메뉴 건너뛰기




Volumn 116, Issue 2, 2013, Pages 463-472

CB1 and CB2 cannabinoid receptor agonists induce peripheral antinociception by activation of the endogenous noradrenergic system

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ANANDAMIDE; GUANETHIDINE; PALMIDROL; PRAZOSIN; PROPRANOLOL; PROSTAGLANDIN E2; RAUWOLSCINE; YOHIMBINE;

EID: 84872842122     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3182707859     Document Type: Article
Times cited : (56)

References (75)
  • 1
    • 0029890878 scopus 로고    scopus 로고
    • Contribution of peripheral alpha 1A-adrenoceptors to pain induced by formalin or by alphamethyl-5-hydroxytryptamine plus noradrenaline
    • Hong Y, Abbott FV. Contribution of peripheral alpha 1A-adrenoceptors to pain induced by formalin or by alphamethyl-5-hydroxytryptamine plus noradrenaline. Eur J Pharmacol 1996;301:41-8
    • (1996) Eur J Pharmacol , vol.301 , pp. 41-48
    • Hong, Y.1    Abbott, F.V.2
  • 2
    • 0033105552 scopus 로고    scopus 로고
    • Expression of alpha2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation
    • Birder LA, Perl ER. Expression of alpha2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation. J Physiol (Lond) 1999;515 (Pt 2):533-42
    • (1999) J Physiol (Lond) , vol.515 , Issue.PART. 2 , pp. 533-542
    • Birder, L.A.1    Perl, E.R.2
  • 4
    • 67449113523 scopus 로고    scopus 로고
    • Dual regulation of heat-activated K+ channel in rat DRG neurons via alpha(1) and beta adrenergic receptors
    • Yamamoto S, Kanno T, Yamada K, Yasuda Y, Nishizaki T. Dual regulation of heat-activated K+ channel in rat DRG neurons via alpha(1) and beta adrenergic receptors. Life Sci 2009;85:167-71
    • (2009) Life Sci , vol.85 , pp. 167-171
    • Yamamoto, S.1    Kanno, T.2    Yamada, K.3    Yasuda, Y.4    Nishizaki, T.5
  • 5
    • 63149143193 scopus 로고    scopus 로고
    • Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine
    • Romero TR, de Castro Perez A, de Francischi JN, Gama Duarte ID. Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine. Eur J Pharmacol 2009;608:23-7
    • (2009) Eur J Pharmacol , vol.608 , pp. 23-27
    • Romero, T.R.1    De Castro Perez, A.2    De Francischi, J.N.3    Gama Duarte, I.D.4
  • 6
    • 65949085163 scopus 로고    scopus 로고
    • Alpha(2)-Adrenoceptor agonist xylazine induces peripheral antinociceptive effect by activation of the L-arginine/nitric oxide/cyclic GMP pathway in rat
    • Romero TR, Duarte ID. Alpha(2)-Adrenoceptor agonist xylazine induces peripheral antinociceptive effect by activation of the L-arginine/nitric oxide/cyclic GMP pathway in rat. Eur J Pharmacol 2009;613:64-7
    • (2009) Eur J Pharmacol , vol.613 , pp. 64-67
    • Romero, T.R.1    Duarte, I.D.2
  • 7
    • 74849136148 scopus 로고    scopus 로고
    • Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by the alpha(2)-adrenoceptor agonist xylazine
    • Romero TR, Duarte ID. Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by the alpha(2)-adrenoceptor agonist xylazine. J Pharmacol Sci 2009;111:323-7
    • (2009) J Pharmacol Sci , vol.111 , pp. 323-327
    • Romero, T.R.1    Duarte, I.D.2
  • 10
  • 11
    • 3142708596 scopus 로고    scopus 로고
    • Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue
    • Binder W, Mousa SA, Sitte N, Kaiser M, Stein C, Schäfer M. Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue. Eur J Neurosci 2004;20:92-100
    • (2004) Eur J Neurosci , vol.20 , pp. 92-100
    • Binder, W.1    Mousa, S.A.2    Sitte, N.3    Kaiser, M.4    Stein, C.5    Schäfer, M.6
  • 13
    • 18844419446 scopus 로고    scopus 로고
    • Effects of cannabinoids on neurotransmission
    • Szabo B, Schlicker E. Effects of cannabinoids on neurotransmission. Handb Exp Pharmacol 2005;168:327-65
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 327-365
    • Szabo, B.1    Schlicker, E.2
  • 14
    • 0029786614 scopus 로고    scopus 로고
    • Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nerves
    • Ishac EJ, Jiang L, Lake KD, Varga K, Abood ME, Kunos G. Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nerves. Br J Pharmacol 1996;118:2023-8
    • (1996) Br J Pharmacol , vol.118 , pp. 2023-2028
    • Ishac, E.J.1    Jiang, L.2    Lake, K.D.3    Varga, K.4    Abood, M.E.5    Kunos, G.6
  • 15
    • 0038796906 scopus 로고    scopus 로고
    • The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression
    • Niederhoffer N, Schmid K, Szabo B. The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression. Naunyn Schmiedebergs Arch Pharmacol 2003;367:434-43
    • (2003) Naunyn Schmiedebergs Arch Pharmacol , vol.367 , pp. 434-443
    • Niederhoffer, N.1    Schmid, K.2    Szabo, B.3
  • 16
    • 34247133978 scopus 로고    scopus 로고
    • Raised tone reveals purinergic-mediated responses to sympathetic nerve stimulation in the rat perfused mesenteric vascular bed
    • Pakdeechote P, Rummery NM, Ralevic V, Dunn WR. Raised tone reveals purinergic-mediated responses to sympathetic nerve stimulation in the rat perfused mesenteric vascular bed. Eur J Pharmacol 2007;563:180-6
    • (2007) Eur J Pharmacol , vol.563 , pp. 180-186
    • Pakdeechote, P.1    Rummery, N.M.2    Ralevic, V.3    Dunn, W.R.4
  • 17
    • 38049026711 scopus 로고    scopus 로고
    • Local administration of a cannabinoid agonist alters norepinephrine efflux in the rat frontal cortex
    • Page ME, Oropeza VC, Van Bockstaele EJ. Local administration of a cannabinoid agonist alters norepinephrine efflux in the rat frontal cortex. Neurosci Lett 2008;431:1-5
    • (2008) Neurosci Lett , vol.431 , pp. 1-5
    • Page, M.E.1    Oropeza, V.C.2    Van Bockstaele, E.J.3
  • 18
    • 20144378367 scopus 로고    scopus 로고
    • Systemic administration of WIN 55,212-2 increases norepinephrine release in the rat frontal cortex
    • Oropeza VC, Page ME, Van Bockstaele EJ. Systemic administration of WIN 55,212-2 increases norepinephrine release in the rat frontal cortex. Brain Res 2005;1046:45-54
    • (2005) Brain Res , vol.1046 , pp. 45-54
    • Oropeza, V.C.1    Page, M.E.2    Van Bockstaele, E.J.3
  • 19
    • 0023694787 scopus 로고
    • Characteristics of antinociception induced by noncatecholic phenylethylamine derivatives: The relation of endogenous norepinephrine to phenylethylamine analog-induced antinociception
    • Matsuoka Y, Sakuma M, Sugioka T, Terawaki Y, Uruno T, Kubota K. Characteristics of antinociception induced by noncatecholic phenylethylamine derivatives: the relation of endogenous norepinephrine to phenylethylamine analog-induced antinociception. Jpn J Pharmacol 1988;48:263-72
    • (1988) Jpn J Pharmacol , vol.48 , pp. 263-272
    • Matsuoka, Y.1    Sakuma, M.2    Sugioka, T.3    Terawaki, Y.4    Uruno, T.5    Kubota, K.6
  • 20
    • 0025934332 scopus 로고
    • Cannabinoid-induced antinociception is mediated by a spinal alpha 2-noradrenergic mechanism
    • Lichtman AH, Martin BR. Cannabinoid-induced antinociception is mediated by a spinal alpha 2-noradrenergic mechanism. Brain Res 1991;559:309-14
    • (1991) Brain Res , vol.559 , pp. 309-314
    • Lichtman, A.H.1    Martin, B.R.2
  • 21
    • 0041324602 scopus 로고    scopus 로고
    • Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test
    • Yoon MH, Choi JI. Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test. Anesthesiology 2003;99:701-7
    • (2003) Anesthesiology , vol.99 , pp. 701-707
    • Yoon, M.H.1    Choi, J.I.2
  • 22
    • 0021966740 scopus 로고
    • Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing
    • Yaksh TL. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol Biochem Behav 1985;22:845-58
    • (1985) Pharmacol Biochem Behav , vol.22 , pp. 845-858
    • Yaksh, T.L.1
  • 23
    • 0033555286 scopus 로고    scopus 로고
    • Transmitters involved in antinociception in the spinal cord
    • Fürst S. Transmitters involved in antinociception in the spinal cord. Brain Res Bull 1999;48:129-41
    • (1999) Brain Res Bull , vol.48 , pp. 129-141
    • Fürst, S.1
  • 25
    • 79953276634 scopus 로고    scopus 로고
    • Endogenous cannabinoid receptor agonist anandamide induces peripheral antinociception by activation of ATP-sensitive K+ channels
    • Reis GM, Ramos MA, Pacheco Dda F, Klein A, Perez AC, Duarte ID. Endogenous cannabinoid receptor agonist anandamide induces peripheral antinociception by activation of ATP-sensitive K+ channels. Life Sci 2011;88:653-7
    • (2011) Life Sci , vol.88 , pp. 653-657
    • Reis, G.M.1    Ramos, M.A.2    Pacheco Dda, F.3    Klein, A.4    Perez, A.C.5    Duarte, I.D.6
  • 26
    • 84958295215 scopus 로고
    • A comparison of heat and pressure analgesiometric methods in rats
    • Green AF, Young PA. A comparison of heat and pressure analgesiometric methods in rats. Br J Pharmacol Chemother 1951;6:572-85
    • (1951) Br J Pharmacol Chemother , vol.6 , pp. 572-585
    • Green, A.F.1    Young, P.A.2
  • 27
    • 84960959252 scopus 로고
    • A method for measurement of analgesic activity on inflamed tissue
    • Randall LO, Selitto JJ. A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn Ther 1957;111:409-19
    • (1957) Arch Int Pharmacodyn Ther , vol.111 , pp. 409-419
    • Randall, L.O.1    Selitto, J.J.2
  • 28
    • 0023124730 scopus 로고
    • A peripheral sympathetic component in inflammatory hyperalgesia
    • Nakamura M, Ferreira SH. A peripheral sympathetic component in inflammatory hyperalgesia. Eur J Pharmacol 1987;135:145-53
    • (1987) Eur J Pharmacol , vol.135 , pp. 145-153
    • Nakamura, M.1    Ferreira, S.H.2
  • 29
    • 0041570182 scopus 로고    scopus 로고
    • Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat
    • Helyes Z, Németh J, Thán M, Bölcskei K, Pintér E, Szolcsányi J. Inhibitory effect of anandamide on resiniferatoxin- induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat. Life Sci 2003;73:2345-53
    • (2003) Life Sci , vol.73 , pp. 2345-2353
    • Helyes, Z.1    Németh, J.2    Thán, M.3    Bölcskei, K.4    Pintér, E.5    Szolcsányi, J.6
  • 30
    • 0033538561 scopus 로고    scopus 로고
    • Discovery and characterization of endogenous cannabinoids
    • Martin BR, Mechoulam R, Razdan RK. Discovery and characterization of endogenous cannabinoids. Life Sci 1999;65:573-95
    • (1999) Life Sci , vol.65 , pp. 573-595
    • Martin, B.R.1    Mechoulam, R.2    Razdan, R.K.3
  • 32
    • 0032537734 scopus 로고    scopus 로고
    • Control of pain initiation by endogenous cannabinoids
    • Calignano A, La Rana G, Giuffrida A, Piomelli D. Control of pain initiation by endogenous cannabinoids. Nature 1998;394:277-81
    • (1998) Nature , vol.394 , pp. 277-281
    • Calignano, A.1    La Rana, G.2    Giuffrida, A.3    Piomelli, D.4
  • 33
    • 0342762087 scopus 로고    scopus 로고
    • The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain
    • Herzberg U, Eliav E, Bennett GJ, Kopin IJ. The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain. Neurosci Lett 1997;221:157-60
    • (1997) Neurosci Lett , vol.221 , pp. 157-160
    • Herzberg, U.1    Eliav, E.2    Bennett, G.J.3    Kopin, I.J.4
  • 35
    • 33746621595 scopus 로고    scopus 로고
    • The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin
    • Patwardhan AM, Jeske NA, Price TJ, Gamper N, Akopian AN, Hargreaves KM. The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proc Natl Acad Sci USA 2006;103:11393-8
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11393-11398
    • Patwardhan, A.M.1    Jeske, N.A.2    Price, T.J.3    Gamper, N.4    Akopian, A.N.5    Hargreaves, K.M.6
  • 37
    • 0036221971 scopus 로고    scopus 로고
    • CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain
    • Clayton N, Marshall FH, Bountra C, O'Shaughnessy CT. CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Pain 2002;96:253-60
    • (2002) Pain , vol.96 , pp. 253-260
    • Clayton, N.1    Marshall, F.H.2    Bountra, C.3    O'shaughnessy, C.T.4
  • 38
    • 0038521050 scopus 로고    scopus 로고
    • Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation
    • Nackley AG, Makriyannis A, Hohmann AG. Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. Neuroscience 2003;119:747-57
    • (2003) Neuroscience , vol.119 , pp. 747-757
    • Nackley, A.G.1    Makriyannis, A.2    Hohmann, A.G.3
  • 39
    • 69049084382 scopus 로고    scopus 로고
    • Opioid receptor and NO/cGMP pathway as a mechanism of peripheral antinociceptive action of the cannabinoid receptor agonist anandamide
    • Reis GM, Pacheco D, Perez AC, Klein A, Ramos MA, Duarte ID. Opioid receptor and NO/cGMP pathway as a mechanism of peripheral antinociceptive action of the cannabinoid receptor agonist anandamide. Life Sci 2009;85:351-6
    • (2009) Life Sci , vol.85 , pp. 351-356
    • Reis, G.M.1    Pacheco, D.2    Perez, A.C.3    Klein, A.4    Ramos, M.A.5    Duarte, I.D.6
  • 41
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990;346:561-4
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 42
    • 33846378110 scopus 로고    scopus 로고
    • Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: Potential use in companion animals
    • Re G, Barbero R, Miolo A, Di Marzo V. Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. Vet J 2007;173:21-30
    • (2007) Vet J , vol.173 , pp. 21-30
    • Re, G.1    Barbero, R.2    Miolo, A.3    Di Marzo, V.4
  • 43
    • 0035843772 scopus 로고    scopus 로고
    • Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide
    • Calignano A, La Rana G, Piomelli D. Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur J Pharmacol 2001;419:191-8
    • (2001) Eur J Pharmacol , vol.419 , pp. 191-198
    • Calignano, A.1    La Rana, G.2    Piomelli, D.3
  • 44
    • 33144480327 scopus 로고    scopus 로고
    • Cannabinoid receptors as therapeutic targets
    • Mackie K. Cannabinoid receptors as therapeutic targets. Annu Rev Pharmacol Toxicol 2006;46:101-22
    • (2006) Annu Rev Pharmacol Toxicol , vol.46 , pp. 101-122
    • MacKie, K.1
  • 45
    • 53349089891 scopus 로고    scopus 로고
    • The endogenous fatty acid amide, palmitoylethanolamide, has antiallodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: Involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors
    • Costa B, Comelli F, Bettoni I, Colleoni M, Giagnoni G. The endogenous fatty acid amide, palmitoylethanolamide, has antiallodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors. Pain 2008;139:541-50
    • (2008) Pain , vol.139 , pp. 541-550
    • Costa, B.1    Comelli, F.2    Bettoni, I.3    Colleoni, M.4    Giagnoni, G.5
  • 46
    • 0033586332 scopus 로고    scopus 로고
    • Pre-and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord
    • Hohmann AG, Briley EM, Herkenham M. Pre-and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord. Brain Res 1999;822:17-25
    • (1999) Brain Res , vol.822 , pp. 17-25
    • Hohmann, A.G.1    Briley, E.M.2    Herkenham, M.3
  • 47
    • 0034638450 scopus 로고    scopus 로고
    • Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons
    • Ahluwalia J, Urban L, Capogna M, Bevan S, Nagy I. Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons. Neuroscience 2000;100:685-8
    • (2000) Neuroscience , vol.100 , pp. 685-688
    • Ahluwalia, J.1    Urban, L.2    Capogna, M.3    Bevan, S.4    Nagy, I.5
  • 48
    • 0035116496 scopus 로고    scopus 로고
    • Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens
    • Ross RA, Gibson TM, Brockie HC, Leslie M, Pashmi G, Craib SJ, Di Marzo V, Pertwee RG. Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. Br J Pharmacol 2001;132:631-40
    • (2001) Br J Pharmacol , vol.132 , pp. 631-640
    • Ross, R.A.1    Gibson, T.M.2    Brockie, H.C.3    Leslie, M.4    Pashmi, G.5    Craib, S.J.6    Di Marzo, V.7    Pertwee, R.G.8
  • 49
    • 84872865398 scopus 로고    scopus 로고
    • 2-Adrenergic receptor subtypes in rat dorsal root and superior cervical ganglion neurons
    • Gold MS, Dastmalchi S, Levine JD. 2-Adrenergic receptor subtypes in rat dorsal root and superior cervical ganglion neurons. Pain 1997;691:79-90
    • (1997) Pain , vol.691 , pp. 79-90
    • Gold, M.S.1    Dastmalchi, S.2    Levine, J.D.3
  • 50
    • 0033967452 scopus 로고    scopus 로고
    • Distribution and regulation of alpha(2)-adrenoceptors in rat dorsal root ganglia
    • Shi TS, Winzer-Serhan U, Leslie F, Hökfelt T. Distribution and regulation of alpha(2)-adrenoceptors in rat dorsal root ganglia. Pain 2000;84:319-30
    • (2000) Pain , vol.84 , pp. 319-330
    • Shi, T.S.1    Winzer-Serhan, U.2    Leslie, F.3    Hökfelt, T.4
  • 51
    • 0028932390 scopus 로고
    • Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat
    • Khasar SG, Green PG, Chou B, Levine JD. Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat. Neuroscience 1995;66:427-32
    • (1995) Neuroscience , vol.66 , pp. 427-432
    • Khasar, S.G.1    Green, P.G.2    Chou, B.3    Levine, J.D.4
  • 52
    • 0025204495 scopus 로고
    • Expression of three alpha 2-adrenergic receptor subtypes in rat tissues: Implications for alpha 2 receptor classification
    • Lorenz W, Lomasney JW, Collins S, Regan JW, Caron MG, Lefkowitz RJ. Expression of three alpha 2-adrenergic receptor subtypes in rat tissues: implications for alpha 2 receptor classification. Mol Pharmacol 1990;38:599-603
    • (1990) Mol Pharmacol , vol.38 , pp. 599-603
    • Lorenz, W.1    Lomasney, J.W.2    Collins, S.3    Regan, J.W.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 53
    • 0026743218 scopus 로고
    • The effect of intrathecally administered imiloxan and WB4101: Possible role of alpha 2-adrenoceptor subtypes in the spinal cord
    • Takano Y, Takano M, Yaksh TL. The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord. Eur J Pharmacol 1992;219:465-8
    • (1992) Eur J Pharmacol , vol.219 , pp. 465-468
    • Takano, Y.1    Takano, M.2    Yaksh, T.L.3
  • 54
    • 0030427019 scopus 로고    scopus 로고
    • Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes
    • Piletz JE, Zhu H, Chikkala DN.comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes. J Pharmacol Exp Ther 1996;279:694-702
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 694-702
    • Piletz, J.E.1    Zhu, H.2    Chikkala, D.N.3
  • 55
    • 0032589078 scopus 로고    scopus 로고
    • Moxonidine, a selective alpha2-adrenergic and imidazoline receptor agonist, produces spinal antinociception in mice
    • Fairbanks CA, Wilcox GL. Moxonidine, a selective alpha2-adrenergic and imidazoline receptor agonist, produces spinal antinociception in mice. J Pharmacol Exp Ther 1999;290:403-12
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 403-412
    • Fairbanks, C.A.1    Wilcox, G.L.2
  • 56
    • 0030611098 scopus 로고    scopus 로고
    • The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy
    • Stone LS, MacMillan LB, Kitto KF, Limbird LE, Wilcox GL. The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 1997;17:7157-65
    • (1997) J Neurosci , vol.17 , pp. 7157-7165
    • Stone, L.S.1    MacMillan, L.B.2    Kitto, K.F.3    Limbird, L.E.4    Wilcox, G.L.5
  • 57
    • 0030609171 scopus 로고    scopus 로고
    • Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice
    • Hunter JC, Fontana DJ, Hedley LR, Jasper JR, Lewis R, Link RE, Secchi R, Sutton J, Eglen RM. Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br J Pharmacol 1997;122:1339-44
    • (1997) Br J Pharmacol , vol.122 , pp. 1339-1344
    • Hunter, J.C.1    Fontana, D.J.2    Hedley, L.R.3    Jasper, J.R.4    Lewis, R.5    Link, R.E.6    Secchi, R.7    Sutton, J.8    Eglen, R.M.9
  • 58
    • 0027364822 scopus 로고
    • Characteristics of antinociception induced by noncatecholic phenylethylamine derivatives: The involvement of alpha-2-adrenoceptors
    • Matsuoka Y, Sugioka T, Terawaki Y, Uruno T, Kubota K. Characteristics of antinociception induced by noncatecholic phenylethylamine derivatives: the involvement of alpha-2-adrenoceptors. Jpn J Pharmacol 1993;63:101-8
    • (1993) Jpn J Pharmacol , vol.63 , pp. 101-108
    • Matsuoka, Y.1    Sugioka, T.2    Terawaki, Y.3    Uruno, T.4    Kubota, K.5
  • 59
    • 18144427906 scopus 로고    scopus 로고
    • Noradrenergic receptor mRNA expression in adult rat superficial dorsal horn and dorsal root ganglion neurons
    • Nicholson R, Dixon AK, Spanswick D, Lee K. Noradrenergic receptor mRNA expression in adult rat superficial dorsal horn and dorsal root ganglion neurons. Neurosci Lett 2005;380:316-21
    • (2005) Neurosci Lett , vol.380 , pp. 316-321
    • Nicholson, R.1    Dixon, A.K.2    Spanswick, D.3    Lee, K.4
  • 60
    • 0035975650 scopus 로고    scopus 로고
    • Differential expression of alpha1-adrenoceptor subtype mRNAs in the dorsal root ganglion after spinal nerve ligation
    • Xie J, Ho Lee Y, Wang C, Mo Chung J, Chung K. Differential expression of alpha1-adrenoceptor subtype mRNAs in the dorsal root ganglion after spinal nerve ligation. Brain Res Mol Brain Res 2001;93:164-72
    • (2001) Brain Res Mol Brain Res , vol.93 , pp. 164-172
    • Xie, J.1    Ho Lee, Y.2    Wang, C.3    Mo Chung, J.4    Chung, K.5
  • 61
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993;365:61-5
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 62
    • 0031056438 scopus 로고    scopus 로고
    • Effect of adrenergic receptor activation on post-herpetic neuralgia pain and sensory disturbances
    • Choi B, Rowbotham MC. Effect of adrenergic receptor activation on post-herpetic neuralgia pain and sensory disturbances. Pain 1997;69:55-63
    • (1997) Pain , vol.69 , pp. 55-63
    • Choi, B.1    Rowbotham, M.C.2
  • 63
    • 0032977884 scopus 로고    scopus 로고
    • Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors
    • Khasar SG, McCarter G, Levine JD. Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol 1999;81:1104-12
    • (1999) J Neurophysiol , vol.81 , pp. 1104-1112
    • Khasar, S.G.1    McCarter, G.2    Levine, J.D.3
  • 64
    • 0034333009 scopus 로고    scopus 로고
    • Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain
    • Ali Z, Raja SN, Wesselmann U, Fuchs PN, Meyer RA, Campbell JN. Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain. Pain 2000;88:161-8
    • (2000) Pain , vol.88 , pp. 161-168
    • Ali, Z.1    Raja, S.N.2    Wesselmann, U.3    Fuchs, P.N.4    Meyer, R.A.5    Campbell, J.N.6
  • 65
    • 0037031567 scopus 로고    scopus 로고
    • Alpha(1)-adrenoceptor-mediated depolarization and beta-mediated hyperpolarization in cultured rat dorsal root ganglion neurones
    • Pluteanu F, Ristoiu V, Flonta ML, Reid G. Alpha(1)-adrenoceptor-mediated depolarization and beta-mediated hyperpolarization in cultured rat dorsal root ganglion neurones. Neurosci Lett 2002;329:277-80
    • (2002) Neurosci Lett , vol.329 , pp. 277-280
    • Pluteanu, F.1    Ristoiu, V.2    Flonta, M.L.3    Reid, G.4
  • 66
    • 33645225468 scopus 로고    scopus 로고
    • Antinociceptive effect of spinally administered cannabinergic and 2-adrenoceptor drugs on the formalin test in rat: Possible interactions
    • Khodayar MJ, Shafaghi B, Naderi N, Zarrindast MR. Antinociceptive effect of spinally administered cannabinergic and 2-adrenoceptor drugs on the formalin test in rat: possible interactions. J Psychopharmacol (Oxford) 2006;20:67-74
    • (2006) J Psychopharmacol (Oxford) , vol.20 , pp. 67-74
    • Khodayar, M.J.1    Shafaghi, B.2    Naderi, N.3    Zarrindast, M.R.4
  • 67
    • 0346788536 scopus 로고    scopus 로고
    • The promises and pitfalls of reboxetine
    • Page ME. The promises and pitfalls of reboxetine. CNS Drug Rev 2003;9:327-42
    • (2003) CNS Drug Rev , vol.9 , pp. 327-342
    • Page, M.E.1
  • 68
    • 20044386244 scopus 로고    scopus 로고
    • Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin
    • Ständer S, Schmelz M, Metze D, Luger T, Rukwied R. Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J Dermatol Sci 2005;38:177-88
    • (2005) J Dermatol Sci , vol.38 , pp. 177-188
    • Ständer, S.1    Schmelz, M.2    Metze, D.3    Luger, T.4    Rukwied, R.5
  • 72
    • 0030765622 scopus 로고    scopus 로고
    • Epidermal adrenergic signal transduction as part of the neuronal network in the human epidermis
    • Schallreuter KU. Epidermal adrenergic signal transduction as part of the neuronal network in the human epidermis. J Investig Dermatol Symp Proc 1997;2:37-40
    • (1997) J Investig Dermatol Symp Proc , vol.2 , pp. 37-40
    • Schallreuter, K.U.1
  • 74
    • 77952648547 scopus 로고    scopus 로고
    • Physical and functional interaction between CB1 cannabinoid receptors and beta2-adrenoceptors
    • Hudson BD, Hébert TE, Kelly ME. Physical and functional interaction between CB1 cannabinoid receptors and beta2-adrenoceptors. Br J Pharmacol 2010;160:627-42
    • (2010) Br J Pharmacol , vol.160 , pp. 627-642
    • Hudson, B.D.1    Hébert, T.E.2    Kelly, M.E.3
  • 75
    • 0024404604 scopus 로고
    • The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies
    • Sawynok J. The 1988 Merck Frosst Award. The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies. Can J Physiol Pharmacol 1989;67: 975-88
    • (1989) Can J Physiol Pharmacol , vol.67 , pp. 975-988
    • Sawynok, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.