Safrole induces G 0/G 1 phase arrest via inhibition of cyclin E and provokes apoptosis through endoplasmic reticulum stress and mitochondrion-dependent pathways in human leukemia HL-60 cells

Anticancer Research

Volumn 32, Issue 5, 2012, Pages 1671-1680

  Yu, Chun Shu ^a   Huang, An Cheng ^b   Yang, Jai Sing ^a   Yu, Chien Chih ^a   Lin, Chin Chung ^c,d   Chung, Hsiung Kwang ^a,e   Huang, Yi Ping ^a   Chueh, Fu Shin ^f   Chung, Jing Gung ^a,f  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b St Mary's Medicine Nursing and Management College   (Taiwan)

^c FENG YUAN HOSPITAL   (Taiwan)

^d Hung Kung University   (Taiwan)

^e CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f ASIA UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; ER stress; HSC 3 cells; Human leukemia HL 60 cells; Mitochondria; Safrole

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ACTIVATING TRANSCRIPTION FACTOR 6; APOPTOSIS INDUCING FACTOR; CALCIUM; CYCLIN E; ENDONUCLEASE G; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SAFROLE; DDIT3 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRUCTURE; CELL VIABILITY; CHROMATIN CONDENSATION; COMET ASSAY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; CELL CYCLE CHECKPOINT; CELL STRAIN HL 60; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; MOUSE; PHYSIOLOGY;

ANIMALS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; CALCIUM; CELL CYCLE CHECKPOINTS; CYCLIN E; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; G0 PHASE; G1 PHASE; HL-60 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; SAFROLE; TRANSCRIPTION FACTOR CHOP;

EID: 84861516008     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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