메뉴 건너뛰기




Volumn 91, Issue 21-22, 2012, Pages 1126-1133

Regulation of airway inflammation and remodeling by muscarinic receptors: Perspectives on anticholinergic therapy in asthma and COPD

Author keywords

Acetylcholine; Airway inflammation; Airway remodeling; Anticholinergics; Asthma; COPD; Non neuronal

Indexed keywords

ACETYLCHOLINE; ACLIDINIUM BROMIDE; ATROPINE; BENCYCLOQUIDIUM BROMIDE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINE ACETYLTRANSFERASE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; IPRATROPIUM BROMIDE; MUSCARINIC RECEPTOR; TIOTROPIUM BROMIDE; UNCLASSIFIED DRUG; MUSCARINIC RECEPTOR BLOCKING AGENT;

EID: 84872826158     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.02.021     Document Type: Conference Paper
Times cited : (72)

References (108)
  • 2
    • 34248204113 scopus 로고    scopus 로고
    • Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma
    • S.S. An, T.R. Bai, J.H. Bates, J.L. Black, R.H. Brown, and V. Brusasco Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma Eur Respir J 29 2007 834 860
    • (2007) Eur Respir J , vol.29 , pp. 834-860
    • An, S.S.1    Bai, T.R.2    Bates, J.H.3    Black, J.L.4    Brown, R.H.5    Brusasco, V.6
  • 3
    • 0027962628 scopus 로고
    • Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study
    • N.R. Anthonisen, J.E. Connett, J.P. Kiley, M.D. Altose, W.C. Bailey, A.S. Buist, P.L. Enright, R.E. Kanner, and P. O'Hara Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study JAMA 272 1994 1497 1505
    • (1994) JAMA , vol.272 , pp. 1497-1505
    • Anthonisen, N.R.1    Connett, J.E.2    Kiley, J.P.3    Altose, M.D.4    Bailey, W.C.5    Buist, A.S.6    Enright, P.L.7    Kanner, R.E.8    O'Hara, P.9
  • 4
    • 77951962428 scopus 로고    scopus 로고
    • Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice
    • N. Arai, M. Kondo, T. Izumo, J. Tamaoki, and A. Nagai Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice Eur Respir J 35 2010 1164 1171
    • (2010) Eur Respir J , vol.35 , pp. 1164-1171
    • Arai, N.1    Kondo, M.2    Izumo, T.3    Tamaoki, J.4    Nagai, A.5
  • 5
    • 60249094602 scopus 로고    scopus 로고
    • Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro
    • K. Asano, Y. Shikama, Y. Shibuya, H. Nakajima, K. Kanai, and N. Yamada Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro Int J Chron Obstruct Pulmon Dis 3 2008 781 789
    • (2008) Int J Chron Obstruct Pulmon Dis , vol.3 , pp. 781-789
    • Asano, K.1    Shikama, Y.2    Shibuya, Y.3    Nakajima, H.4    Kanai, K.5    Yamada, N.6
  • 6
    • 79952056758 scopus 로고    scopus 로고
    • Tiotropium bromide inhibits TGF-beta-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro
    • K. Asano, Y. Shikama, N. Shoji, K. Hirano, H. Suzaki, and H. Nakajima Tiotropium bromide inhibits TGF-beta-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro Int J Chron Obstruct Pulmon Dis 5 2010 277 286
    • (2010) Int J Chron Obstruct Pulmon Dis , vol.5 , pp. 277-286
    • Asano, K.1    Shikama, Y.2    Shoji, N.3    Hirano, K.4    Suzaki, H.5    Nakajima, H.6
  • 7
    • 13844318259 scopus 로고    scopus 로고
    • The role of anticholinergics in chronic obstructive pulmonary disease
    • P.J. Barnes The role of anticholinergics in chronic obstructive pulmonary disease Am J Med 117 Suppl 12A 2004 24S 32S
    • (2004) Am J Med , vol.117 , Issue.SUPPL. 12A
    • Barnes, P.J.1
  • 8
    • 40049104892 scopus 로고    scopus 로고
    • Immunology of asthma and chronic obstructive pulmonary disease
    • P.J. Barnes Immunology of asthma and chronic obstructive pulmonary disease Nat Rev Immunol 8 2008 183 192
    • (2008) Nat Rev Immunol , vol.8 , pp. 183-192
    • Barnes, P.J.1
  • 9
    • 0028922990 scopus 로고
    • Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease
    • P.J. Barnes, M.G. Belvisi, J.C. Mak, E.B. Haddad, and B. O'Connor Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease Life Sci 56 1995 853 859
    • (1995) Life Sci , vol.56 , pp. 853-859
    • Barnes, P.J.1    Belvisi, M.G.2    Mak, J.C.3    Haddad, E.B.4    O'Connor, B.5
  • 11
    • 79960973276 scopus 로고    scopus 로고
    • Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma
    • E.D. Bateman, O. Kornmann, P. Schmidt, A. Pivovarova, M. Engel, and L.M. Fabbri Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma J Allergy Clin Immunol 128 2011 315 322
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 315-322
    • Bateman, E.D.1    Kornmann, O.2    Schmidt, P.3    Pivovarova, A.4    Engel, M.5    Fabbri, L.M.6
  • 12
    • 27644530096 scopus 로고    scopus 로고
    • Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease
    • K.E. Belmonte Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease Proc Am Thorac Soc 2 2005 297 304
    • (2005) Proc Am Thorac Soc , vol.2 , pp. 297-304
    • Belmonte, K.E.1
  • 13
    • 0034018102 scopus 로고    scopus 로고
    • Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations
    • A. Bhowmik, T.A. Seemungal, R.J. Sapsford, and J.A. Wedzicha Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations Thorax 55 2000 114 120
    • (2000) Thorax , vol.55 , pp. 114-120
    • Bhowmik, A.1    Seemungal, T.A.2    Sapsford, R.J.3    Wedzicha, J.A.4
  • 14
    • 27644491911 scopus 로고    scopus 로고
    • Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth
    • C.K. Billington, K.C. Kong, R. Bhattacharyya, P.B. Wedegaertner, R.A. Panettieri Jr., and T.O. Chan Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth Biochemistry 44 2005 14595 14605
    • (2005) Biochemistry , vol.44 , pp. 14595-14605
    • Billington, C.K.1    Kong, K.C.2    Bhattacharyya, R.3    Wedegaertner, P.B.4    Panettieri, Jr.R.A.5    Chan, T.O.6
  • 15
    • 38449113726 scopus 로고    scopus 로고
    • Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: A comparison
    • I.S. Bos, R. Gosens, A.B. Zuidhof, D. Schaafsma, A.J. Halayko, and H. Meurs Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison Eur Respir J 30 2007 653 661
    • (2007) Eur Respir J , vol.30 , pp. 653-661
    • Bos, I.S.1    Gosens, R.2    Zuidhof, A.B.3    Schaafsma, D.4    Halayko, A.J.5    Meurs, H.6
  • 16
    • 84455187608 scopus 로고    scopus 로고
    • Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea pig model of allergic asthma
    • K.S. Buels, D.B. Jacoby, and A.D. Fryer Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea pig model of allergic asthma Br J Pharmacol 2011
    • (2011) Br J Pharmacol
    • Buels, K.S.1    Jacoby, D.B.2    Fryer, A.D.3
  • 17
    • 34748819974 scopus 로고    scopus 로고
    • Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro
    • F. Buhling, N. Lieder, U.C. Kuhlmann, N. Waldburg, and T. Welte Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro Respir Med 101 2007 2386 2394
    • (2007) Respir Med , vol.101 , pp. 2386-2394
    • Buhling, F.1    Lieder, N.2    Kuhlmann, U.C.3    Waldburg, N.4    Welte, T.5
  • 18
    • 0034222422 scopus 로고    scopus 로고
    • Clinical aspects of inhaled anticholinergic therapy
    • S.C. Campbell Clinical aspects of inhaled anticholinergic therapy Respir Care 45 2000 864 867
    • (2000) Respir Care , vol.45 , pp. 864-867
    • Campbell, S.C.1
  • 19
    • 79952534622 scopus 로고    scopus 로고
    • M(3) muscarinic receptor antagonist bencycloquidium bromide attenuates allergic airway inflammation, hyperresponsiveness and remodeling in mice
    • R. Cao, X.W. Dong, J.X. Jiang, X.F. Yan, J.S. He, and Y.M. Deng M(3) muscarinic receptor antagonist bencycloquidium bromide attenuates allergic airway inflammation, hyperresponsiveness and remodeling in mice Eur J Pharmacol 655 2011 83 90
    • (2011) Eur J Pharmacol , vol.655 , pp. 83-90
    • Cao, R.1    Dong, X.W.2    Jiang, J.X.3    Yan, X.F.4    He, J.S.5    Deng, Y.M.6
  • 20
    • 0033663165 scopus 로고    scopus 로고
    • MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease
    • D. Cataldo, C. Munaut, A. Noel, F. Frankenne, P. Bartsch, and J.M. Foidart MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease Int Arch Allergy Immunol 123 2000 259 267
    • (2000) Int Arch Allergy Immunol , vol.123 , pp. 259-267
    • Cataldo, D.1    Munaut, C.2    Noel, A.3    Frankenne, F.4    Bartsch, P.5    Foidart, J.M.6
  • 21
    • 79953646222 scopus 로고    scopus 로고
    • Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways
    • J. Cortijo, M. Mata, J. Milara, E. Donet, A. Gavalda, and M. Miralpeix Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways Eur Respir J 37 2011 244 254
    • (2011) Eur Respir J , vol.37 , pp. 244-254
    • Cortijo, J.1    Mata, M.2    Milara, J.3    Donet, E.4    Gavalda, A.5    Miralpeix, M.6
  • 22
    • 78649654897 scopus 로고    scopus 로고
    • Nicotinic modulation of innate immune pathways via alpha7 nicotinic acetylcholine receptor
    • W.Y. Cui, and M.D. Li Nicotinic modulation of innate immune pathways via alpha7 nicotinic acetylcholine receptor J Neuroimmune Pharmacol 5 2010 479 488
    • (2010) J Neuroimmune Pharmacol , vol.5 , pp. 479-488
    • Cui, W.Y.1    Li, M.D.2
  • 23
    • 77953522835 scopus 로고    scopus 로고
    • Tiotropium reduction of lung inflammation in a model of chronic gastro-oesophageal reflux
    • Y. Cui, P. Devillier, X. Kuang, H. Wang, L. Zhu, and Z. Xu Tiotropium reduction of lung inflammation in a model of chronic gastro-oesophageal reflux Eur Respir J 35 2010 1370 1376
    • (2010) Eur Respir J , vol.35 , pp. 1370-1376
    • Cui, Y.1    Devillier, P.2    Kuang, X.3    Wang, H.4    Zhu, L.5    Xu, Z.6
  • 24
    • 78049265848 scopus 로고    scopus 로고
    • Aclidinium bromide abrogates allergen-induced hyperresponsiveness and reduces eosinophilia in murine model of airway inflammation
    • G. Damera, M. Jiang, H. Zhao, H.W. Fogle, W.F. Jester, and J. Freire Aclidinium bromide abrogates allergen-induced hyperresponsiveness and reduces eosinophilia in murine model of airway inflammation Eur J Pharmacol 649 2010 349 353
    • (2010) Eur J Pharmacol , vol.649 , pp. 349-353
    • Damera, G.1    Jiang, M.2    Zhao, H.3    Fogle, H.W.4    Jester, W.F.5    Freire, J.6
  • 25
    • 39149107800 scopus 로고    scopus 로고
    • Proliferative actions of muscarinic receptors expressed in macrophages derived from normal and tumor bearing mice
    • E. de la Torre, A.M. Genaro, M.L. Ribeiro, R. Pagotto, O.P. Pignataro, and M.E. Sales Proliferative actions of muscarinic receptors expressed in macrophages derived from normal and tumor bearing mice Biochim Biophys Acta 1782 2008 82 89
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 82-89
    • De La Torre, E.1    Genaro, A.M.2    Ribeiro, M.L.3    Pagotto, R.4    Pignataro, O.P.5    Sales, M.E.6
  • 26
    • 18144393509 scopus 로고    scopus 로고
    • Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: The UPLIFT trial
    • M. Decramer, B. Celli, D.P. Tashkin, R.A. Pauwels, D. Burkhart, and C. Cassino Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial COPD 1 2004 303 312
    • (2004) COPD , vol.1 , pp. 303-312
    • Decramer, M.1    Celli, B.2    Tashkin, D.P.3    Pauwels, R.A.4    Burkhart, D.5    Cassino, C.6
  • 27
    • 70349547108 scopus 로고    scopus 로고
    • Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): A prespecified subgroup analysis of a randomised controlled trial
    • M. Decramer, B. Celli, S. Kesten, T. Lystig, S. Mehra, and D.P. Tashkin Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial Lancet 374 2009 1171 1178
    • (2009) Lancet , vol.374 , pp. 1171-1178
    • Decramer, M.1    Celli, B.2    Kesten, S.3    Lystig, T.4    Mehra, S.5    Tashkin, D.P.6
  • 28
    • 44349190984 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3beta is sufficient for airway smooth muscle hypertrophy
    • H. Deng, G.A. Dokshin, J. Lei, A.M. Goldsmith, K.N. Bitar, and D.C. Fingar Inhibition of glycogen synthase kinase-3beta is sufficient for airway smooth muscle hypertrophy J Biol Chem 283 2008 10198 10207
    • (2008) J Biol Chem , vol.283 , pp. 10198-10207
    • Deng, H.1    Dokshin, G.A.2    Lei, J.3    Goldsmith, A.M.4    Bitar, K.N.5    Fingar, D.C.6
  • 29
    • 0033534194 scopus 로고    scopus 로고
    • Tiotropium (Spiriva): Mechanistical considerations and clinical profile in obstructive lung disease
    • B. Disse, G.A. Speck, K.L. Rominger, T.J. Witek Jr., and R. Hammer Tiotropium (Spiriva): mechanistical considerations and clinical profile in obstructive lung disease Life Sci 64 1999 457 464
    • (1999) Life Sci , vol.64 , pp. 457-464
    • Disse, B.1    Speck, G.A.2    Rominger, K.L.3    Witek, Jr.T.J.4    Hammer, R.5
  • 32
    • 18644380685 scopus 로고    scopus 로고
    • Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling
    • R. Gosens, I.S. Bos, J. Zaagsma, and H. Meurs Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling Am J Respir Crit Care Med 171 2005 1096 1102
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 1096-1102
    • Gosens, R.1    Bos, I.S.2    Zaagsma, J.3    Meurs, H.4
  • 33
    • 33745218112 scopus 로고    scopus 로고
    • Muscarinic receptor signaling in the pathophysiology of asthma and COPD
    • R. Gosens, J. Zaagsma, H. Meurs, and A.J. Halayko Muscarinic receptor signaling in the pathophysiology of asthma and COPD Respir Res 7 2006 73
    • (2006) Respir Res , vol.7 , pp. 73
    • Gosens, R.1    Zaagsma, J.2    Meurs, H.3    Halayko, A.J.4
  • 35
    • 73249148900 scopus 로고    scopus 로고
    • Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells
    • R. Gosens, D. Rieks, H. Meurs, D.K. Ninaber, K.F. Rabe, and J. Nanninga Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells Eur Respir J 34 2009 1436 1443
    • (2009) Eur Respir J , vol.34 , pp. 1436-1443
    • Gosens, R.1    Rieks, D.2    Meurs, H.3    Ninaber, D.K.4    Rabe, K.F.5    Nanninga, J.6
  • 37
    • 0021175444 scopus 로고
    • Role of the parasympathetic system in airway obstruction due to emphysema
    • N.J. Gross, and M.S. Skorodin Role of the parasympathetic system in airway obstruction due to emphysema N Engl J Med 311 1984 421 425
    • (1984) N Engl J Med , vol.311 , pp. 421-425
    • Gross, N.J.1    Skorodin, M.S.2
  • 38
    • 58149376396 scopus 로고    scopus 로고
    • Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts
    • S. Haag, S. Matthiesen, U.R. Juergens, and K. Racke Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts Eur Respir J 32 2008 555 562
    • (2008) Eur Respir J , vol.32 , pp. 555-562
    • Haag, S.1    Matthiesen, S.2    Juergens, U.R.3    Racke, K.4
  • 39
    • 37849043647 scopus 로고    scopus 로고
    • Phenotype and functional plasticity of airway smooth muscle: Role of caveolae and caveolins
    • A.J. Halayko, T. Tran, and R. Gosens Phenotype and functional plasticity of airway smooth muscle: role of caveolae and caveolins Proc Am Thorac Soc 5 2008 80 88
    • (2008) Proc Am Thorac Soc , vol.5 , pp. 80-88
    • Halayko, A.J.1    Tran, T.2    Gosens, R.3
  • 40
    • 2942720573 scopus 로고    scopus 로고
    • The nature of small-airway obstruction in chronic obstructive pulmonary disease
    • J.C. Hogg, F. Chu, S. Utokaparch, R. Woods, W.M. Elliott, and L. Buzatu The nature of small-airway obstruction in chronic obstructive pulmonary disease N Engl J Med 350 2004 2645 2653
    • (2004) N Engl J Med , vol.350 , pp. 2645-2653
    • Hogg, J.C.1    Chu, F.2    Utokaparch, S.3    Woods, R.4    Elliott, W.M.5    Buzatu, L.6
  • 41
    • 56649085193 scopus 로고    scopus 로고
    • Tiotropium bromide attenuates respiratory syncytial virus replication in epithelial cells
    • K. Iesato, K. Tatsumi, K. Saito, T. Ogasawara, S. Sakao, and Y. Tada Tiotropium bromide attenuates respiratory syncytial virus replication in epithelial cells Respiration 76 2008 434 441
    • (2008) Respiration , vol.76 , pp. 434-441
    • Iesato, K.1    Tatsumi, K.2    Saito, K.3    Ogasawara, T.4    Sakao, S.5    Tada, Y.6
  • 42
    • 0035077465 scopus 로고    scopus 로고
    • Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema
    • K. Imai, S.S. Dalal, E.S. Chen, R. Downey, L.L. Schulman, and M. Ginsburg Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema Am J Respir Crit Care Med 163 2001 786 791
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 786-791
    • Imai, K.1    Dalal, S.S.2    Chen, E.S.3    Downey, R.4    Schulman, L.L.5    Ginsburg, M.6
  • 43
    • 33750069111 scopus 로고    scopus 로고
    • Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction
    • A.L. Innes, P.G. Woodruff, R.E. Ferrando, S. Donnelly, G.M. Dolganov, and S.C. Lazarus Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction Chest 130 2006 1102 1108
    • (2006) Chest , vol.130 , pp. 1102-1108
    • Innes, A.L.1    Woodruff, P.G.2    Ferrando, R.E.3    Donnelly, S.4    Dolganov, G.M.5    Lazarus, S.C.6
  • 45
    • 0037019784 scopus 로고    scopus 로고
    • Differential effect of epidermal growth factor on serous and mucous cells in porcine airway submucosal gland
    • N. Iwase, T. Sasaki, T. Oshiro, T. Tamada, M. Nara, and K. Sasamori Differential effect of epidermal growth factor on serous and mucous cells in porcine airway submucosal gland Respir Physiol Neurobiol 132 2002 307 319
    • (2002) Respir Physiol Neurobiol , vol.132 , pp. 307-319
    • Iwase, N.1    Sasaki, T.2    Oshiro, T.3    Tamada, T.4    Nara, M.5    Sasamori, K.6
  • 46
    • 0027232088 scopus 로고
    • Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor
    • D.B. Jacoby, G.J. Gleich, and A.D. Fryer Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor J Clin Invest 91 1993 1314 1318
    • (1993) J Clin Invest , vol.91 , pp. 1314-1318
    • Jacoby, D.B.1    Gleich, G.J.2    Fryer, A.D.3
  • 47
    • 70349146860 scopus 로고    scopus 로고
    • Airway smooth muscle thickness in asthma is related to severity but not duration of asthma
    • A.L. James, T.R. Bai, T. Mauad, M.J. Abramson, M. Dolhnikoff, and K.O. McKay Airway smooth muscle thickness in asthma is related to severity but not duration of asthma Eur Respir J 34 2009 1040 1045
    • (2009) Eur Respir J , vol.34 , pp. 1040-1045
    • James, A.L.1    Bai, T.R.2    Mauad, T.3    Abramson, M.J.4    Dolhnikoff, M.5    McKay, K.O.6
  • 48
    • 0035891664 scopus 로고    scopus 로고
    • Remodeling in asthma and chronic obstructive lung disease
    • P.K. Jeffery Remodeling in asthma and chronic obstructive lung disease Am J Respir Crit Care Med 164 2001 S28 S38
    • (2001) Am J Respir Crit Care Med , vol.164
    • Jeffery, P.K.1
  • 49
    • 37349122112 scopus 로고    scopus 로고
    • The similarities and differences of epidemic cycles of chronic obstructive pulmonary disease and asthma exacerbations
    • N.W. Johnston The similarities and differences of epidemic cycles of chronic obstructive pulmonary disease and asthma exacerbations Proc Am Thorac Soc 4 2007 591 596
    • (2007) Proc Am Thorac Soc , vol.4 , pp. 591-596
    • Johnston, N.W.1
  • 50
    • 33645679788 scopus 로고    scopus 로고
    • Cholinergic receptor and cyclic stretch-mediated inflammatory gene expression in intact ASM
    • J. Kanefsky, M. Lenburg, and C.M. Hai Cholinergic receptor and cyclic stretch-mediated inflammatory gene expression in intact ASM Am J Respir Cell Mol Biol 34 2006 417 425
    • (2006) Am J Respir Cell Mol Biol , vol.34 , pp. 417-425
    • Kanefsky, J.1    Lenburg, M.2    Hai, C.M.3
  • 51
    • 0037212314 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in asthma
    • E.A. Kelly, and N.N. Jarjour Role of matrix metalloproteinases in asthma Curr Opin Pulm Med 9 2003 28 33
    • (2003) Curr Opin Pulm Med , vol.9 , pp. 28-33
    • Kelly, E.A.1    Jarjour, N.N.2
  • 54
    • 33845621932 scopus 로고    scopus 로고
    • Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11)
    • K.C. Kong, C.K. Billington, U. Gandhi, R.A. Panettieri Jr., and R.B. Penn Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11) FASEB J 20 2006 1558 1560
    • (2006) FASEB J , vol.20 , pp. 1558-1560
    • Kong, K.C.1    Billington, C.K.2    Gandhi, U.3    Panettieri, Jr.R.A.4    Penn, R.B.5
  • 55
    • 0026697298 scopus 로고
    • Acetylcholine stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity
    • S. Koyama, S.I. Rennard, and R.A. Robbins Acetylcholine stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity Am J Physiol 262 1992 L466 L471
    • (1992) Am J Physiol , vol.262
    • Koyama, S.1    Rennard, S.I.2    Robbins, R.A.3
  • 56
    • 0031957332 scopus 로고    scopus 로고
    • Acetylcholine and substance P stimulate bronchial epithelial cells to release eosinophil chemotactic activity
    • S. Koyama, E. Sato, H. Nomura, K. Kubo, S. Nagai, and T. Izumi Acetylcholine and substance P stimulate bronchial epithelial cells to release eosinophil chemotactic activity J Appl Physiol 84 1998 1528 1534
    • (1998) J Appl Physiol , vol.84 , pp. 1528-1534
    • Koyama, S.1    Sato, E.2    Nomura, H.3    Kubo, K.4    Nagai, S.5    Izumi, T.6
  • 57
    • 0033787918 scopus 로고    scopus 로고
    • Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle
    • V.P. Krymskaya, M.J. Orsini, A.J. Eszterhas, K.C. Brodbeck, J.L. Benovic, and R.A. Panettieri Jr. Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle Am J Respir Cell Mol Biol 23 2000 546 554
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 546-554
    • Krymskaya, V.P.1    Orsini, M.J.2    Eszterhas, A.J.3    Brodbeck, K.C.4    Benovic, J.L.5    Panettieri, Jr.R.A.6
  • 58
    • 33845920612 scopus 로고    scopus 로고
    • Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse
    • W. Kummer, S. Wiegand, S. Akinci, A.H. Schinkel, J. Wess, and H. Koepsell Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse J Mol Neurosci 30 2006 67 68
    • (2006) J Mol Neurosci , vol.30 , pp. 67-68
    • Kummer, W.1    Wiegand, S.2    Akinci, S.3    Schinkel, A.H.4    Wess, J.5    Koepsell, H.6
  • 59
    • 33646856174 scopus 로고    scopus 로고
    • Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse
    • W. Kummer, S. Wiegand, S. Akinci, I. Wessler, A.H. Schinkel, and J. Wess Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse Respir Res 7 2006 65
    • (2006) Respir Res , vol.7 , pp. 65
    • Kummer, W.1    Wiegand, S.2    Akinci, S.3    Wessler, I.4    Schinkel, A.H.5    Wess, J.6
  • 60
    • 48749124897 scopus 로고    scopus 로고
    • The epithelial cholinergic system of the airways
    • W. Kummer, K.S. Lips, and U. Pfeil The epithelial cholinergic system of the airways Histochem Cell Biol 130 2008 219 234
    • (2008) Histochem Cell Biol , vol.130 , pp. 219-234
    • Kummer, W.1    Lips, K.S.2    Pfeil, U.3
  • 61
    • 77649272395 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in the inflammatory process of respiratory diseases
    • V. Lagente, and E. Boichot Role of matrix metalloproteinases in the inflammatory process of respiratory diseases J Mol Cell Cardiol 48 2010 440 444
    • (2010) J Mol Cell Cardiol , vol.48 , pp. 440-444
    • Lagente, V.1    Boichot, E.2
  • 62
    • 21844457187 scopus 로고    scopus 로고
    • Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium
    • K.S. Lips, C. Volk, B.M. Schmitt, U. Pfeil, P. Arndt, and D. Miska Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium Am J Respir Cell Mol Biol 33 2005 79 88
    • (2005) Am J Respir Cell Mol Biol , vol.33 , pp. 79-88
    • Lips, K.S.1    Volk, C.2    Schmitt, B.M.3    Pfeil, U.4    Arndt, P.5    Miska, D.6
  • 63
    • 34249726587 scopus 로고    scopus 로고
    • Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse
    • K.S. Lips, A. Luhrmann, T. Tschernig, T. Stoeger, F. Alessandrini, and V. Grau Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse Life Sci 80 2007 2263 2269
    • (2007) Life Sci , vol.80 , pp. 2263-2269
    • Lips, K.S.1    Luhrmann, A.2    Tschernig, T.3    Stoeger, T.4    Alessandrini, F.5    Grau, V.6
  • 66
    • 34249284422 scopus 로고    scopus 로고
    • MAPK pathway mediates muscarinic receptor-induced human lung fibroblast proliferation
    • S. Matthiesen, A. Bahulayan, O. Holz, and K. Racke MAPK pathway mediates muscarinic receptor-induced human lung fibroblast proliferation Life Sci 2007
    • (2007) Life Sci
    • Matthiesen, S.1    Bahulayan, A.2    Holz, O.3    Racke, K.4
  • 67
  • 68
    • 0037470643 scopus 로고    scopus 로고
    • Proliferative effect of acetylcholine on rat trachea epithelial cells is mediated by nicotinic receptors and muscarinic receptors of the M1-subtype
    • J. Metzen, F. Bittinger, C.J. Kirkpatrick, H. Kilbinger, and I. Wessler Proliferative effect of acetylcholine on rat trachea epithelial cells is mediated by nicotinic receptors and muscarinic receptors of the M1-subtype Life Sci 72 2003 2075 2080
    • (2003) Life Sci , vol.72 , pp. 2075-2080
    • Metzen, J.1    Bittinger, F.2    Kirkpatrick, C.J.3    Kilbinger, H.4    Wessler, I.5
  • 69
    • 2342622638 scopus 로고    scopus 로고
    • Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated trachea
    • J.D. Moffatt, T.M. Cocks, and C.P. Page Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated trachea Br J Pharmacol 141 2004 1159 1166
    • (2004) Br J Pharmacol , vol.141 , pp. 1159-1166
    • Moffatt, J.D.1    Cocks, T.M.2    Page, C.P.3
  • 71
    • 77957157119 scopus 로고    scopus 로고
    • COPD in young patients: A pre-specified analysis of the four-year trial of tiotropium (UPLIFT)
    • A.H. Morice, B. Celli, S. Kesten, T. Lystig, D. Tashkin, and M. Decramer COPD in young patients: a pre-specified analysis of the four-year trial of tiotropium (UPLIFT) Respir Med 104 2010 1659 1667
    • (2010) Respir Med , vol.104 , pp. 1659-1667
    • Morice, A.H.1    Celli, B.2    Kesten, S.3    Lystig, T.4    Tashkin, D.5    Decramer, M.6
  • 73
    • 84886781849 scopus 로고    scopus 로고
    • Muscarinic receptor stimulation augments TGF-B1 induced contractile protein and fibronectin stimulation in airway smooth muscle cells
    • T.A. Oenema, M. Smit, K. Racke, A.J. Halayko, H. Meurs, and R. Gosens Muscarinic receptor stimulation augments TGF-B1 induced contractile protein and fibronectin stimulation in airway smooth muscle cells Am J Respir Crit Care Med 181 2010 A5314
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 5314
    • Oenema, T.A.1    Smit, M.2    Racke, K.3    Halayko, A.J.4    Meurs, H.5    Gosens, R.6
  • 74
    • 77954357471 scopus 로고    scopus 로고
    • Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma
    • S. Ohta, N. Oda, T. Yokoe, A. Tanaka, Y. Yamamoto, and Y. Watanabe Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma Clin Exp Allergy 40 2010 1266 1275
    • (2010) Clin Exp Allergy , vol.40 , pp. 1266-1275
    • Ohta, S.1    Oda, N.2    Yokoe, T.3    Tanaka, A.4    Yamamoto, Y.5    Watanabe, Y.6
  • 75
    • 33751111748 scopus 로고    scopus 로고
    • Synergistic effects of the anti-cholinergic R, R-glycopyrrolate with anti-inflammatory drugs
    • A. Pahl, A. Bauhofer, U. Petzold, P.J. Cnota, J. Maus, and K. Brune Synergistic effects of the anti-cholinergic R, R-glycopyrrolate with anti-inflammatory drugs Biochem Pharmacol 72 2006 1690 1696
    • (2006) Biochem Pharmacol , vol.72 , pp. 1690-1696
    • Pahl, A.1    Bauhofer, A.2    Petzold, U.3    Cnota, P.J.4    Maus, J.5    Brune, K.6
  • 77
    • 0035722954 scopus 로고    scopus 로고
    • Matrix metalloproteinases in lung biology
    • W.C. Parks, and S.D. Shapiro Matrix metalloproteinases in lung biology Respir Res 2 2001 10 19
    • (2001) Respir Res , vol.2 , pp. 10-19
    • Parks, W.C.1    Shapiro, S.D.2
  • 79
    • 63849165456 scopus 로고    scopus 로고
    • Anti-inflammatory effects of salmeterol/fluticasone, tiotropium/ fluticasone or tiotropium in COPD
    • D.W. Perng, C.W. Tao, K.C. Su, C.C. Tsai, L.Y. Liu, and Y.C. Lee Anti-inflammatory effects of salmeterol/fluticasone, tiotropium/fluticasone or tiotropium in COPD Eur Respir J 33 2009 778 784
    • (2009) Eur Respir J , vol.33 , pp. 778-784
    • Perng, D.W.1    Tao, C.W.2    Su, K.C.3    Tsai, C.C.4    Liu, L.Y.5    Lee, Y.C.6
  • 81
    • 37849014833 scopus 로고    scopus 로고
    • Effect of tiotropium on sputum and serum inflammatory markers and exacerbations in COPD
    • D.J. Powrie, T.M. Wilkinson, G.C. Donaldson, P. Jones, K. Scrine, and K. Viel Effect of tiotropium on sputum and serum inflammatory markers and exacerbations in COPD Eur Respir J 30 2007 472 478
    • (2007) Eur Respir J , vol.30 , pp. 472-478
    • Powrie, D.J.1    Wilkinson, T.M.2    Donaldson, G.C.3    Jones, P.4    Scrine, K.5    Viel, K.6
  • 82
    • 26944437890 scopus 로고    scopus 로고
    • Muscarinic receptors, leukotriene B4 production and neutrophilic inflammation in COPD patients
    • M. Profita, R.D. Giorgi, A. Sala, A. Bonanno, L. Riccobono, and F. Mirabella Muscarinic receptors, leukotriene B4 production and neutrophilic inflammation in COPD patients Allergy 60 2005 1361 1369
    • (2005) Allergy , vol.60 , pp. 1361-1369
    • Profita, M.1    Giorgi, R.D.2    Sala, A.3    Bonanno, A.4    Riccobono, L.5    Mirabella, F.6
  • 83
    • 39149132101 scopus 로고    scopus 로고
    • Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism
    • M. Profita, A. Bonanno, L. Siena, M. Ferraro, A.M. Montalbano, and F. Pompeo Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism Eur J Pharmacol 582 2008 145 153
    • (2008) Eur J Pharmacol , vol.582 , pp. 145-153
    • Profita, M.1    Bonanno, A.2    Siena, L.3    Ferraro, M.4    Montalbano, A.M.5    Pompeo, F.6
  • 85
    • 79959346315 scopus 로고    scopus 로고
    • Cigarette smoke extract activates human bronchial epithelial cells affecting non-neuronal cholinergic system signalling in vitro
    • M. Profita, A. Bonanno, A.M. Montalbano, M. Ferraro, L. Siena, and A. Bruno Cigarette smoke extract activates human bronchial epithelial cells affecting non-neuronal cholinergic system signalling in vitro Life Sci 89 2011 36 43
    • (2011) Life Sci , vol.89 , pp. 36-43
    • Profita, M.1    Bonanno, A.2    Montalbano, A.M.3    Ferraro, M.4    Siena, L.5    Bruno, A.6
  • 86
    • 2042443069 scopus 로고    scopus 로고
    • Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells
    • B.J. Proskocil, H.S. Sekhon, Y. Jia, V. Savchenko, R.D. Blakely, and J. Lindstrom Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells Endocrinology 145 2004 2498 2506
    • (2004) Endocrinology , vol.145 , pp. 2498-2506
    • Proskocil, B.J.1    Sekhon, H.S.2    Jia, Y.3    Savchenko, V.4    Blakely, R.D.5    Lindstrom, J.6
  • 87
    • 3042525451 scopus 로고    scopus 로고
    • The airway cholinergic system: Physiology and pharmacology
    • K. Racke, and S. Matthiesen The airway cholinergic system: physiology and pharmacology Pulm Pharmacol Ther 17 2004 181 198
    • (2004) Pulm Pharmacol Ther , vol.17 , pp. 181-198
    • Racke, K.1    Matthiesen, S.2
  • 89
    • 0029793984 scopus 로고    scopus 로고
    • On muscarinic control of neurogenic mucus secretion in ferret trachea
    • S.I. Ramnarine, E.B. Haddad, A.M. Khawaja, J.C. Mak, and D.F. Rogers On muscarinic control of neurogenic mucus secretion in ferret trachea J Physiol 494 Pt 2 1996 577 586
    • (1996) J Physiol , vol.494 , Issue.PART 2 , pp. 577-586
    • Ramnarine, S.I.1    Haddad, E.B.2    Khawaja, A.M.3    Mak, J.C.4    Rogers, D.F.5
  • 91
    • 0035126934 scopus 로고    scopus 로고
    • Motor control of airway goblet cells and glands
    • D.F. Rogers Motor control of airway goblet cells and glands Respir Physiol 125 2001 129 144
    • (2001) Respir Physiol , vol.125 , pp. 129-144
    • Rogers, D.F.1
  • 92
    • 2342523999 scopus 로고    scopus 로고
    • Airway mucus hypersecretion in asthma: An undervalued pathology?
    • D.F. Rogers Airway mucus hypersecretion in asthma: an undervalued pathology? Curr Opin Pharmacol 4 2004 241 250
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 241-250
    • Rogers, D.F.1
  • 93
    • 66149103723 scopus 로고    scopus 로고
    • Cholinergic control of inflammation
    • M. Rosas-Ballina, and K.J. Tracey Cholinergic control of inflammation J Intern Med 265 2009 663 679
    • (2009) J Intern Med , vol.265 , pp. 663-679
    • Rosas-Ballina, M.1    Tracey, K.J.2
  • 94
    • 0031778288 scopus 로고    scopus 로고
    • Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity
    • E. Sato, S. Koyama, Y. Okubo, K. Kubo, and M. Sekiguchi Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity Am J Physiol 274 1998 L970 L979
    • (1998) Am J Physiol , vol.274
    • Sato, E.1    Koyama, S.2    Okubo, Y.3    Kubo, K.4    Sekiguchi, M.5
  • 95
    • 0037879081 scopus 로고    scopus 로고
    • Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses
    • D. Tashkin, and S. Kesten Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses Chest 123 2003 1441 1449
    • (2003) Chest , vol.123 , pp. 1441-1449
    • Tashkin, D.1    Kesten, S.2
  • 97
    • 0028986478 scopus 로고
    • Dysfunction of muscarinic M2 receptors after the early allergic reaction: Possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs
    • R.E. ten Berge, R.E. Santing, J.J. Hamstra, A.F. Roffel, and J. Zaagsma Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs Br J Pharmacol 114 1995 881 887
    • (1995) Br J Pharmacol , vol.114 , pp. 881-887
    • Ten Berge, R.E.1    Santing, R.E.2    Hamstra, J.J.3    Roffel, A.F.4    Zaagsma, J.5
  • 98
    • 84886801619 scopus 로고    scopus 로고
    • Noncontractile functions of airway smooth muscle cells in asthma
    • O. Tliba, and R.A. Panettieri Jr. Noncontractile functions of airway smooth muscle cells in asthma Annu Rev Physiol 2008
    • (2008) Annu Rev Physiol
    • Tliba, O.1    Panettieri, Jr.R.A.2
  • 99
  • 100
    • 79951951764 scopus 로고    scopus 로고
    • Inhibition of granulocyte migration by tiotropium bromide
    • G. Vacca, W.J. Randerath, and A. Gillissen Inhibition of granulocyte migration by tiotropium bromide Respir Res 12 2011 24
    • (2011) Respir Res , vol.12 , pp. 24
    • Vacca, G.1    Randerath, W.J.2    Gillissen, A.3
  • 101
    • 77956687583 scopus 로고    scopus 로고
    • Does tiotropium lower exacerbation and hospitalization frequency in COPD patients: Results of a meta-analysis
    • B.A. Van Den, J. Gailly, and M. Neyt Does tiotropium lower exacerbation and hospitalization frequency in COPD patients: results of a meta-analysis BMC Pulm Med 10 2010 50
    • (2010) BMC Pulm Med , vol.10 , pp. 50
    • Van Den, B.A.1    Gailly, J.2    Neyt, M.3
  • 102
    • 55749112997 scopus 로고    scopus 로고
    • Formoterol mono- and combination therapy with tiotropium in patients with COPD: A 6-month study
    • C. Vogelmeier, P. Kardos, S. Harari, S.J. Gans, S. Stenglein, and J. Thirlwell Formoterol mono- and combination therapy with tiotropium in patients with COPD: a 6-month study Respir Med 102 2008 1511 1520
    • (2008) Respir Med , vol.102 , pp. 1511-1520
    • Vogelmeier, C.1    Kardos, P.2    Harari, S.3    Gans, S.J.4    Stenglein, S.5    Thirlwell, J.6
  • 103
    • 34548362105 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors: Mutant mice provide new insights for drug development
    • J. Wess, R.M. Eglen, and D. Gautam Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development Nat Rev Drug Discov 6 2007 721 733
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 721-733
    • Wess, J.1    Eglen, R.M.2    Gautam, D.3
  • 104
    • 49449094458 scopus 로고    scopus 로고
    • Acetylcholine beyond neurons: The non-neuronal cholinergic system in humans
    • I. Wessler, and C.J. Kirkpatrick Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans Br J Pharmacol 154 2008 1558 1571
    • (2008) Br J Pharmacol , vol.154 , pp. 1558-1571
    • Wessler, I.1    Kirkpatrick, C.J.2
  • 106
    • 77953123408 scopus 로고    scopus 로고
    • Tiotropium bromide exerts anti-inflammatory activity in a cigarette smoke mouse model of COPD
    • L. Wollin, and M.P. Pieper Tiotropium bromide exerts anti-inflammatory activity in a cigarette smoke mouse model of COPD Pulm Pharmacol Ther 23 2010 345 354
    • (2010) Pulm Pharmacol Ther , vol.23 , pp. 345-354
    • Wollin, L.1    Pieper, M.P.2
  • 107
    • 73649091049 scopus 로고    scopus 로고
    • Anti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats
    • W. Zhang, L. Fievez, E. Cheu, F. Bureau, W. Rong, and F. Zhang Anti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats Eur J Pharmacol 628 2010 171 178
    • (2010) Eur J Pharmacol , vol.628 , pp. 171-178
    • Zhang, W.1    Fievez, L.2    Cheu, E.3    Bureau, F.4    Rong, W.5    Zhang, F.6
  • 108
    • 24344471377 scopus 로고    scopus 로고
    • 4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy
    • L. Zhou, A.M. Goldsmith, J.K. Bentley, Y. Jia, M.L. Rodriguez, and M.K. Abe 4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy Am J Respir Cell Mol Biol 33 2005 195 202
    • (2005) Am J Respir Cell Mol Biol , vol.33 , pp. 195-202
    • Zhou, L.1    Goldsmith, A.M.2    Bentley, J.K.3    Jia, Y.4    Rodriguez, M.L.5    Abe, M.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.