Matrix metalloproteinases in lung biology

Respiratory Research

Volumn 2, Issue 1, 2001, Pages 10-19

  Parks, William C ^a   Shapiro, Steven D ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cystic fibrosis; Emphysema; Epithelium; Innate defense; Wound repair

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; PROTEINASE; SCLEROPROTEIN; STROMELYSIN; STROMELYSIN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRANCHING MORPHOGENESIS; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME SUBSTRATE; GENE OVEREXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG DEVELOPMENT; LUNG DISEASE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PNEUMONIA; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN METABOLISM; REVIEW; TISSUE INJURY; TISSUE REPAIR;

ANIMALS; HUMANS; LUNG; MATRIX METALLOPROTEINASE 12; MATRIX METALLOPROTEINASE 7; MATRIX METALLOPROTEINASES; METALLOENDOPEPTIDASES; SUBSTRATE SPECIFICITY;

EID: 0035722954     PISSN: 14659921     EISSN: None     Source Type: Journal    
DOI: 10.1186/rr33     Document Type: Review

References (71)

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2. Matrix metalloproteinases
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4. Matrilysin
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6. Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity
7. Cloning of MMP-26. A novel matrilysin-like proteinase
8. Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidylinositol (GPI)-anchored MMP
9. Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase
10. CA-MMP: A matrix metalloproteinase with a novel cysteine array, but without the classic cystein switch
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13. Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP
14. Leukolysin/MMP25/MT6-MMP: A novel matrix metalloproteinase specifically expressed in the leukocyte lineage
15. A pilot study of the safety and effects of the matrix metalloproteinase inhibitor marimastat in gastric cancer
16. Marimastat (BB2516): Current status of development
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19. Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense
20. Matrilysin is much more efficient than other metalloproteinases in the proteolytic inactivation of α-1 antitrypsin
21. Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3
22. The serpin α1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo
23. Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption
24. Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1
25. Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site
26. Processing of tumour necrosis factor-alpha precursor by metalloproteinases
27. Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor
28. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
29. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3
30. Studies on the ability of 65-kDa and 92-kDa tumor cell gelatinases to degrade type IV collagen
31. Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme
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33. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3
34. Heparan sulfate proteoglycans as extracellular docking molecules for matrilysin (matrix metalloproteinase 7)
35. TIMP-2 is required for efficient activation of proMMP-2 in vivo
36. Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2 (TIMP-2) gene alters proMMP-2 activation
37. Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing
38. The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix
39. Matrilysin expression and function in airway epithelium
40. Bacterial exposure induces and activates matrilysin in mucosal epithelial cells
41. Immunology: Defensins and host defense
42. Matrilysin (PUMP) correlates with dermal invasion during appendageal development and cutaneous neoplasia
43. The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse
44. Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells
45. Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin
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47. Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon
48. Spatial distribution of collagen and elastin fibers in the lungs
49. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema
50. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema
51. Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema
52. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema
53. Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice
54. Requirement for macrophage elastase for cigarette smoke-induced emphysema
55. Chemotactic activity of elastin-derived peptides
56. Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice
57. Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
58. Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction
59. Impaired wound contraction in stromelysin-1-deficient mice
60. Matrix metalloproteinase deficiencies affect contact hypersensitivity: Stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response
61. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin
62. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
63. Neutrophil emigration in the lungs, peritoneum, and skin does not require gelatinase B
64. Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid
65. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms
66. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure
67. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
68. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
69. In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy
70. Accelerated neointima formation after vascular injury in mice with stromelysin-3 (MMP-11) gene inactivation
71. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover