Triptolide inhibits cyclooxygenase-2 and inducible nitric oxide synthase expression in human colon cancer and leukemia cells

Acta Biochimica et Biophysica Sinica

Volumn 39, Issue 2, 2007, Pages 89-95

  Tong, Xiangmin ^a   Zheng, Shui'er ^a   Jin, Jie ^a   Zhu, Lifen ^a   Lou, Yinjun ^a   Yao, Hangping ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Colon cancer; Cyclooxygenase 2; Inducible nitric oxide synthase; Leukemia; Triptolide

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DITERPENE; EPOXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; PHENANTHRENE DERIVATIVE; PRIMER DNA; TRIPTOLIDE;

ARTICLE; CELL STRAIN K 562; CELL SURVIVAL; CHINA; CHINESE MEDICINE; COLON TUMOR; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; HUMAN; LEUKEMIA; NUCLEOTIDE SEQUENCE; TUMOR CELL LINE;

BASE SEQUENCE; CELL LINE, TUMOR; CELL SURVIVAL; CHINA; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DITERPENES; DNA PRIMERS; EPOXY COMPOUNDS; HUMANS; K562 CELLS; LEUKEMIA; MEDICINE, CHINESE TRADITIONAL; NITRIC OXIDE SYNTHASE TYPE II; PHENANTHRENES; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 33846949655     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1111/j.1745-7270.2007.00254.x     Document Type: Article

References (31)

1. Hseu YC, Wu FY, Wu JJ, Chen JY, Chang WH, Lu FJ, Lai YC et al. Anti-inflammatory potential of Antrodia camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-κB pathway. Int Immunopharmacol 2005, 5: 1914-1925
2. Chen CN, Hsieh FJ, Cheng YM, Chang KJ, Lee PH. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer. J Surg Oncol 2006, 94: 226-233
3. Cianchi F, Cortesini C, Fantappie O, Messerini L, Sardi I, Lasagna N, Perna F et al. Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. Clin Cancer Res 2004, 10: 2694-2704
4. Soo R, Putti T, Tao Q, Goh BC, Lee KH, Kwok-Seng L, Tan L et al. Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with epidermal growth factor receptor expression. Arch Otolaryngol Head Neck Surg 2005, 131: 147-152
5. Shin KM, Kim IT, Park YM, Ha J, Choi JW, Park HJ, Lee YS et al. Anti-inflammatory effect of caffeic acid methyl ester and its mode of action through the inhibition of prostaglandin E2, nitric oxide and tumor necrosis factor-α production. Biochem Pharmacol 2004, 68: 2327-2336
6. Yu JX, Cui L, Zhang QY, Chen H, Ji P, Wei HJ, Ma HY. Expression of NOS and HIF-1 in human colorectal carcinoma and implication in tumor angiogenesis. World J Gastroenterol 2006, 12: 4660-4664
7. Rao CV, Reddy BS, Steele VE, Wang CX, Liu X, Ouyang N, Patlolla JM et al. Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: Effects on molecular targets. Mol Cancer Ther 2006, 5: 1530-1538
8. Ekmekcioglu S, Ellerhorst JA, Prieto VG, Johnson MM, Broemeling LD, Grimm EA. Tumor iNOS predicts poor survival for stage III melanoma patients. Int J Cancer 2006, 119: 861-866
9. Chen BJ. Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F. Leuk Lymphoma 2001, 42: 253-265
10. Liu H, Liu ZH, Chen ZH, Yang JW, Li LS. Triptolide: A potent inhibitor of NF-κB in T-lymphocytes. Acta Pharmacol Sin 2000, 21: 782-786
11. Chan EW, Cheng SC, Sin FW, Xie Y. Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines. Toxicol Lett 2001, 122: 81-87
12. Wu Y, Cui J, Bao X, Chan S, Young DO, Liu D, Shen P. Triptolide attenuates oxidative stress, NF-κB activation and multiple cytokine gene expression in murine peritoneal macrophage. Int J Mol Med 2006, 17: 141-150
13. Lou YJ, Jin J. Triptolide down-regulates Bcr-abl expression and induces apoptosis in chronic myelogenous leukemia cells. Leuk Lymphoma 2004, 45: 373-376
14. Hu KB, Liu ZH, Liu D, Li LS. Inhibition of vascular endothelial growth factor expression and production by triptolide. Planta Med 2002, 68: 368-369
15. 2 and NO in TNF-α-stimulated synovial fibroblasts from rheumatoid arthritic patients. Eur J Med Res 2005, 10: 110-116
16. Ohshima H, Tazawa H, Sylla BS, Sawa T. Prevention of human cancer by modulation of chronic inflammatory processes. Mutat Res 2005, 591: 110-122.
17. Johnson FM, Yang P, Newman RA, Donato NJ. Cyclooxygenase-2 induction and prostaglandin E2 accumulation in squamous cell carcinoma as a consequence of epidermal growth factor receptor activation by imatinib mesylate. J Exp Ther Oncol 2004, 4: 317-325
18. Lala PK, Chakraborty C. Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol 2001, 2: 149-156
19. Ohta T, Takahashi M, Ochiai A. Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers. Cancer Lett 2006, 239: 246-253
20. Banerjee T, Van der Vliet A, Ziboh VA. Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line. Prostaglandins Leukot Essent Fatty Acids 2002, 66: 485-492
21. Min/+ mouse model of intestinal tumorigenesis. Carcinogenesis 2006, 27: 382-391
22. Brandao MM, Soares E, Salles TS, Saad ST. Expression of inducible nitric oxide synthase is increased in acute myeloid leukaemia. Acta Haematol 2001, 106: 95-99
23. Ichinoe M, Mikami T, Shiraishi H, Okayasu I. High microvascular density is correlated with high VEGF, iNOS and COX-2 expression in penetrating growth-type early gastric carcinomas. Histopathology 2004, 45: 612-618
24. Chen HH, Su WC, Chou CY, Guo HR, Ho SY, Que J, Lee WY. Increased expression of nitric oxide synthase and cyclooxygenase-2 is associated with poor survival in cervical cancer treated with radiotherapy. Int J Radiat Oncol Biol Phys 2005, 63: 1093-1100
25. Zetterberg E, Lundberg LG, Palmblad J. Expression of cox-2, tie-2 and glycodelin by megakaryocytes in patients with chronic myeloid leukaemia and polycythaemia vera. Br J Haematol 2003, 121: 497-499
26. Ozel E, Pestereli HE, Simsek T, Erdogan G, Karaveli FS. Expression of cyclooxygenase-2 and inducible nitric oxide synthase in ovarian surface epithelial carcinomas: Is there any correlation with angiogenesis or clinicopathologic parameters? Int J Gynecol Cancer 2006, 16: 549-555
27. Cianchi F, Cortesini C, Fantappie O, Messerini L, Sardi I, Lasagna N, Perna F et al. Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. Clin Cancer Res 2004, 10: 2694-2704
28. Yinjun L, Jie J, Yungui W. Triptolide inhibits transcription factor NF-κB and induces apoptosis of multiple myeloma cells. Leuk Res 2005, 29: 99-105
29. Kaur T, Khanduja KL, Kaushik T, Kaushik G, Gupta R, Gupta NM, Vaiphei K. P53, COX-2, iNOS protein expression changes and their relationship with anti-oxidant enzymes in surgically and multi-modality treated esophageal carcinoma patients. J Chemother 2006, 18: 74-84
30. Pyatt DW, Yang Y, Mehos B, Le A, Stillman W, Irons RD. Hematotoxicity of the Chinese herbal medicine Tripterygium wilfordii hook f in CD34-positive human bone marrow cells. Mol Pharmacol 2000, 57: 512-518
31. Xia ZL, Zhen YL. The pharmacological and clinical application of triptolide. Chinese Pharmacol Bull 1992, 6: 427-431