메뉴 건너뛰기




Volumn 119, Issue 3, 2003, Pages 747-757

Selective activation of cannabinoid CB2 receptors suppresses spinal Fos protein expression and pain behavior in a rat model of inflammation

Author keywords

Allodynia; Carrageenan; Dorsal horn; Endocannabinoid; Hyperalgesia; Peripheral analgesia

Indexed keywords

3 (2 IODO 5 NITROBENZOYL) 1 (1 METHYL 2 PIPERIDINYLMETHYL)INDOLE; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CARRAGEENAN; PROTEIN FOS; UNCLASSIFIED DRUG;

EID: 0038521050     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(03)00126-X     Document Type: Article
Times cited : (153)

References (59)
  • 1
    • 0037012480 scopus 로고    scopus 로고
    • Cannabinoid 1 receptors are expressed by nerve growth factor- and glial cell-derived neurotrophic factor-responsive primary sensory neurones
    • Ahluwalia J., Urban L., Bevan S., Capogna M., Nagy I. Cannabinoid 1 receptors are expressed by nerve growth factor- and glial cell-derived neurotrophic factor-responsive primary sensory neurones. Neuroscience. 110:2002;747-753.
    • (2002) Neuroscience , vol.110 , pp. 747-753
    • Ahluwalia, J.1    Urban, L.2    Bevan, S.3    Capogna, M.4    Nagy, I.5
  • 2
    • 0034638450 scopus 로고    scopus 로고
    • Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons
    • Ahluwalia J., Urban L., Capogna M., Bevan S., Nagy I. Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons. Neuroscience. 100:2000;685-688.
    • (2000) Neuroscience , vol.100 , pp. 685-688
    • Ahluwalia, J.1    Urban, L.2    Capogna, M.3    Bevan, S.4    Nagy, I.5
  • 3
    • 0028789427 scopus 로고
    • The peripheral cannabinoid receptor: Adenylate cyclase inhibition and G protein coupling
    • Bayewitch M., Avidor-Reiss T., Levy R., Barg J., Mechoulam R., Vogel Z. The peripheral cannabinoid receptor adenylate cyclase inhibition and G protein coupling . FEBS Lett. 375:1995;143-147.
    • (1995) FEBS Lett , vol.375 , pp. 143-147
    • Bayewitch, M.1    Avidor-Reiss, T.2    Levy, R.3    Barg, J.4    Mechoulam, R.5    Vogel, Z.6
  • 4
    • 0034685707 scopus 로고    scopus 로고
    • Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor
    • Buckley N.E., McCoy K.L., Mezey E., Bonner T., Zimmer A., Felder C.C., Glass M. Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor. Eur J Pharmacol. 396:2000;141-149.
    • (2000) Eur J Pharmacol , vol.396 , pp. 141-149
    • Buckley, N.E.1    McCoy, K.L.2    Mezey, E.3    Bonner, T.4    Zimmer, A.5    Felder, C.C.6    Glass, M.7
  • 5
    • 0029659012 scopus 로고    scopus 로고
    • B receptor-mediated events to inflammatory pain processing: Carrageenan oedema and associated spinal c-Fos expression in the rat
    • B receptor-mediated events to inflammatory pain processing carrageenan oedema and associated spinal c-Fos expression in the rat . Neuroscience. 73:1996;487-496.
    • (1996) Neuroscience , vol.73 , pp. 487-496
    • Buritova, J.1    Chapman Honore, P.2    Besson, J.M.3
  • 6
    • 0031039328 scopus 로고    scopus 로고
    • The contribution of peripheral bradykinin B2 receptors to carrageenan-evoked oedema and spinal c-Fos expression in rats
    • Buritova J., Chapman V., Honore P., Besson J.M. The contribution of peripheral bradykinin B2 receptors to carrageenan-evoked oedema and spinal c-Fos expression in rats. Eur J Pharmacol. 320:1997;73-80.
    • (1997) Eur J Pharmacol , vol.320 , pp. 73-80
    • Buritova, J.1    Chapman, V.2    Honore, P.3    Besson, J.M.4
  • 7
    • 0032537734 scopus 로고    scopus 로고
    • Control of pain initiation by endogenous cannabinoids
    • Calignano A., La Rana G., Giuffrida A., Piomelli D. Control of pain initiation by endogenous cannabinoids. Nature. 394:1998;277-281.
    • (1998) Nature , vol.394 , pp. 277-281
    • Calignano, A.1    La Rana, G.2    Giuffrida, A.3    Piomelli, D.4
  • 8
    • 0035843772 scopus 로고    scopus 로고
    • Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide
    • Calignano A., La Rana G., Piomelli D. Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur J Pharmacol. 419:2001;191-198.
    • (2001) Eur J Pharmacol , vol.419 , pp. 191-198
    • Calignano, A.1    La Rana, G.2    Piomelli, D.3
  • 10
    • 0034778455 scopus 로고    scopus 로고
    • Functional changes in the inhibitory effect of spinal cannabinoid (CB) receptor activation in nerve injured rats
    • Chapman V. Functional changes in the inhibitory effect of spinal cannabinoid (CB) receptor activation in nerve injured rats. Neuropharmacology. 41:2001;870-877.
    • (2001) Neuropharmacology , vol.41 , pp. 870-877
    • Chapman, V.1
  • 11
    • 0036221971 scopus 로고    scopus 로고
    • CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain
    • Clayton N., Marshall F.H., Bountra C., O'Shaughnessy C.T. CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Pain. 96:2002;253-260.
    • (2002) Pain , vol.96 , pp. 253-260
    • Clayton, N.1    Marshall, F.H.2    Bountra, C.3    O'Shaughnessy, C.T.4
  • 13
    • 0028906566 scopus 로고
    • Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide
    • Facci L., Dal Toso R., Romanello S., Buriani A., Skaper S.D., Leon A. Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proc Natl Acad Sci USA. 92:1995;3376-3380.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3376-3380
    • Facci, L.1    Dal Toso, R.2    Romanello, S.3    Buriani, A.4    Skaper, S.D.5    Leon, A.6
  • 14
    • 0035089509 scopus 로고    scopus 로고
    • Administration of endocannabinoids prevents a referred hyperalgesia associated with inflammation of the urinary bladder
    • Farquhar-Smith W.P., Rice A.S. Administration of endocannabinoids prevents a referred hyperalgesia associated with inflammation of the urinary bladder. Anesthesiology. 94:2001;507-513.
    • (2001) Anesthesiology , vol.94 , pp. 507-513
    • Farquhar-Smith, W.P.1    Rice, A.S.2
  • 15
    • 0036276727 scopus 로고    scopus 로고
    • Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors
    • Farquhar-Smith W.P., Jaggar S.I., Rice A.S. Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors. Pain. 97:2002;11-21.
    • (2002) Pain , vol.97 , pp. 11-21
    • Farquhar-Smith, W.P.1    Jaggar, S.I.2    Rice, A.S.3
  • 18
    • 34250927314 scopus 로고
    • On methods in the analysis of profile data
    • Greenhouse S.W., Geisser S. On methods in the analysis of profile data. Psychometrika. 24:1959;95-112.
    • (1959) Psychometrika , vol.24 , pp. 95-112
    • Greenhouse, S.W.1    Geisser, S.2
  • 20
    • 0023924046 scopus 로고
    • A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
    • Hargreaves K., Dubner R., Brown F., Flores C., Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 32:1988;77-88.
    • (1988) Pain , vol.32 , pp. 77-88
    • Hargreaves, K.1    Dubner, R.2    Brown, F.3    Flores, C.4    Joris, J.5
  • 21
    • 0034699017 scopus 로고    scopus 로고
    • Spinal anandamine inhibits nociceptive transmission via cannabinoid receptor activation in vivo
    • Harris J., Liam J., Chapman D., Chapman V. Spinal anandamine inhibits nociceptive transmission via cannabinoid receptor activation in vivo. Neuroreport. 2000;2817-2819.
    • (2000) Neuroreport , pp. 2817-2819
    • Harris, J.1    Liam, J.2    Chapman, D.3    Chapman, V.4
  • 22
    • 0032999084 scopus 로고    scopus 로고
    • Time-course of spinal sensitization following carrageenan-induced inflammation in the young rat: A comparative electrophysiological and behavioural study in vitro and in vivo
    • Hedo G., Laird J.M.A., Lopez-Garcia J.A. Time-course of spinal sensitization following carrageenan-induced inflammation in the young rat a comparative electrophysiological and behavioural study in vitro and in vivo . Neuroscience. 92:1998;309-318.
    • (1998) Neuroscience , vol.92 , pp. 309-318
    • Hedo, G.1    Laird, J.M.A.2    Lopez-Garcia, J.A.3
  • 23
    • 0033016805 scopus 로고    scopus 로고
    • Cannabinoid receptors undergo axonal flow in sensory nerves
    • Hohmann A.G., Herkenham M. Cannabinoid receptors undergo axonal flow in sensory nerves. Neuroscience. 92:1999;1171-1175.
    • (1999) Neuroscience , vol.92 , pp. 1171-1175
    • Hohmann, A.G.1    Herkenham, M.2
  • 24
    • 0032940633 scopus 로고    scopus 로고
    • Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: A double-label in situ hybridization study
    • Hohmann A.G., Herkenham M. Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia a double-label in situ hybridization study . Neuroscience. 90:1999;923-931.
    • (1999) Neuroscience , vol.90 , pp. 923-931
    • Hohmann, A.G.1    Herkenham, M.2
  • 25
    • 0029070520 scopus 로고
    • Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55, 212-2
    • Hohmann A.G., Martin W.J., Tsou K., Walker J.M. Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55, 212-2. Life Sci. 56:1995;2111-2118.
    • (1995) Life Sci , vol.56 , pp. 2111-2118
    • Hohmann, A.G.1    Martin, W.J.2    Tsou, K.3    Walker, J.M.4
  • 26
    • 0032484245 scopus 로고    scopus 로고
    • Cannabinoid modulation of wide dynamic range neurons in the lumbar dorsal horn of the rat by spinally administered WIN55, 212-2
    • Hohmann A.G., Tsou K., Walker J.M. Cannabinoid modulation of wide dynamic range neurons in the lumbar dorsal horn of the rat by spinally administered WIN55, 212-2. Neurosci Lett. 257:1998;119-122.
    • (1998) Neurosci Lett , vol.257 , pp. 119-122
    • Hohmann, A.G.1    Tsou, K.2    Walker, J.M.3
  • 27
    • 0033064793 scopus 로고    scopus 로고
    • Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat
    • Hohmann A.G., Tsou K., Walker J.M. Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat. J Neurophysiol. 81:1999;575-583.
    • (1999) J Neurophysiol , vol.81 , pp. 575-583
    • Hohmann, A.G.1    Tsou, K.2    Walker, J.M.3
  • 28
    • 13044258892 scopus 로고    scopus 로고
    • Intrathecal cannabinoid administration suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in rat spinal cord: Comparison with morphine
    • Hohmann A.G., Tsou K., Walker J.M. Intrathecal cannabinoid administration suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in rat spinal cord comparison with morphine . Acta Pharmacol Sinica. 20:1999;1132-1136.
    • (1999) Acta Pharmacol Sinica , vol.20 , pp. 1132-1136
    • Hohmann, A.G.1    Tsou, K.2    Walker, J.M.3
  • 29
    • 0029951653 scopus 로고    scopus 로고
    • Intraplantar morphine depresses spinal c-Fos expression induced by carrageenin inflammation but not by noxious heat
    • Honore P., Buritova J., Besson J.M. Intraplantar morphine depresses spinal c-Fos expression induced by carrageenin inflammation but not by noxious heat. Br J Pharmacol. 118:1996;671-680.
    • (1996) Br J Pharmacol , vol.118 , pp. 671-680
    • Honore, P.1    Buritova, J.2    Besson, J.M.3
  • 30
    • 0030973038 scopus 로고    scopus 로고
    • Chronic treatment with systemic morphine induced tolerance to the systemic and peripheral antinociceptive effects of morphine on both carrageenin induced mechanical hyperalgesia and spinal c-Fos expression in awake rats
    • Honore P., Catheline G., Le Guen S., Besson J.M. Chronic treatment with systemic morphine induced tolerance to the systemic and peripheral antinociceptive effects of morphine on both carrageenin induced mechanical hyperalgesia and spinal c-Fos expression in awake rats. Pain. 71:1997;99-108.
    • (1997) Pain , vol.71 , pp. 99-108
    • Honore, P.1    Catheline, G.2    Le Guen, S.3    Besson, J.M.4
  • 31
    • 0029560328 scopus 로고
    • When is the maximal effect of pre-administered systemic morphine on carrageenin evoked spinal c-Fos expression in the rat?
    • Honore P., Chapman V., Buritova J., Besson J.M. When is the maximal effect of pre-administered systemic morphine on carrageenin evoked spinal c-Fos expression in the rat? Brain Res. 705:1995;91-96.
    • (1995) Brain Res , vol.705 , pp. 91-96
    • Honore, P.1    Chapman, V.2    Buritova, J.3    Besson, J.M.4
  • 32
    • 0019423594 scopus 로고
    • Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures
    • Hsu S.M., Raine L., Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques a comparison between ABC and unlabeled antibody (PAP) procedures . J Histochem Cytochem. 29:1981;577-580.
    • (1981) J Histochem Cytochem , vol.29 , pp. 577-580
    • Hsu, S.M.1    Raine, L.2    Fanger, H.3
  • 33
    • 0023277535 scopus 로고
    • Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
    • Hunt S.P., Pini A., Evan G. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature. 328:1987;632-634.
    • (1987) Nature , vol.328 , pp. 632-634
    • Hunt, S.P.1    Pini, A.2    Evan, G.3
  • 34
    • 0034890340 scopus 로고    scopus 로고
    • Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms
    • Johanek L.M., Heitmiller D.R., Turner M., Nader N., Hodges J., Simone D.A. Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms. Pain. 93:2001;303-315.
    • (2001) Pain , vol.93 , pp. 303-315
    • Johanek, L.M.1    Heitmiller, D.R.2    Turner, M.3    Nader, N.4    Hodges, J.5    Simone, D.A.6
  • 35
    • 0025043463 scopus 로고
    • Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia
    • Joris J., Costello A., Dubner R., Hargreaves K.M. Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia. Pain. 43:1990;95-103.
    • (1990) Pain , vol.43 , pp. 95-103
    • Joris, J.1    Costello, A.2    Dubner, R.3    Hargreaves, K.M.4
  • 36
    • 0032587227 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys: A peripheral cannabinoid action
    • 9-tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys a peripheral cannabinoid action . Psychopharmacology (Berl). 143:1999;322-326.
    • (1999) Psychopharmacology (Berl) , vol.143 , pp. 322-326
    • Ko, M.C.1    Woods, J.H.2
  • 38
    • 0032766027 scopus 로고    scopus 로고
    • The palmitoylethanolamide and oleamide enigmas: Are these two fatty acid amides cannabimimetic?
    • Lambert D.M., Di Marzo V. The palmitoylethanolamide and oleamide enigmas are these two fatty acid amides cannabimimetic? Curr Med Chem. 6:1999;757-773.
    • (1999) Curr Med Chem , vol.6 , pp. 757-773
    • Lambert, D.M.1    Di Marzo, V.2
  • 39
    • 0028325790 scopus 로고
    • Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: Implications for receptor-mediated immune modulation by cannabinoids
    • Lynn A.B., Herkenham M. Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat implications for receptor-mediated immune modulation by cannabinoids . J Pharmacol Exp Ther. 268:1994;1612-1623.
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 1612-1623
    • Lynn, A.B.1    Herkenham, M.2
  • 41
    • 0029816889 scopus 로고    scopus 로고
    • Suppression of noxious stimulus-evoked activity in the ventral posterolateral nucleus of the thalamus by a cannabinoid agonist: Correlation between electrophysiological and antinociceptive effects
    • Martin W.J., Hohmann A.G., Walker J.M. Suppression of noxious stimulus-evoked activity in the ventral posterolateral nucleus of the thalamus by a cannabinoid agonist correlation between electrophysiological and antinociceptive effects . J Neurosci. 16:1996;6601-6611.
    • (1996) J Neurosci , vol.16 , pp. 6601-6611
    • Martin, W.J.1    Hohmann, A.G.2    Walker, J.M.3
  • 42
    • 0032489002 scopus 로고    scopus 로고
    • Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla
    • Martin W.J., Tsou K., Walker J.M. Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla. Neurosci Lett. 242:1998;33-36.
    • (1998) Neurosci Lett , vol.242 , pp. 33-36
    • Martin, W.J.1    Tsou, K.2    Walker, J.M.3
  • 43
    • 0033027735 scopus 로고    scopus 로고
    • Spinal cannabinoids are anti-allodynic in rats with persistent inflammation
    • Martin W.J., Loo C.M., Basbaum A.I. Spinal cannabinoids are anti-allodynic in rats with persistent inflammation. Pain. 82:1999;199-205.
    • (1999) Pain , vol.82 , pp. 199-205
    • Martin, W.J.1    Loo, C.M.2    Basbaum, A.I.3
  • 44
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 346:1990;561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 45
    • 0029865544 scopus 로고    scopus 로고
    • N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation
    • Mazzari S., Canella R., Petrelli L., Marcolongo G., Leon A. N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation. Eur J Pharmacol. 300:1996;227-236.
    • (1996) Eur J Pharmacol , vol.300 , pp. 227-236
    • Mazzari, S.1    Canella, R.2    Petrelli, L.3    Marcolongo, G.4    Leon, A.5
  • 46
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S., Thomas K.L., Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature. 365:1993;61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 47
    • 0037475146 scopus 로고    scopus 로고
    • A peripheral cannabinoid mechanism suppresses spinal Fos protein-expression and pain behavior in a rat model of inflammation
    • Nackley, AG, Suplita, RL, Hohmann, AG (2003) A peripheral cannabinoid mechanism suppresses spinal Fos protein-expression and pain behavior in a rat model of inflammation. Neuroscience 117:659-670.
    • (2003) Neuroscience , vol.117 , pp. 659-670
    • Nackley, A.G.1    Suplita, R.L.2    Hohmann, A.G.3
  • 48
    • 0026515646 scopus 로고
    • Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins
    • Noguchi K., Dubner R., Ruda M.A. Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins. Neuroscience. 46:1992;561-570.
    • (1992) Neuroscience , vol.46 , pp. 561-570
    • Noguchi, K.1    Dubner, R.2    Ruda, M.A.3
  • 49
    • 0025853449 scopus 로고
    • Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons
    • Noguchi K., Kowalski K., Traub R., Solodkin A., Iadarola M.J., Ruda M.A. Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons. Brain Res Mol Brain Res. 10:1991;227-233.
    • (1991) Brain Res Mol Brain Res , vol.10 , pp. 227-233
    • Noguchi, K.1    Kowalski, K.2    Traub, R.3    Solodkin, A.4    Iadarola, M.J.5    Ruda, M.A.6
  • 51
    • 0025137135 scopus 로고
    • Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord
    • Presley R.W., Menetrey D., Levine J.D., Basbaum A.I. Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord. J Neurosci. 10:1990;323-335.
    • (1990) J Neurosci , vol.10 , pp. 323-335
    • Presley, R.W.1    Menetrey, D.2    Levine, J.D.3    Basbaum, A.I.4
  • 52
    • 0003224689 scopus 로고    scopus 로고
    • Expression and distribution of cannabinoid receptor subtypes in trigeminal ganglion: Colocalization with nociceptive markers
    • Price T.J., Dussor G.D., Hargreaves K.M., Flores C.M. Expression and distribution of cannabinoid receptor subtypes in trigeminal ganglion colocalization with nociceptive markers . Soc Neurosci Abst. 31:2001;716.13.
    • (2001) Soc Neurosci Abst , vol.31 , pp. 71613
    • Price, T.J.1    Dussor, G.D.2    Hargreaves, K.M.3    Flores, C.M.4
  • 53
    • 0031779305 scopus 로고    scopus 로고
    • Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
    • Richardson J.D., Kilo S., Hargreaves K.M. Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain. 75:1998;111-119.
    • (1998) Pain , vol.75 , pp. 111-119
    • Richardson, J.D.1    Kilo, S.2    Hargreaves, K.M.3
  • 54
    • 0036019404 scopus 로고    scopus 로고
    • Endocannabinoids and pain: Spinal and peripheral analgesia in inflammation and neuropathy
    • Rice A.S., Farquhar-Smith W.P., Nagy I. Endocannabinoids and pain spinal and peripheral analgesia in inflammation and neuropathy . Prostaglandins Leukot Essent Fatty Acids. 66:2002;243-256.
    • (2002) Prostaglandins Leukot Essent Fatty Acids , vol.66 , pp. 243-256
    • Rice, A.S.1    Farquhar-Smith, W.P.2    Nagy, I.3
  • 55
    • 0030425575 scopus 로고    scopus 로고
    • Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands
    • Showalter V.M., Compton D.R., Martin B.R., Abood M.E. Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2) identification of cannabinoid receptor subtype selective ligands . J Pharmacol Exp Ther. 278:1996;989-999.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 989-999
    • Showalter, V.M.1    Compton, D.R.2    Martin, B.R.3    Abood, M.E.4
  • 56
    • 0030044427 scopus 로고    scopus 로고
    • Suppression of noxious stimulus-evoked expression of Fos protein-like immunoreactivity in rat spinal cord by a selective cannabinoid agonist
    • Tsou K., Lowitz K.A., Hohmann A.G., Martin W.J., Hathaway C.B., Bereiter D.A., Walker J.M. Suppression of noxious stimulus-evoked expression of Fos protein-like immunoreactivity in rat spinal cord by a selective cannabinoid agonist. Neuroscience. 70:1996;791-798.
    • (1996) Neuroscience , vol.70 , pp. 791-798
    • Tsou, K.1    Lowitz, K.A.2    Hohmann, A.G.3    Martin, W.J.4    Hathaway, C.B.5    Bereiter, D.A.6    Walker, J.M.7
  • 57
    • 0029643521 scopus 로고
    • Physical withdrawal in rats tolerant to delta 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist
    • Tsou K., Patrick S.L., Walker J.M. Physical withdrawal in rats tolerant to delta 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist. Eur J Pharmacol. 280:1995;R13-15.
    • (1995) Eur J Pharmacol , vol.280 , pp. 13-15
    • Tsou, K.1    Patrick, S.L.2    Walker, J.M.3
  • 58
    • 0033545866 scopus 로고    scopus 로고
    • Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
    • Zimmer A., Zimmer A.M., Hohmann A.G., Herkenham M., Bonner T.I. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci USA. 96:1999;5780-5785.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5780-5785
    • Zimmer, A.1    Zimmer, A.M.2    Hohmann, A.G.3    Herkenham, M.4    Bonner, T.I.5
  • 59
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110.
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.