosin light-chain phosphatase in vascular smooth muscle Proc. Natl. Acad. Sci. USA 88 9307 9310 1656467 10.1073/pnas.88.20.9307 1:CAS:528:DyaK3MXmsFaqsL4%3D
22. G.G. Kuiper J.G. Lemmen B. Carlsson J.C. Corton S.H. Safe P.T. Van der Saag B. Van der Burg J.A. Gustafsson 1998 Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta Endocrinology 139 4252 4263 9751507 10.1210/en.139.10.4252 1:CAS:528:DyaK1cXmsVGmsrw%3D
23. V. Kyselova J. Peknicova M. Boubelik D. Buckiova 2004 Body and organ weight, sperm acrosomal status and reproduction after genistein and diethylstilbestrol treatment of CD1 mice in a multigenerational study Theriogenology 61 1307 1325 15036965 10.1016/j.theriogenology.2003.07.017 1:CAS:528:DC%2BD2cXhsVOmtbY%3D (Pubitemid 38300344)
24. C.Y. Liu M. Sturek 1996 Attenuation of endothelin-1-induced calcium response by tyrosine kinase inhibitors in vascular smooth muscle cells Am. J. Physiol. 270 C1825 C1833 8764168 1:CAS:528:DyaK28Xktlagu78%3D
25. 2+ stores in vascular smooth muscles Can. J. Physiol. Pharmacol. 74 298 304 8773410 10.1139/cjpp-74-3-298 1:CAS:528:DyaK28XjsVKhsLc%3D (Pubitemid 26227502)
26. K.D. Luykenaar S.E. Brett B.N. Wu W.B. Wiehler D.G. Welsh 2004 Pyrimidine nucleotides suppress KDR currents and depolarize rat cerebral arteries by activating Rho kinase Am. J. Phyiol. Heart Circ. Physiol. 286 H1088 H1100 10.1152/ajpheart.00903.2003 1:CAS:528:DC%2BD2cXitlShsbg%3D
27. P.M. Martin K.B. Horwitz D.S. Ryan W.L. McGuire 1978 Phytoestrogen interaction with estrogen receptors in human breast cancer cells Endocrinology 103 1860 1867 570914 1:CAS:528:DyaE1MXkvVOrtw%3D%3D 10.1210/endo-103-5-1860
28. J.H. Mitchell A.R. Collins 1999 Effects of a soymilk supplement on plasma cholesterol levels and oxidative DNA damage in men-a pilot study Eur. J. Nutr. 38 143 148 10443336 10.1007/s003940050055 1:CAS:528:DyaK1MXkvVClsL8%3D (Pubitemid 29352530)
29. A. Muranyi J.A. MacDonald J.T. Deng D.P. Wilson T.A. Haystead M.P. Wlash F. Erdodi E. Kiss Y. Wu D.J. Hartshorne 2002 Phosphorylation of the myosin phosphatase target subunitby integrin-linked kinase Biochem. J. 366 211 216 12030846 1:CAS:528:DC%2BD3sXptFOht7k%3D
30. R.A. Murphy 1982 Myosin phosphorylation and crossbridge regulation in arterial smooth muscle Hypertension 4 3 7 6279505 1:CAS:528:DyaL38XktF2is7g%3D
31. 2+ sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway Circ. Res. 91 953 960 12433841 10.1161/01.RES.0000042702.04920.BF 1:CAS:528:DC%2BD38XosFWnsrk%3D (Pubitemid 35373596)
32. M.T. Nelson J.M. Quayle 1995 Physiological roles and properties of potassium channels in arterial smooth muscle Am. J. Physiol. 268 799 822
33. 2+ Circ. Res. 88 1283 1290 11420305 10.1161/hh1201.092035 1:CAS:528:DC%2BD3MXltFCgsL4%3D
34. C.D. Nobes P. Hawkins L. Stephens A. Hall 1995 Activation of the small GTP-binding proteins rho and rac by growth factor receptors J. Cell Sci. 108 225 233 7738099 1:CAS:528:DyaK2MXjsFens7w%3D
35. M. Noda C. Yasuda-Fukazawa K. Moriishi T. Kato T. Okuda K. Kurokawa Y. Takuwa 1995 Involvement of rho in GTP gamma S-induced enhancement of phosphorylation of 20 kDa myosin light chain in vascular smooth muscle cells: inhibition of phosphatase activity FEBS Lett. 367 246 250 7607316 10.1016/0014-5793(95)00573-R 1:CAS:528:DyaK2MXntFags74%3D
36. G. Pfitzer 2001 Invited reviews: regulation of myosin light chain phosphorylation in smooth muscle J. Appl. Physiol. 91 497 503 11408468 1:CAS:528:DC%2BD3MXltFWgu7Y%3D
37. T.R. Räthel J.F. Leikert A.M. Vollmar V.M. Dirsch 2005 The soy isoflavone genistein induces a late but sustained activation of the endothelial nitric oxide-synthase system in vitro Brit. J. Pharmacol. 144 394 399 10.1038/sj.bjp.0706075 1:CAS:528:DC%2BD2MXhtVGmsL8%3D (Pubitemid 40313686)
38. F.M. Sacks A. Lichtenstein L. Van Horn W. Harris P. Kris-Etherton M. Winston 2006 Soy protein, isoflavones, and cardiovascular health: an American heart association science advisory for professionals from the nutrition committee Circulation 113 1034 1044 16418439 10.1161/CIRCULATIONAHA.106.171052 1:CAS:528:DC%2BD28XhtlGktLY%3D (Pubitemid 43879479)
39. 2+-dependent activation of Rho and Rho-kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction Circ. Res. 93 548 556 12919947 10.1161/01.RES.0000090998.08629.60 1:CAS:528:DC%2BD3sXntFCmt7g%3D (Pubitemid 37163235)
40. S. Shenolikar A.C. Nairn 1991 Protein phosphatases: recent progress Adv. Second Messenger Phosphoprotein Res. 23 1 121 1847640 1:STN:280: DyaK3M7ksVyqtQ%3D%3D
41. M. Shimizu I.B. Weinstein 2005 Modulation of signal transduction by tea cathechins and related phytochemicals Mutat. Res. 591 147 160 15992833 1:CAS:528:DC%2BD2MXht1Gnu7%2FP
42. A.P. Somlyo A.V. Somlyo 1994 Signal transduction and regulation in smooth muscle Nature 372 231 236 7969467 10.1038/372231a0 1:CAS:528:DyaK2MXit1Oqs7g%3D (Pubitemid 24352442)
43. A.P. Somlyo A.V. Somlyo 1998 From pharmacomechanical coupling to G-proteins and myosin phosphatase Acta. Physiol. Scand. 164 437 448 9887967 10.1046/j.1365-201X.1998.00454.x 1:CAS:528:DyaK1MXltFCitA%3D%3D (Pubitemid 29015663)
44. A.P. Somlyo A.V. Somlyo 2000 Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II J. Physiol. 522 177 185 10639096 10.1111/j.1469-7793.2000.t01-2-00177.x 1:CAS:528:DC%2BD3cXht12ns7s%3D
45. N.M. Storey J.P. O'Bryan D.L. Armstrong 2002 Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channels Curr. Biol. 12 27 33 11790300 10.1016/S0960-9822(01)00625-X 1:CAS:528: DC%2BD38Xpt1akug%3D%3D (Pubitemid 34063350)
46. F. Squadrito D. Altavilla N. Morabito A. Crisafulli R. D'Anna F. Corrado P. Ruggeri G. M. Campo G. Calapai A.P. Caputi G. Squadrito 2002 The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women Atherosclerosis 163 339 347 12052481 10.1016/S0021-9150(02)00013-8 1:CAS:528:DC%2BD38XktFOntr4%3D (Pubitemid 34615825)
47. K. Tasaki M. Hori H. Ozaki H. Karaki I. Wakabayashi 2003 Difference in signal transduction mechanisms involved in 5-hydroxytryptamine- and U46619-induced vasoconstrictions J. Smooth. Muscle Res. 39 107 117 14695024 10.1540/jsmr.39.107 1:CAS:528:DC%2BD2cXit1GhtA%3D%3D (Pubitemid 38017639)
48. M.H. Tsai M.J. Jiang 2006 Rho-kinase-mediated regulation of receptor-agonist-stimulated smooth muscle contraction Pflugers Arch. 453 223 232 16953424 10.1007/s00424-006-0133-y 1:CAS:528:DC%2BD28XhtFWnsrjE (Pubitemid 44630456)
49. M. Uehata T. Ishizaki H. Satoh T. Ono T. Kawahara T. Morishita H. Tamakawa K. Yamagami J. Inui M. Maekawa 1997 Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension Nature 389 990 994 9353125 10.1038/40187 1:CAS:528:DyaK2sXntVarsbY%3D (Pubitemid 27485693)
50. J. Wang I.E. Eltoum C.A. Lamartiniere 2004 Genistein alters growth factor signaling in transgenic prostate model (TRAMP) Mol. Cell. Endocrinol. 219 171 180 15149738 10.1016/j.mce.2003.12.018 1:CAS:528:DC%2BD2cXktVCmurc%3D (Pubitemid 38638530)
51. S.W. Watts C.H. Yeum G. Campbell R.C. Webb 1996 Serotonin stimulates protein tyrosyl phosphorylation and vascular contraction via tyrosine kinase J. Vasc. Res. 33 288 298 8695753 10.1159/000159156 1:CAS:528:DyaK28XlsVSmsrc%3D
52. W.G. Wier K.G. Morgan 2003 α1-Adrenergic signaling mechanisms in contraction of resistance arteries Rev. Physiol. Biochem. Pharmacol. 150 91 139 12884052 10.1007/s10254-003-0019-8 1:CAS:528:DC%2BD2cXjs1Wmsb0%3D
53. 2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697 Biochem. J. 389 763 774 15823093 10.1042/BJ20050237 1:CAS:528: DC%2BD2MXmsFCitLY%3D (Pubitemid 41121989)
54. A.B. Wisniewski S.L. Klein Y. Lakshmanan J.P. Gearhart 2003 Exposure to genistein during gestation and lactation demasculinizes the reproductive system in rats J. Urol. 169 1582 1586 12629420 10.1097/01.ju.0000046780.23389.e0 1:CAS:528:DC%2BD3sXhvFahsb4%3D (Pubitemid 36323849)
55. A.A. Wooldridge J.A. MacDonald F. Erdodi C. Ma M.A. Borman D.J. Hartshorne T.A. Haystead 2004 Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides J. Biol. Chem. 279 34496 34504 15194681 10.1074/jbc.M405957200 1:CAS:528:DC%2BD2cXmvFenurk%3D (Pubitemid 39318077)
56. Y.Y. Zeng C.G. Benishin P.K. Pang 1989 Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. I. Studies with fluoride J. Pharmacol. Exp. Ther. 250 343 351 2473190 1:CAS:528:DyaL1MXkvFCgt7g%3D