CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain

Pain

Volumn 96, Issue 3, 2002, Pages 253-260

  Clayton, N ^a   Marshall, F H ^a   Bountra, C ^a   O'Shaughnessy, C T ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Cannabinoid receptors; CB1; CB2; Inflammatory pain

Indexed keywords

1 (2,3 DICHLOROBENZOYL) 5 METHOXY 2 METHYL [2 (MORPHOLIN 4 YL)ETHYL] 1H INDOLE; 1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CARRAGEENAN; DEXANABINOL; GW 405833; SRI 144528; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG SELECTIVITY; INFLAMMATION; INFLAMMATORY CELL; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

ACUTE DISEASE; ANIMALS; BORNANES; CANNABINOIDS; CARRAGEENAN; HYPERSENSITIVITY; INDOLES; MALE; MORPHOLINES; NEUROGENIC INFLAMMATION; NOCICEPTORS; PAIN; PYRAZOLES; RATS; RATS, INBRED STRAINS; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL;

EID: 0036221971     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(01)00454-7     Document Type: Article

References (30)

1. Imunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor
2. Control of pain initiation by endogenous cannabinoids
3. Validation of the dual channel weight averager as an instrument for the measurement of inflammatory pain
4. Pharmacological profile of a series of bicyclic cannabinoid analogs: Classification as cannabimimetic agents
5. In vitro functional evidence of neuronal cannabioid CB1 receptors in human ileum
6. Development of cross-tolerance between THC, CP55940 and WIN55212
7. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
8. New class of potent ligands for the human peripheral cannabinoid receptor
9. Imaging the brain marijuana receptor: Development of a radioligand that binds to cannabinoid CB1 receptors in vivo
10. Effect of the cannabinoid receptor SPECT agent, AM281, on hippocampal acetylcholine release from rat brain slices
11. Reporter assays for human cannabinoid CB1 and CB2 receptors for the identification of novel agonists
12. Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals
13. HU-308: A specific agonist for CB2, a peripheral cannabinoid receptor
14. Cannabionoid receptors undergo axonal flow in sensory nerves
15. The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain
16. Tetrahydrocannabinol impairs spatial memory through a cannabioid receptor mechanism
17. The selective cannabinoid antagonist SR141716A blocks cannabinoid-induced antinociception in rats
18. Localisation of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: Implications for receptor-mediated immune modulation by cannabinoids
19. Evidence for the presence of CB1 canabinoid receptors on peripheral neurones and for the existence of neuronal non-cannabinoid receptors
20. Pharmacology of cannabinoid receptor ligands
21. A method for measurement of analgesic activity on inflamed tissue
22. Antihyperalgesic effects of spinal cannabinoids
23. Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
24. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
25. Characterisation of two cloned human CB1 cannabinoid receptor isoforms
26. SR144528, the first potent and selective antagonist of the CB2 cannabinoid receptor
27. In vivo and in vitro treatment with the synthetic cannabinoid CP55,940 decreases the in vitro migration of macrophages in the rat: Involvement of both CB1 and CB2 receptors
28. CB1 receptor localisation in rat spinal cord and roots, dorsal root ganglion and peripheral nerve
29. Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide
30. Increased mortality, hypoactivity and hypoalgesia in cannabinoid CB1 receptor knockout mice