Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes

Oncology Reports

Volumn 29, Issue 2, 2013, Pages 613-618

  Chueh, Fu Shin ^a   Chen, Yung Liang ^b   Hsu, Shu Chun ^c   Yang, Jai Sing ^c   Hsueh, Shu Ching ^d   Ji, Bin Chuan ^e   Lu, Hsu Feng ^d,f   Chung, Jing Gung ^a,c  

^a ASIA UNIVERSITY   (Taiwan)

^b YUANPEI UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHENG HSIN GENERAL HOSPITAL   (Taiwan)

^e CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^f FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

A375. S2 cells; Comet assay; DNA damage; DNA repair; Triptolide

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ATM PROTEIN; ATR PROTEIN; BRCA1 PROTEIN; DNA; DNA DEPENDENT PROTEIN SERINE THREONINE KINASE; MESSENGER RNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN SERINE THREONINE KINASE; TRIPTOLIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN A375.S2; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONDENSATION; DNA DAMAGE; DNA REPAIR; DNA TRANSFER; ELECTROPHORESIS; FLOW CYTOMETRY; GEL ELECTROPHORESIS; GENE EXPRESSION REGULATION; GENETIC PARAMETERS; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MELANOMA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SINGLE CELL ELECTROPHORESIS; STAINING;

ANTINEOPLASTIC AGENTS, ALKYLATING; BRCA1 PROTEIN; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; COMET ASSAY; DITERPENES; DNA DAMAGE; DNA MODIFICATION METHYLASES; DNA REPAIR; DNA REPAIR ENZYMES; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; DOWN-REGULATION; EPOXY COMPOUNDS; GENE EXPRESSION; HUMANS; MELANOMA; PHENANTHRENES; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84872777084     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.2170     Document Type: Article

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