Inhibition of glycogen synthase kinase-3βis sufficient for airway smooth muscle hypertrophy

Journal of Biological Chemistry

Volumn 283, Issue 15, 2008, Pages 10198-10207

  Deng, Huan ^a   Dokshin, Gregoriy A ^a   Lei, Jing ^a   Goldsmith, Adam M ^a   Bitar, Khalil N ^a   Fingar, Diane C ^a   Hershenson, Marc B ^a,b,c   Bentley, J Kelley ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; ELECTRIC INSTRUMENT TRANSFORMERS; ENZYME INHIBITION; ENZYMES; NUCLEIC ACIDS; PATHOLOGY; RNA;

AIRWAY SMOOTH MUSCLES; CARDIOTROPHIN; CELL SIZES; CONSTITUTIVELY ACTIVES; CYTOKINE; EUKARYOTIC TRANSLATION INITIATIONS; GLYCOGEN SYNTHASE KINASES; IN VITRO; IN-VIVO; MRNA EXPRESSIONS; MYOCYTES; MYOSIN LIGHT CHAIN KINASES; NUCLEAR FACTORS; OVALBUMIN; PROTEIN SYNTHESES; RESPONSE FACTORS; RETROVIRAL VECTORS; SMALL INTERFERING RNAS; SMOOTH MUSCLE ACTINS; SMOOTH MUSCLE CELLS; SMOOTH MUSCLES; STRUCTURAL CHANGES; T CELLS; TRANSACTIVATION; TRANSFORMING GROWTH FACTORS; TRANSLATIONAL CONTROLS;

MUSCLE;

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; ALPHA ACTIN; ALPHA SMOOTH MUSCLE ACTIN; CARDIOTROPHIN 1; GLYCOGEN SYNTHASE KINASE 3BETA; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR EPSILON; LITHIUM CHLORIDE; MESSENGER RNA; MYOSIN HEAVY CHAIN; MYOSIN LIGHT CHAIN KINASE; RETROVIRUS VECTOR; SERUM RESPONSE FACTOR; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSGELIN; UNCLASSIFIED DRUG; CYTOKINE; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INDOLE DERIVATIVE; MALEIMIDE DERIVATIVE; MUSCLE PROTEIN;

ARTICLE; ASTHMA; BRONCHUS MUSCLE; CELL ISOLATION; CELL SIZE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MUSCLE CELL; MUSCLE HYPERTROPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SMOOTH MUSCLE FIBER; T LYMPHOCYTE ACTIVATION; ANIMAL; BRONCHUS; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; ETHNOLOGY; GENETICS; HYPERTROPHY; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE;

EUKARYOTA; MUS;

ANIMALS; ASTHMA; BRONCHI; CYTOKINES; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-2B; GLYCOGEN SYNTHASE KINASE 3; HUMANS; HYPERTROPHY; INDOLES; LITHIUM CHLORIDE; MALEIMIDES; MICE; MUSCLE PROTEINS; MUSCLE, SMOOTH; PROTEIN BIOSYNTHESIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 44349190984     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800624200     Document Type: Article

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