Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain

Pain

Volumn 88, Issue 2, 2000, Pages 161-168

  Ali, Zahid ^a   Raja, Srinivasa N ^a   Wesselmann, Ursula ^a   Fuchs, Perry N ^a   Meyer, Richard A ^a   Campbell, James N ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenoceptor; Causalgia; Neuropathic pain; Reflex sympathetic dystrophy

Indexed keywords

ADRENERGIC RECEPTOR; NORADRENALIN;

ADULT; ARTICLE; CAUSALGIA; CLINICAL ARTICLE; HUMAN; HYPERALGESIA; PAIN; PAIN RECEPTOR; PRIORITY JOURNAL; SKIN BLOOD FLOW; STIMULUS RESPONSE; SYMPATHETIC DYSTROPHY; SYMPATHETIC TONE; TISSUE INJURY; VASOCONSTRICTION;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ADULT; COMPLEX REGIONAL PAIN SYNDROMES; FEMALE; GANGLIA, SYMPATHETIC; GANGLIONIC BLOCKERS; HUMAN; HYPERALGESIA; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRADERMAL; MALE; MIDDLE AGE; NOREPINEPHRINE; PAIN; PAIN MEASUREMENT; PHENTOLAMINE; PSYCHOPHYSICS; SUPPORT, U.S. GOV'T, P.H.S.; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION;

EID: 0034333009     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(00)00327-4     Document Type: Article

References (31)

1. Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey
2. Intravenous phentolamine test: Diagnostic and prognostic use in reflex sympathetic dystrophy
3. Increased venous alpha-adrenoceptor responsiveness in patients with reflex sympathetic dystrophy
4. Is nociceptor activation by alpha-1 adrenergic receptors the culprit in sympathetically maintained pain (SMP)?
5. Pain response to perineuromal injection of normal saline, epinephrine, and lidocaine in humans
6. Adrenoreceptor subtype mediating sympathetic-sensory coupling in injured sensory neurons
7. Effect of adrenergic receptor activation on post-herpetic neuralgia pain and sensory disturbances
8. Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain
9. Cutaneous injection of the capsaicin analogue, NE-21610, produces analgesia to heat but not to mechanical stimuli in man
10. The interpretation of pain relief and sensory changes following sympathetic blockade
11. Alpha 1-adrenoceptors in normal and hyperalgesic human skin
12. Local temperature modulates alpha-1 and alpha-2-adrenergic vasoconstriction in men
13. Neural blockade for diagnosis and prognosis. A review
14. Central nervous system correlates and mechanisms of phantom pain
15. Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain
16. Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia
17. Nerve blocks in the evaluation of chronic pain. A plea for caution in their use and interpretation
18. Peripheral modulatory effects of catecholamines in inflammatory and neuropathic pain
19. Systemic alpha-adrenergic blockade with phentolamine: A diagnostic test for sympathetically maintained pain
20. Monitoring adequacy of alpha-adrenoceptor blockade following systemic phentolamine administration
21. Role of α-adrenoceptors in neuroma pain in amputees
22. A hypothesis on the physiological basis for causalgia and related pains
23. Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury
24. Reflex sympathetic dystrophy: Changing concepts and taxonomy
25. Noradrenaline-evoked pain in neuralgia
26. Modulation of postjunctional alpha-adrenergic responsiveness by local changes in temperature
27. Preliminary observations on the pathophysiology of hyperalgesia in the causalgic pain syndrome
28. Vascular abnormalities in acute reflex sympathetic dystrophy (CRPS I): Complete inhibition of sympathetic nerve activity with recovery
29. Reflex sympathetic dystrophy/causalgia
30. Topical clonidine attenuates ongoing pain and hyperalgesia in patients with sympathetically maintained pain (SMP)
31. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion